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Protein

Small nuclear ribonucleoprotein G

Gene

SNRPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing.2 Publications

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • U1 snRNP binding Source: Ensembl

GO - Biological processi

  • histone mRNA metabolic process Source: Reactome
  • mRNA splicing, via spliceosome Source: UniProtKB
  • nuclear import Source: Reactome
  • RNA splicing Source: UniProtKB
  • spliceosomal complex assembly Source: UniProtKB
  • spliceosomal snRNP assembly Source: UniProtKB
  • termination of RNA polymerase II transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143977-MONOMER.
ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-111367. SLBP independent Processing of Histone Pre-mRNAs.
R-HSA-191859. snRNP Assembly.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72165. mRNA Splicing - Minor Pathway.
R-HSA-77588. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein G
Short name:
snRNP-G
Alternative name(s):
Sm protein G
Short name:
Sm-G
Short name:
SmG
Gene namesi
Name:SNRPG
Synonyms:PBSCG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11163. SNRPG.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • cytosol Source: UniProtKB
  • methylosome Source: UniProtKB
  • nucleoplasm Source: Reactome
  • P granule Source: GO_Central
  • precatalytic spliceosome Source: GO_Central
  • small nuclear ribonucleoprotein complex Source: UniProtKB
  • small nucleolar ribonucleoprotein complex Source: InterPro
  • SMN-Sm protein complex Source: UniProtKB
  • spliceosomal complex Source: UniProtKB
  • spliceosomal tri-snRNP complex Source: GO_Central
  • U12-type spliceosomal complex Source: UniProtKB
  • U1 snRNP Source: UniProtKB
  • U2 snRNP Source: GO_Central
  • U2-type prespliceosome Source: GO_Central
  • U4 snRNP Source: UniProtKB
  • U5 snRNP Source: GO_Central
  • U7 snRNP Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143977.
PharmGKBiPA36004.

Polymorphism and mutation databases

BioMutaiSNRPG.
DMDMi59800216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255451 – 76Small nuclear ribonucleoprotein GAdd BLAST76

Proteomic databases

EPDiP62308.
MaxQBiP62308.
PaxDbiP62308.
PeptideAtlasiP62308.
PRIDEiP62308.
TopDownProteomicsiP62308.

PTM databases

iPTMnetiP62308.
PhosphoSitePlusiP62308.
SwissPalmiP62308.

Expressioni

Gene expression databases

BgeeiENSG00000143977.
CleanExiHS_SNRPG.
ExpressionAtlasiP62308. baseline and differential.
GenevisibleiP62308. HS.

Organism-specific databases

HPAiHPA064152.

Interactioni

Subunit structurei

U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP. Interacts with TACC1.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CLNS1AP541056EBI-624585,EBI-724693
DDIT4LQ96D038EBI-624585,EBI-742054
FHL3Q136435EBI-624585,EBI-741101
SNRPEP623044EBI-624585,EBI-348082
TACC1O75410-15EBI-624585,EBI-624252

Protein-protein interaction databases

BioGridi112521. 115 interactors.
DIPiDIP-34627N.
IntActiP62308. 29 interactors.
MINTiMINT-1527983.
STRINGi9606.ENSP00000272348.

Structurei

Secondary structure

176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni11 – 14Combined sources4
Beta strandi16 – 21Combined sources6
Turni22 – 24Combined sources3
Beta strandi25 – 34Combined sources10
Beta strandi40 – 47Combined sources8
Beta strandi57 – 62Combined sources6
Beta strandi64 – 71Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CW1X-ray5.493/4/5/G1-76[»]
3JCRelectron microscopy7.00U/u1-76[»]
3PGWX-ray4.40G/J1-76[»]
3S6NX-ray2.50G1-76[»]
4F7UX-ray1.90G/J1-76[»]
4PJOX-ray3.30G/U/g/u1-76[»]
4V98X-ray3.10A4/AH/AP/AX/Af/An/Av/B4/BH/BP/BX/Bf/Bn/Bv/CH/CP/CX/Cf/Cn/Cv1-76[»]
4WZJX-ray3.60AG/AN/AU/BG/BN/BU/CG/CN/CU/DG/DN/DU1-76[»]
ProteinModelPortaliP62308.
SMRiP62308.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62308.

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG1780. Eukaryota.
ENOG41122Q1. LUCA.
GeneTreeiENSGT00510000046985.
HOVERGENiHBG000513.
InParanoidiP62308.
KOiK11099.
OMAiFMNMVID.
TreeFamiTF315099.

Family and domain databases

InterProiIPR017132. Lsm7/snRNP-G.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF037188. U6_snRNA_Lsm7. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

P62308-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKAHPPELK KFMDKKLSLK LNGGRHVQGI LRGFDPFMNL VIDECVEMAT
60 70
SGQQNNIGMV VIRGNSIIML EALERV
Length:76
Mass (Da):8,496
Last modified:July 5, 2004 - v1
Checksum:i623302BF6BE758FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85373 mRNA. Translation: CAA59689.1.
CR456918 mRNA. Translation: CAG33199.1.
AC079338 Genomic DNA. Translation: AAX81996.1.
CH471053 Genomic DNA. Translation: EAW99817.1.
CH471053 Genomic DNA. Translation: EAW99818.1.
BC000070 mRNA. Translation: AAH00070.1.
BC022432 mRNA. Translation: AAH22432.1.
BC066302 mRNA. Translation: AAH66302.1.
BC070166 mRNA. Translation: AAH70166.1.
BC071880 mRNA. Translation: AAH71880.1.
BC106055 mRNA. Translation: AAI06056.1.
CCDSiCCDS1903.1.
PIRiS55054.
RefSeqiNP_003087.1. NM_003096.3.
UniGeneiHs.465167.
Hs.516076.
Hs.631639.
Hs.654528.

Genome annotation databases

EnsembliENST00000272348; ENSP00000272348; ENSG00000143977.
GeneIDi6637.
KEGGihsa:6637.
UCSCiuc002sgp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85373 mRNA. Translation: CAA59689.1.
CR456918 mRNA. Translation: CAG33199.1.
AC079338 Genomic DNA. Translation: AAX81996.1.
CH471053 Genomic DNA. Translation: EAW99817.1.
CH471053 Genomic DNA. Translation: EAW99818.1.
BC000070 mRNA. Translation: AAH00070.1.
BC022432 mRNA. Translation: AAH22432.1.
BC066302 mRNA. Translation: AAH66302.1.
BC070166 mRNA. Translation: AAH70166.1.
BC071880 mRNA. Translation: AAH71880.1.
BC106055 mRNA. Translation: AAI06056.1.
CCDSiCCDS1903.1.
PIRiS55054.
RefSeqiNP_003087.1. NM_003096.3.
UniGeneiHs.465167.
Hs.516076.
Hs.631639.
Hs.654528.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CW1X-ray5.493/4/5/G1-76[»]
3JCRelectron microscopy7.00U/u1-76[»]
3PGWX-ray4.40G/J1-76[»]
3S6NX-ray2.50G1-76[»]
4F7UX-ray1.90G/J1-76[»]
4PJOX-ray3.30G/U/g/u1-76[»]
4V98X-ray3.10A4/AH/AP/AX/Af/An/Av/B4/BH/BP/BX/Bf/Bn/Bv/CH/CP/CX/Cf/Cn/Cv1-76[»]
4WZJX-ray3.60AG/AN/AU/BG/BN/BU/CG/CN/CU/DG/DN/DU1-76[»]
ProteinModelPortaliP62308.
SMRiP62308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112521. 115 interactors.
DIPiDIP-34627N.
IntActiP62308. 29 interactors.
MINTiMINT-1527983.
STRINGi9606.ENSP00000272348.

PTM databases

iPTMnetiP62308.
PhosphoSitePlusiP62308.
SwissPalmiP62308.

Polymorphism and mutation databases

BioMutaiSNRPG.
DMDMi59800216.

Proteomic databases

EPDiP62308.
MaxQBiP62308.
PaxDbiP62308.
PeptideAtlasiP62308.
PRIDEiP62308.
TopDownProteomicsiP62308.

Protocols and materials databases

DNASUi6637.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272348; ENSP00000272348; ENSG00000143977.
GeneIDi6637.
KEGGihsa:6637.
UCSCiuc002sgp.4. human.

Organism-specific databases

CTDi6637.
GeneCardsiSNRPG.
HGNCiHGNC:11163. SNRPG.
HPAiHPA064152.
MIMi603542. gene.
neXtProtiNX_P62308.
OpenTargetsiENSG00000143977.
PharmGKBiPA36004.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1780. Eukaryota.
ENOG41122Q1. LUCA.
GeneTreeiENSGT00510000046985.
HOVERGENiHBG000513.
InParanoidiP62308.
KOiK11099.
OMAiFMNMVID.
TreeFamiTF315099.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143977-MONOMER.
ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-111367. SLBP independent Processing of Histone Pre-mRNAs.
R-HSA-191859. snRNP Assembly.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72165. mRNA Splicing - Minor Pathway.
R-HSA-77588. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.

Miscellaneous databases

ChiTaRSiSNRPG. human.
EvolutionaryTraceiP62308.
GeneWikiiSNRPG.
GenomeRNAii6637.
PROiP62308.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143977.
CleanExiHS_SNRPG.
ExpressionAtlasiP62308. baseline and differential.
GenevisibleiP62308. HS.

Family and domain databases

InterProiIPR017132. Lsm7/snRNP-G.
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
[Graphical view]
PfamiPF01423. LSM. 1 hit.
[Graphical view]
PIRSFiPIRSF037188. U6_snRNA_Lsm7. 1 hit.
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRUXG_HUMAN
AccessioniPrimary (citable) accession number: P62308
Secondary accession number(s): D6W5G6, Q15357, Q6IB86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.