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Protein

TATA box-binding protein-like protein 1

Gene

TBPL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.4 Publications

GO - Molecular functioni

  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-like protein 1
Short name:
TBP-like protein 1
Alternative name(s):
21 kDa TBP-like protein
Second TBP of unique DNA protein
Short name:
STUD
TATA box-binding protein-related factor 2
Short name:
TBP-related factor 2
TBP-like factor
TBP-related protein
Gene namesi
Name:TBPL1
Synonyms:TLF, TLP, TLP21, TRF2, TRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000028839.9.
HGNCiHGNC:11589. TBPL1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9519.
OpenTargetsiENSG00000028839.
PharmGKBiPA36353.

Polymorphism and mutation databases

BioMutaiTBPL1.
DMDMi61248509.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539921 – 186TATA box-binding protein-like protein 1Add BLAST186

Proteomic databases

EPDiP62380.
MaxQBiP62380.
PaxDbiP62380.
PeptideAtlasiP62380.
PRIDEiP62380.

PTM databases

iPTMnetiP62380.
PhosphoSitePlusiP62380.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in the testis and ovary.2 Publications

Gene expression databases

BgeeiENSG00000028839.
CleanExiHS_TBPL1.
ExpressionAtlasiP62380. baseline and differential.
GenevisibleiP62380. HS.

Organism-specific databases

HPAiHPA071810.
HPA071813.

Interactioni

Subunit structurei

Binds TFIIA and TFIIB.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114896. 23 interactors.
CORUMiP62380.
IntActiP62380. 14 interactors.
STRINGi9606.ENSP00000237264.

Structurei

3D structure databases

ProteinModelPortaliP62380.
SMRiP62380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TBP family.Curated

Phylogenomic databases

eggNOGiKOG3302. Eukaryota.
COG2101. LUCA.
GeneTreeiENSGT00410000025389.
HOGENOMiHOG000105162.
HOVERGENiHBG044997.
InParanoidiP62380.
KOiK03120.
OMAiQAFEMIY.
OrthoDBiEOG091G0K64.
PhylomeDBiP62380.
TreeFamiTF300102.

Family and domain databases

CDDicd04517. TLF. 1 hit.
InterProiView protein in InterPro
IPR000814. TBP.
IPR015445. TBP-like.
PANTHERiPTHR10126. PTHR10126. 1 hit.
PTHR10126:SF30. PTHR10126:SF30. 1 hit.
PfamiView protein in Pfam
PF00352. TBP. 2 hits.
PRINTSiPR00686. TIFACTORIID.

Sequencei

Sequence statusi: Complete.

P62380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK
60 70 80 90 100
LRKPRITATI WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF
110 120 130 140 150
KVVNVLAVCN MPFEIRLPEF TKNNRPHASY EPELHPAVCY RIKSLRATLQ
160 170 180
IFSTGSITVT GPNVKAVATA VEQIYPFVFE SRKEIL
Length:186
Mass (Da):20,887
Last modified:July 5, 2004 - v1
Checksum:i2CDD9F5E7BDDE63F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44V → A in AAH00381 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020881 mRNA. Translation: BAA75218.1.
AF136570 mRNA. Translation: AAD28785.1.
AF130312 mRNA. Translation: AAD24800.1.
AK292320 mRNA. Translation: BAF85009.1.
AK313645 mRNA. Translation: BAG36402.1.
AL035699 Genomic DNA. Translation: CAB43704.1.
CH471051 Genomic DNA. Translation: EAW47995.1.
CH471051 Genomic DNA. Translation: EAW47996.1.
BC000381 mRNA. Translation: AAH00381.1.
BC017559 mRNA. Translation: AAH17559.1.
CCDSiCCDS5168.1.
PIRiJG0162.
RefSeqiNP_001240605.1. NM_001253676.1.
NP_004856.1. NM_004865.3.
XP_016867002.1. XM_017011513.1.
UniGeneiHs.486507.

Genome annotation databases

EnsembliENST00000237264; ENSP00000237264; ENSG00000028839.
ENST00000613034; ENSP00000478795; ENSG00000028839.
GeneIDi9519.
KEGGihsa:9519.
UCSCiuc003qel.4. human.

Similar proteinsi

Entry informationi

Entry nameiTBPL1_HUMAN
AccessioniPrimary (citable) accession number: P62380
Secondary accession number(s): A8K8F5
, O95753, Q9BWD5, Q9Z2Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families