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Protein

Small nuclear ribonucleoprotein G

Gene

Snrpg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein G
Short name:
snRNP-G
Alternative name(s):
Sm protein G
Short name:
Sm-G
Short name:
SmG
Gene namesi
Name:Snrpg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 17, Chromosome 6

Organism-specific databases

MGIiMGI:1915261 Snrpg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255461 – 76Small nuclear ribonucleoprotein GAdd BLAST76

Proteomic databases

EPDiP62309
MaxQBiP62309
PaxDbiP62309
PeptideAtlasiP62309
PRIDEiP62309

PTM databases

iPTMnetiP62309
PhosphoSitePlusiP62309

Expressioni

Gene expression databases

BgeeiENSMUSG00000049124
CleanExiMM_SNRPG
GenevisibleiP62309 MM

Interactioni

Subunit structurei

U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with TACC1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi212595, 1 interactor
IntActiP62309, 1 interactor
MINTiP62309
STRINGi10090.ENSMUSP00000137416

Structurei

3D structure databases

ProteinModelPortaliP62309
SMRiP62309
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1780 Eukaryota
ENOG41122Q1 LUCA
GeneTreeiENSGT00510000046985
HOVERGENiHBG000513
InParanoidiP62309
KOiK11099
OMAiMDKEMDL
OrthoDBiEOG091G14J2
PhylomeDBiP62309
TreeFamiTF315099

Family and domain databases

CDDicd01719 Sm_G, 1 hit
InterProiView protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR034098 Sm_G
PfamiView protein in Pfam
PF01423 LSM, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequencei

Sequence statusi: Complete.

P62309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKAHPPELK KFMDKKLSLK LNGGRHVQGI LRGFDPFMNL VIDECVEMAT
60 70
SGQQNNIGMV VIRGNSIIML EALERV
Length:76
Mass (Da):8,496
Last modified:July 5, 2004 - v1
Checksum:i623302BF6BE758FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012802 mRNA Translation: BAB28480.1
AK013235 mRNA Translation: BAB28732.1
BC027499 mRNA Translation: AAH27499.1
BC051470 mRNA Translation: AAH51470.1
BC094411 mRNA Translation: AAH94411.1
CCDSiCCDS39541.1
RefSeqiNP_080782.1, NM_026506.2
UniGeneiMm.276802

Genome annotation databases

EnsembliENSMUST00000053575; ENSMUSP00000137416; ENSMUSG00000049124
ENSMUST00000089558; ENSMUSP00000086987; ENSMUSG00000057278
GeneIDi68011
KEGGimmu:68011
UCSCiuc009crm.1 mouse

Similar proteinsi

Entry informationi

Entry nameiRUXG_MOUSE
AccessioniPrimary (citable) accession number: P62309
Secondary accession number(s): Q15357, Q52KC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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