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Reviewed, UniProtKB/Swiss-Prot P62310 (LSM3_HUMAN)

Last modified July 7, 2009. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    U6 snRNA-associated Sm-like protein LSm3
Gene names
Name: LSM3
ORF Names: MDS017
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length102 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Binds specifically to the 3'-terminal U-tract of U6 snRNA.

Subunit structure

LSm subunits form a heteromer with a donut shape. Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the snRNP Sm proteins family.

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Ontologies

Keywords
   Biological processmRNA processing
mRNA splicing
   Cellular componentNucleus
Spliceosome
   LigandRNA-binding
   Molecular functionRibonucleoprotein
   PTMAcetylation
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processRNA splicing

Inferred from electronic annotation. Source: UniProtKB-KW

mRNA processing Ref.1

Traceable author statement. Source: UniProtKB

   Cellular componentspliceosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 102101U6 snRNA-associated Sm-like protein LSm3
PRO_0000125560

Amino acid modifications

Modified residue21N-acetylalanine

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Sequences

Sequence LengthMass (Da)Tools
P62310-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 206B0DF0D95CD4D2

FASTA10211,845
        10         20         30         40         50         60 
MADDVDQQQT TNTVEEPLDL IRLSLDERIY VKMRNDRELR GRLHAYDQHL NMILGDVEET 

        70         80         90        100 
VTTIEIDEET YEEIYKSTKR NIPMLFVRGD GVVLVAPPLR VG

« Hide

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References

« Hide 'large scale' references
[1]"Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin."
Salgado-Garrido J., Bragado-Nilsson E., Kandels-Lewis S., Seraphin B.
EMBO J. 18:3451-3462(1999) [PubMed: 10369684] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal liver and Spleen.
[2]"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro."
Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R.
EMBO J. 18:5789-5802(1999) [PubMed: 10523320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[3]"Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
Huang C., Qian B., Tu Y., Gu W., Wang Y., Han Z., Chen Z.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hematopoietic stem cell.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[5]"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
RNA 8:426-439(2002) [PubMed: 11991638] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPICEOSOMAL C COMPLEX.
[6]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

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Cross-references

Sequence databases

AJ238095 mRNA. Translation: CAB45866.1.
AF182289 mRNA. Translation: AAD56227.1.
AF182418 mRNA. Translation: AAG14954.1.
BC007055 mRNA. Translation: AAH07055.1.
IPIIPI00219229.
RefSeqNP_055278.1.
UniGeneHs.111632

3D structure databases

HSSPHSSP built from PDB template 1H64 based on UniProtKB Q9V0Y8.
ModBaseSearch...

Protein-protein interaction databases

IntActP62310. 15 interactions.

Proteomic databases

PeptideAtlasP62310.
PRIDEP62310.

Genome annotation databases

EnsemblENSG00000170860. Homo sapiens. [Contig view]
GeneID27258.
KEGGhsa:27258.
UCSCuc003byn.1. human.

Organism-specific databases

GeneCardsGC03P014195.
H-InvDBHIX0003082.
HGNCHGNC:17874. LSM3.
MIM607283. gene.
PharmGKBPA134881991.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP62310.
HOVERGENP62310.
OMAP62310. VFVRGDS.

Gene expression databases

ArrayExpressP62310.
BgeeP62310.
CleanExHS_LSM3.
GermOnlineENSG00000170860. Homo sapiens.

Family and domain databases

InterProIPR006649. Euk_arc_LSM_core.
IPR001163. LSM_snRNP_core.
[Graphical view]
PfamPF01423. LSM. 1 hit.
[Graphical view]
ProDomPD020287. snRNP. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00651. Sm. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio50206.
SOURCESearch...

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Entry information

Entry nameLSM3_HUMAN
AccessionPrimary (citable) accession number: P62310
Secondary accession number(s): Q9Y4Z1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: July 7, 2009
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents