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Protein

Protein BTG1

Gene

BTG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Anti-proliferative protein.1 Publication

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • kinase binding Source: UniProtKB
  • transcription cofactor activity Source: UniProtKB

GO - Biological processi

  • cell migration Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of endothelial cell differentiation Source: UniProtKB
  • positive regulation of fibroblast apoptotic process Source: UniProtKB
  • positive regulation of myoblast differentiation Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG1
Alternative name(s):
B-cell translocation gene 1 protein
Gene namesi
Name:BTG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:1130. BTG1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA25450.

Polymorphism and mutation databases

BioMutaiBTG1.
DMDMi59799172.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 171171Protein BTG1PRO_0000143800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei159 – 1591PhosphoserineBy similarity
Modified residuei161 – 1611PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP62324.
PaxDbiP62324.
PRIDEiP62324.

PTM databases

PhosphoSiteiP62324.

Expressioni

Developmental stagei

Its expression is associated with the early G1 phase of the cell cycle.1 Publication

Gene expression databases

BgeeiP62324.
CleanExiHS_BTG1.
ExpressionAtlasiP62324. baseline and differential.
GenevisibleiP62324. HS.

Organism-specific databases

HPAiHPA005972.

Interactioni

Subunit structurei

Interacts with CNOT7 and CNOT8.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CNOT7Q9UIV13EBI-742279,EBI-2105113
Cnot7Q608095EBI-742279,EBI-2104739From a different organism.
CNOT8Q9UFF94EBI-742279,EBI-742299

Protein-protein interaction databases

BioGridi107159. 18 interactions.
IntActiP62324. 6 interactions.
MINTiMINT-1446937.
STRINGi9606.ENSP00000256015.

Structurei

3D structure databases

ProteinModelPortaliP62324.
SMRiP62324. Positions 11-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiNOG325491.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiP62324.
KOiK14443.
OMAiEQYKHHW.
OrthoDBiEOG72RN0S.
PhylomeDBiP62324.
TreeFamiTF105272.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
[Graphical view]
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE
60 70 80 90 100
HYKHHWFPEK PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS
110 120 130 140 150
ELTLWVDPYE VSYRIGEDGS ICVLYEASPA GGSTQNSTNV QMVDSRISCK
160 170
EELLLGRTSP SKNYNMMTVS G
Length:171
Mass (Da):19,209
Last modified:July 5, 2004 - v1
Checksum:iEFED8BE09013BE60
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti139 – 1391N → S.1 Publication
Corresponds to variant rs28399541 [ dbSNP | Ensembl ].
VAR_021345
Natural varianti141 – 1411Q → E.1 Publication
Corresponds to variant rs28399542 [ dbSNP | Ensembl ].
VAR_021346

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61123 mRNA. Translation: CAA43435.1.
BT019840 mRNA. Translation: AAV38643.1.
AY850133 Genomic DNA. Translation: AAV97814.1.
BC016759 mRNA. Translation: AAH16759.1.
BC064953 mRNA. Translation: AAH64953.1.
CCDSiCCDS9043.1.
PIRiS20947.
RefSeqiNP_001722.1. NM_001731.2.
UniGeneiHs.255935.

Genome annotation databases

EnsembliENST00000256015; ENSP00000256015; ENSG00000133639.
GeneIDi694.
KEGGihsa:694.
UCSCiuc001tby.3. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61123 mRNA. Translation: CAA43435.1.
BT019840 mRNA. Translation: AAV38643.1.
AY850133 Genomic DNA. Translation: AAV97814.1.
BC016759 mRNA. Translation: AAH16759.1.
BC064953 mRNA. Translation: AAH64953.1.
CCDSiCCDS9043.1.
PIRiS20947.
RefSeqiNP_001722.1. NM_001731.2.
UniGeneiHs.255935.

3D structure databases

ProteinModelPortaliP62324.
SMRiP62324. Positions 11-129.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107159. 18 interactions.
IntActiP62324. 6 interactions.
MINTiMINT-1446937.
STRINGi9606.ENSP00000256015.

PTM databases

PhosphoSiteiP62324.

Polymorphism and mutation databases

BioMutaiBTG1.
DMDMi59799172.

Proteomic databases

MaxQBiP62324.
PaxDbiP62324.
PRIDEiP62324.

Protocols and materials databases

DNASUi694.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256015; ENSP00000256015; ENSG00000133639.
GeneIDi694.
KEGGihsa:694.
UCSCiuc001tby.3. human.

Organism-specific databases

CTDi694.
GeneCardsiGC12M092469.
HGNCiHGNC:1130. BTG1.
HPAiHPA005972.
MIMi109580. gene.
neXtProtiNX_P62324.
PharmGKBiPA25450.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG325491.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000290200.
HOVERGENiHBG004907.
InParanoidiP62324.
KOiK14443.
OMAiEQYKHHW.
OrthoDBiEOG72RN0S.
PhylomeDBiP62324.
TreeFamiTF105272.

Miscellaneous databases

ChiTaRSiBTG1. human.
GeneWikiiBTG1.
GenomeRNAii694.
NextBioi2846.
PROiP62324.
SOURCEiSearch...

Gene expression databases

BgeeiP62324.
CleanExiHS_BTG1.
ExpressionAtlasiP62324. baseline and differential.
GenevisibleiP62324. HS.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
[Graphical view]
PfamiPF07742. BTG. 1 hit.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "BTG1, a member of a new family of antiproliferative genes."
    Rouault J.-P., Rimokh R., Tessa C., Paranhos G., Ffrench M., Duret L., Garoccio M., Germain D., Samarut J., Magaud J.-P.
    EMBO J. 11:1663-1670(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    Tissue: Lymphoblastoma.
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIEHS SNPs program
    Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-139 AND GLU-141.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Skin.
  5. "Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex."
    Rouault J.P., Prevot D., Berthet C., Birot A.M., Billaud M., Magaud J.P., Corbo L.
    J. Biol. Chem. 273:22563-22569(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNOT7.
  6. "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway."
    Prevot D., Morel A.P., Voeltzel T., Rostan M.C., Rimokh R., Magaud J.P., Corbo L.
    J. Biol. Chem. 276:9640-9648(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CNOT8.

Entry informationi

Entry nameiBTG1_HUMAN
AccessioniPrimary (citable) accession number: P62324
Secondary accession number(s): P31607
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 22, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.