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P62321

- RUXF_XENLA

UniProt

P62321 - RUXF_XENLA

Protein

Small nuclear ribonucleoprotein F

Gene

snrpf

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. spliceosomal snRNP assembly Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small nuclear ribonucleoprotein F
    Short name:
    snRNP-F
    Alternative name(s):
    Sm protein F
    Short name:
    Sm-F
    Short name:
    SmF
    Gene namesi
    Name:snrpf
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-1188432. snrpf.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. methylosome Source: UniProtKB
    3. pICln-Sm protein complex Source: UniProtKB
    4. SMN-Sm protein complex Source: UniProtKB
    5. spliceosomal complex Source: UniProtKB-KW
    6. U1 snRNP Source: UniProtKB
    7. U4 snRNP Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8686Small nuclear ribonucleoprotein FPRO_0000125538Add
    BLAST

    Proteomic databases

    PRIDEiP62321.

    Interactioni

    Subunit structurei

    U1 snRNP is for instance composed of the 7 core Sm proteins snrpb, snrpd1, snrpd2, snrpd3, snrpe, snrpf and snrpg that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins snrnp70/U1-70K, snrpa/U1-A and snrpc/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP62321.
    SMRiP62321. Positions 3-76.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG052369.
    KOiK11098.

    Family and domain databases

    InterProiIPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR016487. snRNP_SmF.
    [Graphical view]
    PfamiPF01423. LSM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006609. snRNP_SmF. 1 hit.
    SMARTiSM00651. Sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P62321-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPLNPKPF LNGLTGKPVM VKLKWGMEYK GYLVSVDGYM NMQLANTEEY   50
    IDGALSGHLG EVLIRCNNVL YIRGVEEEEE DGEMRE 86
    Length:86
    Mass (Da):9,725
    Last modified:July 5, 2004 - v1
    Checksum:i416B88D575DAE58A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC056127 mRNA. Translation: AAH56127.1.
    RefSeqiNP_001080901.1. NM_001087432.1.
    UniGeneiXl.55007.

    Genome annotation databases

    GeneIDi380595.
    KEGGixla:380595.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC056127 mRNA. Translation: AAH56127.1 .
    RefSeqi NP_001080901.1. NM_001087432.1.
    UniGenei Xl.55007.

    3D structure databases

    ProteinModelPortali P62321.
    SMRi P62321. Positions 3-76.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P62321.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 380595.
    KEGGi xla:380595.

    Organism-specific databases

    CTDi 6636.
    Xenbasei XB-GENE-1188432. snrpf.

    Phylogenomic databases

    HOVERGENi HBG052369.
    KOi K11098.

    Family and domain databases

    InterProi IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR016487. snRNP_SmF.
    [Graphical view ]
    Pfami PF01423. LSM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006609. snRNP_SmF. 1 hit.
    SMARTi SM00651. Sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiRUXF_XENLA
    AccessioniPrimary (citable) accession number: P62321
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3