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P62380 (TBPL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TATA box-binding protein-like protein 1

Short name=TBP-like protein 1
Alternative name(s):
21 kDa TBP-like protein
Second TBP of unique DNA protein
Short name=STUD
TATA box-binding protein-related factor 2
Short name=TBP-related factor 2
TBP-like factor
TBP-related protein
Gene names
Name:TBPL1
Synonyms:TLF, TLP, TLP21, TRF2, TRP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length186 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Does not bind the TATA box. Has DNA-binding ability. Ref.1 Ref.3

Subunit structure

Binds TFIIA and TFIIB.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Tissue specificity

Ubiquitously expressed, with highest levels in the testis and ovary. Ref.1 Ref.8

Sequence similarities

Belongs to the TBP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 186186TATA box-binding protein-like protein 1
PRO_0000153992

Experimental info

Sequence conflict441V → A in AAH00381. Ref.7

Sequences

Sequence LengthMass (Da)Tools
P62380 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 2CDD9F5E7BDDE63F

FASTA18620,887
        10         20         30         40         50         60 
MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK LRKPRITATI 

        70         80         90        100        110        120 
WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF KVVNVLAVCN MPFEIRLPEF 

       130        140        150        160        170        180 
TKNNRPHASY EPELHPAVCY RIKSLRATLQ IFSTGSITVT GPNVKAVATA VEQIYPFVFE 


SRKEIL 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein."
Ohbayashi T., Kishimoto T., Makino Y., Shimada M., Nakadi T., Aoki T., Kawata T., Niwa S., Tamura T.-A.
Biochem. Biophys. Res. Commun. 255:137-142(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Retina.
[2]"Cloning and characterization of a TBP homolog with unique properties."
Chong J.A., Moran M.M., Clapham D.E.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family."
Rabenstein M.D., Zhou S., Lis J.T., Tjian R.
Proc. Natl. Acad. Sci. U.S.A. 96:4791-4796(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TFIIA AND TFIIB.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis and Uterus.
[5]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Uterus.
[8]"Genomics, evolution, and expression of TBPL2, a member of the TBP family."
Di Pietro C., Ragusa M., Duro L., Guglielmino M.R., Barbagallo D., Carnemolla A., Lagana A., Buffa P., Angelica R., Rinaldi A., Calafato M.S., Milicia I., Caserta C., Giugno R., Pulvirenti A., Giunta V., Rapisarda A., Di Pietro V. expand/collapse author list , Grillo A., Messina A., Ferro A., Grzeschik K.H., Purrello M.
DNA Cell Biol. 26:369-385(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB020881 mRNA. Translation: BAA75218.1.
AF130312 mRNA. Translation: AAD24800.1.
AF136570 mRNA. Translation: AAD28785.1.
AK292320 mRNA. Translation: BAF85009.1.
AK313645 mRNA. Translation: BAG36402.1.
AL035699 Genomic DNA. Translation: CAB43704.1.
CH471051 Genomic DNA. Translation: EAW47995.1.
CH471051 Genomic DNA. Translation: EAW47996.1.
BC000381 mRNA. Translation: AAH00381.1.
BC017559 mRNA. Translation: AAH17559.1.
CCDSCCDS5168.1.
PIRJG0162.
RefSeqNP_001240605.1. NM_001253676.1.
NP_004856.1. NM_004865.3.
UniGeneHs.486507.

3D structure databases

ProteinModelPortalP62380.
SMRP62380. Positions 13-183.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114896. 21 interactions.
IntActP62380. 9 interactions.
STRING9606.ENSP00000237264.

Polymorphism databases

DMDM61248509.

Proteomic databases

MaxQBP62380.
PaxDbP62380.
PRIDEP62380.

Protocols and materials databases

DNASU9519.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000237264; ENSP00000237264; ENSG00000028839.
GeneID9519.
KEGGhsa:9519.
UCSCuc003qel.3. human.

Organism-specific databases

CTD9519.
GeneCardsGC06P134273.
HGNCHGNC:11589. TBPL1.
MIM605521. gene.
neXtProtNX_P62380.
PharmGKBPA36353.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2101.
HOGENOMHOG000105162.
HOVERGENHBG044997.
InParanoidP62380.
KOK03120.
OMANVIYKPE.
OrthoDBEOG7M3J1J.
PhylomeDBP62380.
TreeFamTF300102.

Gene expression databases

ArrayExpressP62380.
BgeeP62380.
CleanExHS_TBPL1.
GenevestigatorP62380.

Family and domain databases

Gene3D3.30.310.10. 2 hits.
InterProIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
[Graphical view]
PANTHERPTHR10126. PTHR10126. 1 hit.
PfamPF00352. TBP. 2 hits.
[Graphical view]
PRINTSPR00686. TIFACTORIID.
ProtoNetSearch...

Other

ChiTaRSTBPL1. human.
GeneWikiTBPL1.
GenomeRNAi9519.
NextBio35674.
PROP62380.
SOURCESearch...

Entry information

Entry nameTBPL1_HUMAN
AccessionPrimary (citable) accession number: P62380
Secondary accession number(s): A8K8F5 expand/collapse secondary AC list , O95753, Q9BWD5, Q9Z2Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM