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P62316

- SMD2_HUMAN

UniProt

P62316 - SMD2_HUMAN

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Protein
Small nuclear ribonucleoprotein Sm D2
Gene
SNRPD2, SNRPD1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.2 Publications

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. RNA metabolic process Source: Reactome
  2. RNA splicing Source: Reactome
  3. gene expression Source: Reactome
  4. mRNA splicing, via spliceosome Source: UniProtKB
  5. ncRNA metabolic process Source: Reactome
  6. spliceosomal complex assembly Source: ProtInc
  7. spliceosomal snRNP assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiREACT_11066. snRNP Assembly.
REACT_1753. mRNA Splicing - Minor Pathway.
REACT_467. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein Sm D2
Short name:
Sm-D2
Alternative name(s):
snRNP core protein D2
Gene namesi
Name:SNRPD2
Synonyms:SNRPD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:11159. SNRPD2.

Subcellular locationi

Cytoplasmcytosol. Nucleus
Note: SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.1 Publication

GO - Cellular componenti

  1. SMN-Sm protein complex Source: UniProtKB
  2. U1 snRNP Source: UniProtKB
  3. U12-type spliceosomal complex Source: UniProtKB
  4. U4 snRNP Source: UniProtKB
  5. catalytic step 2 spliceosome Source: UniProtKB
  6. cytosol Source: UniProtKB
  7. extracellular vesicular exosome Source: UniProt
  8. methylosome Source: UniProtKB
  9. nucleoplasm Source: Reactome
  10. pICln-Sm protein complex Source: UniProtKB
  11. small nuclear ribonucleoprotein complex Source: ProtInc
  12. spliceosomal complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36000.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 118117Small nuclear ribonucleoprotein Sm D2
PRO_0000122207Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications
Modified residuei12 – 121Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP62316.
PaxDbiP62316.
PeptideAtlasiP62316.
PRIDEiP62316.

PTM databases

PhosphoSiteiP62316.

Expressioni

Gene expression databases

ArrayExpressiP62316.
BgeeiP62316.
CleanExiHS_SNRPD1.
HS_SNRPD2.
GenevestigatoriP62316.

Organism-specific databases

HPAiHPA041437.

Interactioni

Subunit structurei

U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CLNS1AP541055EBI-297993,EBI-724693
LSM2Q9Y3333EBI-297993,EBI-347416

Protein-protein interaction databases

BioGridi112517. 99 interactions.
DIPiDIP-31219N.
IntActiP62316. 34 interactions.
MINTiMINT-5002672.
STRINGi9606.ENSP00000342374.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi25 – 273
Helixi28 – 3811
Beta strandi41 – 466
Beta strandi51 – 599
Beta strandi65 – 739
Beta strandi94 – 1018
Helixi103 – 1053
Beta strandi106 – 1116

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B34X-ray2.50B1-118[»]
1VU2X-ray3.10B/J/R/Z/h/p/x1-118[»]
1VU3X-ray3.10B/J/R/Z/h/p1-118[»]
2Y9AX-ray3.60C/J/Q1-118[»]
2Y9BX-ray3.60C/J/Q1-118[»]
2Y9CX-ray3.60C/J/Q1-118[»]
2Y9DX-ray3.60C/J/Q1-118[»]
3CW1X-ray5.49C/P/Q/R1-118[»]
3PGWX-ray4.40V/Y1-118[»]
3S6NX-ray2.50B1-118[»]
4F77X-ray3.10B/J/R/Z/h/p/x1-118[»]
4F7UX-ray1.90B/D1-118[»]
ProteinModelPortaliP62316.
SMRiP62316. Positions 12-118.

Miscellaneous databases

EvolutionaryTraceiP62316.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1958.
HOGENOMiHOG000223545.
HOVERGENiHBG054415.
InParanoidiP62316.
KOiK11096.
OMAiRNELTEY.
OrthoDBiEOG7HB5CJ.
PhylomeDBiP62316.
TreeFamiTF319595.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR027248. Sm_D2.
[Graphical view]
PANTHERiPTHR12777. PTHR12777. 1 hit.
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P62316-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLLNKPKSE MTPEELQKRE EEEFNTGPLS VLTQSVKNNT QVLINCRNNK    50
KLLGRVKAFD RHCNMVLENV KEMWTEVPKS GKGKKKSKPV NKDRYISKMF 100
LRGDSVIVVL RNPLIAGK 118
Length:118
Mass (Da):13,527
Last modified:July 5, 2004 - v1
Checksum:iD986059D82B7E045
GO
Isoform 2 (identifier: P62316-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Note: No experimental confirmation available.

Show »
Length:108
Mass (Da):12,399
Checksum:i3E92B3D47F961A7F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1010Missing in isoform 2.
VSP_045371

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381N → S in BU531743. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15008 mRNA. Translation: AAC13776.1.
AK291912 mRNA. Translation: BAF84601.1.
AC007191 Genomic DNA. Translation: AAD22673.1.
CH471126 Genomic DNA. Translation: EAW57373.1.
CH471126 Genomic DNA. Translation: EAW57374.1.
BC000486 mRNA. Translation: AAH00486.1.
BC001930 mRNA. Translation: AAH01930.1.
BU531743 mRNA. No translation available.
CCDSiCCDS33053.1. [P62316-1]
CCDS54281.1. [P62316-2]
PIRiI38861.
RefSeqiNP_004588.1. NM_004597.5. [P62316-1]
NP_808210.2. NM_177542.2. [P62316-2]
XP_005259237.1. XM_005259180.1. [P62316-1]
UniGeneiHs.515472.

Genome annotation databases

EnsembliENST00000342669; ENSP00000342374; ENSG00000125743. [P62316-1]
ENST00000391932; ENSP00000375798; ENSG00000125743. [P62316-2]
ENST00000587367; ENSP00000465952; ENSG00000125743. [P62316-2]
ENST00000588301; ENSP00000465216; ENSG00000125743. [P62316-1]
ENST00000588599; ENSP00000466152; ENSG00000125743. [P62316-2]
GeneIDi6633.
KEGGihsa:6633.
UCSCiuc002pcv.3. human. [P62316-1]

Polymorphism databases

DMDMi51338666.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15008 mRNA. Translation: AAC13776.1 .
AK291912 mRNA. Translation: BAF84601.1 .
AC007191 Genomic DNA. Translation: AAD22673.1 .
CH471126 Genomic DNA. Translation: EAW57373.1 .
CH471126 Genomic DNA. Translation: EAW57374.1 .
BC000486 mRNA. Translation: AAH00486.1 .
BC001930 mRNA. Translation: AAH01930.1 .
BU531743 mRNA. No translation available.
CCDSi CCDS33053.1. [P62316-1 ]
CCDS54281.1. [P62316-2 ]
PIRi I38861.
RefSeqi NP_004588.1. NM_004597.5. [P62316-1 ]
NP_808210.2. NM_177542.2. [P62316-2 ]
XP_005259237.1. XM_005259180.1. [P62316-1 ]
UniGenei Hs.515472.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1B34 X-ray 2.50 B 1-118 [» ]
1VU2 X-ray 3.10 B/J/R/Z/h/p/x 1-118 [» ]
1VU3 X-ray 3.10 B/J/R/Z/h/p 1-118 [» ]
2Y9A X-ray 3.60 C/J/Q 1-118 [» ]
2Y9B X-ray 3.60 C/J/Q 1-118 [» ]
2Y9C X-ray 3.60 C/J/Q 1-118 [» ]
2Y9D X-ray 3.60 C/J/Q 1-118 [» ]
3CW1 X-ray 5.49 C/P/Q/R 1-118 [» ]
3PGW X-ray 4.40 V/Y 1-118 [» ]
3S6N X-ray 2.50 B 1-118 [» ]
4F77 X-ray 3.10 B/J/R/Z/h/p/x 1-118 [» ]
4F7U X-ray 1.90 B/D 1-118 [» ]
ProteinModelPortali P62316.
SMRi P62316. Positions 12-118.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112517. 99 interactions.
DIPi DIP-31219N.
IntActi P62316. 34 interactions.
MINTi MINT-5002672.
STRINGi 9606.ENSP00000342374.

PTM databases

PhosphoSitei P62316.

Polymorphism databases

DMDMi 51338666.

Proteomic databases

MaxQBi P62316.
PaxDbi P62316.
PeptideAtlasi P62316.
PRIDEi P62316.

Protocols and materials databases

DNASUi 6633.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342669 ; ENSP00000342374 ; ENSG00000125743 . [P62316-1 ]
ENST00000391932 ; ENSP00000375798 ; ENSG00000125743 . [P62316-2 ]
ENST00000587367 ; ENSP00000465952 ; ENSG00000125743 . [P62316-2 ]
ENST00000588301 ; ENSP00000465216 ; ENSG00000125743 . [P62316-1 ]
ENST00000588599 ; ENSP00000466152 ; ENSG00000125743 . [P62316-2 ]
GeneIDi 6633.
KEGGi hsa:6633.
UCSCi uc002pcv.3. human. [P62316-1 ]

Organism-specific databases

CTDi 6633.
GeneCardsi GC19M046190.
HGNCi HGNC:11159. SNRPD2.
HPAi HPA041437.
MIMi 601061. gene.
neXtProti NX_P62316.
PharmGKBi PA36000.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1958.
HOGENOMi HOG000223545.
HOVERGENi HBG054415.
InParanoidi P62316.
KOi K11096.
OMAi RNELTEY.
OrthoDBi EOG7HB5CJ.
PhylomeDBi P62316.
TreeFami TF319595.

Enzyme and pathway databases

Reactomei REACT_11066. snRNP Assembly.
REACT_1753. mRNA Splicing - Minor Pathway.
REACT_467. mRNA Splicing - Major Pathway.

Miscellaneous databases

EvolutionaryTracei P62316.
GenomeRNAii 6633.
NextBioi 25839.
PROi P62316.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62316.
Bgeei P62316.
CleanExi HS_SNRPD1.
HS_SNRPD2.
Genevestigatori P62316.

Family and domain databases

InterProi IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR027248. Sm_D2.
[Graphical view ]
PANTHERi PTHR12777. PTHR12777. 1 hit.
Pfami PF01423. LSM. 1 hit.
[Graphical view ]
SMARTi SM00651. Sm. 1 hit.
[Graphical view ]
SUPFAMi SSF50182. SSF50182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction."
    Lehmeier T., Raker V., Hermann H., Luehrmann R.
    Proc. Natl. Acad. Sci. U.S.A. 91:12317-12321(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 75-96 AND 103-118.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung.
  6. Bienvenut W.V., Calvo F., Matallanas D., Cooper W.N., Kolch W.
    Submitted (FEB-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-47; 72-79 AND 103-118, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma and Mammary carcinoma.
  7. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
    Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
    RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
  8. "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."
    Will C.L., Schneider C., Hossbach M., Urlaub H., Rauhut R., Elbashir S., Tuschl T., Luehrmann R.
    RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH THE U11/U12 SPLICEOSOME, IDENTIFICATION BY MASS SPECTROMETRY.
  9. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."
    Chari A., Golas M.M., Klingenhager M., Neuenkirchen N., Sander B., Englbrecht C., Sickmann A., Stark H., Fischer U.
    Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN SNRNP BIOGENESIS, IDENTIFICATION IN 6S PICLN-SM COMPLEX, IDENTIFICATION IN SMN-SM COMPLEX, SUBCELLULAR LOCATION.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs."
    Kambach C., Walke S., Young R., Avis J.M., de la Fortelle E., Raker V.A., Luehrmann R., Li J., Nagai K.
    Cell 96:375-387(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 26-118 IN COMPLEX WITH SNRPD1.
  15. "Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution."
    Pomeranz Krummel D.A., Oubridge C., Leung A.K., Li J., Nagai K.
    Nature 458:475-480(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (5.49 ANGSTROMS) IN SPLICEOSOMAL U1 SNRNP.
  16. "Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis."
    Leung A.K., Nagai K., Li J.
    Nature 473:536-539(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.60 ANGSTROMS) IN SPLICEOSOMAL CORE U4 SNRNP.
  17. "Structural basis of assembly chaperone-mediated snRNP formation."
    Grimm C., Chari A., Pelz J.P., Kuper J., Kisker C., Diederichs K., Stark H., Schindelin H., Fischer U.
    Mol. Cell 49:692-703(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN 6S PICLN-SM COMPLEX, IDENTIFICATION IN 6S PICLN-SM COMPLEX, FUNCTION IN CORE U1 SNRNP BIOGENESIS.

Entry informationi

Entry nameiSMD2_HUMAN
AccessioniPrimary (citable) accession number: P62316
Secondary accession number(s): A8K797, J3KPM5, P43330
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi