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P62421

- PGK_TREDE

UniProt

P62421 - PGK_TREDE

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351SubstrateUniRule annotation
    Binding sitei136 – 1361SubstrateUniRule annotation
    Binding sitei173 – 1731SubstrateUniRule annotation
    Binding sitei224 – 2241ATPUniRule annotation
    Binding sitei315 – 3151ATP; via carbonyl oxygenUniRule annotation
    Binding sitei346 – 3461ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi375 – 3784ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTDEN243275:GJ7G-1744-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:TDE_1715
    OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
    Taxonomic identifieri243275 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000008212: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 419419Phosphoglycerate kinasePRO_0000146029Add
    BLAST

    Proteomic databases

    PRIDEiP62421.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243275.TDE1715.

    Structurei

    3D structure databases

    ProteinModelPortaliP62421.
    SMRiP62421. Positions 3-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 223Substrate bindingUniRule annotation
    Regioni59 – 624Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    KOiK00927.
    OMAiFNVPLRE.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P62421-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKTVKDVNL KDKRIIMRVD FNVPMKDGVV QDDTRIRAAL PTIKYILEQG    50
    ARSLVLMSHL GDPSKDAKKA KEKAEKDGKP FDEEAYINGK HRMKPVAEYL 100
    SGLLKLPVDF APSCMGQLER VKALPQGGIL MLENTRFHKE ETSKEKAEQQ 150
    ILAKELSLYG DIYVNDAFGT AHRSHASTAE IANFVNTRVA GFLMEKEIKY 200
    LEPMLNNPAK PMTAIIGGAK VSSKIAVLES LLKNASSLII GGGMAYTFLK 250
    VQGKKIGKSL FEEDFMDTAK NLLDKAEKQG VKIILPVDHI CSETFSPNAE 300
    AVLVESTDIP DNLMGMDVGP KTLALYKEII LSSKSIVWNG PVGVFEFEAF 350
    SKGTEETARL VAAATEKGAL TIVGGGDSVA AVNKFNLADK MSHVSTGGGA 400
    SLEFLEGKVL PGIACLDTI 419
    Length:419
    Mass (Da):45,463
    Last modified:July 5, 2004 - v1
    Checksum:i8C0D9AE16A9BE6DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS12230.1.
    RefSeqiNP_972319.1. NC_002967.9.

    Genome annotation databases

    EnsemblBacteriaiAAS12230; AAS12230; TDE_1715.
    GeneIDi2740887.
    KEGGitde:TDE1715.
    PATRICi20525590. VBITreDen445_1640.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS12230.1 .
    RefSeqi NP_972319.1. NC_002967.9.

    3D structure databases

    ProteinModelPortali P62421.
    SMRi P62421. Positions 3-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243275.TDE1715.

    Proteomic databases

    PRIDEi P62421.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS12230 ; AAS12230 ; TDE_1715 .
    GeneIDi 2740887.
    KEGGi tde:TDE1715.
    PATRICi 20525590. VBITreDen445_1640.

    Phylogenomic databases

    eggNOGi COG0126.
    KOi K00927.
    OMAi FNVPLRE.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci TDEN243275:GJ7G-1744-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35405 / CIP 103919 / DSM 14222.

    Entry informationi

    Entry nameiPGK_TREDE
    AccessioniPrimary (citable) accession number: P62421
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3