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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei113SubstrateUniRule annotation1
Binding sitei146SubstrateUniRule annotation1
Binding sitei197ATPUniRule annotation1
Binding sitei319ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi345 – 348ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDVUL882:G1GT1-2598-MONOMER
UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:DVU_2529
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / DSM 644 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002194 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001459401 – 393Phosphoglycerate kinaseAdd BLAST393

Proteomic databases

PaxDbiP62412

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi882.DVU2529

Structurei

3D structure databases

ProteinModelPortaliP62412
SMRiP62412
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN
PhylomeDBiP62412

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P62412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVIKMTDLD LKGKRVLLRE DLNVPLKEGR ITSDKRIRAA LPSIRMAMEA
60 70 80 90 100
GARVLIVSHL GRPVEGEFDE AFSLAPVAAH LSRELGRDVR LVKDYIDGVD
110 120 130 140 150
VAEGDCVLCE NVRFLKGEKK NTEELGRRLA ALCDIFVMDA FGAAHRAQAS
160 170 180 190 200
THAVARFAPV ACAGPLLAAE LDALERALDA PKHPLVGIIG GSKVSTKLTL
210 220 230 240 250
LDNLSHRVDR LIVGGGIANN FIKAAGYEVG KSLYEPELVE EAARLMAAAR
260 270 280 290 300
AAGGEIPVPL DVVVGPELAD GAPATVRKVS EVGPDEMILD IGPATATRYR
310 320 330 340 350
EILLAAGTIV WNGPVGAFEW EQFGAGTRAL CEAVADSPAF SIAGGGDTVA
360 370 380 390
AVEKYGVASR VGYISTGGGA FLEFLEGKEL PAVAILQERA AQS
Length:393
Mass (Da):41,450
Last modified:July 5, 2004 - v1
Checksum:iE8BE4C143010D6CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017285 Genomic DNA Translation: AAS97001.1
RefSeqiWP_010939799.1, NC_002937.3
YP_011741.1, NC_002937.3

Genome annotation databases

EnsemblBacteriaiAAS97001; AAS97001; DVU_2529
GeneIDi2795619
KEGGidvu:DVU2529
PATRICifig|882.5.peg.2287

Similar proteinsi

Entry informationi

Entry nameiPGK_DESVH
AccessioniPrimary (citable) accession number: P62412
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health