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Protein

Small nuclear ribonucleoprotein F

Gene

SNRPF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing.2 Publications

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

  • histone mRNA metabolic process Source: Reactome
  • import into nucleus Source: Reactome
  • mRNA splicing, via spliceosome Source: Reactome
  • RNA splicing Source: UniProtKB
  • spliceosomal snRNP assembly Source: UniProtKB
  • termination of RNA polymerase II transcription Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs
R-HSA-191859 snRNP Assembly
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway
R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein F
Short name:
snRNP-F
Alternative name(s):
Sm protein F
Short name:
Sm-F
Short name:
SmF
Gene namesi
Name:SNRPF
Synonyms:PBSCF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139343.10
HGNCiHGNC:11162 SNRPF
MIMi603541 gene
neXtProtiNX_P62306

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi6636
OpenTargetsiENSG00000139343
PharmGKBiPA36003

Polymorphism and mutation databases

BioMutaiSNRPF
DMDMi61237391

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001255362 – 86Small nuclear ribonucleoprotein FAdd BLAST85

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP62306
MaxQBiP62306
PaxDbiP62306
PeptideAtlasiP62306
PRIDEiP62306
TopDownProteomicsiP62306

PTM databases

iPTMnetiP62306
PhosphoSitePlusiP62306

Miscellaneous databases

PMAP-CutDBP62306

Expressioni

Gene expression databases

BgeeiENSG00000139343
CleanExiHS_SNRPF
ExpressionAtlasiP62306 baseline and differential
GenevisibleiP62306 HS

Interactioni

Subunit structurei

U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112520, 154 interactors
CORUMiP62306
DIPiDIP-31221N
IntActiP62306, 39 interactors
MINTiP62306
STRINGi9606.ENSP00000266735

Structurei

Secondary structure

186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 14Combined sources8
Beta strandi17 – 23Combined sources7
Beta strandi28 – 36Combined sources9
Beta strandi42 – 51Combined sources10
Beta strandi54 – 64Combined sources11
Helixi66 – 68Combined sources3
Beta strandi69 – 74Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3CW1X-ray5.491/2/F/Z1-86[»]
3JCRelectron microscopy7.00T/t1-86[»]
3PGWX-ray4.40F/I1-86[»]
3S6NX-ray2.50F1-86[»]
4F7UX-ray1.90F/I1-86[»]
4PJOX-ray3.30F/T/f/t1-75[»]
4V98X-ray3.10AD/AL/AT/Ab/Aj/Ar/Az/BD/BL/BT/Bb/Bj/Br/Bz/CD/CL/CT/Cb/Cj/Cr1-86[»]
4WZJX-ray3.60AF/AM/AT/BF/BM/BT/CF/CM/CT/DF/DM/DT1-86[»]
5MQFelectron microscopy5.90b/i1-86[»]
5O9Zelectron microscopy4.50T/b/i1-86[»]
5XJCelectron microscopy3.60f/m1-86[»]
ProteinModelPortaliP62306
SMRiP62306
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62306

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3482 Eukaryota
ENOG4111W47 LUCA
GeneTreeiENSGT00730000110856
HOVERGENiHBG052369
InParanoidiP62306
KOiK11098
OMAiKWGHEYK
PhylomeDBiP62306
TreeFamiTF314481

Family and domain databases

CDDicd01722 Sm_F, 1 hit
InterProiView protein in InterPro
IPR016487 Lsm6/sSmF
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR034100 Sm_F
PANTHERiPTHR11021 PTHR11021, 1 hit
PfamiView protein in Pfam
PF01423 LSM, 1 hit
PIRSFiPIRSF006609 snRNP_SmF, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPLNPKPF LNGLTGKPVM VKLKWGMEYK GYLVSVDGYM NMQLANTEEY
60 70 80
IDGALSGHLG EVLIRCNNVL YIRGVEEEEE DGEMRE
Length:86
Mass (Da):9,725
Last modified:July 5, 2004 - v1
Checksum:i416B88D575DAE58A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86E → D in CAG33032 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85372 mRNA Translation: CAA59688.1
CR456751 mRNA Translation: CAG33032.1
AK311752 mRNA Translation: BAG34695.1
CH471054 Genomic DNA Translation: EAW97548.1
BC002505 mRNA Translation: AAH02505.3
BC063397 mRNA Translation: AAH63397.2
BC128452 mRNA Translation: AAI28453.1
BC128453 mRNA Translation: AAI28454.1
CCDSiCCDS9055.1
PIRiS55053
RefSeqiNP_003086.1, NM_003095.2
UniGeneiHs.105465

Genome annotation databases

EnsembliENST00000266735; ENSP00000266735; ENSG00000139343
GeneIDi6636
KEGGihsa:6636
UCSCiuc001tej.5 human

Similar proteinsi

Entry informationi

Entry nameiRUXF_HUMAN
AccessioniPrimary (citable) accession number: P62306
Secondary accession number(s): A2VCR2
, B2R498, Q15356, Q6IBQ1, Q6P4I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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