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P62380

- TBPL1_HUMAN

UniProt

P62380 - TBPL1_HUMAN

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Protein

TATA box-binding protein-like protein 1

Gene

TBPL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.4 Publications

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. acrosome assembly Source: Ensembl
  2. DNA-templated transcription, initiation Source: InterPro
  3. dTTP biosynthetic process Source: Ensembl
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. spermatid nucleus differentiation Source: Ensembl
  6. transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-like protein 1
Short name:
TBP-like protein 1
Alternative name(s):
21 kDa TBP-like protein
Second TBP of unique DNA protein
Short name:
STUD
TATA box-binding protein-related factor 2
Short name:
TBP-related factor 2
TBP-like factor
TBP-related protein
Gene namesi
Name:TBPL1
Synonyms:TLF, TLP, TLP21, TRF2, TRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:11589. TBPL1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. transcription factor TFIIA complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36353.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186TATA box-binding protein-like protein 1PRO_0000153992Add
BLAST

Proteomic databases

MaxQBiP62380.
PaxDbiP62380.
PRIDEiP62380.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in the testis and ovary.2 Publications

Gene expression databases

BgeeiP62380.
CleanExiHS_TBPL1.
ExpressionAtlasiP62380. baseline and differential.
GenevestigatoriP62380.

Interactioni

Subunit structurei

Binds TFIIA and TFIIB.

Protein-protein interaction databases

BioGridi114896. 21 interactions.
IntActiP62380. 10 interactions.
STRINGi9606.ENSP00000237264.

Structurei

3D structure databases

ProteinModelPortaliP62380.
SMRiP62380. Positions 13-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TBP family.Curated

Phylogenomic databases

eggNOGiCOG2101.
GeneTreeiENSGT00410000025389.
HOGENOMiHOG000105162.
HOVERGENiHBG044997.
InParanoidiP62380.
KOiK03120.
OMAiNVIYKPE.
OrthoDBiEOG7M3J1J.
PhylomeDBiP62380.
TreeFamiTF300102.

Family and domain databases

Gene3Di3.30.310.10. 2 hits.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.

Sequencei

Sequence statusi: Complete.

P62380-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK
60 70 80 90 100
LRKPRITATI WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF
110 120 130 140 150
KVVNVLAVCN MPFEIRLPEF TKNNRPHASY EPELHPAVCY RIKSLRATLQ
160 170 180
IFSTGSITVT GPNVKAVATA VEQIYPFVFE SRKEIL
Length:186
Mass (Da):20,887
Last modified:July 5, 2004 - v1
Checksum:i2CDD9F5E7BDDE63F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441V → A in AAH00381. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020881 mRNA. Translation: BAA75218.1.
AF136570 mRNA. Translation: AAD28785.1.
AF130312 mRNA. Translation: AAD24800.1.
AK292320 mRNA. Translation: BAF85009.1.
AK313645 mRNA. Translation: BAG36402.1.
AL035699 Genomic DNA. Translation: CAB43704.1.
CH471051 Genomic DNA. Translation: EAW47995.1.
CH471051 Genomic DNA. Translation: EAW47996.1.
BC000381 mRNA. Translation: AAH00381.1.
BC017559 mRNA. Translation: AAH17559.1.
CCDSiCCDS5168.1.
PIRiJG0162.
RefSeqiNP_001240605.1. NM_001253676.1.
NP_004856.1. NM_004865.3.
UniGeneiHs.486507.

Genome annotation databases

EnsembliENST00000237264; ENSP00000237264; ENSG00000028839.
ENST00000613034; ENSP00000478795; ENSG00000028839.
GeneIDi9519.
KEGGihsa:9519.
UCSCiuc003qel.3. human.

Polymorphism databases

DMDMi61248509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020881 mRNA. Translation: BAA75218.1 .
AF136570 mRNA. Translation: AAD28785.1 .
AF130312 mRNA. Translation: AAD24800.1 .
AK292320 mRNA. Translation: BAF85009.1 .
AK313645 mRNA. Translation: BAG36402.1 .
AL035699 Genomic DNA. Translation: CAB43704.1 .
CH471051 Genomic DNA. Translation: EAW47995.1 .
CH471051 Genomic DNA. Translation: EAW47996.1 .
BC000381 mRNA. Translation: AAH00381.1 .
BC017559 mRNA. Translation: AAH17559.1 .
CCDSi CCDS5168.1.
PIRi JG0162.
RefSeqi NP_001240605.1. NM_001253676.1.
NP_004856.1. NM_004865.3.
UniGenei Hs.486507.

3D structure databases

ProteinModelPortali P62380.
SMRi P62380. Positions 13-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114896. 21 interactions.
IntActi P62380. 10 interactions.
STRINGi 9606.ENSP00000237264.

Polymorphism databases

DMDMi 61248509.

Proteomic databases

MaxQBi P62380.
PaxDbi P62380.
PRIDEi P62380.

Protocols and materials databases

DNASUi 9519.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000237264 ; ENSP00000237264 ; ENSG00000028839 .
ENST00000613034 ; ENSP00000478795 ; ENSG00000028839 .
GeneIDi 9519.
KEGGi hsa:9519.
UCSCi uc003qel.3. human.

Organism-specific databases

CTDi 9519.
GeneCardsi GC06P134273.
HGNCi HGNC:11589. TBPL1.
MIMi 605521. gene.
neXtProti NX_P62380.
PharmGKBi PA36353.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2101.
GeneTreei ENSGT00410000025389.
HOGENOMi HOG000105162.
HOVERGENi HBG044997.
InParanoidi P62380.
KOi K03120.
OMAi NVIYKPE.
OrthoDBi EOG7M3J1J.
PhylomeDBi P62380.
TreeFami TF300102.

Miscellaneous databases

ChiTaRSi TBPL1. human.
GeneWikii TBPL1.
GenomeRNAii 9519.
NextBioi 35674.
PROi P62380.
SOURCEi Search...

Gene expression databases

Bgeei P62380.
CleanExi HS_TBPL1.
ExpressionAtlasi P62380. baseline and differential.
Genevestigatori P62380.

Family and domain databases

Gene3Di 3.30.310.10. 2 hits.
InterProi IPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
[Graphical view ]
PANTHERi PTHR10126. PTHR10126. 1 hit.
Pfami PF00352. TBP. 2 hits.
[Graphical view ]
PRINTSi PR00686. TIFACTORIID.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein."
    Ohbayashi T., Kishimoto T., Makino Y., Shimada M., Nakadi T., Aoki T., Kawata T., Niwa S., Tamura T.-A.
    Biochem. Biophys. Res. Commun. 255:137-142(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Retina.
  2. "TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family."
    Rabenstein M.D., Zhou S., Lis J.T., Tjian R.
    Proc. Natl. Acad. Sci. U.S.A. 96:4791-4796(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TFIIA AND TFIIB.
  3. "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP."
    Chong J.A., Moran M.M., Teichmann M., Kaczmarek J.S., Roeder R., Clapham D.E.
    Mol. Cell. Biol. 25:2632-2643(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis and Uterus.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Uterus.
  8. Cited for: TISSUE SPECIFICITY.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "TRF2, but not TBP, mediates the transcription of ribosomal protein genes."
    Wang Y.L., Duttke S.H., Chen K., Johnston J., Kassavetis G.A., Zeitlinger J., Kadonaga J.T.
    Genes Dev. 28:1550-1555(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiTBPL1_HUMAN
AccessioniPrimary (citable) accession number: P62380
Secondary accession number(s): A8K8F5
, O95753, Q9BWD5, Q9Z2Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3