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P62420 (PGK_THET2) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:TT_C0550
OrganismThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]
Taxonomic identifier262724 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 390389Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000146026

Regions

Nucleotide binding347 – 3504ATP By similarity
Region19 – 213Substrate binding By similarity
Region57 – 604Substrate binding By similarity

Sites

Binding site341Substrate By similarity
Binding site1151Substrate By similarity
Binding site1481Substrate By similarity
Binding site1981ATP By similarity
Binding site2891ATP; via carbonyl oxygen By similarity
Binding site3201ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P62420 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: E446722D231B1FCB

FASTA39041,791
        10         20         30         40         50         60 
MRTLLDLDPK GKRVLVRVDY NVPVQDGKVQ DETRILESLP TLRHLLAGGA SLVLLSHLGR 

        70         80         90        100        110        120 
PKGPDPRYSL APVGEALRAH LPEARFAPFP PGSEEARREA EALRPGEVLL LENVRFEPGE 

       130        140        150        160        170        180 
EKNDPELSAR YARLGEAFVL DAFGSAHRAH ASVVGVARLL PAYAGFLMEK EVRALSRLLK 

       190        200        210        220        230        240 
DPERPYAVVL GGAKVSDKIG VIESLLPRID RLLIGGAMAF TFLKALGGEV GKSLVEEDRL 

       250        260        270        280        290        300 
DLAKDLLGRA EALGVRVYLP EDVVAAERIE AGVETRVFPA RAIPVPYMGL DIGPKTREAF 

       310        320        330        340        350        360 
ARALEGARTV FWNGPMGVFE VPPFDEGTLA VGRAIAALEG AFTVVGGGDS VAAVNRLGLK 

       370        380        390 
DRFGHVSTGG GASLEFLEKG TLPGLEVLEG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017221 Genomic DNA. Translation: AAS80898.1.
RefSeqYP_004525.1. NC_005835.1.

3D structure databases

ProteinModelPortalP62420.
SMRP62420. Positions 3-390.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262724.TTC0550.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS80898; AAS80898; TT_C0550.
GeneID2776450.
KEGGtth:TTC0550.
PATRIC23951505. VBITheThe54392_0549.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
OMATATACKK.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycTTHE262724:GCAT-562-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_THET2
AccessionPrimary (citable) accession number: P62420
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways