Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

U6 snRNA-associated Sm-like protein LSm3

Gene

LSM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm3
Gene namesi
Name:LSM3
ORF Names:MDS017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000170860.3
HGNCiHGNC:17874 LSM3
MIMi607283 gene
neXtProtiNX_P62310

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170860
PharmGKBiPA134881991

Polymorphism and mutation databases

BioMutaiLSM3
DMDMi61227725

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001255602 – 102U6 snRNA-associated Sm-like protein LSm3Add BLAST101

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP62310
MaxQBiP62310
PaxDbiP62310
PeptideAtlasiP62310
PRIDEiP62310
TopDownProteomicsiP62310

PTM databases

iPTMnetiP62310
PhosphoSitePlusiP62310

Expressioni

Gene expression databases

BgeeiENSG00000170860
CleanExiHS_LSM3
GenevisibleiP62310 HS

Organism-specific databases

HPAiHPA044966

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape. Identified in the spliceosome C complex.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi11810582 interactors.
CORUMiP62310
DIPiDIP-31218N
IntActiP62310 37 interactors.
MINTiP62310
STRINGi9606.ENSP00000302160

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCRelectron microscopy7.0031-102[»]
5O9Zelectron microscopy4.50p1-102[»]
ProteinModelPortaliP62310
SMRiP62310
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3460 Eukaryota
ENOG4111PB8 LUCA
GeneTreeiENSGT00390000013951
HOGENOMiHOG000223550
HOVERGENiHBG052368
InParanoidiP62310
KOiK12622
OMAiGHMNLIL
OrthoDBiEOG091G0KWQ
PhylomeDBiP62310
TreeFamiTF312907

Family and domain databases

CDDicd01730 LSm3, 1 hit
InterProiView protein in InterPro
IPR034105 Lsm3
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDVDQQQT TNTVEEPLDL IRLSLDERIY VKMRNDRELR GRLHAYDQHL
60 70 80 90 100
NMILGDVEET VTTIEIDEET YEEIYKSTKR NIPMLFVRGD GVVLVAPPLR

VG
Length:102
Mass (Da):11,845
Last modified:January 23, 2007 - v2
Checksum:i206B0DF0D95CD4D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238095 mRNA Translation: CAB45866.1
AF182289 mRNA Translation: AAD56227.1
AF182418 mRNA Translation: AAG14954.1
CR457185 mRNA Translation: CAG33466.1
CH471055 Genomic DNA Translation: EAW64190.1
BC007055 mRNA Translation: AAH07055.1
CCDSiCCDS2619.1
RefSeqiNP_055278.1, NM_014463.2
UniGeneiHs.111632

Genome annotation databases

EnsembliENST00000306024; ENSP00000302160; ENSG00000170860
GeneIDi27258
KEGGihsa:27258
UCSCiuc003byo.2 human

Similar proteinsi

Entry informationi

Entry nameiLSM3_HUMAN
AccessioniPrimary (citable) accession number: P62310
Secondary accession number(s): Q6IAH0, Q9Y4Z1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome