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P62381 (HIS1_THET2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP phosphoribosyltransferase
Short name=ATP-PRT
Short name=ATP-PRTase
EC=2.4.2.17
Gene names
Name:hisG
Ordered Locus Names:TT_C1866
OrganismThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]
Taxonomic identifier262724 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity By similarity. HAMAP MF_01018

Catalytic activity

1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01018

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. HAMAP MF_01018

Subunit structure

Heteromultimer composed of HisG and HisZ subunits By similarity.

Subcellular location

Cytoplasm By similarity HAMAP MF_01018.

Domain

Lacks the C-terminal regulatory region which is replaced by HisZ. HAMAP MF_01018

Sequence similarities

Belongs to the ATP phosphoribosyltransferase family. Short subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionGlycosyltransferase
Transferase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processhistidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP phosphoribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 206206ATP phosphoribosyltransferase HAMAP MF_01018
PRO_0000151945

Secondary structure

1 .................................... 206
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P62381 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: A9CC57D7E43069FE

FASTA20622,381
        10         20         30         40         50         60 
MRRFALTVAL PKGRMFREAY EVLKRAGLDL PEVEGERTLL HGKEGGVALL ELRNKDVPIY 

        70         80         90        100        110        120 
VDLGIAEIGV VGKDVLLDSG RDLFEPVDLG FGACRLSLIR RPGDTGPIRR VATKYPNFTA 

       130        140        150        160        170        180 
RLLKERGWAA DVVELSGNIE LAAVTGLADA VVDVVQTGAT LRAAGLVEVE VLAHSTARLV 

       190        200 
VNRQALKLKR AVLKPLIQRL RELSGS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE017221 Genomic DNA. Translation: AAS82208.1.
RefSeqYP_005835.1. NC_005835.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1VE4X-ray1.20A1-206[»]
ProteinModelPortalP62381.
SMRP62381. Positions 1-206.
ModBaseSearch...

Protein-protein interaction databases

STRINGP62381.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2775570.
GenomeReviewsGene locus TT_C1866 in contig AE017221_GR.
PATRIC23954203. VBITheThe54392_1865.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0040.
HOGENOMHBG391868.
OMAQVDIIKL.
PhylomeDBP62381.
ProtClustDBPRK01686.

Enzyme and pathway databases

BioCycTTHE262724:TT_C1866-MONOMER.

Family and domain databases

HAMAPMF_01018. HisG_Short.
[Tree]
InterProIPR013820. ATP_PRibTrfase_cat.
IPR018198. ATP_PRibTrfase_CS.
IPR001348. ATP_PRibTrfase_HisG.
IPR024893. ATP_PRibTrfase_HisG_short.
[Graphical view]
PANTHERPTHR21403. ATP_phspho_trans. 1 hit.
PfamPF01634. HisG. 1 hit.
[Graphical view]
TIGRFAMsTIGR00070. HisG. 1 hit.
PROSITEPS01316. ATP_P_PHORIBOSYLTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHIS1_THET2
AccessionPrimary (citable) accession number: P62381
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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