P62308 (RUXG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Small nuclear ribonucleoprotein G
Short name=snRNP-G

Alternative name(s):
Sm protein G
Short name=Sm-G
Short name=SmG

Gene names

Name:	SNRPG
Synonyms:	PBSCG

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	76 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5.
Subunit structure	Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Interacts with TACC1. Ref.6 Ref.7 Ref.8 Ref.9
Subcellular location	Nucleus.
Sequence similarities	Belongs to the snRNP Sm proteins family.

Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus Spliceosome
Ligand	RNA-binding
Molecular function	Ribonucleoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone mRNA metabolic process Traceable author statement. Source: Reactome mRNA 3'-end processing Traceable author statement. Source: Reactome ncRNA metabolic process Traceable author statement. Source: Reactome spliceosomal complex assembly Non-traceable author statement Ref.1. Source: UniProtKB spliceosomal snRNP assembly Traceable author statement. Source: Reactome termination of RNA polymerase II transcription Traceable author statement. Source: Reactome
Cellular_component	U12-type spliceosomal complex Inferred from direct assay Ref.9. Source: UniProtKB U7 snRNP Inferred from direct assay Ref.6. Source: UniProtKB catalytic step 2 spliceosome Inferred from direct assay Ref.8. Source: UniProtKB cytosol Traceable author statement. Source: Reactome nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TACC1	O75410-1	5	EBI-624585,EBI-624252

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 76

76

Small nuclear ribonucleoprotein G

PRO_0000125545

Secondary structure

1

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76

Helix Strand Turn

Details...

Helix

6 – 9

4

Helix

10 – 12

3

Beta strand

16 – 21

6

Turn

22 – 24

3

Beta strand

25 – 34

10

Beta strand

40 – 47

8

Beta strand

57 – 62

6

Beta strand

64 – 71

8

Sequences

	Sequence		Length	Mass (Da)
	P62308 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 623302BF6BE758FE	FASTA	76	8,496
	10 20 30 40 50 60 MSKAHPPELK KFMDKKLSLK LNGGRHVQGI LRGFDPFMNL VIDECVEMAT SGQQNNIGMV 70 VIRGNSIIML EALERV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions." Hermann H., Fabrizio P., Raker V.A., Foulaki K., Hornig H., Brahms H., Luehrmann R. EMBO J. 14:2076-2088(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone, Brain, Pancreas and Placenta.
[6]	"Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein." Pillai R.S., Will C.L., Luehrmann R., Schuemperli D., Mueller B. EMBO J. 20:5470-5479(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE U7 SNRNP COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[7]	"Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators." Conte N., Charafe-Jauffret E., Delaval B., Adelaide J., Ginestier C., Geneix J., Isnardon D., Jacquemier J., Birnbaum D. Oncogene 21:5619-5630(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TACC1.
[8]	"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis." Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J. RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
[9]	"The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome." Will C.L., Schneider C., Hossbach M., Urlaub H., Rauhut R., Elbashir S., Tuschl T., Luehrmann R. RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A COMPLEX WITH THE U11/U12 SPLICEOSOME, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X85373 mRNA. Translation: CAA59689.1.
CR456918 mRNA. Translation: CAG33199.1.
AC079338 Genomic DNA. Translation: AAX81996.1.
CH471053 Genomic DNA. Translation: EAW99817.1.
CH471053 Genomic DNA. Translation: EAW99818.1.
BC000070 mRNA. Translation: AAH00070.1.
BC022432 mRNA. Translation: AAH22432.1.
BC066302 mRNA. Translation: AAH66302.1.
BC070166 mRNA. Translation: AAH70166.1.
BC071880 mRNA. Translation: AAH71880.1.
BC106055 mRNA. Translation: AAI06056.1.

IPI

IPI00016572.

PIR

S55054.

RefSeq

NP_003087.1. NM_003096.2.

UniGene

Hs.465167.
Hs.516076.
Hs.631639.
Hs.654528.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1VU2	X-ray	3.10	4/H/P/X/f/n/v	1-76	[»]
1VU3	X-ray	3.10	H/P/X/f/n/v	1-76	[»]
2Y9A	X-ray	3.60	G/N/U	1-76	[»]
2Y9B	X-ray	3.60	G/N/U	1-76	[»]
2Y9C	X-ray	3.60	G/N/U	1-76	[»]
2Y9D	X-ray	3.60	G/N/U	1-76	[»]
3CW1	X-ray	5.49	3/4/5/G	1-76	[»]
3PGW	X-ray	4.40	G/J	1-76	[»]
3S6N	X-ray	2.50	G	1-76	[»]
4F77	X-ray	3.10	4/H/P/X/f/n/v	1-76	[»]

ProteinModelPortal

P62308.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-34627N.

IntAct

P62308. 19 interactions.

MINT

MINT-1527983.

STRING

9606.ENSP00000272348.

PTM databases

PhosphoSite

P62308.

Polymorphism databases

DMDM

59800216.

Proteomic databases

PeptideAtlas

P62308.

PRIDE

P62308.

Protocols and materials databases

DNASU

6637.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000272348; ENSP00000272348; ENSG00000143977.

GeneID

6637.

KEGG

hsa:6637.

UCSC

uc002sgp.3. human.

Organism-specific databases

CTD

6637.

GeneCards

GC02M070508.

HGNC

HGNC:11163. SNRPG.

MIM

603542. gene.

neXtProt

NX_P62308.

PharmGKB

PA36004.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

HBG000513.

InParanoid

P62308.

KO

K11099.

OMA

ESVEMAP.

PhylomeDB

P62308.

Enzyme and pathway databases

Reactome

REACT_1675. mRNA Processing.
REACT_1788. Transcription.
REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.
REACT_78. Post-Elongation Processing of the Transcript.

Gene expression databases

ArrayExpress

P62308.

Bgee

P62308.

CleanEx

HS_SNRPG.

Genevestigator

P62308.

GermOnline

ENSG00000143977. Homo sapiens.

Family and domain databases

InterPro

IPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
[Graphical view]

Pfam

PF01423. LSM. 1 hit.
[Graphical view]

SMART

SM00651. Sm. 1 hit.
[Graphical view]

SUPFAM

SSF50182. Sm_like_riboprot. 1 hit.

ProtoNet

Search...

Other

ChiTaRS

SNRPG. human.

EvolutionaryTrace

P62308.

GenomeRNAi

6637.

NextBio

25857.

SOURCE

Search...

Entry information

Entry name

RUXG_HUMAN

Accession

Primary (citable) accession number: P62308
Secondary accession number(s): D6W5G6, Q15357, Q6IB86

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.