P62393 (HIS3_BACC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	BCE_1531

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021
Subcellular location	Cytoplasm By similarity HAMAP MF_01021.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 101	101	Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021		PRO_0000136459

Sequences

	Sequence		Length	Mass (Da)
	P62393 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 663626FCDD879390	FASTA	101	11,659
	10 20 30 40 50 60 MKPNFSKGLL PAVVIEEDTK EVLMLAYMNE EAYEKTIETK RTWFYSRSRR SLWNKGETSG 70 80 90 100 NVQHVQSLYL DCDQDSIVVV VKQVGPACHT GEKTCFHYKI I

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017194 Genomic DNA. Translation: AAS40460.1.
RefSeq	NP_977852.1. NC_003909.8.
3D structure databases
ProteinModelPortal	P62393.
ModBase	Search...
Protein-protein interaction databases
STRING	P62393.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000026218; EBBACP00000025568; EBBACG00000026209.
GeneID	2749763.
GenomeReviews	Gene locus BCE_1531 in contig AE017194_GR.
KEGG	bca:BCE_1531.
NMPDR	fig|222523.1.peg.1524.
PATRIC	18851906. VBIBacCer118379_1457.
TIGR	BCE_1531.
Phylogenomic databases
eggNOG	COG0139.
GeneTree	EBGT00050000000892.
HOGENOM	HBG294308.
OMA	GACHVGY.
ProtClustDB	PRK00051.
Enzyme and pathway databases
BioCyc	BCER405917:BCE_1531-MONOMER.
Family and domain databases
HAMAP	MF_01021. HisI. [Tree]
InterPro	IPR002496. PRib_AMP_CycHydrolase. [Graphical view]
KO	K01496.
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_BACC1

Accession

Primary (citable) accession number: P62393

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program