Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P62309

- RUXG_MOUSE

UniProt

P62309 - RUXG_MOUSE

Protein

Small nuclear ribonucleoprotein G

Gene

Snrpg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. spliceosomal snRNP assembly Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_206812. snRNP Assembly.
    REACT_215668. SLBP independent Processing of Histone Pre-mRNAs.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small nuclear ribonucleoprotein G
    Short name:
    snRNP-G
    Alternative name(s):
    Sm protein G
    Short name:
    Sm-G
    Short name:
    SmG
    Gene namesi
    Name:Snrpg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1915261. Snrpg.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Nucleus By similarity
    Note: SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.By similarity

    GO - Cellular componenti

    1. catalytic step 2 spliceosome Source: Ensembl
    2. cytosol Source: UniProtKB
    3. methylosome Source: UniProtKB
    4. SMN-Sm protein complex Source: UniProtKB
    5. U12-type spliceosomal complex Source: Ensembl
    6. U1 snRNP Source: UniProtKB
    7. U4 snRNP Source: UniProtKB
    8. U7 snRNP Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7676Small nuclear ribonucleoprotein GPRO_0000125546Add
    BLAST

    Proteomic databases

    PaxDbiP62309.
    PRIDEiP62309.

    PTM databases

    PhosphoSiteiP62309.

    Expressioni

    Gene expression databases

    ArrayExpressiP62309.
    BgeeiP62309.
    CleanExiMM_SNRPG.
    GenevestigatoriP62309.

    Interactioni

    Subunit structurei

    U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with TACC1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi212595. 1 interaction.
    IntActiP62309. 1 interaction.
    MINTiMINT-4133513.

    Structurei

    3D structure databases

    ProteinModelPortaliP62309.
    SMRiP62309. Positions 7-74.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the snRNP Sm proteins family.Curated

    Phylogenomic databases

    eggNOGiCOG1958.
    GeneTreeiENSGT00510000046985.
    HOVERGENiHBG000513.
    InParanoidiP62309.
    KOiK11099.
    OMAiEKERIGM.
    OrthoDBiEOG7S221K.
    PhylomeDBiP62309.
    TreeFamiTF315099.

    Family and domain databases

    InterProiIPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    [Graphical view]
    PfamiPF01423. LSM. 1 hit.
    [Graphical view]
    SMARTiSM00651. Sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P62309-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKAHPPELK KFMDKKLSLK LNGGRHVQGI LRGFDPFMNL VIDECVEMAT   50
    SGQQNNIGMV VIRGNSIIML EALERV 76
    Length:76
    Mass (Da):8,496
    Last modified:July 5, 2004 - v1
    Checksum:i623302BF6BE758FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012802 mRNA. Translation: BAB28480.1.
    AK013235 mRNA. Translation: BAB28732.1.
    BC027499 mRNA. Translation: AAH27499.1.
    BC051470 mRNA. Translation: AAH51470.1.
    BC094411 mRNA. Translation: AAH94411.1.
    CCDSiCCDS39541.1.
    RefSeqiNP_080782.1. NM_026506.2.
    UniGeneiMm.276802.

    Genome annotation databases

    EnsembliENSMUST00000053575; ENSMUSP00000137416; ENSMUSG00000049124.
    ENSMUST00000089558; ENSMUSP00000086987; ENSMUSG00000057278.
    GeneIDi68011.
    KEGGimmu:68011.
    UCSCiuc009crm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012802 mRNA. Translation: BAB28480.1 .
    AK013235 mRNA. Translation: BAB28732.1 .
    BC027499 mRNA. Translation: AAH27499.1 .
    BC051470 mRNA. Translation: AAH51470.1 .
    BC094411 mRNA. Translation: AAH94411.1 .
    CCDSi CCDS39541.1.
    RefSeqi NP_080782.1. NM_026506.2.
    UniGenei Mm.276802.

    3D structure databases

    ProteinModelPortali P62309.
    SMRi P62309. Positions 7-74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212595. 1 interaction.
    IntActi P62309. 1 interaction.
    MINTi MINT-4133513.

    PTM databases

    PhosphoSitei P62309.

    Proteomic databases

    PaxDbi P62309.
    PRIDEi P62309.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053575 ; ENSMUSP00000137416 ; ENSMUSG00000049124 .
    ENSMUST00000089558 ; ENSMUSP00000086987 ; ENSMUSG00000057278 .
    GeneIDi 68011.
    KEGGi mmu:68011.
    UCSCi uc009crm.1. mouse.

    Organism-specific databases

    CTDi 6637.
    MGIi MGI:1915261. Snrpg.

    Phylogenomic databases

    eggNOGi COG1958.
    GeneTreei ENSGT00510000046985.
    HOVERGENi HBG000513.
    InParanoidi P62309.
    KOi K11099.
    OMAi EKERIGM.
    OrthoDBi EOG7S221K.
    PhylomeDBi P62309.
    TreeFami TF315099.

    Enzyme and pathway databases

    Reactomei REACT_206812. snRNP Assembly.
    REACT_215668. SLBP independent Processing of Histone Pre-mRNAs.

    Miscellaneous databases

    NextBioi 25857.
    PROi P62309.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62309.
    Bgeei P62309.
    CleanExi MM_SNRPG.
    Genevestigatori P62309.

    Family and domain databases

    InterProi IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    [Graphical view ]
    Pfami PF01423. LSM. 1 hit.
    [Graphical view ]
    SMARTi SM00651. Sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland and Thymus.
    3. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 1-10, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiRUXG_MOUSE
    AccessioniPrimary (citable) accession number: P62309
    Secondary accession number(s): Q15357, Q52KC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3