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P62324 (BTG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein BTG1
Alternative name(s):
B-cell translocation gene 1 protein
Gene names
Name:BTG1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length171 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Anti-proliferative protein. Ref.1

Subunit structure

Interacts with CNOT7 and CNOT8. Ref.5 Ref.6

Developmental stage

Its expression is associated with the early G1 phase of the cell cycle. Ref.1

Involvement in disease

A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC.

Sequence similarities

Belongs to the BTG family.

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CNOT7Q9UIV13EBI-742279,EBI-2105113
Cnot7Q608095EBI-742279,EBI-2104739From a different organism.
CNOT8Q9UFF94EBI-742279,EBI-742299

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 171171Protein BTG1
PRO_0000143800

Natural variations

Natural variant1391N → S. Ref.3
Corresponds to variant rs28399541 [ dbSNP | Ensembl ].
VAR_021345
Natural variant1411Q → E. Ref.3
Corresponds to variant rs28399542 [ dbSNP | Ensembl ].
VAR_021346

Sequences

Sequence LengthMass (Da)Tools
P62324 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: EFED8BE09013BE60

FASTA17119,209
        10         20         30         40         50         60 
MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE HYKHHWFPEK 

        70         80         90        100        110        120 
PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS ELTLWVDPYE VSYRIGEDGS 

       130        140        150        160        170 
ICVLYEASPA GGSTQNSTNV QMVDSRISCK EELLLGRTSP SKNYNMMTVS G 

« Hide

References

« Hide 'large scale' references
[1]"BTG1, a member of a new family of antiproliferative genes."
Rouault J.-P., Rimokh R., Tessa C., Paranhos G., Ffrench M., Duret L., Garoccio M., Germain D., Samarut J., Magaud J.-P.
EMBO J. 11:1663-1670(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
Tissue: Lymphoblastoma.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]NIEHS SNPs program
Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-139 AND GLU-141.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon and Skin.
[5]"Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex."
Rouault J.P., Prevot D., Berthet C., Birot A.M., Billaud M., Magaud J.P., Corbo L.
J. Biol. Chem. 273:22563-22569(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CNOT7.
[6]"Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway."
Prevot D., Morel A.P., Voeltzel T., Rostan M.C., Rimokh R., Magaud J.P., Corbo L.
J. Biol. Chem. 276:9640-9648(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CNOT8.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61123 mRNA. Translation: CAA43435.1.
BT019840 mRNA. Translation: AAV38643.1.
AY850133 Genomic DNA. Translation: AAV97814.1.
BC016759 mRNA. Translation: AAH16759.1.
BC064953 mRNA. Translation: AAH64953.1.
PIRS20947.
RefSeqNP_001722.1. NM_001731.2.
UniGeneHs.255935.

3D structure databases

ProteinModelPortalP62324.
SMRP62324. Positions 11-129.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107159. 19 interactions.
IntActP62324. 6 interactions.
MINTMINT-1446937.
STRING9606.ENSP00000256015.

PTM databases

PhosphoSiteP62324.

Polymorphism databases

DMDM59799172.

Proteomic databases

PaxDbP62324.
PRIDEP62324.

Protocols and materials databases

DNASU694.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256015; ENSP00000256015; ENSG00000133639.
GeneID694.
KEGGhsa:694.
UCSCuc001tby.3. human.

Organism-specific databases

CTD694.
GeneCardsGC12M092469.
HGNCHGNC:1130. BTG1.
HPAHPA005972.
MIM109580. gene.
neXtProtNX_P62324.
PharmGKBPA25450.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG325491.
HOGENOMHOG000290200.
HOVERGENHBG004907.
InParanoidP62324.
KOK14443.
OMAEQYKHHW.
OrthoDBEOG72RN0S.
PhylomeDBP62324.
TreeFamTF105272.

Gene expression databases

ArrayExpressP62324.
BgeeP62324.
CleanExHS_BTG1.
GenevestigatorP62324.

Family and domain databases

InterProIPR002087. Anti_prolifrtn.
[Graphical view]
PfamPF07742. BTG. 1 hit.
[Graphical view]
PRINTSPR00310. ANTIPRLFBTG1.
SMARTSM00099. btg1. 1 hit.
[Graphical view]
PROSITEPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiBTG1.
GenomeRNAi694.
NextBio2846.
PROP62324.
SOURCESearch...

Entry information

Entry nameBTG1_HUMAN
AccessionPrimary (citable) accession number: P62324
Secondary accession number(s): P31607
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM