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P62340

- TBPL1_MOUSE

UniProt

P62340 - TBPL1_MOUSE

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Protein

TATA box-binding protein-like protein 1

Gene
Tbpl1, Tlf, Tlp, Tlp21, Trf2, Trp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes By similarity. Seems to also mediate the transcription of NF1. Does not bind the TATA box.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. protein binding Source: MGI

GO - Biological processi

  1. acrosome assembly Source: MGI
  2. DNA-templated transcription, initiation Source: InterPro
  3. dTTP biosynthetic process Source: MGI
  4. spermatid nucleus differentiation Source: MGI
  5. spermatogenesis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TATA box-binding protein-like protein 1
Short name:
TBP-like protein 1
Alternative name(s):
21 kDa TBP-like protein
TATA box-binding protein-related factor 2
Short name:
TBP-related factor 2
TBP-like factor
TBP-related protein
Gene namesi
Name:Tbpl1
Synonyms:Tlf, Tlp, Tlp21, Trf2, Trp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1339946. Tbpl1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
  3. transcription factor TFIIA complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Significantly reduced NF1 levels.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186TATA box-binding protein-like protein 1PRO_0000153993Add
BLAST

Proteomic databases

MaxQBiP62340.
PaxDbiP62340.
PRIDEiP62340.

Expressioni

Tissue specificityi

Ubiquitously expressed.2 Publications

Gene expression databases

BgeeiP62340.
CleanExiMM_TBPL1.
GenevestigatoriP62340.

Interactioni

Subunit structurei

Binds TFIIA and TFIIB By similarity.

Protein-protein interaction databases

BioGridi231864. 3 interactions.
IntActiP62340. 1 interaction.
MINTiMINT-1348231.

Structurei

3D structure databases

ProteinModelPortaliP62340.
SMRiP62340. Positions 13-183.

Family & Domainsi

Sequence similaritiesi

Belongs to the TBP family.

Phylogenomic databases

eggNOGiCOG2101.
GeneTreeiENSGT00410000025389.
HOGENOMiHOG000105162.
HOVERGENiHBG044997.
KOiK03120.
OMAiNVIYKPE.
OrthoDBiEOG7M3J1J.
TreeFamiTF300102.

Family and domain databases

Gene3Di3.30.310.10. 2 hits.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.

Sequencei

Sequence statusi: Complete.

P62340-1 [UniParc]FASTAAdd to Basket

« Hide

MDADSDVALD ILITNVVCVF RTRCHLNLRK IALEGANVIY KRDVGKVLMK    50
LRKPRITATI WSSGKIICTG ATSEEEAKFG ARRLARSLQK LGFQVIFTDF 100
KVVNVLAVCN MPFEIRLPEF TKNNRPHASY EPELHPAVCY RIKSLRATLQ 150
IFSTGSITVT GPNVKAVATA VEQIYPFVFE SRKEIL 186
Length:186
Mass (Da):20,887
Last modified:July 5, 2004 - v1
Checksum:i2CDD9F5E7BDDE63F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017697 mRNA. Translation: BAA74578.1.
AK049975 mRNA. Translation: BAC34014.1.
AK078547 mRNA. Translation: BAC37330.1.
CCDSiCCDS23730.1.
RefSeqiNP_035733.1. NM_011603.5.
XP_006512793.1. XM_006512730.1.
UniGeneiMm.86670.

Genome annotation databases

EnsembliENSMUST00000095794; ENSMUSP00000093470; ENSMUSG00000071359.
ENSMUST00000127698; ENSMUSP00000114223; ENSMUSG00000071359.
GeneIDi237336.
KEGGimmu:237336.
UCSCiuc007epp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB017697 mRNA. Translation: BAA74578.1 .
AK049975 mRNA. Translation: BAC34014.1 .
AK078547 mRNA. Translation: BAC37330.1 .
CCDSi CCDS23730.1.
RefSeqi NP_035733.1. NM_011603.5.
XP_006512793.1. XM_006512730.1.
UniGenei Mm.86670.

3D structure databases

ProteinModelPortali P62340.
SMRi P62340. Positions 13-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 231864. 3 interactions.
IntActi P62340. 1 interaction.
MINTi MINT-1348231.

Proteomic databases

MaxQBi P62340.
PaxDbi P62340.
PRIDEi P62340.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095794 ; ENSMUSP00000093470 ; ENSMUSG00000071359 .
ENSMUST00000127698 ; ENSMUSP00000114223 ; ENSMUSG00000071359 .
GeneIDi 237336.
KEGGi mmu:237336.
UCSCi uc007epp.2. mouse.

Organism-specific databases

CTDi 9519.
MGIi MGI:1339946. Tbpl1.

Phylogenomic databases

eggNOGi COG2101.
GeneTreei ENSGT00410000025389.
HOGENOMi HOG000105162.
HOVERGENi HBG044997.
KOi K03120.
OMAi NVIYKPE.
OrthoDBi EOG7M3J1J.
TreeFami TF300102.

Miscellaneous databases

NextBioi 35674.
PROi P62340.
SOURCEi Search...

Gene expression databases

Bgeei P62340.
CleanExi MM_TBPL1.
Genevestigatori P62340.

Family and domain databases

Gene3Di 3.30.310.10. 2 hits.
InterProi IPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
[Graphical view ]
PANTHERi PTHR10126. PTHR10126. 1 hit.
Pfami PF00352. TBP. 2 hits.
[Graphical view ]
PRINTSi PR00686. TIFACTORIID.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a mouse TBP-like protein (TLP) distantly related to the Drosophila TBP-related factor."
    Ohbayashi T., Makino Y., Tamura T.
    Nucleic Acids Res. 27:750-755(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Hippocampus.
  3. "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP."
    Chong J.A., Moran M.M., Teichmann M., Kaczmarek J.S., Roeder R., Clapham D.E.
    Mol. Cell. Biol. 25:2632-2643(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. "Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice."
    Xiao L., Kim M., DeJong J.
    Gene Expr. Patterns 6:409-419(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiTBPL1_MOUSE
AccessioniPrimary (citable) accession number: P62340
Secondary accession number(s): O95753, Q9Z2Z0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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