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Protein

Protein BTG1

Gene

BTG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Anti-proliferative protein.1 Publication

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • kinase binding Source: UniProtKB
  • transcription cofactor activity Source: UniProtKB

GO - Biological processi

  • cell migration Source: UniProtKB
  • negative regulation of cell growth Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • positive regulation of angiogenesis Source: UniProtKB
  • positive regulation of endothelial cell differentiation Source: UniProtKB
  • positive regulation of fibroblast apoptotic process Source: UniProtKB
  • positive regulation of myoblast differentiation Source: MGI
  • protein methylation Source: Ensembl
  • regulation of transcription, DNA-templated Source: UniProtKB
  • response to oxidative stress Source: Ensembl
  • response to peptide hormone Source: Ensembl
  • spermatogenesis Source: Ensembl

Enzyme and pathway databases

SIGNORiP62324

Names & Taxonomyi

Protein namesi
Recommended name:
Protein BTG1
Alternative name(s):
B-cell translocation gene 1 protein
Gene namesi
Name:BTG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000133639.4
HGNCiHGNC:1130 BTG1
MIMi109580 gene
neXtProtiNX_P62324

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC.1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi694
OpenTargetsiENSG00000133639
PharmGKBiPA25450

Polymorphism and mutation databases

BioMutaiBTG1
DMDMi59799172

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438001 – 171Protein BTG1Add BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei159PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP62324
PaxDbiP62324
PeptideAtlasiP62324
PRIDEiP62324

PTM databases

iPTMnetiP62324
PhosphoSitePlusiP62324

Expressioni

Developmental stagei

Its expression is associated with the early G1 phase of the cell cycle.1 Publication

Gene expression databases

BgeeiENSG00000133639
CleanExiHS_BTG1
ExpressionAtlasiP62324 baseline and differential
GenevisibleiP62324 HS

Organism-specific databases

HPAiHPA005972

Interactioni

Subunit structurei

Interacts with CNOT7 and CNOT8.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi10715918 interactors.
IntActiP62324 8 interactors.
MINTiP62324
STRINGi9606.ENSP00000256015

Structurei

3D structure databases

ProteinModelPortaliP62324
SMRiP62324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000290200
HOVERGENiHBG004907
InParanoidiP62324
KOiK14443
OMAiGHVNDRQ
OrthoDBiEOG091G0RS0
PhylomeDBiP62324
TreeFamiTF105272

Family and domain databases

Gene3Di1.20.120.11201 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
IPR033330 BTG1
PANTHERiPTHR22978:SF30 PTHR22978:SF30, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit

Sequencei

Sequence statusi: Complete.

P62324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE
60 70 80 90 100
HYKHHWFPEK PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS
110 120 130 140 150
ELTLWVDPYE VSYRIGEDGS ICVLYEASPA GGSTQNSTNV QMVDSRISCK
160 170
EELLLGRTSP SKNYNMMTVS G
Length:171
Mass (Da):19,209
Last modified:July 5, 2004 - v1
Checksum:iEFED8BE09013BE60
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021345139N → S1 PublicationCorresponds to variant dbSNP:rs28399541Ensembl.1
Natural variantiVAR_021346141Q → E1 PublicationCorresponds to variant dbSNP:rs28399542Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61123 mRNA Translation: CAA43435.1
BT019840 mRNA Translation: AAV38643.1
AY850133 Genomic DNA Translation: AAV97814.1
BC016759 mRNA Translation: AAH16759.1
BC064953 mRNA Translation: AAH64953.1
CCDSiCCDS9043.1
PIRiS20947
RefSeqiNP_001722.1, NM_001731.2
UniGeneiHs.255935

Genome annotation databases

EnsembliENST00000256015; ENSP00000256015; ENSG00000133639
GeneIDi694
KEGGihsa:694

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBTG1_HUMAN
AccessioniPrimary (citable) accession number: P62324
Secondary accession number(s): P31607
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome