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P62357

- HIS4_METMP

UniProt

P62357 - HIS4_METMP

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Protein
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Gene
hisA, MMP0417
Organism
Methanococcus maripaludis (strain S2 / LL)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81Proton acceptor By similarity
Active sitei130 – 1301Proton donor By similarity

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciMMAR267377:GJ77-444-MONOMER.
UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene namesi
Name:hisA
Ordered Locus Names:MMP0417
OrganismiMethanococcus maripaludis (strain S2 / LL)
Taxonomic identifieri267377 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
ProteomesiUP000000590: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2412411-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation
PRO_0000142095Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi267377.MMP0417.

Structurei

3D structure databases

ProteinModelPortaliP62357.

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.

Phylogenomic databases

eggNOGiCOG0106.
HOGENOMiHOG000224614.
KOiK01814.
OMAiRSEALWS.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01014. HisA.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR006063. HisA.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR00007. TIGR00007. 1 hit.

Sequencei

Sequence statusi: Complete.

P62357-1 [UniParc]FASTAAdd to Basket

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MLVIPAVDMK NKKCVQLIQG NPDKKHVELD NPPEIAKKWV NEGAEMLHLV    50
DLDGALDGKR VNDEFIEEII KKSGVPVQIG GGIRSIEDAE YLVEKGAKKV 100
IIGTIAVENP EIIKELSKRI GSEKIMVSLD AKDGKVVIKG WKEKTKYTPV 150
QIGKILEEMG AGSILFTNVD SEGLLNGINI EPTKELVDNL KIPIVASGGV 200
TTIDDLLKLK EIGVYGVVVG SAIYKNMINL KDAIEAVNKS N 241
Length:241
Mass (Da):26,205
Last modified:July 5, 2004 - v1
Checksum:i913AD47C3EEEE7D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950229 Genomic DNA. Translation: CAF29973.1.
RefSeqiNP_987537.1. NC_005791.1.
WP_011170361.1. NC_005791.1.

Genome annotation databases

EnsemblBacteriaiCAF29973; CAF29973; MMP0417.
GeneIDi2762631.
KEGGimmp:MMP0417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950229 Genomic DNA. Translation: CAF29973.1 .
RefSeqi NP_987537.1. NC_005791.1.
WP_011170361.1. NC_005791.1.

3D structure databases

ProteinModelPortali P62357.
ModBasei Search...

Protein-protein interaction databases

STRINGi 267377.MMP0417.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAF29973 ; CAF29973 ; MMP0417 .
GeneIDi 2762631.
KEGGi mmp:MMP0417.

Phylogenomic databases

eggNOGi COG0106.
HOGENOMi HOG000224614.
KOi K01814.
OMAi RSEALWS.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .
BioCyci MMAR267377:GJ77-444-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01014. HisA.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR006063. HisA.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR00007. TIGR00007. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S2 / LL.

Entry informationi

Entry nameiHIS4_METMP
AccessioniPrimary (citable) accession number: P62357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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