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P62316

- SMD2_HUMAN

UniProt

P62316 - SMD2_HUMAN

Protein

Small nuclear ribonucleoprotein Sm D2

Gene

SNRPD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.2 Publications

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. gene expression Source: Reactome
    2. mRNA splicing, via spliceosome Source: UniProtKB
    3. ncRNA metabolic process Source: Reactome
    4. RNA metabolic process Source: Reactome
    5. RNA splicing Source: Reactome
    6. spliceosomal complex assembly Source: ProtInc
    7. spliceosomal snRNP assembly Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Enzyme and pathway databases

    ReactomeiREACT_11066. snRNP Assembly.
    REACT_1753. mRNA Splicing - Minor Pathway.
    REACT_467. mRNA Splicing - Major Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small nuclear ribonucleoprotein Sm D2
    Short name:
    Sm-D2
    Alternative name(s):
    snRNP core protein D2
    Gene namesi
    Name:SNRPD2
    Synonyms:SNRPD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:11159. SNRPD2.

    Subcellular locationi

    Cytoplasmcytosol 1 Publication. Nucleus 1 Publication
    Note: SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.

    GO - Cellular componenti

    1. catalytic step 2 spliceosome Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. methylosome Source: UniProtKB
    5. nucleoplasm Source: Reactome
    6. pICln-Sm protein complex Source: UniProtKB
    7. small nuclear ribonucleoprotein complex Source: ProtInc
    8. SMN-Sm protein complex Source: UniProtKB
    9. spliceosomal complex Source: ProtInc
    10. U12-type spliceosomal complex Source: UniProtKB
    11. U1 snRNP Source: UniProtKB
    12. U4 snRNP Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Spliceosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36000.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 118117Small nuclear ribonucleoprotein Sm D2PRO_0000122207Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine2 Publications
    Modified residuei12 – 121Phosphothreonine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP62316.
    PaxDbiP62316.
    PeptideAtlasiP62316.
    PRIDEiP62316.

    PTM databases

    PhosphoSiteiP62316.

    Expressioni

    Gene expression databases

    ArrayExpressiP62316.
    BgeeiP62316.
    CleanExiHS_SNRPD1.
    HS_SNRPD2.
    GenevestigatoriP62316.

    Organism-specific databases

    HPAiHPA041437.

    Interactioni

    Subunit structurei

    U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CLNS1AP541055EBI-297993,EBI-724693
    LSM2Q9Y3333EBI-297993,EBI-347416

    Protein-protein interaction databases

    BioGridi112517. 99 interactions.
    DIPiDIP-31219N.
    IntActiP62316. 34 interactions.
    MINTiMINT-5002672.
    STRINGi9606.ENSP00000342374.

    Structurei

    Secondary structure

    1
    118
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi25 – 273
    Helixi28 – 3811
    Beta strandi41 – 466
    Beta strandi51 – 599
    Beta strandi65 – 739
    Beta strandi94 – 1018
    Helixi103 – 1053
    Beta strandi106 – 1116

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1B34X-ray2.50B1-118[»]
    1VU2X-ray3.10B/J/R/Z/h/p/x1-118[»]
    1VU3X-ray3.10B/J/R/Z/h/p1-118[»]
    2Y9AX-ray3.60C/J/Q1-118[»]
    2Y9BX-ray3.60C/J/Q1-118[»]
    2Y9CX-ray3.60C/J/Q1-118[»]
    2Y9DX-ray3.60C/J/Q1-118[»]
    3CW1X-ray5.49C/P/Q/R1-118[»]
    3PGWX-ray4.40V/Y1-118[»]
    3S6NX-ray2.50B1-118[»]
    4F77X-ray3.10B/J/R/Z/h/p/x1-118[»]
    4F7UX-ray1.90B/D1-118[»]
    ProteinModelPortaliP62316.
    SMRiP62316. Positions 12-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP62316.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the snRNP core protein family.Curated

    Phylogenomic databases

    eggNOGiCOG1958.
    HOGENOMiHOG000223545.
    HOVERGENiHBG054415.
    InParanoidiP62316.
    KOiK11096.
    OMAiRNELTEY.
    OrthoDBiEOG7HB5CJ.
    PhylomeDBiP62316.
    TreeFamiTF319595.

    Family and domain databases

    InterProiIPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR027248. Sm_D2.
    [Graphical view]
    PANTHERiPTHR12777. PTHR12777. 1 hit.
    PfamiPF01423. LSM. 1 hit.
    [Graphical view]
    SMARTiSM00651. Sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P62316-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLLNKPKSE MTPEELQKRE EEEFNTGPLS VLTQSVKNNT QVLINCRNNK    50
    KLLGRVKAFD RHCNMVLENV KEMWTEVPKS GKGKKKSKPV NKDRYISKMF 100
    LRGDSVIVVL RNPLIAGK 118
    Length:118
    Mass (Da):13,527
    Last modified:July 5, 2004 - v1
    Checksum:iD986059D82B7E045
    GO
    Isoform 2 (identifier: P62316-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:108
    Mass (Da):12,399
    Checksum:i3E92B3D47F961A7F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381N → S in BU531743. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1010Missing in isoform 2. 1 PublicationVSP_045371

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15008 mRNA. Translation: AAC13776.1.
    AK291912 mRNA. Translation: BAF84601.1.
    AC007191 Genomic DNA. Translation: AAD22673.1.
    CH471126 Genomic DNA. Translation: EAW57373.1.
    CH471126 Genomic DNA. Translation: EAW57374.1.
    BC000486 mRNA. Translation: AAH00486.1.
    BC001930 mRNA. Translation: AAH01930.1.
    BU531743 mRNA. No translation available.
    CCDSiCCDS33053.1. [P62316-1]
    CCDS54281.1. [P62316-2]
    PIRiI38861.
    RefSeqiNP_004588.1. NM_004597.5. [P62316-1]
    NP_808210.2. NM_177542.2. [P62316-2]
    XP_005259237.1. XM_005259180.1. [P62316-1]
    UniGeneiHs.515472.

    Genome annotation databases

    EnsembliENST00000342669; ENSP00000342374; ENSG00000125743. [P62316-1]
    ENST00000391932; ENSP00000375798; ENSG00000125743. [P62316-2]
    ENST00000587367; ENSP00000465952; ENSG00000125743. [P62316-2]
    ENST00000588301; ENSP00000465216; ENSG00000125743. [P62316-1]
    ENST00000588599; ENSP00000466152; ENSG00000125743. [P62316-2]
    GeneIDi6633.
    KEGGihsa:6633.
    UCSCiuc002pcv.3. human. [P62316-1]

    Polymorphism databases

    DMDMi51338666.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15008 mRNA. Translation: AAC13776.1 .
    AK291912 mRNA. Translation: BAF84601.1 .
    AC007191 Genomic DNA. Translation: AAD22673.1 .
    CH471126 Genomic DNA. Translation: EAW57373.1 .
    CH471126 Genomic DNA. Translation: EAW57374.1 .
    BC000486 mRNA. Translation: AAH00486.1 .
    BC001930 mRNA. Translation: AAH01930.1 .
    BU531743 mRNA. No translation available.
    CCDSi CCDS33053.1. [P62316-1 ]
    CCDS54281.1. [P62316-2 ]
    PIRi I38861.
    RefSeqi NP_004588.1. NM_004597.5. [P62316-1 ]
    NP_808210.2. NM_177542.2. [P62316-2 ]
    XP_005259237.1. XM_005259180.1. [P62316-1 ]
    UniGenei Hs.515472.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1B34 X-ray 2.50 B 1-118 [» ]
    1VU2 X-ray 3.10 B/J/R/Z/h/p/x 1-118 [» ]
    1VU3 X-ray 3.10 B/J/R/Z/h/p 1-118 [» ]
    2Y9A X-ray 3.60 C/J/Q 1-118 [» ]
    2Y9B X-ray 3.60 C/J/Q 1-118 [» ]
    2Y9C X-ray 3.60 C/J/Q 1-118 [» ]
    2Y9D X-ray 3.60 C/J/Q 1-118 [» ]
    3CW1 X-ray 5.49 C/P/Q/R 1-118 [» ]
    3PGW X-ray 4.40 V/Y 1-118 [» ]
    3S6N X-ray 2.50 B 1-118 [» ]
    4F77 X-ray 3.10 B/J/R/Z/h/p/x 1-118 [» ]
    4F7U X-ray 1.90 B/D 1-118 [» ]
    ProteinModelPortali P62316.
    SMRi P62316. Positions 12-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112517. 99 interactions.
    DIPi DIP-31219N.
    IntActi P62316. 34 interactions.
    MINTi MINT-5002672.
    STRINGi 9606.ENSP00000342374.

    PTM databases

    PhosphoSitei P62316.

    Polymorphism databases

    DMDMi 51338666.

    Proteomic databases

    MaxQBi P62316.
    PaxDbi P62316.
    PeptideAtlasi P62316.
    PRIDEi P62316.

    Protocols and materials databases

    DNASUi 6633.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342669 ; ENSP00000342374 ; ENSG00000125743 . [P62316-1 ]
    ENST00000391932 ; ENSP00000375798 ; ENSG00000125743 . [P62316-2 ]
    ENST00000587367 ; ENSP00000465952 ; ENSG00000125743 . [P62316-2 ]
    ENST00000588301 ; ENSP00000465216 ; ENSG00000125743 . [P62316-1 ]
    ENST00000588599 ; ENSP00000466152 ; ENSG00000125743 . [P62316-2 ]
    GeneIDi 6633.
    KEGGi hsa:6633.
    UCSCi uc002pcv.3. human. [P62316-1 ]

    Organism-specific databases

    CTDi 6633.
    GeneCardsi GC19M046190.
    HGNCi HGNC:11159. SNRPD2.
    HPAi HPA041437.
    MIMi 601061. gene.
    neXtProti NX_P62316.
    PharmGKBi PA36000.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1958.
    HOGENOMi HOG000223545.
    HOVERGENi HBG054415.
    InParanoidi P62316.
    KOi K11096.
    OMAi RNELTEY.
    OrthoDBi EOG7HB5CJ.
    PhylomeDBi P62316.
    TreeFami TF319595.

    Enzyme and pathway databases

    Reactomei REACT_11066. snRNP Assembly.
    REACT_1753. mRNA Splicing - Minor Pathway.
    REACT_467. mRNA Splicing - Major Pathway.

    Miscellaneous databases

    EvolutionaryTracei P62316.
    GenomeRNAii 6633.
    NextBioi 25839.
    PROi P62316.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62316.
    Bgeei P62316.
    CleanExi HS_SNRPD1.
    HS_SNRPD2.
    Genevestigatori P62316.

    Family and domain databases

    InterProi IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR027248. Sm_D2.
    [Graphical view ]
    PANTHERi PTHR12777. PTHR12777. 1 hit.
    Pfami PF01423. LSM. 1 hit.
    [Graphical view ]
    SMARTi SM00651. Sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction."
      Lehmeier T., Raker V., Hermann H., Luehrmann R.
      Proc. Natl. Acad. Sci. U.S.A. 91:12317-12321(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 75-96 AND 103-118.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lung.
    6. Bienvenut W.V., Calvo F., Matallanas D., Cooper W.N., Kolch W.
      Submitted (FEB-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-47; 72-79 AND 103-118, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma and Mammary carcinoma.
    7. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
      Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
      RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
    8. "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."
      Will C.L., Schneider C., Hossbach M., Urlaub H., Rauhut R., Elbashir S., Tuschl T., Luehrmann R.
      RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH THE U11/U12 SPLICEOSOME, IDENTIFICATION BY MASS SPECTROMETRY.
    9. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."
      Chari A., Golas M.M., Klingenhager M., Neuenkirchen N., Sander B., Englbrecht C., Sickmann A., Stark H., Fischer U.
      Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SNRNP BIOGENESIS, IDENTIFICATION IN 6S PICLN-SM COMPLEX, IDENTIFICATION IN SMN-SM COMPLEX, SUBCELLULAR LOCATION.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-12, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs."
      Kambach C., Walke S., Young R., Avis J.M., de la Fortelle E., Raker V.A., Luehrmann R., Li J., Nagai K.
      Cell 96:375-387(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 26-118 IN COMPLEX WITH SNRPD1.
    15. "Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution."
      Pomeranz Krummel D.A., Oubridge C., Leung A.K., Li J., Nagai K.
      Nature 458:475-480(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (5.49 ANGSTROMS) IN SPLICEOSOMAL U1 SNRNP.
    16. "Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis."
      Leung A.K., Nagai K., Li J.
      Nature 473:536-539(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.60 ANGSTROMS) IN SPLICEOSOMAL CORE U4 SNRNP.
    17. "Structural basis of assembly chaperone-mediated snRNP formation."
      Grimm C., Chari A., Pelz J.P., Kuper J., Kisker C., Diederichs K., Stark H., Schindelin H., Fischer U.
      Mol. Cell 49:692-703(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN 6S PICLN-SM COMPLEX, IDENTIFICATION IN 6S PICLN-SM COMPLEX, FUNCTION IN CORE U1 SNRNP BIOGENESIS.

    Entry informationi

    Entry nameiSMD2_HUMAN
    AccessioniPrimary (citable) accession number: P62316
    Secondary accession number(s): A8K797, J3KPM5, P43330
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3