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P62380

- TBPL1_HUMAN

UniProt

P62380 - TBPL1_HUMAN

Protein

TATA box-binding protein-like protein 1

Gene

TBPL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.4 Publications

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. transcription coactivator activity Source: UniProtKB

    GO - Biological processi

    1. acrosome assembly Source: Ensembl
    2. DNA-templated transcription, initiation Source: InterPro
    3. dTTP biosynthetic process Source: Ensembl
    4. regulation of RNA biosynthetic process Source: GOC
    5. spermatid nucleus differentiation Source: Ensembl
    6. transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TATA box-binding protein-like protein 1
    Short name:
    TBP-like protein 1
    Alternative name(s):
    21 kDa TBP-like protein
    Second TBP of unique DNA protein
    Short name:
    STUD
    TATA box-binding protein-related factor 2
    Short name:
    TBP-related factor 2
    TBP-like factor
    TBP-related protein
    Gene namesi
    Name:TBPL1
    Synonyms:TLF, TLP, TLP21, TRF2, TRP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:11589. TBPL1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. transcription factor TFIIA complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36353.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 186186TATA box-binding protein-like protein 1PRO_0000153992Add
    BLAST

    Proteomic databases

    MaxQBiP62380.
    PaxDbiP62380.
    PRIDEiP62380.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed, with highest levels in the testis and ovary.2 Publications

    Gene expression databases

    ArrayExpressiP62380.
    BgeeiP62380.
    CleanExiHS_TBPL1.
    GenevestigatoriP62380.

    Interactioni

    Subunit structurei

    Binds TFIIA and TFIIB.

    Protein-protein interaction databases

    BioGridi114896. 21 interactions.
    IntActiP62380. 10 interactions.
    STRINGi9606.ENSP00000237264.

    Structurei

    3D structure databases

    ProteinModelPortaliP62380.
    SMRiP62380. Positions 13-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TBP family.Curated

    Phylogenomic databases

    eggNOGiCOG2101.
    HOGENOMiHOG000105162.
    HOVERGENiHBG044997.
    InParanoidiP62380.
    KOiK03120.
    OMAiNVIYKPE.
    OrthoDBiEOG7M3J1J.
    PhylomeDBiP62380.
    TreeFamiTF300102.

    Family and domain databases

    Gene3Di3.30.310.10. 2 hits.
    InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
    IPR000814. TBP.
    [Graphical view]
    PANTHERiPTHR10126. PTHR10126. 1 hit.
    PfamiPF00352. TBP. 2 hits.
    [Graphical view]
    PRINTSiPR00686. TIFACTORIID.

    Sequencei

    Sequence statusi: Complete.

    P62380-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK    50
    LRKPRITATI WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF 100
    KVVNVLAVCN MPFEIRLPEF TKNNRPHASY EPELHPAVCY RIKSLRATLQ 150
    IFSTGSITVT GPNVKAVATA VEQIYPFVFE SRKEIL 186
    Length:186
    Mass (Da):20,887
    Last modified:July 5, 2004 - v1
    Checksum:i2CDD9F5E7BDDE63F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441V → A in AAH00381. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020881 mRNA. Translation: BAA75218.1.
    AF136570 mRNA. Translation: AAD28785.1.
    AF130312 mRNA. Translation: AAD24800.1.
    AK292320 mRNA. Translation: BAF85009.1.
    AK313645 mRNA. Translation: BAG36402.1.
    AL035699 Genomic DNA. Translation: CAB43704.1.
    CH471051 Genomic DNA. Translation: EAW47995.1.
    CH471051 Genomic DNA. Translation: EAW47996.1.
    BC000381 mRNA. Translation: AAH00381.1.
    BC017559 mRNA. Translation: AAH17559.1.
    CCDSiCCDS5168.1.
    PIRiJG0162.
    RefSeqiNP_001240605.1. NM_001253676.1.
    NP_004856.1. NM_004865.3.
    UniGeneiHs.486507.

    Genome annotation databases

    EnsembliENST00000237264; ENSP00000237264; ENSG00000028839.
    GeneIDi9519.
    KEGGihsa:9519.
    UCSCiuc003qel.3. human.

    Polymorphism databases

    DMDMi61248509.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB020881 mRNA. Translation: BAA75218.1 .
    AF136570 mRNA. Translation: AAD28785.1 .
    AF130312 mRNA. Translation: AAD24800.1 .
    AK292320 mRNA. Translation: BAF85009.1 .
    AK313645 mRNA. Translation: BAG36402.1 .
    AL035699 Genomic DNA. Translation: CAB43704.1 .
    CH471051 Genomic DNA. Translation: EAW47995.1 .
    CH471051 Genomic DNA. Translation: EAW47996.1 .
    BC000381 mRNA. Translation: AAH00381.1 .
    BC017559 mRNA. Translation: AAH17559.1 .
    CCDSi CCDS5168.1.
    PIRi JG0162.
    RefSeqi NP_001240605.1. NM_001253676.1.
    NP_004856.1. NM_004865.3.
    UniGenei Hs.486507.

    3D structure databases

    ProteinModelPortali P62380.
    SMRi P62380. Positions 13-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114896. 21 interactions.
    IntActi P62380. 10 interactions.
    STRINGi 9606.ENSP00000237264.

    Polymorphism databases

    DMDMi 61248509.

    Proteomic databases

    MaxQBi P62380.
    PaxDbi P62380.
    PRIDEi P62380.

    Protocols and materials databases

    DNASUi 9519.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000237264 ; ENSP00000237264 ; ENSG00000028839 .
    GeneIDi 9519.
    KEGGi hsa:9519.
    UCSCi uc003qel.3. human.

    Organism-specific databases

    CTDi 9519.
    GeneCardsi GC06P134273.
    HGNCi HGNC:11589. TBPL1.
    MIMi 605521. gene.
    neXtProti NX_P62380.
    PharmGKBi PA36353.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2101.
    HOGENOMi HOG000105162.
    HOVERGENi HBG044997.
    InParanoidi P62380.
    KOi K03120.
    OMAi NVIYKPE.
    OrthoDBi EOG7M3J1J.
    PhylomeDBi P62380.
    TreeFami TF300102.

    Miscellaneous databases

    ChiTaRSi TBPL1. human.
    GeneWikii TBPL1.
    GenomeRNAii 9519.
    NextBioi 35674.
    PROi P62380.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62380.
    Bgeei P62380.
    CleanExi HS_TBPL1.
    Genevestigatori P62380.

    Family and domain databases

    Gene3Di 3.30.310.10. 2 hits.
    InterProi IPR012295. Beta2_adaptin/TBP_C_dom.
    IPR000814. TBP.
    [Graphical view ]
    PANTHERi PTHR10126. PTHR10126. 1 hit.
    Pfami PF00352. TBP. 2 hits.
    [Graphical view ]
    PRINTSi PR00686. TIFACTORIID.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein."
      Ohbayashi T., Kishimoto T., Makino Y., Shimada M., Nakadi T., Aoki T., Kawata T., Niwa S., Tamura T.-A.
      Biochem. Biophys. Res. Commun. 255:137-142(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Retina.
    2. "TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family."
      Rabenstein M.D., Zhou S., Lis J.T., Tjian R.
      Proc. Natl. Acad. Sci. U.S.A. 96:4791-4796(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TFIIA AND TFIIB.
    3. "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP."
      Chong J.A., Moran M.M., Teichmann M., Kaczmarek J.S., Roeder R., Clapham D.E.
      Mol. Cell. Biol. 25:2632-2643(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis and Uterus.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Uterus.
    8. Cited for: TISSUE SPECIFICITY.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "TRF2, but not TBP, mediates the transcription of ribosomal protein genes."
      Wang Y.L., Duttke S.H., Chen K., Johnston J., Kassavetis G.A., Zeitlinger J., Kadonaga J.T.
      Genes Dev. 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiTBPL1_HUMAN
    AccessioniPrimary (citable) accession number: P62380
    Secondary accession number(s): A8K8F5
    , O95753, Q9BWD5, Q9Z2Z0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3