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Protein

Thymosin beta-4

Gene

Tmsb4x

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).By similarity
Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymosin beta-4
Short name:
T beta 4
Cleaved into the following chain:
Alternative name(s):
Seraspenide
Gene namesi
Name:Tmsb4x
Synonyms:Thyb4, Tmsb4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi621622 Tmsb4x

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000459272 – 44Thymosin beta-4Add BLAST43
PeptideiPRO_00000343012 – 5Hematopoietic system regulatory peptideBy similarity4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineCombined sources1
Modified residuei4N6-acetyllysineBy similarity1
Modified residuei12N6-acetyllysine; alternateBy similarity1
Cross-linki12Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei23PhosphothreonineBy similarity1
Modified residuei26N6-acetyllysineBy similarity1
Modified residuei31PhosphoserineBy similarity1
Modified residuei32N6-acetyllysineBy similarity1
Modified residuei34PhosphothreonineCombined sources1
Modified residuei39N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP62329
PRIDEiP62329

PTM databases

iPTMnetiP62329
PhosphoSitePlusiP62329

Expressioni

Tissue specificityi

Originally found in thymus but it is widely distributed in many tissues.1 Publication

Inductioni

By NGF and fibroblast growth factors.1 Publication

Gene expression databases

BgeeiENSRNOG00000047931
GenevisibleiP62329 RN

Interactioni

Subunit structurei

Interacts with SERPINB1. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066062

Structurei

3D structure databases

ProteinModelPortaliP62329
SMRiP62329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymosin beta family.Curated

Phylogenomic databases

eggNOGiKOG4794 Eukaryota
ENOG410Y3I4 LUCA
GeneTreeiENSGT00390000007040
HOVERGENiHBG012534
InParanoidiP62329
KOiK05764
OrthoDBiEOG091G1AVI
PhylomeDBiP62329

Family and domain databases

Gene3Di1.20.5.520, 1 hit
InterProiView protein in InterPro
IPR001152 Beta-thymosin
IPR038386 Beta-thymosin_sf
PANTHERiPTHR12021 PTHR12021, 1 hit
PfamiView protein in Pfam
PF01290 Thymosin, 1 hit
PIRSFiPIRSF001828 Thymosin_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005116 Thymosin_b4, 1 hit
SMARTiView protein in SMART
SM00152 THY, 1 hit
PROSITEiView protein in PROSITE
PS00500 THYMOSIN_B4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62329-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MSDKPDMAEI EKFDKSKLKK TETQEKNPLP SKETIEQEKQ AGES
Length:44
Mass (Da):5,053
Last modified:January 23, 2007 - v2
Checksum:i440C6158482DAAD0
GO

Sequence cautioni

The sequence AAA42246 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8A → V in AAA42245 (PubMed:6201851).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34043 mRNA Translation: AAA42062.1
K01334 mRNA Translation: AAA42245.1
M26759 mRNA Translation: AAA42246.1 Different initiation.
BC058137 mRNA Translation: AAH58137.1
PIRiA01522 TNRTB4
I52084
RefSeqiNP_112398.1, NM_031136.1
UniGeneiRn.146389
Rn.201192
Rn.203155
Rn.230178
Rn.2605

Genome annotation databases

EnsembliENSRNOT00000071708; ENSRNOP00000066062; ENSRNOG00000047931
GeneIDi81814
KEGGirno:81814

Similar proteinsi

Entry informationi

Entry nameiTYB4_RAT
AccessioniPrimary (citable) accession number: P62329
Secondary accession number(s): P01253
, P01254, Q0P5V6, Q63576
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health