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P62416 (PGK_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:MAP_1165
OrganismMycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) [Complete proteome] [HAMAP]
Taxonomic identifier262316 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145969

Regions

Nucleotide binding363 – 3664ATP By similarity
Region24 – 263Substrate binding By similarity
Region66 – 694Substrate binding By similarity

Sites

Binding site431Substrate By similarity
Binding site1251Substrate By similarity
Binding site1651Substrate By similarity
Binding site2151ATP By similarity
Binding site3031ATP; via carbonyl oxygen By similarity
Binding site3341ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P62416 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: A66A383F0A73530B

FASTA41542,437
        10         20         30         40         50         60 
MAVHNLKDLL AEGVSGRGVL VRSDLNVPLD SDGEQGRITD PGRITASVPT LSALVEAGAK 

        70         80         90        100        110        120 
VVVAAHLGRP KNGPDPALSL APVAAALGEQ LGRHVQLASD VVGTDALARA EGLTDGDVLL 

       130        140        150        160        170        180 
LENIRFDARE TSKDDAERLA LARQLAELVG PTGAFVSDGF GVVHRKQASV YDVATLLPHY 

       190        200        210        220        230        240 
AGTLVAEEIA VLEQLTGSTK RPYAVVLGGS KVSDKLGVIE SLATKADSIV IGGGMCFTFL 

       250        260        270        280        290        300 
AAQGFSVGKS LLETEMVDTC RRLLDTYVDV LRLPVDIVAA DRFAADAAPQ TVPADAIPDD 

       310        320        330        340        350        360 
LMGLDIGPGS VKRFTALLSN AETIFWNGPM GVFEFPAFAA GTKGLAEAIA AATGKGAFSV 

       370        380        390        400        410 
VGGGDSAAAV RALGIPESGF SHISTGGGAS LEYLEGKALP GIEVLGRPQP TGGAA 

« Hide

References

[1]"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-968 / K-10.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE016958 Genomic DNA. Translation: AAS03482.1.
RefSeqNP_960099.1. NC_002944.2.

3D structure databases

ProteinModelPortalP62416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING262316.MAP1165.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS03482; AAS03482; MAP_1165.
GeneID2718074.
KEGGmpa:MAP1165.
PATRIC17994791. VBIMycAvi108102_1226.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
OMAHASVYDI.
OrthoDBEOG64N9Z0.

Enzyme and pathway databases

BioCycMAVI262316:GCQR-1185-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_MYCPA
AccessionPrimary (citable) accession number: P62416
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways