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P62325

- BTG1_MOUSE

UniProt

P62325 - BTG1_MOUSE

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Protein

Protein BTG1

Gene

Btg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Anti-proliferative protein.By similarity

GO - Molecular functioni

  1. enzyme binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of cell proliferation Source: UniProtKB
  2. positive regulation of angiogenesis Source: UniProtKB
  3. positive regulation of catalytic activity Source: UniProtKB
  4. positive regulation of endothelial cell differentiation Source: UniProtKB
  5. positive regulation of fibroblast apoptotic process Source: UniProtKB
  6. protein methylation Source: MGI
  7. response to oxidative stress Source: Ensembl
  8. response to peptide hormone Source: Ensembl
  9. spermatogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG1
Alternative name(s):
B-cell translocation gene 1 protein
Gene namesi
Name:Btg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:88215. Btg1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Protein BTG1PRO_0000143801Add
BLAST

Proteomic databases

MaxQBiP62325.
PRIDEiP62325.

PTM databases

PhosphoSiteiP62325.

Expressioni

Gene expression databases

BgeeiP62325.
CleanExiMM_BTG1.
ExpressionAtlasiP62325. baseline and differential.
GenevestigatoriP62325.

Interactioni

Subunit structurei

Interacts with CNOT7 and CNOT8.By similarity

Protein-protein interaction databases

BioGridi198397. 2 interactions.
MINTiMINT-118196.

Structurei

3D structure databases

ProteinModelPortaliP62325.
SMRiP62325. Positions 11-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiNOG325491.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiP62325.
KOiK14443.
OMAiCARSRIK.
OrthoDBiEOG72RN0S.
PhylomeDBiP62325.
TreeFamiTF105272.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
[Graphical view]
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62325-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE
60 70 80 90 100
HYKHHWFPEK PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS
110 120 130 140 150
ELTLWVDPYE VSYRIGEDGS ICVLYEASPA GGSTQNSTNV QMVDSRISCK
160 170
EELLLGRTSP SKNYNMMTVS G
Length:171
Mass (Da):19,209
Last modified:July 5, 2004 - v1
Checksum:iEFED8BE09013BE60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z16410 Genomic DNA. Translation: CAA78902.1.
L16846 mRNA. Translation: AAA37327.1.
BC006834 mRNA. Translation: AAH06834.1.
BC018309 mRNA. Translation: AAH18309.1.
CCDSiCCDS24140.1.
PIRiI48272.
RefSeqiNP_031595.1. NM_007569.2.
UniGeneiMm.23811.

Genome annotation databases

EnsembliENSMUST00000038377; ENSMUSP00000038863; ENSMUSG00000036478.
GeneIDi12226.
KEGGimmu:12226.
UCSCiuc007gww.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z16410 Genomic DNA. Translation: CAA78902.1 .
L16846 mRNA. Translation: AAA37327.1 .
BC006834 mRNA. Translation: AAH06834.1 .
BC018309 mRNA. Translation: AAH18309.1 .
CCDSi CCDS24140.1.
PIRi I48272.
RefSeqi NP_031595.1. NM_007569.2.
UniGenei Mm.23811.

3D structure databases

ProteinModelPortali P62325.
SMRi P62325. Positions 11-129.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198397. 2 interactions.
MINTi MINT-118196.

PTM databases

PhosphoSitei P62325.

Proteomic databases

MaxQBi P62325.
PRIDEi P62325.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038377 ; ENSMUSP00000038863 ; ENSMUSG00000036478 .
GeneIDi 12226.
KEGGi mmu:12226.
UCSCi uc007gww.2. mouse.

Organism-specific databases

CTDi 694.
MGIi MGI:88215. Btg1.

Phylogenomic databases

eggNOGi NOG325491.
HOGENOMi HOG000290200.
HOVERGENi HBG004907.
InParanoidi P62325.
KOi K14443.
OMAi CARSRIK.
OrthoDBi EOG72RN0S.
PhylomeDBi P62325.
TreeFami TF105272.

Miscellaneous databases

ChiTaRSi Btg1. mouse.
NextBioi 280635.
PROi P62325.
SOURCEi Search...

Gene expression databases

Bgeei P62325.
CleanExi MM_BTG1.
ExpressionAtlasi P62325. baseline and differential.
Genevestigatori P62325.

Family and domain databases

InterProi IPR002087. Anti_prolifrtn.
[Graphical view ]
Pfami PF07742. BTG. 1 hit.
[Graphical view ]
PRINTSi PR00310. ANTIPRLFBTG1.
SMARTi SM00099. btg1. 1 hit.
[Graphical view ]
PROSITEi PS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis reveals that the BTG1 anti-proliferative gene is conserved throughout evolution in its coding and 3' non-coding regions."
    Rouault J.-P., Samarut C., Duret L., Tessa C., Samarut J., Magaud J.-P.
    Gene 129:303-306(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Suk K., Erickson K.L.
    Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.

Entry informationi

Entry nameiBTG1_MOUSE
AccessioniPrimary (citable) accession number: P62325
Secondary accession number(s): P31607
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 26, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3