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P62386

- HIS3_DESVH

UniProt

P62386 - HIS3_DESVH

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Protein

Phosphoribosyl-AMP cyclohydrolase

Gene
hisI, DVU_0113
Organism
Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP By similarity.

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.
Binds 1 zinc ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Magnesium By similarity
Metal bindingi77 – 771Zinc; shared with dimeric partner By similarity
Metal bindingi78 – 781Magnesium By similarity
Metal bindingi80 – 801Magnesium By similarity
Metal bindingi94 – 941Zinc; shared with dimeric partner By similarity
Metal bindingi101 – 1011Zinc; shared with dimeric partner By similarity

GO - Molecular functioni

  1. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciDVUL882:GJIL-121-MONOMER.
UniPathwayiUPA00031; UER00008.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosyl-AMP cyclohydrolase (EC:3.5.4.19)
Short name:
PRA-CH
Gene namesi
Name:hisI
Ordered Locus Names:DVU_0113
OrganismiDesulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
Taxonomic identifieri882 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002194: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 126126Phosphoribosyl-AMP cyclohydrolaseUniRule annotationPRO_0000136476Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi882.DVU0113.

Structurei

3D structure databases

ProteinModelPortaliP62386.
SMRiP62386. Positions 3-121.

Family & Domainsi

Sequence similaritiesi

Belongs to the PRA-CH family.

Phylogenomic databases

eggNOGiCOG0139.
KOiK01496.
OMAiHEPGIAC.
OrthoDBiEOG6PGKB6.
PhylomeDBiP62386.

Family and domain databases

HAMAPiMF_01021. HisI.
InterProiIPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view]
PfamiPF01502. PRA-CH. 1 hit.
[Graphical view]
ProDomiPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P62386-1 [UniParc]FASTAAdd to Basket

« Hide

MTAFVPDFGK AGGLVPAIAQ DADTGEVLMM AWMNAEAFEM TLKTGEAHYF    50
SRSRGRLWHK GGTSGHTQHI RAVRLDCDSD TILLLVEQRG GAACHEGYRS 100
CFYREMKDGE VSICSPKVFD PKEVYK 126
Length:126
Mass (Da):13,991
Last modified:July 5, 2004 - v1
Checksum:iAD4F63840DC10E29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS94597.1.
RefSeqiYP_009338.1. NC_002937.3.

Genome annotation databases

EnsemblBacteriaiAAS94597; AAS94597; DVU_0113.
GeneIDi2794982.
KEGGidvu:DVU0113.
PATRICi32060210. VBIDesVul119526_0111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017285 Genomic DNA. Translation: AAS94597.1 .
RefSeqi YP_009338.1. NC_002937.3.

3D structure databases

ProteinModelPortali P62386.
SMRi P62386. Positions 3-121.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 882.DVU0113.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS94597 ; AAS94597 ; DVU_0113 .
GeneIDi 2794982.
KEGGi dvu:DVU0113.
PATRICi 32060210. VBIDesVul119526_0111.

Phylogenomic databases

eggNOGi COG0139.
KOi K01496.
OMAi HEPGIAC.
OrthoDBi EOG6PGKB6.
PhylomeDBi P62386.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00008 .
BioCyci DVUL882:GJIL-121-MONOMER.

Family and domain databases

HAMAPi MF_01021. HisI.
InterProi IPR026660. PRA-CH.
IPR002496. PRib_AMP_CycHydrolase_dom.
[Graphical view ]
Pfami PF01502. PRA-CH. 1 hit.
[Graphical view ]
ProDomi PD002610. PRA_CycHdrlase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hildenborough / ATCC 29579 / NCIMB 8303.

Entry informationi

Entry nameiHIS3_DESVH
AccessioniPrimary (citable) accession number: P62386
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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