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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Photobacterium profundum (strain SS9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (PYKA), Pyruvate kinase (Y1944)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41SubstrateUniRule annotation1
Binding sitei118SubstrateUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Binding sitei202ATPUniRule annotation1
Binding sitei319ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi345 – 348ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:PBPRA3131
OrganismiPhotobacterium profundum (strain SS9)
Taxonomic identifieri298386 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaePhotobacterium
Proteomesi
  • UP000000593 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001459831 – 392Phosphoglycerate kinaseAdd BLAST392

Proteomic databases

PRIDEiP62418

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi298386.PBPRA3131

Structurei

3D structure databases

ProteinModelPortaliP62418
SMRiP62418
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 28Substrate bindingUniRule annotation3
Regioni64 – 67Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P62418-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGRTMSVIK MTDLELAGKR VFIRADLNVP VKDGKVTSDA RILASLPTIK
60 70 80 90 100
RCLEAGAKVM VTSHLGRPTE GEYNEEFSLA PVVNYLNDAL DCDVKLAKDY
110 120 130 140 150
LDGIELNAGE LVVLENVRFN KGEKKNDEAL SKKYAALCDI FVMDAFGTAH
160 170 180 190 200
RAQASTHGVG MNAAIACAGP LLANELEALG KAMDNPARPL VAIVGGSKVS
210 220 230 240 250
TKLTVLESLS KIADQLVVGG GIANTFIAAE GHNVGKSLYE ADLVETAKKL
260 270 280 290 300
MKDCAIPVAT DVACAKAFDE NAEAVIKHVS EVQDDDMIFD LGPDSTAVLA
310 320 330 340 350
EIISNAKTIL WNGPVGVFEF KNFEAGTAGI AKAIADSEGF SVAGGGDTLA
360 370 380 390
AIDKFGIKAD VSYISTGGGA FLEFVEGKVL PAVAMLEERA KA
Length:392
Mass (Da):41,269
Last modified:July 5, 2004 - v1
Checksum:i58F61FC3A6166189
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR378673 Genomic DNA Translation: CAG21446.1

Genome annotation databases

EnsemblBacteriaiCAG21446; CAG21446; PBPRA3131
KEGGippr:PBPRA3131

Similar proteinsi

Entry informationi

Entry nameiPGK_PHOPR
AccessioniPrimary (citable) accession number: P62418
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health