Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P62312 (LSM6_HUMAN)

Last modified July 7, 2009. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    U6 snRNA-associated Sm-like protein LSm6
Gene names
Name: LSM6
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length80 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA By similarity.

Subunit structure

Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a donut shape.

Subcellular location

Cytoplasm. Nucleus By similarity.

Sequence similarities

Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 8080U6 snRNA-associated Sm-like protein LSm6
PRO_0000125575

Sequences

Sequence LengthMass (Da)Tools
P62312-1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 21167891FDE804F1

FASTA809,128
        10         20         30         40         50         60 
MSLRKQTPSD FLKQIIGRPV VVKLNSGVDY RGVLACLDGY MNIALEQTEE YVNGQLKNKY 

        70         80 
GDAFIRGNNV LYISTQKRRM 

« Hide

References

« Hide 'large scale' references
[1]"Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin."
Salgado-Garrido J., Bragado-Nilsson E., Kandels-Lewis S., Seraphin B.
EMBO J. 18:3451-3462(1999) [PubMed: 10369684] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro."
Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R.
EMBO J. 18:5789-5802(1999) [PubMed: 10523320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, IDENTIFICATION IN THE LSM2-LSM8 COMPLEX.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[4]"The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci."
Ingelfinger D., Arndt-Jovin D.J., Luehrmann R., Achsel T.
RNA 8:1489-1501(2002) [PubMed: 12515382] [Abstract]
Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN THE LSM1-LSM7 COMPLEX.
[5]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases

AJ238098 mRNA. Translation: CAB45869.1.
AF182292 mRNA. Translation: AAD56230.1.
BC016026 mRNA. Translation: AAH16026.1.
IPIIPI00001146.
RefSeqNP_009011.1.
UniGeneHs.190520

3D structure databases

HSSPHSSP built from PDB template 1N9R based on UniProtKB P54999.
ModBaseSearch...

Protein-protein interaction databases

IntActP62312. 8 interactions.

Proteomic databases

PeptideAtlasP62312.
PRIDEP62312.

Genome annotation databases

EnsemblENSG00000164167. Homo sapiens. [Contig view]
GeneID11157.
KEGGhsa:11157.
UCSCuc003ikq.2. human.

Organism-specific databases

GeneCardsGC04P147316.
H-InvDBHIX0004547.
HGNCHGNC:17017. LSM6.
MIM607286. gene.
PharmGKBPA128394584.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP62312.
HOVERGENP62312.
OMAP62312. EQTEEYS.

Gene expression databases

ArrayExpressP62312.
BgeeP62312.
CleanExHS_LSM6.
GermOnlineENSG00000164167. Homo sapiens.

Family and domain databases

InterProIPR006649. Euk_arc_LSM_core.
IPR001163. LSM_snRNP_core.
[Graphical view]
PfamPF01423. LSM. 1 hit.
[Graphical view]
SMARTSM00651. Sm. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio42433.
SOURCESearch...

Entry information

Entry nameLSM6_HUMAN
AccessionPrimary (citable) accession number: P62312
Secondary accession number(s): Q9Y4Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: July 7, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents