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Protein

U6 snRNA-associated Sm-like protein LSm3

Gene

LSM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-430039. mRNA decay by 5' to 3' exoribonuclease.
R-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm3
Gene namesi
Name:LSM3
ORF Names:MDS017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:17874. LSM3.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • cytoplasmic mRNA processing body Source: GO_Central
  • cytosol Source: Reactome
  • Lsm1-7-Pat1 complex Source: GO_Central
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • precatalytic spliceosome Source: GO_Central
  • U4/U6 x U5 tri-snRNP complex Source: GO_Central
  • U6 snRNP Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134881991.

Polymorphism and mutation databases

BioMutaiLSM3.
DMDMi61227725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 102101U6 snRNA-associated Sm-like protein LSm3PRO_0000125560Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP62310.
MaxQBiP62310.
PaxDbiP62310.
PeptideAtlasiP62310.
PRIDEiP62310.
TopDownProteomicsiP62310.

PTM databases

iPTMnetiP62310.
PhosphoSiteiP62310.

Expressioni

Gene expression databases

BgeeiENSG00000170860.
CleanExiHS_LSM3.
GenevisibleiP62310. HS.

Organism-specific databases

HPAiHPA044966.

Interactioni

Subunit structurei

LSm subunits form a heteromer with a doughnut shape. Identified in the spliceosome C complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CLNS1AP541054EBI-348239,EBI-724693
KEAP1Q141453EBI-348239,EBI-751001
LSM1O151166EBI-348239,EBI-347619
LSM10Q969L44EBI-348239,EBI-373268
LSM2Q9Y33322EBI-348239,EBI-347416
LSM5Q9Y4Y93EBI-348239,EBI-373007
LSM6P623126EBI-348239,EBI-373310
LSM7Q9UK454EBI-348239,EBI-348372
LSM8O957776EBI-348239,EBI-347779
TCL1AP562793EBI-348239,EBI-749995
YBX1P678092EBI-348239,EBI-354065

Protein-protein interaction databases

BioGridi118105. 48 interactions.
DIPiDIP-31218N.
IntActiP62310. 33 interactions.
MINTiMINT-1036960.
STRINGi9606.ENSP00000302160.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JCRelectron microscopy7.0031-102[»]
ProteinModelPortaliP62310.
SMRiP62310. Positions 16-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3460. Eukaryota.
ENOG4111PB8. LUCA.
GeneTreeiENSGT00390000013951.
HOGENOMiHOG000223550.
HOVERGENiHBG052368.
InParanoidiP62310.
KOiK12622.
OMAiHLNMILS.
OrthoDBiEOG091G0KWQ.
PhylomeDBiP62310.
TreeFamiTF312907.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDVDQQQT TNTVEEPLDL IRLSLDERIY VKMRNDRELR GRLHAYDQHL
60 70 80 90 100
NMILGDVEET VTTIEIDEET YEEIYKSTKR NIPMLFVRGD GVVLVAPPLR

VG
Length:102
Mass (Da):11,845
Last modified:January 23, 2007 - v2
Checksum:i206B0DF0D95CD4D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238095 mRNA. Translation: CAB45866.1.
AF182289 mRNA. Translation: AAD56227.1.
AF182418 mRNA. Translation: AAG14954.1.
CR457185 mRNA. Translation: CAG33466.1.
CH471055 Genomic DNA. Translation: EAW64190.1.
BC007055 mRNA. Translation: AAH07055.1.
CCDSiCCDS2619.1.
RefSeqiNP_055278.1. NM_014463.2.
UniGeneiHs.111632.

Genome annotation databases

EnsembliENST00000306024; ENSP00000302160; ENSG00000170860.
GeneIDi27258.
KEGGihsa:27258.
UCSCiuc003byo.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238095 mRNA. Translation: CAB45866.1.
AF182289 mRNA. Translation: AAD56227.1.
AF182418 mRNA. Translation: AAG14954.1.
CR457185 mRNA. Translation: CAG33466.1.
CH471055 Genomic DNA. Translation: EAW64190.1.
BC007055 mRNA. Translation: AAH07055.1.
CCDSiCCDS2619.1.
RefSeqiNP_055278.1. NM_014463.2.
UniGeneiHs.111632.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JCRelectron microscopy7.0031-102[»]
ProteinModelPortaliP62310.
SMRiP62310. Positions 16-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118105. 48 interactions.
DIPiDIP-31218N.
IntActiP62310. 33 interactions.
MINTiMINT-1036960.
STRINGi9606.ENSP00000302160.

PTM databases

iPTMnetiP62310.
PhosphoSiteiP62310.

Polymorphism and mutation databases

BioMutaiLSM3.
DMDMi61227725.

Proteomic databases

EPDiP62310.
MaxQBiP62310.
PaxDbiP62310.
PeptideAtlasiP62310.
PRIDEiP62310.
TopDownProteomicsiP62310.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306024; ENSP00000302160; ENSG00000170860.
GeneIDi27258.
KEGGihsa:27258.
UCSCiuc003byo.2. human.

Organism-specific databases

CTDi27258.
GeneCardsiLSM3.
HGNCiHGNC:17874. LSM3.
HPAiHPA044966.
MIMi607283. gene.
neXtProtiNX_P62310.
PharmGKBiPA134881991.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3460. Eukaryota.
ENOG4111PB8. LUCA.
GeneTreeiENSGT00390000013951.
HOGENOMiHOG000223550.
HOVERGENiHBG052368.
InParanoidiP62310.
KOiK12622.
OMAiHLNMILS.
OrthoDBiEOG091G0KWQ.
PhylomeDBiP62310.
TreeFamiTF312907.

Enzyme and pathway databases

ReactomeiR-HSA-430039. mRNA decay by 5' to 3' exoribonuclease.
R-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiLSM3. human.
GeneWikiiLSM3.
GenomeRNAii27258.
PROiP62310.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170860.
CleanExiHS_LSM3.
GenevisibleiP62310. HS.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLSM3_HUMAN
AccessioniPrimary (citable) accession number: P62310
Secondary accession number(s): Q6IAH0, Q9Y4Z1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.