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P62340

- TBPL1_MOUSE

UniProt

P62340 - TBPL1_MOUSE

Protein

TATA box-binding protein-like protein 1

Gene

Tbpl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes By similarity. Seems to also mediate the transcription of NF1. Does not bind the TATA box.By similarity2 Publications

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: MGI

    GO - Biological processi

    1. acrosome assembly Source: MGI
    2. DNA-templated transcription, initiation Source: InterPro
    3. dTTP biosynthetic process Source: MGI
    4. spermatid nucleus differentiation Source: MGI
    5. spermatogenesis Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TATA box-binding protein-like protein 1
    Short name:
    TBP-like protein 1
    Alternative name(s):
    21 kDa TBP-like protein
    TATA box-binding protein-related factor 2
    Short name:
    TBP-related factor 2
    TBP-like factor
    TBP-related protein
    Gene namesi
    Name:Tbpl1
    Synonyms:Tlf, Tlp, Tlp21, Trf2, Trp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1339946. Tbpl1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI
    3. transcription factor TFIIA complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Significantly reduced NF1 levels.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 186186TATA box-binding protein-like protein 1PRO_0000153993Add
    BLAST

    Proteomic databases

    MaxQBiP62340.
    PaxDbiP62340.
    PRIDEiP62340.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.2 Publications

    Gene expression databases

    BgeeiP62340.
    CleanExiMM_TBPL1.
    GenevestigatoriP62340.

    Interactioni

    Subunit structurei

    Binds TFIIA and TFIIB.By similarity

    Protein-protein interaction databases

    BioGridi231864. 3 interactions.
    IntActiP62340. 1 interaction.
    MINTiMINT-1348231.

    Structurei

    3D structure databases

    ProteinModelPortaliP62340.
    SMRiP62340. Positions 13-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TBP family.Curated

    Phylogenomic databases

    eggNOGiCOG2101.
    GeneTreeiENSGT00410000025389.
    HOGENOMiHOG000105162.
    HOVERGENiHBG044997.
    KOiK03120.
    OMAiNVIYKPE.
    OrthoDBiEOG7M3J1J.
    TreeFamiTF300102.

    Family and domain databases

    Gene3Di3.30.310.10. 2 hits.
    InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
    IPR000814. TBP.
    [Graphical view]
    PANTHERiPTHR10126. PTHR10126. 1 hit.
    PfamiPF00352. TBP. 2 hits.
    [Graphical view]
    PRINTSiPR00686. TIFACTORIID.

    Sequencei

    Sequence statusi: Complete.

    P62340-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK    50
    LRKPRITATI WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF 100
    KVVNVLAVCN MPFEIRLPEF TKNNRPHASY EPELHPAVCY RIKSLRATLQ 150
    IFSTGSITVT GPNVKAVATA VEQIYPFVFE SRKEIL 186
    Length:186
    Mass (Da):20,887
    Last modified:July 5, 2004 - v1
    Checksum:i2CDD9F5E7BDDE63F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017697 mRNA. Translation: BAA74578.1.
    AK049975 mRNA. Translation: BAC34014.1.
    AK078547 mRNA. Translation: BAC37330.1.
    CCDSiCCDS23730.1.
    RefSeqiNP_035733.1. NM_011603.5.
    XP_006512793.1. XM_006512730.1.
    UniGeneiMm.86670.

    Genome annotation databases

    EnsembliENSMUST00000095794; ENSMUSP00000093470; ENSMUSG00000071359.
    ENSMUST00000127698; ENSMUSP00000114223; ENSMUSG00000071359.
    GeneIDi237336.
    KEGGimmu:237336.
    UCSCiuc007epp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB017697 mRNA. Translation: BAA74578.1 .
    AK049975 mRNA. Translation: BAC34014.1 .
    AK078547 mRNA. Translation: BAC37330.1 .
    CCDSi CCDS23730.1.
    RefSeqi NP_035733.1. NM_011603.5.
    XP_006512793.1. XM_006512730.1.
    UniGenei Mm.86670.

    3D structure databases

    ProteinModelPortali P62340.
    SMRi P62340. Positions 13-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 231864. 3 interactions.
    IntActi P62340. 1 interaction.
    MINTi MINT-1348231.

    Proteomic databases

    MaxQBi P62340.
    PaxDbi P62340.
    PRIDEi P62340.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095794 ; ENSMUSP00000093470 ; ENSMUSG00000071359 .
    ENSMUST00000127698 ; ENSMUSP00000114223 ; ENSMUSG00000071359 .
    GeneIDi 237336.
    KEGGi mmu:237336.
    UCSCi uc007epp.2. mouse.

    Organism-specific databases

    CTDi 9519.
    MGIi MGI:1339946. Tbpl1.

    Phylogenomic databases

    eggNOGi COG2101.
    GeneTreei ENSGT00410000025389.
    HOGENOMi HOG000105162.
    HOVERGENi HBG044997.
    KOi K03120.
    OMAi NVIYKPE.
    OrthoDBi EOG7M3J1J.
    TreeFami TF300102.

    Miscellaneous databases

    NextBioi 35674.
    PROi P62340.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62340.
    CleanExi MM_TBPL1.
    Genevestigatori P62340.

    Family and domain databases

    Gene3Di 3.30.310.10. 2 hits.
    InterProi IPR012295. Beta2_adaptin/TBP_C_dom.
    IPR000814. TBP.
    [Graphical view ]
    PANTHERi PTHR10126. PTHR10126. 1 hit.
    Pfami PF00352. TBP. 2 hits.
    [Graphical view ]
    PRINTSi PR00686. TIFACTORIID.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a mouse TBP-like protein (TLP) distantly related to the Drosophila TBP-related factor."
      Ohbayashi T., Makino Y., Tamura T.
      Nucleic Acids Res. 27:750-755(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Hippocampus.
    3. "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP."
      Chong J.A., Moran M.M., Teichmann M., Kaczmarek J.S., Roeder R., Clapham D.E.
      Mol. Cell. Biol. 25:2632-2643(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    4. "Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice."
      Xiao L., Kim M., DeJong J.
      Gene Expr. Patterns 6:409-419(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTBPL1_MOUSE
    AccessioniPrimary (citable) accession number: P62340
    Secondary accession number(s): O95753, Q9Z2Z0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3