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Protein

Thymosin beta-4

Gene

Tmsb4x

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity
Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.By similarity

GO - Molecular functioni

GO - Biological processi

  • actin filament organization Source: InterPro
  • osteoblast differentiation Source: RGD
  • regulation of cell migration Source: Ensembl
  • sequestering of actin monomers Source: RGD
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-4
Short name:
T beta 4
Cleaved into the following chain:
Alternative name(s):
Seraspenide
Gene namesi
Name:Tmsb4x
Synonyms:Thyb4, Tmsb4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi621622. Tmsb4x.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000459272 – 44Thymosin beta-4Add BLAST43
PeptideiPRO_00000343012 – 5Hematopoietic system regulatory peptideBy similarity4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineCombined sources1
Modified residuei4N6-acetyllysineBy similarity1
Modified residuei12N6-acetyllysineBy similarity1
Modified residuei23PhosphothreonineBy similarity1
Modified residuei26N6-acetyllysineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei32N6-acetyllysineBy similarity1
Modified residuei34PhosphothreonineCombined sources1
Modified residuei39N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP62329.
PRIDEiP62329.

PTM databases

iPTMnetiP62329.
PhosphoSitePlusiP62329.

Expressioni

Tissue specificityi

Originally found in thymus but it is widely distributed in many tissues.1 Publication

Inductioni

By NGF and fibroblast growth factors.1 Publication

Gene expression databases

BgeeiENSRNOG00000047931.
GenevisibleiP62329. RN.

Interactioni

Subunit structurei

Interacts with SERPINB1. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066062.

Structurei

3D structure databases

ProteinModelPortaliP62329.
SMRiP62329.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiKOG4794. Eukaryota.
ENOG410Y3I4. LUCA.
GeneTreeiENSGT00390000007040.
HOVERGENiHBG012534.
InParanoidiP62329.
KOiK05764.
OrthoDBiEOG091G1AVI.
PhylomeDBiP62329.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Beta-thymosin.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MSDKPDMAEI EKFDKSKLKK TETQEKNPLP SKETIEQEKQ AGES
Length:44
Mass (Da):5,053
Last modified:January 23, 2007 - v2
Checksum:i440C6158482DAAD0
GO

Sequence cautioni

The sequence AAA42246 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8A → V in AAA42245 (PubMed:6201851).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34043 mRNA. Translation: AAA42062.1.
K01334 mRNA. Translation: AAA42245.1.
M26759 mRNA. Translation: AAA42246.1. Different initiation.
BC058137 mRNA. Translation: AAH58137.1.
PIRiA01522. TNRTB4.
I52084.
RefSeqiNP_112398.1. NM_031136.1.
UniGeneiRn.146389.
Rn.201192.
Rn.203155.
Rn.230178.
Rn.2605.

Genome annotation databases

EnsembliENSRNOT00000071708; ENSRNOP00000066062; ENSRNOG00000047931.
GeneIDi81814.
KEGGirno:81814.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34043 mRNA. Translation: AAA42062.1.
K01334 mRNA. Translation: AAA42245.1.
M26759 mRNA. Translation: AAA42246.1. Different initiation.
BC058137 mRNA. Translation: AAH58137.1.
PIRiA01522. TNRTB4.
I52084.
RefSeqiNP_112398.1. NM_031136.1.
UniGeneiRn.146389.
Rn.201192.
Rn.203155.
Rn.230178.
Rn.2605.

3D structure databases

ProteinModelPortaliP62329.
SMRiP62329.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066062.

PTM databases

iPTMnetiP62329.
PhosphoSitePlusiP62329.

Proteomic databases

PaxDbiP62329.
PRIDEiP62329.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071708; ENSRNOP00000066062; ENSRNOG00000047931.
GeneIDi81814.
KEGGirno:81814.

Organism-specific databases

CTDi7114.
RGDi621622. Tmsb4x.

Phylogenomic databases

eggNOGiKOG4794. Eukaryota.
ENOG410Y3I4. LUCA.
GeneTreeiENSGT00390000007040.
HOVERGENiHBG012534.
InParanoidiP62329.
KOiK05764.
OrthoDBiEOG091G1AVI.
PhylomeDBiP62329.

Miscellaneous databases

PROiP62329.

Gene expression databases

BgeeiENSRNOG00000047931.
GenevisibleiP62329. RN.

Family and domain databases

Gene3Di1.20.5.520. 1 hit.
InterProiIPR001152. Beta-thymosin.
[Graphical view]
PANTHERiPTHR12021. PTHR12021. 1 hit.
PfamiPF01290. Thymosin. 1 hit.
[Graphical view]
PIRSFiPIRSF001828. Thymosin_beta. 1 hit.
ProDomiPD005116. Thymosin_b4. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00152. THY. 1 hit.
[Graphical view]
PROSITEiPS00500. THYMOSIN_B4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYB4_RAT
AccessioniPrimary (citable) accession number: P62329
Secondary accession number(s): P01253
, P01254, Q0P5V6, Q63576
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.