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Protein

Thymosin beta-4

Gene

Tmsb4x

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity
Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-4
Short name:
T beta 4
Cleaved into the following chain:
Alternative name(s):
Seraspenide
Gene namesi
Name:Tmsb4x
Synonyms:Thyb4, Tmsb4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi621622. Tmsb4x.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000459272 – 44Thymosin beta-4Add BLAST43
PeptideiPRO_00000343012 – 5Hematopoietic system regulatory peptideBy similarity4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineCombined sources1
Modified residuei4N6-acetyllysineBy similarity1
Modified residuei12N6-acetyllysine; alternateBy similarity1
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei23PhosphothreonineBy similarity1
Modified residuei26N6-acetyllysineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei32N6-acetyllysineBy similarity1
Modified residuei34PhosphothreonineCombined sources1
Modified residuei39N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP62329.
PRIDEiP62329.

PTM databases

iPTMnetiP62329.
PhosphoSitePlusiP62329.

Expressioni

Tissue specificityi

Originally found in thymus but it is widely distributed in many tissues.1 Publication

Inductioni

By NGF and fibroblast growth factors.1 Publication

Gene expression databases

BgeeiENSRNOG00000047931.
GenevisibleiP62329. RN.

Interactioni

Subunit structurei

Interacts with SERPINB1. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066062.

Structurei

3D structure databases

ProteinModelPortaliP62329.
SMRiP62329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiKOG4794. Eukaryota.
ENOG410Y3I4. LUCA.
GeneTreeiENSGT00390000007040.
HOVERGENiHBG012534.
InParanoidiP62329.
KOiK05764.
OrthoDBiEOG091G1AVI.
PhylomeDBiP62329.

Family and domain databases

InterProiView protein in InterPro
IPR001152. Beta-thymosin.
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiView protein in Pfam
PF01290. Thymosin. 1 hit.
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005116. Thymosin_b4. 1 hit.
SMARTiView protein in SMART
SM00152. THY. 1 hit.
PROSITEiView protein in PROSITE
PS00500. THYMOSIN_B4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MSDKPDMAEI EKFDKSKLKK TETQEKNPLP SKETIEQEKQ AGES
Length:44
Mass (Da):5,053
Last modified:January 23, 2007 - v2
Checksum:i440C6158482DAAD0
GO

Sequence cautioni

The sequence AAA42246 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8A → V in AAA42245 (PubMed:6201851).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34043 mRNA. Translation: AAA42062.1.
K01334 mRNA. Translation: AAA42245.1.
M26759 mRNA. Translation: AAA42246.1. Different initiation.
BC058137 mRNA. Translation: AAH58137.1.
PIRiA01522. TNRTB4.
I52084.
RefSeqiNP_112398.1. NM_031136.1.
UniGeneiRn.146389.
Rn.201192.
Rn.203155.
Rn.230178.
Rn.2605.

Genome annotation databases

EnsembliENSRNOT00000071708; ENSRNOP00000066062; ENSRNOG00000047931.
GeneIDi81814.
KEGGirno:81814.

Similar proteinsi

Entry informationi

Entry nameiTYB4_RAT
AccessioniPrimary (citable) accession number: P62329
Secondary accession number(s): P01253
, P01254, Q0P5V6, Q63576
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families