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Protein

Protein BTG1

Gene

Btg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Anti-proliferative protein.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG1
Alternative name(s):
B-cell translocation gene 1 protein
Gene namesi
Name:Btg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:88215. Btg1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Protein BTG1PRO_0000143801Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei159 – 1591PhosphoserineBy similarity
Modified residuei161 – 1611PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP62325.
PRIDEiP62325.

PTM databases

PhosphoSiteiP62325.

Expressioni

Gene expression databases

BgeeiP62325.
CleanExiMM_BTG1.
ExpressionAtlasiP62325. baseline and differential.
GenevisibleiP62325. MM.

Interactioni

Subunit structurei

Interacts with CNOT7 and CNOT8.By similarity

Protein-protein interaction databases

BioGridi198397. 2 interactions.
MINTiMINT-118196.
STRINGi10090.ENSMUSP00000038863.

Structurei

3D structure databases

ProteinModelPortaliP62325.
SMRiP62325. Positions 11-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiNOG325491.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiP62325.
KOiK14443.
OMAiEQYKHHW.
OrthoDBiEOG72RN0S.
PhylomeDBiP62325.
TreeFamiTF105272.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
[Graphical view]
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE
60 70 80 90 100
HYKHHWFPEK PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS
110 120 130 140 150
ELTLWVDPYE VSYRIGEDGS ICVLYEASPA GGSTQNSTNV QMVDSRISCK
160 170
EELLLGRTSP SKNYNMMTVS G
Length:171
Mass (Da):19,209
Last modified:July 5, 2004 - v1
Checksum:iEFED8BE09013BE60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z16410 Genomic DNA. Translation: CAA78902.1.
L16846 mRNA. Translation: AAA37327.1.
BC006834 mRNA. Translation: AAH06834.1.
BC018309 mRNA. Translation: AAH18309.1.
CCDSiCCDS24140.1.
PIRiI48272.
RefSeqiNP_031595.1. NM_007569.2.
UniGeneiMm.23811.

Genome annotation databases

EnsembliENSMUST00000038377; ENSMUSP00000038863; ENSMUSG00000036478.
GeneIDi12226.
KEGGimmu:12226.
UCSCiuc007gww.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z16410 Genomic DNA. Translation: CAA78902.1.
L16846 mRNA. Translation: AAA37327.1.
BC006834 mRNA. Translation: AAH06834.1.
BC018309 mRNA. Translation: AAH18309.1.
CCDSiCCDS24140.1.
PIRiI48272.
RefSeqiNP_031595.1. NM_007569.2.
UniGeneiMm.23811.

3D structure databases

ProteinModelPortaliP62325.
SMRiP62325. Positions 11-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198397. 2 interactions.
MINTiMINT-118196.
STRINGi10090.ENSMUSP00000038863.

PTM databases

PhosphoSiteiP62325.

Proteomic databases

MaxQBiP62325.
PRIDEiP62325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038377; ENSMUSP00000038863; ENSMUSG00000036478.
GeneIDi12226.
KEGGimmu:12226.
UCSCiuc007gww.2. mouse.

Organism-specific databases

CTDi694.
MGIiMGI:88215. Btg1.

Phylogenomic databases

eggNOGiNOG325491.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiP62325.
KOiK14443.
OMAiEQYKHHW.
OrthoDBiEOG72RN0S.
PhylomeDBiP62325.
TreeFamiTF105272.

Miscellaneous databases

ChiTaRSiBtg1. mouse.
NextBioi280635.
PROiP62325.
SOURCEiSearch...

Gene expression databases

BgeeiP62325.
CleanExiMM_BTG1.
ExpressionAtlasiP62325. baseline and differential.
GenevisibleiP62325. MM.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
[Graphical view]
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis reveals that the BTG1 anti-proliferative gene is conserved throughout evolution in its coding and 3' non-coding regions."
    Rouault J.-P., Samarut C., Duret L., Tessa C., Samarut J., Magaud J.-P.
    Gene 129:303-306(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Suk K., Erickson K.L.
    Submitted (MAY-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.

Entry informationi

Entry nameiBTG1_MOUSE
AccessioniPrimary (citable) accession number: P62325
Secondary accession number(s): P31607
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.