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Protein

U6 snRNA-associated Sm-like protein LSm5

Gene

Lsm5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating formation of the spliceosomal U4/U6 duplex in vitro (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.
R-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm5
Gene namesi
Name:Lsm5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1913623. Lsm5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001255732 – 91U6 snRNA-associated Sm-like protein LSm5Add BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP62322.
PaxDbiP62322.
PeptideAtlasiP62322.
PRIDEiP62322.
TopDownProteomicsiP62322.

PTM databases

iPTMnetiP62322.
PhosphoSitePlusiP62322.

Expressioni

Gene expression databases

BgeeiENSMUSG00000091625.
ExpressionAtlasiP62322. baseline and differential.
GenevisibleiP62322. MM.

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211422. 1 interactor.
IntActiP62322. 1 interactor.
STRINGi10090.ENSMUSP00000126565.

Structurei

3D structure databases

ProteinModelPortaliP62322.
SMRiP62322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1775. Eukaryota.
COG1958. LUCA.
GeneTreeiENSGT00390000001455.
HOVERGENiHBG107310.
InParanoidiP62322.
KOiK12624.
OMAiSRIWIAM.
OrthoDBiEOG091G10CG.
PhylomeDBiP62322.
TreeFamiTF313575.

Family and domain databases

CDDicd01732. LSm5. 1 hit.
InterProiIPR033871. LSm5.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62322-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANATTNPS QLLPLELVDK CIGSRIHIVM KSDKEIVGTL LGFDDFVNMV
60 70 80 90
LEDVTEFEIT PEGRRITKLD QILLNGNNIT MLVPGGEGPE V
Length:91
Mass (Da):9,937
Last modified:January 23, 2007 - v2
Checksum:i82B5C8830E64C992
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009617 mRNA. Translation: BAB26394.1.
AK011218 mRNA. Translation: BAB27475.1.
BC048459 mRNA. Translation: AAH48459.1.
BC061085 mRNA. Translation: AAH61085.1.
BC132626 mRNA. Translation: AAI32627.1.
BC132628 mRNA. Translation: AAI32629.1.
CCDSiCCDS51788.1.
RefSeqiNP_079796.1. NM_025520.3.
UniGeneiMm.25642.

Genome annotation databases

EnsembliENSMUST00000170382; ENSMUSP00000126565; ENSMUSG00000091625.
GeneIDi66373.
KEGGimmu:66373.
UCSCiuc009cbj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009617 mRNA. Translation: BAB26394.1.
AK011218 mRNA. Translation: BAB27475.1.
BC048459 mRNA. Translation: AAH48459.1.
BC061085 mRNA. Translation: AAH61085.1.
BC132626 mRNA. Translation: AAI32627.1.
BC132628 mRNA. Translation: AAI32629.1.
CCDSiCCDS51788.1.
RefSeqiNP_079796.1. NM_025520.3.
UniGeneiMm.25642.

3D structure databases

ProteinModelPortaliP62322.
SMRiP62322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211422. 1 interactor.
IntActiP62322. 1 interactor.
STRINGi10090.ENSMUSP00000126565.

PTM databases

iPTMnetiP62322.
PhosphoSitePlusiP62322.

Proteomic databases

MaxQBiP62322.
PaxDbiP62322.
PeptideAtlasiP62322.
PRIDEiP62322.
TopDownProteomicsiP62322.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170382; ENSMUSP00000126565; ENSMUSG00000091625.
GeneIDi66373.
KEGGimmu:66373.
UCSCiuc009cbj.2. mouse.

Organism-specific databases

CTDi23658.
MGIiMGI:1913623. Lsm5.

Phylogenomic databases

eggNOGiKOG1775. Eukaryota.
COG1958. LUCA.
GeneTreeiENSGT00390000001455.
HOVERGENiHBG107310.
InParanoidiP62322.
KOiK12624.
OMAiSRIWIAM.
OrthoDBiEOG091G10CG.
PhylomeDBiP62322.
TreeFamiTF313575.

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.
R-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiP62322.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000091625.
ExpressionAtlasiP62322. baseline and differential.
GenevisibleiP62322. MM.

Family and domain databases

CDDicd01732. LSm5. 1 hit.
InterProiIPR033871. LSm5.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLSM5_MOUSE
AccessioniPrimary (citable) accession number: P62322
Secondary accession number(s): A2RTT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.