ID   BTG1_HUMAN              Reviewed;         171 AA.
AC   P62324; P31607;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 149.
DE   RecName: Full=Protein BTG1;
DE   AltName: Full=B-cell translocation gene 1 protein;
GN   Name=BTG1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Lymphoblastoma;
RX   PubMed=1373383; DOI=10.1002/j.1460-2075.1992.tb05213.x;
RA   Rouault J.-P., Rimokh R., Tessa C., Paranhos G., Ffrench M., Duret L.,
RA   Garoccio M., Germain D., Samarut J., Magaud J.-P.;
RT   "BTG1, a member of a new family of antiproliferative genes.";
RL   EMBO J. 11:1663-1670(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS SER-139 AND GLU-141.
RG   NIEHS SNPs program;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon, and Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   INTERACTION WITH CNOT7.
RX   PubMed=9712883; DOI=10.1074/jbc.273.35.22563;
RA   Rouault J.P., Prevot D., Berthet C., Birot A.M., Billaud M., Magaud J.P.,
RA   Corbo L.;
RT   "Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the
RT   murine homolog of a component of the yeast CCR4 transcriptional regulatory
RT   complex.";
RL   J. Biol. Chem. 273:22563-22569(1998).
RN   [6]
RP   INTERACTION WITH CNOT8.
RX   PubMed=11136725; DOI=10.1074/jbc.m008201200;
RA   Prevot D., Morel A.P., Voeltzel T., Rostan M.C., Rimokh R., Magaud J.P.,
RA   Corbo L.;
RT   "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1,
RT   the human homolog of a component of the yeast CCR4 transcriptional complex:
RT   involvement in estrogen receptor alpha signaling pathway.";
RL   J. Biol. Chem. 276:9640-9648(2001).
RN   [7]
RP   CHROMOSOMAL TRANSLOCATION WITH MYC.
RX   PubMed=2069907; DOI=10.1002/gcc.2870030106;
RA   Rimokh R., Rouault J.P., Wahbi K., Gadoux M., Lafage M., Archimbaud E.,
RA   Charrin C., Gentilhomme O., Germain D., Samarut J.;
RT   "A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus
RT   in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic
RT   leukemia.";
RL   Genes Chromosomes Cancer 3:24-36(1991).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-159, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Erythroleukemia;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: Anti-proliferative protein. {ECO:0000269|PubMed:1373383}.
CC   -!- SUBUNIT: Interacts with CNOT7 and CNOT8. {ECO:0000269|PubMed:11136725,
CC       ECO:0000269|PubMed:9712883}.
CC   -!- INTERACTION:
CC       P62324; Q9UIV1: CNOT7; NbExp=4; IntAct=EBI-742279, EBI-2105113;
CC       P62324; Q9UFF9: CNOT8; NbExp=6; IntAct=EBI-742279, EBI-742299;
CC       P62324; Q13158: FADD; NbExp=5; IntAct=EBI-742279, EBI-494804;
CC       P62324; P62993: GRB2; NbExp=3; IntAct=EBI-742279, EBI-401755;
CC       P62324; O43639: NCK2; NbExp=3; IntAct=EBI-742279, EBI-713635;
CC       P62324; Q60809: Cnot7; Xeno; NbExp=5; IntAct=EBI-742279, EBI-2104739;
CC   -!- DEVELOPMENTAL STAGE: Its expression is associated with the early G1
CC       phase of the cell cycle. {ECO:0000269|PubMed:1373383}.
CC   -!- DISEASE: Note=A chromosomal aberration involving BTG1 may be a cause of
CC       a form of B-cell chronic lymphocytic leukemia. Translocation
CC       t(8;12)(q24;q22) with MYC. {ECO:0000269|PubMed:2069907}.
CC   -!- SIMILARITY: Belongs to the BTG family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC       URL="http://egp.gs.washington.edu/data/btg1/";
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DR   EMBL; X61123; CAA43435.1; -; mRNA.
DR   EMBL; BT019840; AAV38643.1; -; mRNA.
DR   EMBL; AY850133; AAV97814.1; -; Genomic_DNA.
DR   EMBL; BC016759; AAH16759.1; -; mRNA.
DR   EMBL; BC064953; AAH64953.1; -; mRNA.
DR   CCDS; CCDS9043.1; -.
DR   PIR; S20947; S20947.
DR   RefSeq; NP_001722.1; NM_001731.2.
DR   AlphaFoldDB; P62324; -.
DR   SMR; P62324; -.
DR   BioGRID; 107159; 22.
DR   IntAct; P62324; 10.
DR   MINT; P62324; -.
DR   STRING; 9606.ENSP00000256015; -.
DR   iPTMnet; P62324; -.
DR   PhosphoSitePlus; P62324; -.
DR   BioMuta; BTG1; -.
DR   DMDM; 59799172; -.
DR   EPD; P62324; -.
DR   MassIVE; P62324; -.
DR   PaxDb; 9606-ENSP00000256015; -.
DR   PeptideAtlas; P62324; -.
DR   ProteomicsDB; 57394; -.
DR   Pumba; P62324; -.
DR   Antibodypedia; 1186; 248 antibodies from 29 providers.
DR   DNASU; 694; -.
DR   Ensembl; ENST00000256015.5; ENSP00000256015.3; ENSG00000133639.6.
DR   GeneID; 694; -.
DR   KEGG; hsa:694; -.
DR   MANE-Select; ENST00000256015.5; ENSP00000256015.3; NM_001731.3; NP_001722.1.
DR   AGR; HGNC:1130; -.
DR   CTD; 694; -.
DR   DisGeNET; 694; -.
DR   GeneCards; BTG1; -.
DR   HGNC; HGNC:1130; BTG1.
DR   HPA; ENSG00000133639; Low tissue specificity.
DR   MIM; 109580; gene.
DR   neXtProt; NX_P62324; -.
DR   OpenTargets; ENSG00000133639; -.
DR   PharmGKB; PA25450; -.
DR   VEuPathDB; HostDB:ENSG00000133639; -.
DR   eggNOG; KOG4006; Eukaryota.
DR   GeneTree; ENSGT00950000182952; -.
DR   HOGENOM; CLU_079660_4_0_1; -.
DR   InParanoid; P62324; -.
DR   OMA; YNNMMTV; -.
DR   OrthoDB; 11568at2759; -.
DR   PhylomeDB; P62324; -.
DR   TreeFam; TF105272; -.
DR   PathwayCommons; P62324; -.
DR   Reactome; R-HSA-9617828; FOXO-mediated transcription of cell cycle genes.
DR   SignaLink; P62324; -.
DR   SIGNOR; P62324; -.
DR   BioGRID-ORCS; 694; 23 hits in 1157 CRISPR screens.
DR   ChiTaRS; BTG1; human.
DR   GeneWiki; BTG1; -.
DR   GenomeRNAi; 694; -.
DR   Pharos; P62324; Tbio.
DR   PRO; PR:P62324; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; P62324; Protein.
DR   Bgee; ENSG00000133639; Expressed in lower lobe of lung and 219 other cell types or tissues.
DR   ExpressionAtlas; P62324; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0019899; F:enzyme binding; IPI:UniProtKB.
DR   GO; GO:0019900; F:kinase binding; NAS:UniProtKB.
DR   GO; GO:0003712; F:transcription coregulator activity; NAS:UniProtKB.
DR   GO; GO:0016477; P:cell migration; NAS:UniProtKB.
DR   GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR   GO; GO:0030308; P:negative regulation of cell growth; NAS:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:UniProtKB.
DR   GO; GO:0045930; P:negative regulation of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IMP:UniProtKB.
DR   GO; GO:0045603; P:positive regulation of endothelial cell differentiation; IMP:UniProtKB.
DR   GO; GO:2000271; P:positive regulation of fibroblast apoptotic process; IMP:UniProtKB.
DR   GO; GO:0045663; P:positive regulation of myoblast differentiation; IDA:MGI.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; NAS:UniProtKB.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:Ensembl.
DR   GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
DR   GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR   Gene3D; 3.90.640.90; Anti-proliferative protein, N-terminal domain; 1.
DR   InterPro; IPR002087; Anti_prolifrtn.
DR   InterPro; IPR033332; BTG.
DR   InterPro; IPR036054; BTG-like_sf.
DR   PANTHER; PTHR22978; B-CELL TRANSLOCATION GENE; 1.
DR   PANTHER; PTHR22978:SF30; PROTEIN BTG1; 1.
DR   Pfam; PF07742; BTG; 1.
DR   PRINTS; PR00310; ANTIPRLFBTG1.
DR   SMART; SM00099; btg1; 1.
DR   SUPFAM; SSF160696; BTG domain-like; 1.
DR   PROSITE; PS00960; BTG_1; 1.
DR   PROSITE; PS01203; BTG_2; 1.
DR   Genevisible; P62324; HS.
PE   1: Evidence at protein level;
KW   Chromosomal rearrangement; Phosphoprotein; Proto-oncogene;
KW   Reference proteome.
FT   CHAIN           1..171
FT                   /note="Protein BTG1"
FT                   /id="PRO_0000143800"
FT   MOD_RES         159
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VARIANT         139
FT                   /note="N -> S (in dbSNP:rs28399541)"
FT                   /evidence="ECO:0000269|Ref.3"
FT                   /id="VAR_021345"
FT   VARIANT         141
FT                   /note="Q -> E (in dbSNP:rs28399542)"
FT                   /evidence="ECO:0000269|Ref.3"
FT                   /id="VAR_021346"
SQ   SEQUENCE   171 AA;  19209 MW;  EFED8BE09013BE60 CRC64;
     MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE HYKHHWFPEK
     PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS ELTLWVDPYE VSYRIGEDGS
     ICVLYEASPA GGSTQNSTNV QMVDSRISCK EELLLGRTSP SKNYNMMTVS G
//