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Protein

Selenoprotein T

Gene

SELT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • selenium binding Source: UniProtKB

GO - Biological processi

  • selenocysteine incorporation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein T
Short name:
SelT
Gene namesi
Name:SELT
ORF Names:UNQ150/PRO176
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiSELT.
DMDMi190358765.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 195176Selenoprotein TPRO_0000032290Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki46 ↔ 49Cysteinyl-selenocysteine (Cys-Sec)Sequence analysis

Post-translational modificationi

May contain a selenide-sulfide bond between Cys-46 and Sec-49. This bond is speculated to serve as redox-active pair (By similarity).By similarity

Proteomic databases

EPDiP62341.
MaxQBiP62341.
PaxDbiP62341.
PeptideAtlasiP62341.
PRIDEiP62341.

PTM databases

iPTMnetiP62341.
PhosphoSiteiP62341.
SwissPalmiP62341.

Expressioni

Tissue specificityi

Ubiquitous.

Organism-specific databases

HPAiHPA039780.

Interactioni

Protein-protein interaction databases

BioGridi119693. 13 interactions.
IntActiP62341. 1 interaction.
MINTiMINT-1404117.
STRINGi9606.ENSP00000418910.

Structurei

3D structure databases

ProteinModelPortaliP62341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SelWTH family. SELT subfamily.Curated

Keywords - Domaini

Redox-active center, Signal

Phylogenomic databases

eggNOGiKOG3286. Eukaryota.
ENOG4111J49. LUCA.
GeneTreeiENSGT00390000011725.
HOGENOMiHOG000045222.
HOVERGENiHBG056808.
InParanoidiP62341.
PhylomeDBiP62341.

Family and domain databases

Gene3Di3.40.30.10. 2 hits.
InterProiIPR011893. Selenoprotein_Rdx-typ.
IPR019389. Selenoprotein_T.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR13544. PTHR13544. 1 hit.
PfamiPF10262. Rdx. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 2 hits.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62341-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLLLLLVA ASAMVRSEAS ANLGGVPSKR LKMQYATGPL LKFQICVSUG
60 70 80 90 100
YRRVFEEYMR VISQRYPDIR IEGENYLPQP IYRHIASFLS VFKLVLIGLI
110 120 130 140 150
IVGKDPFAFF GMQAPSIWQW GQENKVYACM MVFFLSNMIE NQCMSTGAFE
160 170 180 190
ITLNDVPVWS KLESGHLPSM QQLVQILDNE MKLNVHMDSI PHHRS
Length:195
Mass (Da):22,324
Last modified:February 26, 2008 - v2
Checksum:i5B7949FA7711AE9D
GO

Sequence cautioni

The sequence AAD20063.1 differs from that shown. Reason: Erroneous termination at position 49. Translated as Sec.Curated
The sequence AAF13696.1 differs from that shown. Reason: Frameshift at position 27. Curated
The sequence AAQ88462.1 differs from that shown. Reason: Erroneous termination at position 49. Translated as Sec.Curated
The sequence AAQ88463.1 differs from that shown. Reason: Erroneous termination at position 49. Translated as Sec.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 183RSE → WSD in AAH09611 (PubMed:15489334).Curated
Sequence conflicti26 – 261V → M in AAH09611 (PubMed:15489334).Curated

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei49 – 491Selenocysteine

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195141 mRNA. Translation: AAF13696.1. Frameshift.
AF131856 mRNA. Translation: AAD20063.1. Sequence problems.
AY358095 mRNA. Translation: AAQ88462.1. Sequence problems.
AY358096 mRNA. Translation: AAQ88463.1. Sequence problems.
BC006012 mRNA. Translation: AAH06012.2.
BC008411 mRNA. Translation: AAH08411.2.
BC009556 mRNA. Translation: AAH09556.2.
BC009611 mRNA. Translation: AAH09611.2.
BC026350 mRNA. Translation: AAH26350.2.
BC036738 mRNA. Translation: AAH36738.3.
BC071699 mRNA. Translation: AAH71699.1.
CCDSiCCDS46936.1.
RefSeqiNP_057359.2. NM_016275.3.
UniGeneiHs.369052.

Genome annotation databases

GeneIDi51714.
KEGGihsa:51714.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195141 mRNA. Translation: AAF13696.1. Frameshift.
AF131856 mRNA. Translation: AAD20063.1. Sequence problems.
AY358095 mRNA. Translation: AAQ88462.1. Sequence problems.
AY358096 mRNA. Translation: AAQ88463.1. Sequence problems.
BC006012 mRNA. Translation: AAH06012.2.
BC008411 mRNA. Translation: AAH08411.2.
BC009556 mRNA. Translation: AAH09556.2.
BC009611 mRNA. Translation: AAH09611.2.
BC026350 mRNA. Translation: AAH26350.2.
BC036738 mRNA. Translation: AAH36738.3.
BC071699 mRNA. Translation: AAH71699.1.
CCDSiCCDS46936.1.
RefSeqiNP_057359.2. NM_016275.3.
UniGeneiHs.369052.

3D structure databases

ProteinModelPortaliP62341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119693. 13 interactions.
IntActiP62341. 1 interaction.
MINTiMINT-1404117.
STRINGi9606.ENSP00000418910.

PTM databases

iPTMnetiP62341.
PhosphoSiteiP62341.
SwissPalmiP62341.

Polymorphism and mutation databases

BioMutaiSELT.
DMDMi190358765.

Proteomic databases

EPDiP62341.
MaxQBiP62341.
PaxDbiP62341.
PeptideAtlasiP62341.
PRIDEiP62341.

Protocols and materials databases

DNASUi51714.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi51714.
KEGGihsa:51714.

Organism-specific databases

CTDi51714.
GeneCardsiSELT.
HPAiHPA039780.
MIMi607912. gene.
neXtProtiNX_P62341.

Phylogenomic databases

eggNOGiKOG3286. Eukaryota.
ENOG4111J49. LUCA.
GeneTreeiENSGT00390000011725.
HOGENOMiHOG000045222.
HOVERGENiHBG056808.
InParanoidiP62341.
PhylomeDBiP62341.

Miscellaneous databases

ChiTaRSiSELT. human.
GeneWikiiSELT.
GenomeRNAii51714.
PROiP62341.
SOURCEiSearch...

Family and domain databases

Gene3Di3.40.30.10. 2 hits.
InterProiIPR011893. Selenoprotein_Rdx-typ.
IPR019389. Selenoprotein_T.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR13544. PTHR13544. 1 hit.
PfamiPF10262. Rdx. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 2 hits.
TIGRFAMsiTIGR02174. CXXU_selWTH. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements."
    Kryukov G.V., Kryukov V.M., Gladyshev V.N.
    J. Biol. Chem. 274:33888-33897(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Mei G., Yu W., Gibbs R.A.
    Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow, Brain, Pancreas, Skin and Urinary bladder.

Entry informationi

Entry nameiSELT_HUMAN
AccessioniPrimary (citable) accession number: P62341
Secondary accession number(s): O95904
, Q8IY80, Q9CZ45, Q9NZJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: February 26, 2008
Last modified: July 6, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.