Reviewed,
UniProtKB/Swiss-Prot P62304 (RUXE_HUMAN)
Last modified
February 9, 2010.
Version 60.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Small nuclear ribonucleoprotein E Short name=snRNP-E Short name=Sm protein E Short name=Sm-E Short name=SmE | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 92 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5. |
| Subunit structure | Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. |
| Subcellular location | |
| Involvement in disease | Patients with systemic lupus erythematosus produces antibodies which interact with snRNP proteins. |
| Sequence similarities | Belongs to the snRNP Sm proteins family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | mRNA processing mRNA splicing |
| Cellular component | Nucleus Spliceosome |
| Disease | Systemic lupus erythematosus |
| Ligand | RNA-binding |
| Molecular function | Ribonucleoprotein |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | spliceosomal snRNP assembly Inferred from Experiment. Source: Reactome spliceosome assembly Ref.1Non-traceable author statement. Source: UniProtKB |
| Cellular component | U7 snRNP Ref.7 Inferred from direct assay. Source: UniProtKB cytosolInferred from Experiment. Source: Reactome nucleoplasmInferred from Experiment. Source: Reactome spliceosomal complex Ref.1Non-traceable author statement. Source: UniProtKB |
| Molecular function | RNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from physical interaction. Source: UniProtKB |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| GEMIN5 | Q8TEQ6 | 1 | EBI-348082,EBI-443630 | |
| LSM2 | Q9Y333 | 2 | EBI-348082,EBI-347416 | |
| LSM3 | P62310 | 1 | EBI-348082,EBI-348239 | |
| LSM4 | Q9Y4Z0 | 1 | EBI-348082,EBI-372521 | |
| LSM5 | Q9Y4Y9 | 1 | EBI-348082,EBI-373007 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 92 | 92 | Small nuclear ribonucleoprotein E | PRO_0000125529 | |||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "The complete primary structure of the human snRNP E protein." Stanford D.R., Kehl M., Perry C.A., Holicky E., Harvey S.E., Rohleder A.M., Rehder K., Luehrmann R., Wieben E.D. Nucleic Acids Res. 16:10593-10605(1988) [PubMed: 2974536] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins." Stanford D.R., Perry C.A., Holicky E., Rohleder A.M., Wieben E.D. J. Biol. Chem. 263:17772-17779(1988) [PubMed: 2972723] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Uterus. |
| [6] | "DNA sequence of a human Sm autoimmune antigen. The multigene family contains a processed pseudogene." Stanford D.R., Rohleder A., Neiswanger K., Wieben E.D. J. Biol. Chem. 262:9931-9934(1987) [PubMed: 2440864] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-92. |
| [7] | "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein." Pillai R.S., Will C.L., Luehrmann R., Schuemperli D., Mueller B. EMBO J. 20:5470-5479(2001) [PubMed: 11574479] [Abstract] Cited for: IDENTIFICATION IN THE U7 SNRNP COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY. |
| [8] | "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis." Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J. RNA 8:426-439(2002) [PubMed: 11991638] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPICEOSOMAL C COMPLEX. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | M37716 mRNA. Translation: AAA90926.1. M15919 mRNA. Translation: AAA36621.1. X12466 mRNA. Translation: CAA31007.1. AK312130 mRNA. Translation: BAG35066.1. CH471067 Genomic DNA. Translation: EAW91494.1. BC002639 mRNA. Translation: AAH02639.1. BC090951 mRNA. Translation: AAH90951.1. M21258, M21253 Genomic DNA. Translation: AAB59365.1. Sequence problems. | ||||||||||||
| IPI | IPI00029266. | ||||||||||||
| PIR | A32127. | ||||||||||||
| RefSeq | NP_003085.1. | ||||||||||||
| UniGene | Hs.334612 Hs.654418 | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | P62304. 13 interactions. | ||||||||||||
| STRING | P62304. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | P62304. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000414487; ENSP00000400591; ENSG00000182004; Homo sapiens. [Genome view] | ||||||||||||
| GeneID | 6635. | ||||||||||||
| KEGG | hsa:6635. | ||||||||||||
| UCSC | uc001hai.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 6635. | ||||||||||||
| GeneCards | GC01P202097. GC19M005531. | ||||||||||||
| HGNC | HGNC:11161. SNRPE. | ||||||||||||
| MIM | 128260. gene. | ||||||||||||
| PharmGKB | PA36002. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG21276. | ||||||||||||
| HOGENOM | HBG749684. | ||||||||||||
| HOVERGEN | P62304. | ||||||||||||
| InParanoid | P62304. | ||||||||||||
| OMA | EGHIVGF. | ||||||||||||
| PhylomeDB | P62304. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Reactome | REACT_11052. Metabolism of non-coding RNA. REACT_125. Processing of Capped Intron-Containing Pre-mRNA. REACT_6167. Influenza Infection. REACT_71. Gene Expression. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P62304. | ||||||||||||
| Bgee | P62304. | ||||||||||||
| CleanEx | HS_SNRPE. | ||||||||||||
| Genevestigator | P62304. | ||||||||||||
| GermOnline | ENSG00000182004. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR001163. LSM_domain. IPR006649. LSM_domain_euk/arc. IPR010920. LSM_related_domain. [Graphical view] | ||||||||||||
| Pfam | PF01423. LSM. 1 hit. [Graphical view] | ||||||||||||
| SMART | SM00651. Sm. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 25849. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | RUXE_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P62304 Secondary accession number(s): B2R5B9 Q5BKT2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


