Reviewed,
UniProtKB/Swiss-Prot P62324 (BTG1_HUMAN)
Last modified
November 4, 2008.
Version 37.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein BTG1 Alternative name(s): B-cell translocation gene 1 protein | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 171 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Anti-proliferative protein. |
| Developmental stage | Its expression is associated with the early G1 phase of the cell cycle. |
| Involvement in disease | A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC. |
| Sequence similarities | Belongs to the BTG family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "BTG1, a member of a new family of antiproliferative genes." Rouault J.-P., Rimokh R., Tessa C., Paranhos G., Ffrench M., Duret L., Garoccio M., Germain D., Samarut J., Magaud J.-P. EMBO J. 11:1663-1670(1992) [PubMed: 1373383] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE. Tissue: Lymphoblastoma. |
| [2] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-139 AND GLU-141. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Skin. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X61123 mRNA. Translation: CAA43435.1. BT019840 mRNA. Translation: AAV38643.1. AY850133 Genomic DNA. Translation: AAV97814.1. BC016759 mRNA. Translation: AAH16759.1. BC064953 mRNA. Translation: AAH64953.1. | |
| PIR | S20947. |
| RefSeq | NP_001722.1. |
| UniGene | Hs.255935 Hs.651357 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P62324. |
PTM databases | |
| PhosphoSite | P62324. |
Polymorphism databases | |
| NIEHS-SNPs | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000133639. Homo sapiens. [Contig view] |
| GeneID | 694. |
| KEGG | hsa:694. |
Organism-specific databases | |
| H-InvDB | HIX0020195. |
| HGNC | HGNC:1130. BTG1. |
| HPA | HPA005972. |
| MIM | 109580. gene. |
| PharmGKB | PA25450. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P62324. |
| HOVERGEN | P62324. |
Gene expression databases | |
| ArrayExpress | P62324. |
| CleanEx | HS_BTG1. |
| GermOnline | ENSG00000133639. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002087. Anti_prolifrtn. [Graphical view] |
| Pfam | PF07742. BTG. 1 hit. [Graphical view] |
| PRINTS | PR00310. ANTIPRLFBTG1. |
| SMART | SM00099. btg1. 1 hit. [Graphical view] |
| PROSITE | PS00960. BTG_1. 1 hit. PS01203. BTG_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | P62324. |
| NextBio | 2846. |
| SOURCE | Search... |
Entry information
| Entry name | BTG1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P62324 Secondary accession number(s): P31607 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


