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P62314

- SMD1_HUMAN

UniProt

P62314 - SMD1_HUMAN

Protein

Small nuclear ribonucleoprotein Sm D1

Gene

SNRPD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA.2 Publications

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. RNA binding Source: ProtInc

    GO - Biological processi

    1. gene expression Source: Reactome
    2. mRNA splicing, via spliceosome Source: UniProtKB
    3. ncRNA metabolic process Source: Reactome
    4. RNA metabolic process Source: Reactome
    5. RNA splicing Source: Reactome
    6. spliceosomal complex assembly Source: ProtInc
    7. spliceosomal snRNP assembly Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Enzyme and pathway databases

    ReactomeiREACT_11066. snRNP Assembly.
    REACT_1753. mRNA Splicing - Minor Pathway.
    REACT_467. mRNA Splicing - Major Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small nuclear ribonucleoprotein Sm D1
    Short name:
    Sm-D1
    Alternative name(s):
    Sm-D autoantigen
    snRNP core protein D1
    Gene namesi
    Name:SNRPD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:11158. SNRPD1.

    Subcellular locationi

    Cytoplasmcytosol 1 Publication. Nucleus 1 Publication
    Note: SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.

    GO - Cellular componenti

    1. catalytic step 2 spliceosome Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. methylosome Source: UniProtKB
    4. nucleoplasm Source: Reactome
    5. nucleus Source: UniProt
    6. pICln-Sm protein complex Source: UniProtKB
    7. small nuclear ribonucleoprotein complex Source: ProtInc
    8. SMN-Sm protein complex Source: UniProtKB
    9. U12-type spliceosomal complex Source: UniProtKB
    10. U1 snRNP Source: UniProtKB
    11. U4 snRNP Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Spliceosome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi58 – 581L → K: Loss of interaction with CLNS1A. 1 Publication
    Mutagenesisi60 – 601I → R: Loss of interaction with CLNS1A. 1 Publication

    Organism-specific databases

    PharmGKBiPA164742464.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 119119Small nuclear ribonucleoprotein Sm D1PRO_0000122201Add
    BLAST

    Post-translational modificationi

    Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs.2 Publications

    Keywords - PTMi

    Methylation

    Proteomic databases

    MaxQBiP62314.
    PaxDbiP62314.
    PeptideAtlasiP62314.
    PRIDEiP62314.

    PTM databases

    PhosphoSiteiP62314.

    Expressioni

    Gene expression databases

    ArrayExpressiP62314.
    BgeeiP62314.
    CleanExiHS_SNRPD1.
    GenevestigatoriP62314.

    Organism-specific databases

    HPAiHPA040516.

    Interactioni

    Subunit structurei

    U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    P279587EBI-372177,EBI-3649474From a different organism.
    CLNS1AP541056EBI-372177,EBI-724693

    Protein-protein interaction databases

    BioGridi112516. 112 interactions.
    DIPiDIP-31207N.
    IntActiP62314. 40 interactions.
    MINTiMINT-1530147.
    STRINGi9606.ENSP00000300413.

    Structurei

    Secondary structure

    1
    119
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 86
    Turni9 – 124
    Beta strandi14 – 196
    Beta strandi24 – 329
    Beta strandi38 – 469
    Beta strandi53 – 608
    Helixi62 – 643
    Beta strandi65 – 695
    Helixi76 – 794

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1B34X-ray2.50A1-119[»]
    1VU2X-ray3.10A/I/Q/Y/g/o/w1-119[»]
    1VU3X-ray3.10A/I/Q/Y/g/o1-119[»]
    2Y9AX-ray3.60B/I/P1-119[»]
    2Y9BX-ray3.60B/I/P1-119[»]
    2Y9CX-ray3.60B/I/P1-119[»]
    2Y9DX-ray3.60B/I/P1-119[»]
    3CW1X-ray5.49B/M/N/O1-119[»]
    3PGWX-ray4.40U/X1-119[»]
    3S6NX-ray2.50A1-119[»]
    4F77X-ray3.10A/I/Q/Y/g/o/w1-119[»]
    4F7UX-ray1.90A/C1-119[»]
    ProteinModelPortaliP62314.
    SMRiP62314. Positions 1-96.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP62314.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 8080Sufficient for interaction with CLNS1AAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi86 – 11934Arg/Lys-rich (basic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the snRNP core protein family.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1958.
    HOGENOMiHOG000182713.
    HOVERGENiHBG061491.
    InParanoidiP62314.
    KOiK11087.
    OMAiQMNTALR.
    OrthoDBiEOG7BZVWB.
    PhylomeDBiP62314.
    TreeFamiTF314224.

    Family and domain databases

    InterProiIPR027141. LSm4/Sm_D1/D3.
    IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    [Graphical view]
    PANTHERiPTHR23338. PTHR23338. 1 hit.
    PfamiPF01423. LSM. 1 hit.
    [Graphical view]
    SMARTiSM00651. Sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P62314-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLVRFLMKL SHETVTIELK NGTQVHGTIT GVDVSMNTHL KAVKMTLKNR    50
    EPVQLETLSI RGNNIRYFIL PDSLPLDTLL VDVEPKVKSK KREAVAGRGR 100
    GRGRGRGRGR GRGRGGPRR 119
    Length:119
    Mass (Da):13,282
    Last modified:July 5, 2004 - v1
    Checksum:i0C81C94BF98E0810
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03798 mRNA. Translation: AAA36620.1.
    L36188
    , L36182, L36186, L36187 Genomic DNA. Translation: AAA85339.1.
    CR542239 mRNA. Translation: CAG47035.1.
    AB451227 mRNA. Translation: BAG70041.1.
    AB451350 mRNA. Translation: BAG70164.1.
    CH471088 Genomic DNA. Translation: EAX01130.1.
    BC001721 mRNA. Translation: AAH01721.1.
    BC072427 mRNA. Translation: AAH72427.1.
    CCDSiCCDS32801.1.
    PIRiA94201. A27668.
    RefSeqiNP_001278845.1. NM_001291916.1.
    NP_008869.1. NM_006938.3.
    UniGeneiHs.464734.

    Genome annotation databases

    EnsembliENST00000300413; ENSP00000300413; ENSG00000167088.
    GeneIDi6632.
    KEGGihsa:6632.
    UCSCiuc002ktj.1. human.

    Polymorphism databases

    DMDMi51338665.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J03798 mRNA. Translation: AAA36620.1 .
    L36188
    , L36182 , L36186 , L36187 Genomic DNA. Translation: AAA85339.1 .
    CR542239 mRNA. Translation: CAG47035.1 .
    AB451227 mRNA. Translation: BAG70041.1 .
    AB451350 mRNA. Translation: BAG70164.1 .
    CH471088 Genomic DNA. Translation: EAX01130.1 .
    BC001721 mRNA. Translation: AAH01721.1 .
    BC072427 mRNA. Translation: AAH72427.1 .
    CCDSi CCDS32801.1.
    PIRi A94201. A27668.
    RefSeqi NP_001278845.1. NM_001291916.1.
    NP_008869.1. NM_006938.3.
    UniGenei Hs.464734.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1B34 X-ray 2.50 A 1-119 [» ]
    1VU2 X-ray 3.10 A/I/Q/Y/g/o/w 1-119 [» ]
    1VU3 X-ray 3.10 A/I/Q/Y/g/o 1-119 [» ]
    2Y9A X-ray 3.60 B/I/P 1-119 [» ]
    2Y9B X-ray 3.60 B/I/P 1-119 [» ]
    2Y9C X-ray 3.60 B/I/P 1-119 [» ]
    2Y9D X-ray 3.60 B/I/P 1-119 [» ]
    3CW1 X-ray 5.49 B/M/N/O 1-119 [» ]
    3PGW X-ray 4.40 U/X 1-119 [» ]
    3S6N X-ray 2.50 A 1-119 [» ]
    4F77 X-ray 3.10 A/I/Q/Y/g/o/w 1-119 [» ]
    4F7U X-ray 1.90 A/C 1-119 [» ]
    ProteinModelPortali P62314.
    SMRi P62314. Positions 1-96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112516. 112 interactions.
    DIPi DIP-31207N.
    IntActi P62314. 40 interactions.
    MINTi MINT-1530147.
    STRINGi 9606.ENSP00000300413.

    PTM databases

    PhosphoSitei P62314.

    Polymorphism databases

    DMDMi 51338665.

    Proteomic databases

    MaxQBi P62314.
    PaxDbi P62314.
    PeptideAtlasi P62314.
    PRIDEi P62314.

    Protocols and materials databases

    DNASUi 6632.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300413 ; ENSP00000300413 ; ENSG00000167088 .
    GeneIDi 6632.
    KEGGi hsa:6632.
    UCSCi uc002ktj.1. human.

    Organism-specific databases

    CTDi 6632.
    GeneCardsi GC18P019192.
    HGNCi HGNC:11158. SNRPD1.
    HPAi HPA040516.
    MIMi 601063. gene.
    neXtProti NX_P62314.
    PharmGKBi PA164742464.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1958.
    HOGENOMi HOG000182713.
    HOVERGENi HBG061491.
    InParanoidi P62314.
    KOi K11087.
    OMAi QMNTALR.
    OrthoDBi EOG7BZVWB.
    PhylomeDBi P62314.
    TreeFami TF314224.

    Enzyme and pathway databases

    Reactomei REACT_11066. snRNP Assembly.
    REACT_1753. mRNA Splicing - Minor Pathway.
    REACT_467. mRNA Splicing - Major Pathway.

    Miscellaneous databases

    ChiTaRSi SNRPD1. human.
    EvolutionaryTracei P62314.
    GeneWikii Small_nuclear_ribonucleoprotein_D1.
    GenomeRNAii 6632.
    NextBioi 25835.
    PROi P62314.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62314.
    Bgeei P62314.
    CleanExi HS_SNRPD1.
    Genevestigatori P62314.

    Family and domain databases

    InterProi IPR027141. LSm4/Sm_D1/D3.
    IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    [Graphical view ]
    PANTHERi PTHR23338. PTHR23338. 1 hit.
    Pfami PF01423. LSM. 1 hit.
    [Graphical view ]
    SMARTi SM00651. Sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a cDNA encoding the human Sm-D autoantigen."
      Rokeach L.A., Haselby J.A., Hoch S.O.
      Proc. Natl. Acad. Sci. U.S.A. 85:4832-4836(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-11.
      Tissue: Placenta.
    2. Rokeach L.A.
      Submitted (JUL-1988) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "Expression of the major human ribonucleoprotein (RNP) autoantigens in Escherichia coli and their use in an EIA for screening sera from patients with autoimmune diseases."
      Renz M., Heim C., Braeunling O., Czichos A., Wieland C., Seelig H.P.
      Clin. Chem. 35:1861-1863(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
      Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
      , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
      Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    8. "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln."
      Meister G., Eggert C., Buehler D., Brahms H., Kambach C., Fischer U.
      Curr. Biol. 11:1990-1994(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: METHYLATION, INTERACTION WITH CLNS1A, MUTAGENESIS OF LEU-58 AND ILE-60.
    9. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
      Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
      RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
    10. "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."
      Will C.L., Schneider C., Hossbach M., Urlaub H., Rauhut R., Elbashir S., Tuschl T., Luehrmann R.
      RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH THE U11/U12 SPLICEOSOME, IDENTIFICATION BY MASS SPECTROMETRY.
    11. "Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins."
      Gonsalvez G.B., Tian L., Ospina J.K., Boisvert F.-M., Lamond A.I., Matera A.G.
      J. Cell Biol. 178:733-740(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: METHYLATION, INTERACTION WITH PRMT5 AND PRMT7.
    12. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."
      Chari A., Golas M.M., Klingenhager M., Neuenkirchen N., Sander B., Englbrecht C., Sickmann A., Stark H., Fischer U.
      Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SNRNP BIOGENESIS, IDENTIFICATION IN 6S PICLN-SM COMPLEX, IDENTIFICATION IN SMN-SM COMPLEX, SUBCELLULAR LOCATION.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs."
      Kambach C., Walke S., Young R., Avis J.M., de la Fortelle E., Raker V.A., Luehrmann R., Li J., Nagai K.
      Cell 96:375-387(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 2-81 IN COMPLEX WITH SNRPD2.
    15. "Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution."
      Pomeranz Krummel D.A., Oubridge C., Leung A.K., Li J., Nagai K.
      Nature 458:475-480(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (5.49 ANGSTROMS) IN SPLICEOSOMAL U1 SNRNP.
    16. "Functional organization of the Sm core in the crystal structure of human U1 snRNP."
      Weber G., Trowitzsch S., Kastner B., Luhrmann R., Wahl M.C.
      EMBO J. 29:4172-4184(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.40 ANGSTROMS) IN SPLICEOSOMAL U1 SNRNP.
    17. "Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis."
      Leung A.K., Nagai K., Li J.
      Nature 473:536-539(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.60 ANGSTROMS) IN SPLICEOSOMAL CORE U4 SNRNP.
    18. "Structural basis of assembly chaperone-mediated snRNP formation."
      Grimm C., Chari A., Pelz J.P., Kuper J., Kisker C., Diederichs K., Stark H., Schindelin H., Fischer U.
      Mol. Cell 49:692-703(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN 6S PICLN-SM COMPLEX, IDENTIFICATION IN 6S PICLN-SM COMPLEX, FUNCTION IN CORE U1 SNRNP BIOGENESIS.

    Entry informationi

    Entry nameiSMD1_HUMAN
    AccessioniPrimary (citable) accession number: P62314
    Secondary accession number(s): B5BTZ1, P13641
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3