P62346 (HIS2_BACC1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-ATP pyrophosphatase
Short name=PRA-PH
EC=3.6.1.31

Gene names

Name:	hisE
Ordered Locus Names:	BCE_1532

Organism

Bacillus cereus (strain ATCC 10987) [Complete proteome] [HAMAP]

Taxonomic identifier

222523 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01020
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01020
Subcellular location	Cytoplasm By similarity HAMAP MF_01020.
Sequence similarities	Belongs to the PRA-PH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosyl-ATP diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 107	107	Phosphoribosyl-ATP pyrophosphatase HAMAP MF_01020		PRO_0000136344

Sequences

	Sequence		Length	Mass (Da)
	P62346 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1454004A20BE22B2	FASTA	107	12,467
	10 20 30 40 50 60 MKNAFTLLFE TIEERKRNPL PESYTNYLFS KGEDKILKKI GEECTEVIIA SKNNDNEELV 70 80 90 100 KEIVDVLYHC FVLLAEKNIS LEDIMEEVTE RNGKLSRVGD RREIDTL

References

[1]

"The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1." Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L., Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F., Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D. Nucleic Acids Res. 32:977-988(2004) [PubMed: 14960714] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 10987.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE017194 Genomic DNA. Translation: AAS40461.1.
RefSeq	NP_977853.1. NC_003909.8.
3D structure databases
ProteinModelPortal	P62346.
SMR	P62346. Positions 4-95.
ModBase	Search...
Protein-protein interaction databases
STRING	P62346.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000026401; EBBACP00000025751; EBBACG00000026392.
GeneID	2751481.
GenomeReviews	Gene locus BCE_1532 in contig AE017194_GR.
KEGG	bca:BCE_1532.
NMPDR	fig|222523.1.peg.1525.
PATRIC	18851908. VBIBacCer118379_1458.
TIGR	BCE_1532.
Phylogenomic databases
eggNOG	COG0140.
GeneTree	EBGT00050000000893.
HOGENOM	HBG646527.
OMA	CSEVIIA.
ProtClustDB	PRK00400.
Enzyme and pathway databases
BioCyc	BCER405917:BCE_1532-MONOMER.
Family and domain databases
HAMAP	MF_01020. HisE. [Tree]
InterPro	IPR023287. alpha_NTP_pyrophos_dom. IPR008179. PRib-ATP_PPHydrolase. IPR021130. PRib-ATP_PPHydrolase-like. [Graphical view]
Gene3D	G3DSA:1.10.3310.10. G3DSA:1.10.3310.10. 1 hit.
KO	K01523.
Pfam	PF01503. PRA-PH. 1 hit. [Graphical view]
TIGRFAMs	TIGR03188. Histidine_hisI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS2_BACC1

Accession

Primary (citable) accession number: P62346

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program