Reviewed, UniProtKB/Swiss-Prot P62324 (BTG1_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein BTG1
Alternative name(s):
    B-cell translocation gene 1 protein

Gene names

Name:

BTG1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Anti-proliferative protein.
Developmental stage	Its expression is associated with the early G1 phase of the cell cycle.
Involvement in disease	A chromosomal aberration involving BTG1 may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with MYC.
Sequence similarities	Belongs to the BTG family.

Ontologies

Keywords
Coding sequence diversity	Chromosomal rearrangement Polymorphism
Disease	Proto-oncogene
Gene Ontology (GO)
Biological process	cell migration Non-traceable author statement. Source: UniProtKB negative regulation of cell growth Non-traceable author statement. Source: UniProtKB negative regulation of cell proliferation Ref.1 Inferred from direct assay. Source: UniProtKB positive regulation of angiogenesis Inferred from mutant phenotype. Source: UniProtKB positive regulation of endothelial cell differentiation Inferred from mutant phenotype. Source: UniProtKB positive regulation of myoblast differentiation Non-traceable author statement. Source: UniProtKB regulation of apoptosis Inferred from mutant phenotype. Source: UniProtKB regulation of transcription Non-traceable author statement. Source: UniProtKB
Cellular component	cytoplasm Inferred from mutant phenotype. Source: UniProtKB nucleus Inferred from direct assay. Source: UniProtKB
Molecular function	kinase binding Non-traceable author statement. Source: UniProtKB transcription cofactor activity Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 171	171	Protein BTG1		PRO_0000143800
Natural variations
	Natural variant	139	1	N → S		VAR_021345
	Natural variant	141	1	Q → E		VAR_021346

Sequences

	Sequence		Length	Mass (Da)
	P62324-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: EFED8BE09013BE60	FASTA	171	19,209
	10 20 30 40 50 60 MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE HYKHHWFPEK 70 80 90 100 110 120 PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS ELTLWVDPYE VSYRIGEDGS 130 140 150 160 170 ICVLYEASPA GGSTQNSTNV QMVDSRISCK EELLLGRTSP SKNYNMMTVS G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BTG1, a member of a new family of antiproliferative genes." Rouault J.-P., Rimokh R., Tessa C., Paranhos G., Ffrench M., Duret L., Garoccio M., Germain D., Samarut J., Magaud J.-P. EMBO J. 11:1663-1670(1992) [PubMed: 1373383] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE. Tissue: Lymphoblastoma.
[2]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS SER-139 AND GLU-141.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon and Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X61123 mRNA. Translation: CAA43435.1. BT019840 mRNA. Translation: AAV38643.1. AY850133 Genomic DNA. Translation: AAV97814.1. BC016759 mRNA. Translation: AAH16759.1. BC064953 mRNA. Translation: AAH64953.1.
PIR	S20947.
RefSeq	NP_001722.1.
UniGene	Hs.255935 Hs.651357
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P62324.
PTM databases
PhosphoSite	P62324.
Polymorphism databases
NIEHS-SNPs	Search...
Genome annotation databases
Ensembl	ENSG00000133639. Homo sapiens. [Contig view]
GeneID	694.
KEGG	hsa:694.
Organism-specific databases
H-InvDB	HIX0020195.
HGNC	HGNC:1130. BTG1.
HPA	HPA005972.
MIM	109580. gene.
PharmGKB	PA25450.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P62324.
HOVERGEN	P62324.
Gene expression databases
ArrayExpress	P62324.
CleanEx	HS_BTG1.
GermOnline	ENSG00000133639. Homo sapiens.
Family and domain databases
InterPro	IPR002087. Anti_prolifrtn. [Graphical view]
Pfam	PF07742. BTG. 1 hit. [Graphical view]
PRINTS	PR00310. ANTIPRLFBTG1.
SMART	SM00099. btg1. 1 hit. [Graphical view]
PROSITE	PS00960. BTG_1. 1 hit. PS01203. BTG_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	P62324.
NextBio	2846.
SOURCE	Search...

Entry information

Entry name

BTG1_HUMAN

Accession

Primary (citable) accession number: P62324
Secondary accession number(s): P31607

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	November 4, 2008
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)