Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P62421 (PGK_TREDE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:TDE_1715
OrganismTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP]
Taxonomic identifier243275 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 419419Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000146029

Regions

Nucleotide binding375 – 3784ATP By similarity
Region20 – 223Substrate binding By similarity
Region59 – 624Substrate binding By similarity

Sites

Binding site351Substrate By similarity
Binding site1361Substrate By similarity
Binding site1731Substrate By similarity
Binding site2241ATP By similarity
Binding site3151ATP; via carbonyl oxygen By similarity
Binding site3461ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P62421 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 8C0D9AE16A9BE6DD

FASTA41945,463
        10         20         30         40         50         60 
MIKTVKDVNL KDKRIIMRVD FNVPMKDGVV QDDTRIRAAL PTIKYILEQG ARSLVLMSHL 

        70         80         90        100        110        120 
GDPSKDAKKA KEKAEKDGKP FDEEAYINGK HRMKPVAEYL SGLLKLPVDF APSCMGQLER 

       130        140        150        160        170        180 
VKALPQGGIL MLENTRFHKE ETSKEKAEQQ ILAKELSLYG DIYVNDAFGT AHRSHASTAE 

       190        200        210        220        230        240 
IANFVNTRVA GFLMEKEIKY LEPMLNNPAK PMTAIIGGAK VSSKIAVLES LLKNASSLII 

       250        260        270        280        290        300 
GGGMAYTFLK VQGKKIGKSL FEEDFMDTAK NLLDKAEKQG VKIILPVDHI CSETFSPNAE 

       310        320        330        340        350        360 
AVLVESTDIP DNLMGMDVGP KTLALYKEII LSSKSIVWNG PVGVFEFEAF SKGTEETARL 

       370        380        390        400        410 
VAAATEKGAL TIVGGGDSVA AVNKFNLADK MSHVSTGGGA SLEFLEGKVL PGIACLDTI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017226 Genomic DNA. Translation: AAS12230.1.
RefSeqNP_972319.1. NC_002967.9.

3D structure databases

ProteinModelPortalP62421.
SMRP62421. Positions 3-418.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243275.TDE1715.

Proteomic databases

PRIDEP62421.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS12230; AAS12230; TDE_1715.
GeneID2740887.
KEGGtde:TDE1715.
PATRIC20525590. VBITreDen445_1640.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
OMAFNVPLRE.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycTDEN243275:GJ7G-1744-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGK_TREDE
AccessionPrimary (citable) accession number: P62421
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways