P62324 (BTG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein BTG1

Alternative name(s):
B-cell translocation gene 1 protein

Gene names

Name:

BTG1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Anti-proliferative protein. Ref.1
Developmental stage	Its expression is associated with the early G1 phase of the cell cycle. Ref.1
Involvement in disease	A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC.
Sequence similarities	Belongs to the BTG family.

Ontologies

Keywords
Coding sequence diversity	Chromosomal rearrangement Polymorphism
Disease	Proto-oncogene
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell migration Non-traceable author statement PubMed 15033446. Source: UniProtKB negative regulation of cell growth Non-traceable author statement PubMed 15033446. Source: UniProtKB negative regulation of cell proliferation Inferred from direct assay Ref.1. Source: UniProtKB positive regulation of angiogenesis Inferred from mutant phenotype PubMed 15033446. Source: UniProtKB positive regulation of endothelial cell differentiation Inferred from mutant phenotype PubMed 15033446. Source: UniProtKB positive regulation of myoblast differentiation Non-traceable author statement PubMed 15033446. Source: UniProtKB regulation of apoptotic process Inferred from mutant phenotype PubMed 9690562. Source: UniProtKB regulation of transcription, DNA-dependent Non-traceable author statement PubMed 11420681. Source: UniProtKB
Cellular_component	cytoplasm Inferred from mutant phenotype PubMed 11420681. Source: UniProtKB nucleus Inferred from direct assay PubMed 9820826. Source: UniProtKB
Molecular_function	kinase binding Non-traceable author statement PubMed 9820826. Source: UniProtKB transcription cofactor activity Non-traceable author statement PubMed 11420681. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Protein BTG1		PRO_0000143800
Natural variations
	Natural variant	139	1	N → S. Ref.3 Corresponds to variant rs28399541 [ dbSNP | Ensembl ].		VAR_021345
	Natural variant	141	1	Q → E. Ref.3 Corresponds to variant rs28399542 [ dbSNP | Ensembl ].		VAR_021346

Sequences

	Sequence		Length	Mass (Da)
	P62324 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: EFED8BE09013BE60	FASTA	171	19,209
	10 20 30 40 50 60 MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE HYKHHWFPEK 70 80 90 100 110 120 PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS ELTLWVDPYE VSYRIGEDGS 130 140 150 160 170 ICVLYEASPA GGSTQNSTNV QMVDSRISCK EELLLGRTSP SKNYNMMTVS G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BTG1, a member of a new family of antiproliferative genes." Rouault J.-P., Rimokh R., Tessa C., Paranhos G., Ffrench M., Duret L., Garoccio M., Germain D., Samarut J., Magaud J.-P. EMBO J. 11:1663-1670(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE. Tissue: Lymphoblastoma.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	NIEHS SNPs program Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-139 AND GLU-141.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Skin.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	X61123 mRNA. Translation: CAA43435.1. BT019840 mRNA. Translation: AAV38643.1. AY850133 Genomic DNA. Translation: AAV97814.1. BC016759 mRNA. Translation: AAH16759.1. BC064953 mRNA. Translation: AAH64953.1.
IPI	IPI00012364.
PIR	S20947.
RefSeq	NP_001722.1. NM_001731.2.
UniGene	Hs.255935.
3D structure databases
ProteinModelPortal	P62324.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62324. 2 interactions.
MINT	MINT-1446937.
STRING	9606.ENSP00000256015.
PTM databases
PhosphoSite	P62324.
Polymorphism databases
DMDM	59799172.
Proteomic databases
PaxDb	P62324.
PRIDE	P62324.
Protocols and materials databases
DNASU	694.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000256015; ENSP00000256015; ENSG00000133639.
GeneID	694.
KEGG	hsa:694.
UCSC	uc001tby.3. human.
Organism-specific databases
CTD	694.
GeneCards	GC12M092469.
HGNC	HGNC:1130. BTG1.
HPA	HPA005972.
MIM	109580. gene.
neXtProt	NX_P62324.
PharmGKB	PA25450.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG325491.
HOGENOM	HOG000290200.
HOVERGEN	HBG004907.
InParanoid	P62324.
KO	K14443.
OMA	AEQYKHH.
OrthoDB	EOG4C87TM.
PhylomeDB	P62324.
Gene expression databases
ArrayExpress	P62324.
Bgee	P62324.
CleanEx	HS_BTG1.
Genevestigator	P62324.
GermOnline	ENSG00000133639. Homo sapiens.
Family and domain databases
InterPro	IPR002087. Anti_prolifrtn. [Graphical view]
Pfam	PF07742. BTG. 1 hit. [Graphical view]
PRINTS	PR00310. ANTIPRLFBTG1.
SMART	SM00099. btg1. 1 hit. [Graphical view]
PROSITE	PS00960. BTG_1. 1 hit. PS01203. BTG_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	694.
NextBio	2846.
SOURCE	Search...

Entry information

Entry name

BTG1_HUMAN

Accession

Primary (citable) accession number: P62324
Secondary accession number(s): P31607

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.