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Protein

60S ribosomal protein L7a

Gene

Rpl7a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to Thyroid stimulating hormone Source: RGD
  • maturation of LSU-rRNA Source: GO_Central
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7a
Gene namesi
Name:Rpl7a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1307586. Rpl7a.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: RGD
  • ribosome Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001367502 – 26660S ribosomal protein L7aAdd BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34N6-acetyllysineBy similarity1
Modified residuei97N6-acetyllysineBy similarity1
Modified residuei217N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP62425.
PRIDEiP62425.

PTM databases

iPTMnetiP62425.
PhosphoSitePlusiP62425.

Expressioni

Gene expression databases

BgeeiENSRNOG00000047737.

Interactioni

Subunit structurei

Interacts with CRY1 (By similarity). Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (By similarity).By similarity

Protein-protein interaction databases

IntActiP62425. 1 interactor.
MINTiMINT-4578549.
STRINGi10116.ENSRNOP00000063128.

Structurei

3D structure databases

ProteinModelPortaliP62425.
SMRiP62425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L7Ae family.Curated

Phylogenomic databases

eggNOGiKOG3166. Eukaryota.
COG1358. LUCA.
HOGENOMiHOG000216644.
HOVERGENiHBG002936.
InParanoidiP62425.
KOiK02936.
PhylomeDBiP62425.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR001921. Ribosomal_L7A/L8.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
IPR004037. Ribosomal_L7Ae_CS.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00881. L7ARS6FAMILY.
PR00882. RIBOSOMALL7A.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01082. RIBOSOMAL_L7AE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD
60 70 80 90 100
LTRFVKWPRY IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH
110 120 130 140 150
KYRPETKQEK KQRLLARAEK KAAGKGDVPT KRPPVLRAGV NTVTTLVENK
160 170 180 190 200
KAQLVVIAHD VDPIELVVFL PALCRKMGVP YCIIKGKARL GRLVHRKTCT
210 220 230 240 250
TVAFTQVNSE DKGALAKLVE AIRTNYNDRY DEIRRHWGGN VLGPKSVARI
260
AKLEKAKAKE LATKLG
Length:266
Mass (Da):29,996
Last modified:January 23, 2007 - v2
Checksum:i54EF43F221D9F704
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33E → Q AA sequence (PubMed:398910).Curated1
Sequence conflicti35R → S AA sequence (PubMed:398910).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15013 mRNA. Translation: CAA33117.1.
PIRiS04712. R5RT7A.
RefSeqiNP_001107863.1. NM_001114391.1.
UniGeneiRn.144857.

Genome annotation databases

GeneIDi296596.
KEGGirno:296596.
UCSCiRGD:1307586. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15013 mRNA. Translation: CAA33117.1.
PIRiS04712. R5RT7A.
RefSeqiNP_001107863.1. NM_001114391.1.
UniGeneiRn.144857.

3D structure databases

ProteinModelPortaliP62425.
SMRiP62425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP62425. 1 interactor.
MINTiMINT-4578549.
STRINGi10116.ENSRNOP00000063128.

PTM databases

iPTMnetiP62425.
PhosphoSitePlusiP62425.

Proteomic databases

PaxDbiP62425.
PRIDEiP62425.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi296596.
KEGGirno:296596.
UCSCiRGD:1307586. rat.

Organism-specific databases

CTDi6130.
RGDi1307586. Rpl7a.

Phylogenomic databases

eggNOGiKOG3166. Eukaryota.
COG1358. LUCA.
HOGENOMiHOG000216644.
HOVERGENiHBG002936.
InParanoidiP62425.
KOiK02936.
PhylomeDBiP62425.

Miscellaneous databases

PROiP62425.

Gene expression databases

BgeeiENSRNOG00000047737.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR001921. Ribosomal_L7A/L8.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
IPR004037. Ribosomal_L7Ae_CS.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00881. L7ARS6FAMILY.
PR00882. RIBOSOMALL7A.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01082. RIBOSOMAL_L7AE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL7A_RAT
AccessioniPrimary (citable) accession number: P62425
Secondary accession number(s): P11518
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.