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P62325

- BTG1_MOUSE

UniProt

P62325 - BTG1_MOUSE

Protein

Protein BTG1

Gene

Btg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Anti-proliferative protein.By similarity

    GO - Molecular functioni

    1. enzyme binding Source: UniProtKB
    2. protein binding Source: MGI

    GO - Biological processi

    1. negative regulation of cell proliferation Source: UniProtKB
    2. positive regulation of angiogenesis Source: UniProtKB
    3. positive regulation of catalytic activity Source: UniProtKB
    4. positive regulation of endothelial cell differentiation Source: UniProtKB
    5. positive regulation of fibroblast apoptotic process Source: UniProtKB
    6. protein methylation Source: MGI
    7. response to oxidative stress Source: Ensembl
    8. response to peptide hormone Source: Ensembl
    9. spermatogenesis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein BTG1
    Alternative name(s):
    B-cell translocation gene 1 protein
    Gene namesi
    Name:Btg1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:88215. Btg1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 171171Protein BTG1PRO_0000143801Add
    BLAST

    Proteomic databases

    PRIDEiP62325.

    PTM databases

    PhosphoSiteiP62325.

    Expressioni

    Gene expression databases

    ArrayExpressiP62325.
    BgeeiP62325.
    CleanExiMM_BTG1.
    GenevestigatoriP62325.

    Interactioni

    Subunit structurei

    Interacts with CNOT7 and CNOT8.By similarity

    Protein-protein interaction databases

    BioGridi198397. 2 interactions.
    MINTiMINT-118196.

    Structurei

    3D structure databases

    ProteinModelPortaliP62325.
    SMRiP62325. Positions 11-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BTG family.Curated

    Phylogenomic databases

    eggNOGiNOG325491.
    HOGENOMiHOG000290200.
    HOVERGENiHBG004907.
    InParanoidiP62325.
    KOiK14443.
    OMAiCARSRIK.
    OrthoDBiEOG72RN0S.
    PhylomeDBiP62325.
    TreeFamiTF105272.

    Family and domain databases

    InterProiIPR002087. Anti_prolifrtn.
    [Graphical view]
    PfamiPF07742. BTG. 1 hit.
    [Graphical view]
    PRINTSiPR00310. ANTIPRLFBTG1.
    SMARTiSM00099. btg1. 1 hit.
    [Graphical view]
    PROSITEiPS00960. BTG_1. 1 hit.
    PS01203. BTG_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62325-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE    50
    HYKHHWFPEK PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS 100
    ELTLWVDPYE VSYRIGEDGS ICVLYEASPA GGSTQNSTNV QMVDSRISCK 150
    EELLLGRTSP SKNYNMMTVS G 171
    Length:171
    Mass (Da):19,209
    Last modified:July 5, 2004 - v1
    Checksum:iEFED8BE09013BE60
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z16410 Genomic DNA. Translation: CAA78902.1.
    L16846 mRNA. Translation: AAA37327.1.
    BC006834 mRNA. Translation: AAH06834.1.
    BC018309 mRNA. Translation: AAH18309.1.
    CCDSiCCDS24140.1.
    PIRiI48272.
    RefSeqiNP_031595.1. NM_007569.2.
    UniGeneiMm.23811.

    Genome annotation databases

    EnsembliENSMUST00000038377; ENSMUSP00000038863; ENSMUSG00000036478.
    GeneIDi12226.
    KEGGimmu:12226.
    UCSCiuc007gww.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z16410 Genomic DNA. Translation: CAA78902.1 .
    L16846 mRNA. Translation: AAA37327.1 .
    BC006834 mRNA. Translation: AAH06834.1 .
    BC018309 mRNA. Translation: AAH18309.1 .
    CCDSi CCDS24140.1.
    PIRi I48272.
    RefSeqi NP_031595.1. NM_007569.2.
    UniGenei Mm.23811.

    3D structure databases

    ProteinModelPortali P62325.
    SMRi P62325. Positions 11-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198397. 2 interactions.
    MINTi MINT-118196.

    PTM databases

    PhosphoSitei P62325.

    Proteomic databases

    PRIDEi P62325.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038377 ; ENSMUSP00000038863 ; ENSMUSG00000036478 .
    GeneIDi 12226.
    KEGGi mmu:12226.
    UCSCi uc007gww.2. mouse.

    Organism-specific databases

    CTDi 694.
    MGIi MGI:88215. Btg1.

    Phylogenomic databases

    eggNOGi NOG325491.
    HOGENOMi HOG000290200.
    HOVERGENi HBG004907.
    InParanoidi P62325.
    KOi K14443.
    OMAi CARSRIK.
    OrthoDBi EOG72RN0S.
    PhylomeDBi P62325.
    TreeFami TF105272.

    Miscellaneous databases

    ChiTaRSi BTG1. mouse.
    NextBioi 280635.
    PROi P62325.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62325.
    Bgeei P62325.
    CleanExi MM_BTG1.
    Genevestigatori P62325.

    Family and domain databases

    InterProi IPR002087. Anti_prolifrtn.
    [Graphical view ]
    Pfami PF07742. BTG. 1 hit.
    [Graphical view ]
    PRINTSi PR00310. ANTIPRLFBTG1.
    SMARTi SM00099. btg1. 1 hit.
    [Graphical view ]
    PROSITEi PS00960. BTG_1. 1 hit.
    PS01203. BTG_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis reveals that the BTG1 anti-proliferative gene is conserved throughout evolution in its coding and 3' non-coding regions."
      Rouault J.-P., Samarut C., Duret L., Tessa C., Samarut J., Magaud J.-P.
      Gene 129:303-306(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Suk K., Erickson K.L.
      Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Salivary gland.

    Entry informationi

    Entry nameiBTG1_MOUSE
    AccessioniPrimary (citable) accession number: P62325
    Secondary accession number(s): P31607
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3