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P62324

- BTG1_HUMAN

UniProt

P62324 - BTG1_HUMAN

Protein

Protein BTG1

Gene

BTG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Anti-proliferative protein.1 Publication

    GO - Molecular functioni

    1. enzyme binding Source: UniProtKB
    2. kinase binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. transcription cofactor activity Source: UniProtKB

    GO - Biological processi

    1. cell migration Source: UniProtKB
    2. negative regulation of cell growth Source: UniProtKB
    3. negative regulation of cell proliferation Source: UniProtKB
    4. positive regulation of angiogenesis Source: UniProtKB
    5. positive regulation of endothelial cell differentiation Source: UniProtKB
    6. positive regulation of fibroblast apoptotic process Source: UniProtKB
    7. positive regulation of myoblast differentiation Source: UniProtKB
    8. regulation of transcription, DNA-templated Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein BTG1
    Alternative name(s):
    B-cell translocation gene 1 protein
    Gene namesi
    Name:BTG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:1130. BTG1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA25450.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 171171Protein BTG1PRO_0000143800Add
    BLAST

    Proteomic databases

    PaxDbiP62324.
    PRIDEiP62324.

    PTM databases

    PhosphoSiteiP62324.

    Expressioni

    Developmental stagei

    Its expression is associated with the early G1 phase of the cell cycle.1 Publication

    Gene expression databases

    ArrayExpressiP62324.
    BgeeiP62324.
    CleanExiHS_BTG1.
    GenevestigatoriP62324.

    Organism-specific databases

    HPAiHPA005972.

    Interactioni

    Subunit structurei

    Interacts with CNOT7 and CNOT8.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CNOT7Q9UIV13EBI-742279,EBI-2105113
    Cnot7Q608095EBI-742279,EBI-2104739From a different organism.
    CNOT8Q9UFF94EBI-742279,EBI-742299

    Protein-protein interaction databases

    BioGridi107159. 19 interactions.
    IntActiP62324. 6 interactions.
    MINTiMINT-1446937.
    STRINGi9606.ENSP00000256015.

    Structurei

    3D structure databases

    ProteinModelPortaliP62324.
    SMRiP62324. Positions 11-129.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BTG family.Curated

    Phylogenomic databases

    eggNOGiNOG325491.
    HOGENOMiHOG000290200.
    HOVERGENiHBG004907.
    InParanoidiP62324.
    KOiK14443.
    OMAiMQMVDSR.
    OrthoDBiEOG72RN0S.
    PhylomeDBiP62324.
    TreeFamiTF105272.

    Family and domain databases

    InterProiIPR002087. Anti_prolifrtn.
    [Graphical view]
    PfamiPF07742. BTG. 1 hit.
    [Graphical view]
    PRINTSiPR00310. ANTIPRLFBTG1.
    SMARTiSM00099. btg1. 1 hit.
    [Graphical view]
    PROSITEiPS00960. BTG_1. 1 hit.
    PS01203. BTG_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62324-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE    50
    HYKHHWFPEK PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS 100
    ELTLWVDPYE VSYRIGEDGS ICVLYEASPA GGSTQNSTNV QMVDSRISCK 150
    EELLLGRTSP SKNYNMMTVS G 171
    Length:171
    Mass (Da):19,209
    Last modified:July 5, 2004 - v1
    Checksum:iEFED8BE09013BE60
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti139 – 1391N → S.1 Publication
    Corresponds to variant rs28399541 [ dbSNP | Ensembl ].
    VAR_021345
    Natural varianti141 – 1411Q → E.1 Publication
    Corresponds to variant rs28399542 [ dbSNP | Ensembl ].
    VAR_021346

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61123 mRNA. Translation: CAA43435.1.
    BT019840 mRNA. Translation: AAV38643.1.
    AY850133 Genomic DNA. Translation: AAV97814.1.
    BC016759 mRNA. Translation: AAH16759.1.
    BC064953 mRNA. Translation: AAH64953.1.
    CCDSiCCDS9043.1.
    PIRiS20947.
    RefSeqiNP_001722.1. NM_001731.2.
    UniGeneiHs.255935.

    Genome annotation databases

    EnsembliENST00000256015; ENSP00000256015; ENSG00000133639.
    GeneIDi694.
    KEGGihsa:694.
    UCSCiuc001tby.3. human.

    Polymorphism databases

    DMDMi59799172.

    Keywords - Coding sequence diversityi

    Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61123 mRNA. Translation: CAA43435.1 .
    BT019840 mRNA. Translation: AAV38643.1 .
    AY850133 Genomic DNA. Translation: AAV97814.1 .
    BC016759 mRNA. Translation: AAH16759.1 .
    BC064953 mRNA. Translation: AAH64953.1 .
    CCDSi CCDS9043.1.
    PIRi S20947.
    RefSeqi NP_001722.1. NM_001731.2.
    UniGenei Hs.255935.

    3D structure databases

    ProteinModelPortali P62324.
    SMRi P62324. Positions 11-129.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107159. 19 interactions.
    IntActi P62324. 6 interactions.
    MINTi MINT-1446937.
    STRINGi 9606.ENSP00000256015.

    PTM databases

    PhosphoSitei P62324.

    Polymorphism databases

    DMDMi 59799172.

    Proteomic databases

    PaxDbi P62324.
    PRIDEi P62324.

    Protocols and materials databases

    DNASUi 694.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256015 ; ENSP00000256015 ; ENSG00000133639 .
    GeneIDi 694.
    KEGGi hsa:694.
    UCSCi uc001tby.3. human.

    Organism-specific databases

    CTDi 694.
    GeneCardsi GC12M092469.
    HGNCi HGNC:1130. BTG1.
    HPAi HPA005972.
    MIMi 109580. gene.
    neXtProti NX_P62324.
    PharmGKBi PA25450.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG325491.
    HOGENOMi HOG000290200.
    HOVERGENi HBG004907.
    InParanoidi P62324.
    KOi K14443.
    OMAi MQMVDSR.
    OrthoDBi EOG72RN0S.
    PhylomeDBi P62324.
    TreeFami TF105272.

    Miscellaneous databases

    GeneWikii BTG1.
    GenomeRNAii 694.
    NextBioi 2846.
    PROi P62324.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62324.
    Bgeei P62324.
    CleanExi HS_BTG1.
    Genevestigatori P62324.

    Family and domain databases

    InterProi IPR002087. Anti_prolifrtn.
    [Graphical view ]
    Pfami PF07742. BTG. 1 hit.
    [Graphical view ]
    PRINTSi PR00310. ANTIPRLFBTG1.
    SMARTi SM00099. btg1. 1 hit.
    [Graphical view ]
    PROSITEi PS00960. BTG_1. 1 hit.
    PS01203. BTG_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "BTG1, a member of a new family of antiproliferative genes."
      Rouault J.-P., Rimokh R., Tessa C., Paranhos G., Ffrench M., Duret L., Garoccio M., Germain D., Samarut J., Magaud J.-P.
      EMBO J. 11:1663-1670(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
      Tissue: Lymphoblastoma.
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. NIEHS SNPs program
      Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-139 AND GLU-141.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon and Skin.
    5. "Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex."
      Rouault J.P., Prevot D., Berthet C., Birot A.M., Billaud M., Magaud J.P., Corbo L.
      J. Biol. Chem. 273:22563-22569(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CNOT7.
    6. "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway."
      Prevot D., Morel A.P., Voeltzel T., Rostan M.C., Rimokh R., Magaud J.P., Corbo L.
      J. Biol. Chem. 276:9640-9648(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CNOT8.

    Entry informationi

    Entry nameiBTG1_HUMAN
    AccessioniPrimary (citable) accession number: P62324
    Secondary accession number(s): P31607
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3