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Protein

Small nuclear ribonucleoprotein E

Gene

Snrpe

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development (By similarity).By similarity

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. hair cycle Source: UniProtKB
  2. spliceosomal snRNP assembly Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_271571. mRNA Splicing - Minor Pathway.
REACT_278946. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
REACT_307866. mRNA Splicing - Major Pathway.
REACT_333207. snRNP Assembly.
REACT_343355. SLBP independent Processing of Histone Pre-mRNAs.
REACT_351784. Cleavage of Growing Transcript in the Termination Region.

Names & Taxonomyi

Protein namesi
Recommended name:
Small nuclear ribonucleoprotein E
Short name:
snRNP-E
Alternative name(s):
Sm protein E
Short name:
Sm-E
Short name:
SmE
Gene namesi
Name:Snrpe
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98346. Snrpe.

Subcellular locationi

Cytoplasmcytosol By similarity. Nucleus By similarity
Note: SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.By similarity

GO - Cellular componenti

  1. catalytic step 2 spliceosome Source: Ensembl
  2. cytosol Source: UniProtKB
  3. extracellular vesicular exosome Source: Ensembl
  4. methylosome Source: UniProtKB
  5. nucleus Source: UniProtKB
  6. pICln-Sm protein complex Source: UniProtKB
  7. precatalytic spliceosome Source: GO_Central
  8. SMN-Sm protein complex Source: UniProtKB
  9. U12-type spliceosomal complex Source: Ensembl
  10. U1 snRNP Source: UniProtKB
  11. U2 snRNP Source: GO_Central
  12. U4/U6 x U5 tri-snRNP complex Source: GO_Central
  13. U4 snRNP Source: UniProtKB
  14. U5 snRNP Source: GO_Central
  15. U7 snRNP Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Small nuclear ribonucleoprotein EPRO_0000125530Add
BLAST

Proteomic databases

MaxQBiP62305.
PRIDEiP62305.

PTM databases

PhosphoSiteiP62305.

Expressioni

Gene expression databases

BgeeiP62305.
CleanExiMM_SNRPE.
ExpressionAtlasiP62305. baseline and differential.
GenevestigatoriP62305.

Interactioni

Subunit structurei

U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (By similarity).By similarity

Protein-protein interaction databases

BioGridi203380. 1 interaction.
IntActiP62305. 2 interactions.
MINTiMINT-1853918.

Structurei

3D structure databases

ProteinModelPortaliP62305.
SMRiP62305. Positions 14-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000012818.
HOVERGENiHBG003229.
InParanoidiP62305.
KOiK11097.
OMAiFDEFMNI.
OrthoDBiEOG7GFB5W.
PhylomeDBiP62305.
TreeFamiTF314419.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR027078. snRNP-E.
[Graphical view]
PANTHERiPTHR11193. PTHR11193. 1 hit.
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

P62305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF
60 70 80 90
DEYMNLVLDD AEEIHSKTKS RKQLGRIMLK GDNITLLQSV SN
Length:92
Mass (Da):10,804
Last modified:July 5, 2004 - v1
Checksum:i7D8881CE1F4FA2FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65703 Genomic DNA. Translation: CAA46625.1. Sequence problems.
X65704 mRNA. Translation: CAA46626.1.
AK019462 mRNA. Translation: BAB31734.1.
BC008262 mRNA. Translation: AAH08262.1.
BC051207 mRNA. Translation: AAH51207.1.
BC055765 mRNA. Translation: AAH55765.1.
CCDSiCCDS48364.1.
PIRiI48778.
RefSeqiNP_033253.1. NM_009227.3.
UniGeneiMm.249110.

Genome annotation databases

EnsembliENSMUST00000166915; ENSMUSP00000128400; ENSMUSG00000090553.
GeneIDi20643.
KEGGimmu:20643.
UCSCiuc007cql.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65703 Genomic DNA. Translation: CAA46625.1. Sequence problems.
X65704 mRNA. Translation: CAA46626.1.
AK019462 mRNA. Translation: BAB31734.1.
BC008262 mRNA. Translation: AAH08262.1.
BC051207 mRNA. Translation: AAH51207.1.
BC055765 mRNA. Translation: AAH55765.1.
CCDSiCCDS48364.1.
PIRiI48778.
RefSeqiNP_033253.1. NM_009227.3.
UniGeneiMm.249110.

3D structure databases

ProteinModelPortaliP62305.
SMRiP62305. Positions 14-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203380. 1 interaction.
IntActiP62305. 2 interactions.
MINTiMINT-1853918.

PTM databases

PhosphoSiteiP62305.

Proteomic databases

MaxQBiP62305.
PRIDEiP62305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000166915; ENSMUSP00000128400; ENSMUSG00000090553.
GeneIDi20643.
KEGGimmu:20643.
UCSCiuc007cql.2. mouse.

Organism-specific databases

CTDi6635.
MGIiMGI:98346. Snrpe.

Phylogenomic databases

GeneTreeiENSGT00390000012818.
HOVERGENiHBG003229.
InParanoidiP62305.
KOiK11097.
OMAiFDEFMNI.
OrthoDBiEOG7GFB5W.
PhylomeDBiP62305.
TreeFamiTF314419.

Enzyme and pathway databases

ReactomeiREACT_271571. mRNA Splicing - Minor Pathway.
REACT_278946. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
REACT_307866. mRNA Splicing - Major Pathway.
REACT_333207. snRNP Assembly.
REACT_343355. SLBP independent Processing of Histone Pre-mRNAs.
REACT_351784. Cleavage of Growing Transcript in the Termination Region.

Miscellaneous databases

NextBioi299051.
PROiP62305.
SOURCEiSearch...

Gene expression databases

BgeeiP62305.
CleanExiMM_SNRPE.
ExpressionAtlasiP62305. baseline and differential.
GenevestigatoriP62305.

Family and domain databases

InterProiIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR027078. snRNP-E.
[Graphical view]
PANTHERiPTHR11193. PTHR11193. 1 hit.
PfamiPF01423. LSM. 1 hit.
[Graphical view]
SMARTiSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMiSSF50182. SSF50182. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Conservation of coding and transcriptional control sequences within the snRNP E protein gene."
    Fautsch M., Thompson M.A., Holicky E.L., Schultz P.J., Hallett J.B., Wieben E.D.
    Genomics 14:883-890(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiRUXE_MOUSE
AccessioniPrimary (citable) accession number: P62305
Secondary accession number(s): P08578, Q15498
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.