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P62317

- SMD2_MOUSE

UniProt

P62317 - SMD2_MOUSE

Protein

Small nuclear ribonucleoprotein Sm D2

Gene

Snrpd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP By similarity.By similarity

    GO - Biological processi

    1. spliceosomal snRNP assembly Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Enzyme and pathway databases

    ReactomeiREACT_206812. snRNP Assembly.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small nuclear ribonucleoprotein Sm D2
    Short name:
    Sm-D2
    Alternative name(s):
    snRNP core protein D2
    Gene namesi
    Name:Snrpd2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:98345. Snrpd2.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Nucleus By similarity
    Note: SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. methylosome Source: UniProtKB
    3. pICln-Sm protein complex Source: UniProtKB
    4. SMN-Sm protein complex Source: UniProtKB
    5. spliceosomal complex Source: UniProtKB-KW
    6. U1 snRNP Source: UniProtKB
    7. U4 snRNP Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 118117Small nuclear ribonucleoprotein Sm D2PRO_0000122208Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei12 – 121PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP62317.
    PaxDbiP62317.
    PRIDEiP62317.

    PTM databases

    PhosphoSiteiP62317.

    Expressioni

    Gene expression databases

    ArrayExpressiP62317.
    BgeeiP62317.
    CleanExiMM_SNRPD2.
    GenevestigatoriP62317.

    Interactioni

    Subunit structurei

    U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi223486. 1 interaction.
    IntActiP62317. 1 interaction.
    MINTiMINT-124854.
    STRINGi10090.ENSMUSP00000037597.

    Structurei

    3D structure databases

    ProteinModelPortaliP62317.
    SMRiP62317. Positions 12-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the snRNP core protein family.Curated

    Phylogenomic databases

    eggNOGiCOG1958.
    HOGENOMiHOG000223545.
    HOVERGENiHBG054415.
    InParanoidiP62317.
    KOiK11096.
    OMAiRNELTEY.
    OrthoDBiEOG7HB5CJ.
    PhylomeDBiP62317.
    TreeFamiTF319595.

    Family and domain databases

    InterProiIPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR027248. Sm_D2.
    [Graphical view]
    PANTHERiPTHR12777. PTHR12777. 1 hit.
    PfamiPF01423. LSM. 1 hit.
    [Graphical view]
    SMARTiSM00651. Sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62317-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLLNKPKSE MTPEELQKRE EEEFNTGPLS VLTQSVKNNT QVLINCRNNK    50
    KLLGRVKAFD RHCNMVLENV KEMWTEVPKS GKGKKKSKPV NKDRYISKMF 100
    LRGDSVIVVL RNPLIAGK 118
    Length:118
    Mass (Da):13,527
    Last modified:July 5, 2004 - v1
    Checksum:iD986059D82B7E045
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311V → M in BAC32551. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007389 mRNA. Translation: BAB25006.1.
    AK045968 mRNA. Translation: BAC32551.1.
    AK088105 mRNA. Translation: BAC40147.1.
    BC043014 mRNA. Translation: AAH43014.1.
    BC051208 mRNA. Translation: AAH51208.1.
    CCDSiCCDS20892.1.
    RefSeqiNP_081219.1. NM_026943.1.
    UniGeneiMm.29135.

    Genome annotation databases

    EnsembliENSMUST00000049294; ENSMUSP00000037597; ENSMUSG00000040824.
    GeneIDi107686.
    KEGGimmu:107686.
    UCSCiuc009fkv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007389 mRNA. Translation: BAB25006.1 .
    AK045968 mRNA. Translation: BAC32551.1 .
    AK088105 mRNA. Translation: BAC40147.1 .
    BC043014 mRNA. Translation: AAH43014.1 .
    BC051208 mRNA. Translation: AAH51208.1 .
    CCDSi CCDS20892.1.
    RefSeqi NP_081219.1. NM_026943.1.
    UniGenei Mm.29135.

    3D structure databases

    ProteinModelPortali P62317.
    SMRi P62317. Positions 12-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 223486. 1 interaction.
    IntActi P62317. 1 interaction.
    MINTi MINT-124854.
    STRINGi 10090.ENSMUSP00000037597.

    PTM databases

    PhosphoSitei P62317.

    Proteomic databases

    MaxQBi P62317.
    PaxDbi P62317.
    PRIDEi P62317.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049294 ; ENSMUSP00000037597 ; ENSMUSG00000040824 .
    GeneIDi 107686.
    KEGGi mmu:107686.
    UCSCi uc009fkv.1. mouse.

    Organism-specific databases

    CTDi 6633.
    MGIi MGI:98345. Snrpd2.

    Phylogenomic databases

    eggNOGi COG1958.
    HOGENOMi HOG000223545.
    HOVERGENi HBG054415.
    InParanoidi P62317.
    KOi K11096.
    OMAi RNELTEY.
    OrthoDBi EOG7HB5CJ.
    PhylomeDBi P62317.
    TreeFami TF319595.

    Enzyme and pathway databases

    Reactomei REACT_206812. snRNP Assembly.

    Miscellaneous databases

    NextBioi 25839.
    PROi P62317.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62317.
    Bgeei P62317.
    CleanExi MM_SNRPD2.
    Genevestigatori P62317.

    Family and domain databases

    InterProi IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR027248. Sm_D2.
    [Graphical view ]
    PANTHERi PTHR12777. PTHR12777. 1 hit.
    Pfami PF01423. LSM. 1 hit.
    [Graphical view ]
    SMARTi SM00651. Sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Corpora quadrigemina, Pancreas and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Mammary gland.

    Entry informationi

    Entry nameiSMD2_MOUSE
    AccessioniPrimary (citable) accession number: P62317
    Secondary accession number(s): P43330
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3