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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 (gpmA1), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 2 (gpmA2)
  4. Enolase 2 (eno2), Enolase 1 (eno1), Enolase 3 (eno3)
  5. Pyruvate kinase (LJ_1080)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei159SubstrateUniRule annotation1
Binding sitei214ATPUniRule annotation1
Binding sitei301ATP; via carbonyl oxygenUniRule annotation1
Binding sitei332ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi359 – 362ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLJOH257314:G1G0M-736-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:LJ_0873
OrganismiLactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Taxonomic identifieri257314 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000581 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001459541 – 403Phosphoglycerate kinaseAdd BLAST403

Proteomic databases

PRIDEiP62413

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi257314.LJ0873

Structurei

3D structure databases

ProteinModelPortaliP62413
SMRiP62413
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
KOiK00927
OMAiDMIFDIG

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 2 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P62413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLIVSDLD LKGKKVLVRV DFNVPIKNGV IGDDNRIVAA LPTIKYIIDH
60 70 80 90 100
GGKAILLSHL GRVKSDADKK ELSLRPVAER LSELLEKPVT FVPENEGKEV
110 120 130 140 150
EEAIDNMKDG DVVVLENTRF QDIDNDFGKR ESKNDPKLGE YWASLGDVFV
160 170 180 190 200
NDAFGTAHRS HASNVGIATA MKKAGKPAAA GYLLEKEIKF LGDAVENPVH
210 220 230 240 250
PFVTILGGAK VSDKIGVIEN LIPKSDHILI GGGMAYTFLA AQGHKIGKSL
260 270 280 290 300
FEADKVELAK SLLEKAGDKI VLPVDNVAAT EFSNDAPHEI VGDDIPDNEM
310 320 330 340 350
GLDIGPKTVE KFRDILKDAK TVVWNGPMGA FEMPNYAEGT LEVGRALADL
360 370 380 390 400
KDAVTIIGGG DSTAAAKQLG IAPKISHIST GGGASLNYLE GKELPGIACV

SDK
Length:403
Mass (Da):43,018
Last modified:July 5, 2004 - v1
Checksum:i1B2F3C5671BBAB71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017198 Genomic DNA Translation: AAS08694.1
RefSeqiWP_011161784.1, NC_005362.1

Genome annotation databases

EnsemblBacteriaiAAS08694; AAS08694; LJ_0873
KEGGiljo:LJ_0873
PATRICifig|257314.6.peg.730

Similar proteinsi

Entry informationi

Entry nameiPGK_LACJO
AccessioniPrimary (citable) accession number: P62413
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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