ADP-ribosylation factor 6 - Mus musculus (Mouse)

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P62331 (ARF6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
ADP-ribosylation factor 6

Gene names

Name:

Arf6

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GTP-binding protein involved in protein trafficking; regulates endocytic recycling and cytoskeleton remodeling. May modulate vesicle budding and uncoating within the Golgi apparatus Contributes to the regulation of dendritic branching and filopodia extension By similarity. Involved in the regulation of dendritic spine development. Ref.3
Subunit structure	Interacts with ARHGAP21, ASAP2, HERC1, PIP5K1C and UACA By similarity. Interacts with NCS1/FREQ at the plasma membrane. Interacts with RAB11FIP3 and RAB11FIP4 By similarity. Interacts with USP6 (via Rab-GAP TBC domain) By similarity. Interacts with ECM29 By similarity. Interacts with TBC1D24 By similarity.
Subcellular location	Golgi apparatus By similarity. Cell membrane; Lipid-anchor By similarity. Endosome membrane; Lipid-anchor By similarity. Cell membrane By similarity. Cell projection › filopodium membrane; Lipid-anchor By similarity. Note: Recruited to the cell membrane in association with CYTH2 and ARL4C By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Arf family.

Ontologies

Keywords
Biological process	Differentiation ER-Golgi transport Neurogenesis Protein transport Transport
Cellular component	Cell membrane Cell projection Endosome Golgi apparatus Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Myristate
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from mutant phenotype PubMed 16880525. Source: MGI cortical actin cytoskeleton organization Inferred from electronic annotation. Source: Compara establishment of epithelial cell polarity Inferred from mutant phenotype PubMed 20080746. Source: MGI liver development Inferred from mutant phenotype PubMed 16880525. Source: MGI positive regulation of actin filament polymerization Inferred from electronic annotation. Source: Compara positive regulation of establishment of protein localization to plasma membrane Inferred from direct assay PubMed 16751103. Source: BHF-UCL protein localization to cell surface Inferred from direct assay PubMed 16751103. Source: BHF-UCL protein transport Traceable author statement Ref.1. Source: MGI regulation of Rac protein signal transduction Inferred from electronic annotation. Source: Compara regulation of dendritic spine development Inferred from mutant phenotype Ref.3. Source: UniProtKB regulation of filopodium assembly Inferred from electronic annotation. Source: Compara regulation of toll-like receptor 4 signaling pathway Non-traceable author statement PubMed 16751103. Source: BHF-UCL ruffle organization Inferred from electronic annotation. Source: Compara small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell cell cortex Inferred from electronic annotation. Source: Compara early endosome Inferred from electronic annotation. Source: Compara endosome Inferred from sequence or structural similarity. Source: UniProtKB endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell filopodium membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay Ref.1. Source: MGI recycling endosome Inferred from electronic annotation. Source: Compara ruffle Inferred from electronic annotation. Source: Compara
Molecular_function	GTP binding Traceable author statement PubMed 16751103. Source: BHF-UCL GTPase activity Traceable author statement PubMed 16751103. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 175

175

ADP-ribosylation factor 6

PRO_0000207401

Regions

Nucleotide binding

20 – 27

GTP By similarity

Nucleotide binding

63 – 67

GTP By similarity

Nucleotide binding

122 – 125

GTP By similarity

Amino acid modifications

Lipidation

N-myristoyl glycine By similarity

Secondary structure

175

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P62331 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 49E38E59AEA52B98
Show »

FASTA

175

20,082

        10         20         30         40         50         60 
MGKVLSKIFG NKEMRILMLG LDAAGKTTIL YKLKLGQSVT TIPTVGFNVE TVTYKNVKFN 

        70         80         90        100        110        120 
VWDVGGQDKI RPLWRHYYTG TQGLIFVVDC ADRDRIDEAR QELHRIINDR EMRDAIILIF 

       130        140        150        160        170 
ANKQDLPDAM KPHEIQEKLG LTRIRDRNWY VQPSCATSGD GLYEGLTWLT SNYKS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6)." Hosaka M., Toda K., Takatsu H., Torii S., Murakami K., Nakayama K. J. Biochem. 120:813-819(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ICR. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[3]	"The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation." Miyazaki H., Yamazaki M., Watanabe H., Maehama T., Yokozeki T., Kanaho Y. FEBS Lett. 579:6834-6838(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS REGULATOR OF DENDRITIC SPINE DEVELOPMENT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D87903 mRNA. Translation: BAA13495.1.
BC003478 mRNA. Translation: AAH03478.1.
BC083112 mRNA. Translation: AAH83112.1.

IPI

IPI00221616.

PIR

JC4950.

RefSeq

NP_031507.1. NM_007481.3.

UniGene

Mm.27308.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3VHX	X-ray	2.81	A/C/E/G	13-175	[»]

ProteinModelPortal

P62331.

ModBase

Search...

Protein-protein interaction databases

IntAct

P62331. 2 interactions.

STRING

10090.ENSMUSP00000055862.

PTM databases

PhosphoSite

P62331.

Proteomic databases

PaxDb

P62331.

PRIDE

P62331.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000050063; ENSMUSP00000055862; ENSMUSG00000044147.

GeneID

11845.

KEGG

mmu:11845.

Organism-specific databases

CTD

382.

MGI

MGI:99435. Arf6.

Phylogenomic databases

eggNOG

COG1100.

HOGENOM

HOG000163691.

HOVERGEN

HBG002073.

InParanoid

P62331.

K07941.

OMA

DREMKDA.

OrthoDB

EOG4GQQ62.

Gene expression databases

ArrayExpress

P62331.

Bgee

P62331.

CleanEx

MM_ARF6.

Genevestigator

P62331.

GermOnline

ENSMUSG00000044147. Mus musculus.

Family and domain databases

InterPro

IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]

Pfam

PF00025. Arf. 1 hit.
[Graphical view]

PRINTS

PR00328. SAR1GTPBP.

SMART

SM00177. ARF. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00231. small_GTP. 1 hit.

PROSITE

PS51417. ARF. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChEMBL

CHEMBL1075274.

NextBio

1599.

SOURCE

Search...

Entry information

Entry name

ARF6_MOUSE

Accession

Primary (citable) accession number: P62331
Secondary accession number(s): P26438

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents