Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P62315

- SMD1_MOUSE

UniProt

P62315 - SMD1_MOUSE

Protein

Small nuclear ribonucleoprotein Sm D1

Gene

Snrpd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA By similarity.By similarity

    GO - Biological processi

    1. spliceosomal snRNP assembly Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Enzyme and pathway databases

    ReactomeiREACT_206812. snRNP Assembly.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small nuclear ribonucleoprotein Sm D1
    Short name:
    Sm-D1
    Alternative name(s):
    Sm-D autoantigen
    snRNP core protein D1
    Gene namesi
    Name:Snrpd1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:98344. Snrpd1.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Nucleus By similarity
    Note: SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.By similarity

    GO - Cellular componenti

    1. catalytic step 2 spliceosome Source: Ensembl
    2. cytoplasm Source: MGI
    3. cytosol Source: UniProtKB
    4. methylosome Source: UniProtKB
    5. nucleus Source: MGI
    6. pICln-Sm protein complex Source: UniProtKB
    7. SMN-Sm protein complex Source: UniProtKB
    8. U12-type spliceosomal complex Source: Ensembl
    9. U1 snRNP Source: UniProtKB
    10. U4 snRNP Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 119119Small nuclear ribonucleoprotein Sm D1PRO_0000122202Add
    BLAST

    Post-translational modificationi

    Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.By similarity

    Keywords - PTMi

    Methylation

    Proteomic databases

    MaxQBiP62315.
    PaxDbiP62315.
    PRIDEiP62315.

    PTM databases

    PhosphoSiteiP62315.

    Expressioni

    Gene expression databases

    BgeeiP62315.
    CleanExiMM_SNRPD1.
    GenevestigatoriP62315.

    Interactioni

    Subunit structurei

    U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi203379. 2 interactions.
    IntActiP62315. 3 interactions.
    MINTiMINT-124808.
    STRINGi10090.ENSMUSP00000002551.

    Structurei

    3D structure databases

    ProteinModelPortaliP62315.
    SMRiP62315. Positions 1-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 8080Sufficient for interaction with CLNS1ABy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi86 – 11934Arg/Lys-rich (basic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the snRNP core protein family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1958.
    GeneTreeiENSGT00510000047245.
    HOGENOMiHOG000182713.
    HOVERGENiHBG061491.
    InParanoidiP62315.
    KOiK11087.
    OMAiYLCISIF.
    OrthoDBiEOG7BZVWB.
    PhylomeDBiP62315.
    TreeFamiTF314224.

    Family and domain databases

    InterProiIPR027141. LSm4/Sm_D1/D3.
    IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    [Graphical view]
    PANTHERiPTHR23338. PTHR23338. 1 hit.
    PfamiPF01423. LSM. 1 hit.
    [Graphical view]
    SMARTiSM00651. Sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P62315-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLVRFLMKL SHETVTIELK NGTQVHGTIT GVDVSMNTHL KAVKMTLKNR    50
    EPVQLETLSI RGNNIRYFIL PDSLPLDTLL VDVEPKVKSK KREAVAGRGR 100
    GRGRGRGRGR GRGRGGPRR 119
    Length:119
    Mass (Da):13,282
    Last modified:July 5, 2004 - v1
    Checksum:i0C81C94BF98E0810
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58558 mRNA. Translation: AAA96493.1.
    AK005517 mRNA. Translation: BAB24092.1.
    AK007674 mRNA. Translation: BAB25178.1.
    AK011455 mRNA. Translation: BAB27628.1.
    AK013075 mRNA. Translation: BAB28635.1.
    AK134582 mRNA. Translation: BAE22192.1.
    AK135979 mRNA. Translation: BAE22759.1.
    BC024875 mRNA. Translation: AAH24875.1.
    CCDSiCCDS29056.1.
    RefSeqiNP_033252.1. NM_009226.4.
    UniGeneiMm.603.

    Genome annotation databases

    EnsembliENSMUST00000002551; ENSMUSP00000002551; ENSMUSG00000002477.
    GeneIDi20641.
    KEGGimmu:20641.
    UCSCiuc008eaz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58558 mRNA. Translation: AAA96493.1 .
    AK005517 mRNA. Translation: BAB24092.1 .
    AK007674 mRNA. Translation: BAB25178.1 .
    AK011455 mRNA. Translation: BAB27628.1 .
    AK013075 mRNA. Translation: BAB28635.1 .
    AK134582 mRNA. Translation: BAE22192.1 .
    AK135979 mRNA. Translation: BAE22759.1 .
    BC024875 mRNA. Translation: AAH24875.1 .
    CCDSi CCDS29056.1.
    RefSeqi NP_033252.1. NM_009226.4.
    UniGenei Mm.603.

    3D structure databases

    ProteinModelPortali P62315.
    SMRi P62315. Positions 1-96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203379. 2 interactions.
    IntActi P62315. 3 interactions.
    MINTi MINT-124808.
    STRINGi 10090.ENSMUSP00000002551.

    PTM databases

    PhosphoSitei P62315.

    Proteomic databases

    MaxQBi P62315.
    PaxDbi P62315.
    PRIDEi P62315.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002551 ; ENSMUSP00000002551 ; ENSMUSG00000002477 .
    GeneIDi 20641.
    KEGGi mmu:20641.
    UCSCi uc008eaz.1. mouse.

    Organism-specific databases

    CTDi 6632.
    MGIi MGI:98344. Snrpd1.

    Phylogenomic databases

    eggNOGi COG1958.
    GeneTreei ENSGT00510000047245.
    HOGENOMi HOG000182713.
    HOVERGENi HBG061491.
    InParanoidi P62315.
    KOi K11087.
    OMAi YLCISIF.
    OrthoDBi EOG7BZVWB.
    PhylomeDBi P62315.
    TreeFami TF314224.

    Enzyme and pathway databases

    Reactomei REACT_206812. snRNP Assembly.

    Miscellaneous databases

    ChiTaRSi SNRPD1. mouse.
    NextBioi 25835.
    PROi P62315.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62315.
    CleanExi MM_SNRPD1.
    Genevestigatori P62315.

    Family and domain databases

    InterProi IPR027141. LSm4/Sm_D1/D3.
    IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    [Graphical view ]
    PANTHERi PTHR23338. PTHR23338. 1 hit.
    Pfami PF01423. LSM. 1 hit.
    [Graphical view ]
    SMARTi SM00651. Sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The murine Sm-D autoantigen: multiple genes, genetic polymorphism, evolutionary conservation and lack of intervening sequences in the coding region."
      Mitsuda T., Eisenberg R.A., Cohen P.L.
      J. Autoimmun. 5:277-287(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Lymphoma.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Egg, Medulla oblongata, Pancreas and Placenta.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiSMD1_MOUSE
    AccessioniPrimary (citable) accession number: P62315
    Secondary accession number(s): P13641, Q3UYM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3