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P62304 (RUXE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Small nuclear ribonucleoprotein E

Short name=snRNP-E
Alternative name(s):
Sm protein E
Short name=Sm-E
Short name=SmE
Gene names
Name:SNRPE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length92 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5.

Subunit structure

Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Ref.7 Ref.8 Ref.9

Subcellular location

Nucleus.

Miscellaneous

Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins.

Sequence similarities

Belongs to the snRNP Sm proteins family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GEMIN5Q8TEQ62EBI-348082,EBI-443630

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9292Small nuclear ribonucleoprotein E
PRO_0000125529

Secondary structure

................ 92
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P62304 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 7D8881CE1F4FA2FD

FASTA9210,804
        10         20         30         40         50         60 
MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF DEYMNLVLDD 

        70         80         90 
AEEIHSKTKS RKQLGRIMLK GDNITLLQSV SN 

« Hide

References

« Hide 'large scale' references
[1]"The complete primary structure of the human snRNP E protein."
Stanford D.R., Kehl M., Perry C.A., Holicky E., Harvey S.E., Rohleder A.M., Rehder K., Luehrmann R., Wieben E.D.
Nucleic Acids Res. 16:10593-10605(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins."
Stanford D.R., Perry C.A., Holicky E., Rohleder A.M., Wieben E.D.
J. Biol. Chem. 263:17772-17779(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Uterus.
[6]"DNA sequence of a human Sm autoimmune antigen. The multigene family contains a processed pseudogene."
Stanford D.R., Rohleder A., Neiswanger K., Wieben E.D.
J. Biol. Chem. 262:9931-9934(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-92.
[7]"Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein."
Pillai R.S., Will C.L., Luehrmann R., Schuemperli D., Mueller B.
EMBO J. 20:5470-5479(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE U7 SNRNP COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[8]"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
[9]"The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."
Will C.L., Schneider C., Hossbach M., Urlaub H., Rauhut R., Elbashir S., Tuschl T., Luehrmann R.
RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A COMPLEX WITH THE U11/U12 SPLICEOSOME, MASS SPECTROMETRY.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M37716 mRNA. Translation: AAA90926.1.
M15919 mRNA. Translation: AAA36621.1.
X12466 mRNA. Translation: CAA31007.1.
AK312130 mRNA. Translation: BAG35066.1.
CH471067 Genomic DNA. Translation: EAW91494.1.
BC002639 mRNA. Translation: AAH02639.1.
BC090951 mRNA. Translation: AAH90951.1.
M21258, M21253 Genomic DNA. Translation: AAB59365.1. Sequence problems.
IPIIPI00029266.
PIRA32127.
RefSeqNP_003085.1. NM_003094.2.
UniGeneHs.334612.
Hs.654418.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1VU2X-ray3.10C/K/S/a/i/q/y1-92[»]
1VU3X-ray3.10C/K/S/a/i/q1-92[»]
2Y9AX-ray3.60E/L/S1-92[»]
2Y9BX-ray3.60E/L/S1-92[»]
2Y9CX-ray3.60E/L/S1-92[»]
2Y9DX-ray3.60E/L/S1-92[»]
3CW1X-ray5.49E/W/X/Y1-92[»]
3PGWX-ray4.40E/H1-92[»]
3S6NX-ray2.50E1-92[»]
4F77X-ray3.10C/K/S/a/i/q/y1-92[»]
ProteinModelPortalP62304.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-31220N.
IntActP62304. 26 interactions.
MINTMINT-225773.
STRING9606.ENSP00000400591.

PTM databases

PhosphoSiteP62304.

Polymorphism databases

DMDM61237380.

Proteomic databases

PaxDbP62304.
PRIDEP62304.

Protocols and materials databases

DNASU6635.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000414487; ENSP00000400591; ENSG00000182004.
GeneID6635.
KEGGhsa:6635.
UCSCuc001hai.3. human.

Organism-specific databases

CTD6635.
GeneCardsGC01P203834.
HGNCHGNC:11161. SNRPE.
MIM128260. gene.
neXtProtNX_P62304.
PharmGKBPA36002.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1958.
HOVERGENHBG003229.
InParanoidP62304.
KOK11097.
OMAVQIWLYE.
OrthoDBEOG4DBTGC.

Enzyme and pathway databases

ReactomeREACT_1675. mRNA Processing.
REACT_1788. Transcription.
REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.
REACT_78. Post-Elongation Processing of the Transcript.

Gene expression databases

ArrayExpressP62304.
BgeeP62304.
CleanExHS_SNRPE.
GenevestigatorP62304.
GermOnlineENSG00000182004. Homo sapiens.

Family and domain databases

InterProIPR010920. LSM_dom.
IPR001163. Ribonucl_LSM.
IPR006649. Ribonucl_LSM_euk/arc.
IPR027078. snRNP-E.
[Graphical view]
PANTHERPTHR11193. PTHR11193. 1 hit.
PfamPF01423. LSM. 1 hit.
[Graphical view]
SMARTSM00651. Sm. 1 hit.
[Graphical view]
SUPFAMSSF50182. Sm_like_riboprot. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSNRPE. human.
EvolutionaryTraceP62304.
GenomeRNAi6635.
NextBio25849.
SOURCESearch...

Entry information

Entry nameRUXE_HUMAN
AccessionPrimary (citable) accession number: P62304
Secondary accession number(s): B2R5B9 expand/collapse secondary AC list , P08578, Q15498, Q5BKT2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families