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Protein

U6 snRNA-associated Sm-like protein LSm3

Gene

Lsm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.
R-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm3
Gene namesi
Name:Lsm3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914928. Lsm3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 102101U6 snRNA-associated Sm-like protein LSm3PRO_0000125561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP62311.
MaxQBiP62311.
PaxDbiP62311.
PeptideAtlasiP62311.
PRIDEiP62311.

2D gel databases

REPRODUCTION-2DPAGEIPI00230388.
P62311.

PTM databases

PhosphoSiteiP62311.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034192.
GenevisibleiP62311. MM.

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape. Identified in the spliceosome C complex (By similarity).By similarity

Protein-protein interaction databases

IntActiP62311. 2 interactions.
MINTiMINT-4100576.
STRINGi10090.ENSMUSP00000044178.

Structurei

3D structure databases

ProteinModelPortaliP62311.
SMRiP62311. Positions 16-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3460. Eukaryota.
ENOG4111PB8. LUCA.
GeneTreeiENSGT00390000013951.
HOGENOMiHOG000223550.
HOVERGENiHBG052368.
InParanoidiP62311.
KOiK12622.
OMAiHLNMILS.
OrthoDBiEOG091G0KWQ.
PhylomeDBiP62311.
TreeFamiTF312907.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDVDQQQT TNTVEEPLDL IRLSLDERIY VKMRNDRELR GRLHAYDQHL
60 70 80 90 100
NMILGDVEET VTTIEIDEET YEEIYKSTKR NIPMLFVRGD GVVLVAPPLR

VG
Length:102
Mass (Da):11,845
Last modified:January 23, 2007 - v2
Checksum:i206B0DF0D95CD4D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003125 mRNA. Translation: BAB22585.1.
AK007849 mRNA. Translation: BAB25303.1.
AK021251 mRNA. No translation available.
BC054368 mRNA. Translation: AAH54368.1.
BC062875 mRNA. Translation: AAH62875.1.
CCDSiCCDS20369.1.
RefSeqiNP_080585.1. NM_026309.2.
UniGeneiMm.246693.
Mm.410956.

Genome annotation databases

EnsembliENSMUST00000040607; ENSMUSP00000044178; ENSMUSG00000034192.
ENSMUST00000206947; ENSMUSP00000145568; ENSMUSG00000034192.
GeneIDi67678.
KEGGimmu:67678.
UCSCiuc009cye.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003125 mRNA. Translation: BAB22585.1.
AK007849 mRNA. Translation: BAB25303.1.
AK021251 mRNA. No translation available.
BC054368 mRNA. Translation: AAH54368.1.
BC062875 mRNA. Translation: AAH62875.1.
CCDSiCCDS20369.1.
RefSeqiNP_080585.1. NM_026309.2.
UniGeneiMm.246693.
Mm.410956.

3D structure databases

ProteinModelPortaliP62311.
SMRiP62311. Positions 16-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP62311. 2 interactions.
MINTiMINT-4100576.
STRINGi10090.ENSMUSP00000044178.

PTM databases

PhosphoSiteiP62311.

2D gel databases

REPRODUCTION-2DPAGEIPI00230388.
P62311.

Proteomic databases

EPDiP62311.
MaxQBiP62311.
PaxDbiP62311.
PeptideAtlasiP62311.
PRIDEiP62311.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040607; ENSMUSP00000044178; ENSMUSG00000034192.
ENSMUST00000206947; ENSMUSP00000145568; ENSMUSG00000034192.
GeneIDi67678.
KEGGimmu:67678.
UCSCiuc009cye.1. mouse.

Organism-specific databases

CTDi27258.
MGIiMGI:1914928. Lsm3.

Phylogenomic databases

eggNOGiKOG3460. Eukaryota.
ENOG4111PB8. LUCA.
GeneTreeiENSGT00390000013951.
HOGENOMiHOG000223550.
HOVERGENiHBG052368.
InParanoidiP62311.
KOiK12622.
OMAiHLNMILS.
OrthoDBiEOG091G0KWQ.
PhylomeDBiP62311.
TreeFamiTF312907.

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.
R-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiP62311.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034192.
GenevisibleiP62311. MM.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLSM3_MOUSE
AccessioniPrimary (citable) accession number: P62311
Secondary accession number(s): Q9Y4Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.