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P62386

- HIS3_DESVH

UniProt

P62386 - HIS3_DESVH

Protein

Phosphoribosyl-AMP cyclohydrolase

Gene

hisI

Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation
    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi76 – 761MagnesiumUniRule annotation
    Metal bindingi77 – 771Zinc; shared with dimeric partnerUniRule annotation
    Metal bindingi78 – 781MagnesiumUniRule annotation
    Metal bindingi80 – 801MagnesiumUniRule annotation
    Metal bindingi94 – 941Zinc; shared with dimeric partnerUniRule annotation
    Metal bindingi101 – 1011Zinc; shared with dimeric partnerUniRule annotation

    GO - Molecular functioni

    1. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciDVUL882:GJIL-121-MONOMER.
    UniPathwayiUPA00031; UER00008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
    Short name:
    PRA-CHUniRule annotation
    Gene namesi
    Name:hisIUniRule annotation
    Ordered Locus Names:DVU_0113
    OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
    Taxonomic identifieri882 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000002194: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 126126Phosphoribosyl-AMP cyclohydrolasePRO_0000136476Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi882.DVU0113.

    Structurei

    3D structure databases

    ProteinModelPortaliP62386.
    SMRiP62386. Positions 3-121.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PRA-CH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0139.
    KOiK01496.
    OMAiHEPGIAC.
    OrthoDBiEOG6PGKB6.
    PhylomeDBiP62386.

    Family and domain databases

    HAMAPiMF_01021. HisI.
    InterProiIPR026660. PRA-CH.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view]
    PfamiPF01502. PRA-CH. 1 hit.
    [Graphical view]
    ProDomiPD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P62386-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAFVPDFGK AGGLVPAIAQ DADTGEVLMM AWMNAEAFEM TLKTGEAHYF    50
    SRSRGRLWHK GGTSGHTQHI RAVRLDCDSD TILLLVEQRG GAACHEGYRS 100
    CFYREMKDGE VSICSPKVFD PKEVYK 126
    Length:126
    Mass (Da):13,991
    Last modified:July 5, 2004 - v1
    Checksum:iAD4F63840DC10E29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017285 Genomic DNA. Translation: AAS94597.1.
    RefSeqiYP_009338.1. NC_002937.3.

    Genome annotation databases

    EnsemblBacteriaiAAS94597; AAS94597; DVU_0113.
    GeneIDi2794982.
    KEGGidvu:DVU0113.
    PATRICi32060210. VBIDesVul119526_0111.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017285 Genomic DNA. Translation: AAS94597.1 .
    RefSeqi YP_009338.1. NC_002937.3.

    3D structure databases

    ProteinModelPortali P62386.
    SMRi P62386. Positions 3-121.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 882.DVU0113.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS94597 ; AAS94597 ; DVU_0113 .
    GeneIDi 2794982.
    KEGGi dvu:DVU0113.
    PATRICi 32060210. VBIDesVul119526_0111.

    Phylogenomic databases

    eggNOGi COG0139.
    KOi K01496.
    OMAi HEPGIAC.
    OrthoDBi EOG6PGKB6.
    PhylomeDBi P62386.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00008 .
    BioCyci DVUL882:GJIL-121-MONOMER.

    Family and domain databases

    HAMAPi MF_01021. HisI.
    InterProi IPR026660. PRA-CH.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view ]
    Pfami PF01502. PRA-CH. 1 hit.
    [Graphical view ]
    ProDomi PD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

    Entry informationi

    Entry nameiHIS3_DESVH
    AccessioniPrimary (citable) accession number: P62386
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3