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P62423 (PGK_METMP) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:MMP1532
OrganismMethanococcus maripaludis (strain S2 / LL) [Complete proteome] [HAMAP]
Taxonomic identifier267377 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Sequence caution

The sequence CAF31088.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000146061

Regions

Nucleotide binding364 – 3674ATP By similarity
Region20 – 223Substrate binding By similarity
Region60 – 634Substrate binding By similarity

Sites

Binding site371Substrate By similarity
Binding site1171Substrate By similarity
Binding site1641Substrate By similarity
Binding site3381ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P62423 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: C53F5B915B72E0D6

FASTA41445,329
        10         20         30         40         50         60 
MFLTLDDFEL EGKTVALRVD INSPIDVNTG DILDDTRIKA CSDTIKSLSE KGAKVVILAH 

        70         80         90        100        110        120 
QSRPGKKDFT TLEAHAKKLS EVLNMEVTHV DGLICASARE AILAMDNGEI ILLENVRLLA 

       130        140        150        160        170        180 
EEVLSDWKSW EEITPEKQAK TVMIKKLHPF FDYFVNDAFA AAHRAQPSLV GFSYYVPMLC 

       190        200        210        220        230        240 
GRVMEKELFT LTKVLKNPER PCVFALGGAK ADDSIEVLKN VLEKQTADQV LTSGVVANIF 

       250        260        270        280        290        300 
LVAKGYKIGP NENVIADMGY TNQIEIAKEL ISKYGDKIVV PIDAALNVDG ERVEKELDLN 

       310        320        330        340        350        360 
EEITYPIHDM GEKTMKLYEE ILKDAKTVVA NGPAGVFENK NFLKGTEELL KSTANSKGFS 

       370        380        390        400        410 
VIGGGHLSAA AEVVGLAGKM DHISTGGGAC IEFLAGKKLP VIEMLSKSYE KHKL 

« Hide

References

[1]"Complete genome sequence of the genetically tractable hydrogenotrophic methanogen Methanococcus maripaludis."
Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J., Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M., Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A., Moore B.C. expand/collapse author list , Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D., Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W., Olson M.V., Leigh J.A.
J. Bacteriol. 186:6956-6969(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: S2 / LL.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX950229 Genomic DNA. Translation: CAF31088.1. Different initiation.
RefSeqNP_988652.1. NC_005791.1.

3D structure databases

ProteinModelPortalP62423.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING267377.MMP1532.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAF31088; CAF31088; MMP1532.
GeneID2762605.
KEGGmmp:MMP1532.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227108.
KOK00927.
OMAAGHPVGK.

Enzyme and pathway databases

BioCycMMAR267377:GJ77-1571-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGK_METMP
AccessionPrimary (citable) accession number: P62423
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways