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P62304

- RUXE_HUMAN

UniProt

P62304 - RUXE_HUMAN

Protein

Small nuclear ribonucleoprotein E

Gene

SNRPE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. gene expression Source: Reactome
    2. hair cycle Source: UniProtKB
    3. histone mRNA metabolic process Source: Reactome
    4. mRNA 3'-end processing Source: Reactome
    5. mRNA splicing, via spliceosome Source: UniProtKB
    6. ncRNA metabolic process Source: Reactome
    7. RNA metabolic process Source: Reactome
    8. RNA splicing Source: Reactome
    9. spliceosomal complex assembly Source: UniProtKB
    10. spliceosomal snRNP assembly Source: UniProtKB
    11. termination of RNA polymerase II transcription Source: Reactome
    12. transcription from RNA polymerase II promoter Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_11066. snRNP Assembly.
    REACT_1364. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
    REACT_1753. mRNA Splicing - Minor Pathway.
    REACT_185. SLBP independent Processing of Histone Pre-mRNAs.
    REACT_467. mRNA Splicing - Major Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small nuclear ribonucleoprotein E
    Short name:
    snRNP-E
    Alternative name(s):
    Sm protein E
    Short name:
    Sm-E
    Short name:
    SmE
    Gene namesi
    Name:SNRPE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11161. SNRPE.

    Subcellular locationi

    Cytoplasmcytosol. Nucleus
    Note: SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.

    GO - Cellular componenti

    1. catalytic step 2 spliceosome Source: UniProtKB
    2. cytosol Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. methylosome Source: UniProtKB
    5. nucleoplasm Source: Reactome
    6. nucleus Source: UniProtKB
    7. pICln-Sm protein complex Source: UniProtKB
    8. small nuclear ribonucleoprotein complex Source: UniProtKB
    9. SMN-Sm protein complex Source: UniProtKB
    10. spliceosomal complex Source: UniProtKB
    11. U12-type spliceosomal complex Source: UniProtKB
    12. U1 snRNP Source: UniProtKB
    13. U4 snRNP Source: UniProtKB
    14. U7 snRNP Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Spliceosome

    Pathology & Biotechi

    Involvement in diseasei

    Hypotrichosis 11 (HYPT11) [MIM:615059]: A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT11 is characterized by scanty or absent eyebrows and a highly variable degree of alopecia since birth, ranging from slight thinning of scalp and axillary hair to complete loss of scalp and body hair. Pubic hair remains mainly unaffected.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451G → S in HYPT11; does not affect subcellular localization. 1 Publication
    VAR_069619

    Keywords - Diseasei

    Disease mutation, Hypotrichosis

    Organism-specific databases

    MIMi615059. phenotype.
    Orphaneti55654. Hypotrichosis simplex.
    PharmGKBiPA36002.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9292Small nuclear ribonucleoprotein EPRO_0000125529Add
    BLAST

    Proteomic databases

    MaxQBiP62304.
    PaxDbiP62304.
    PRIDEiP62304.

    PTM databases

    PhosphoSiteiP62304.

    Expressioni

    Tissue specificityi

    Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis.1 Publication

    Gene expression databases

    ArrayExpressiP62304.
    BgeeiP62304.
    CleanExiHS_SNRPE.
    GenevestigatoriP62304.

    Interactioni

    Subunit structurei

    U1 snRNP is for instance composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GEMIN5Q8TEQ62EBI-348082,EBI-443630
    SNRPFP623064EBI-348082,EBI-356900
    SNRPGP623084EBI-348082,EBI-624585

    Protein-protein interaction databases

    BioGridi112519. 54 interactions.
    DIPiDIP-31220N.
    IntActiP62304. 29 interactions.
    MINTiMINT-225773.
    STRINGi9606.ENSP00000400591.

    Structurei

    Secondary structure

    1
    92
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi17 – 2711
    Beta strandi30 – 389
    Beta strandi40 – 5011
    Beta strandi56 – 649
    Beta strandi66 – 683
    Beta strandi71 – 799
    Helixi81 – 833
    Beta strandi84 – 896

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VU2X-ray3.10C/K/S/a/i/q/y1-92[»]
    1VU3X-ray3.10C/K/S/a/i/q1-92[»]
    2Y9AX-ray3.60E/L/S1-92[»]
    2Y9BX-ray3.60E/L/S1-92[»]
    2Y9CX-ray3.60E/L/S1-92[»]
    2Y9DX-ray3.60E/L/S1-92[»]
    3CW1X-ray5.49E/W/X/Y1-92[»]
    3PGWX-ray4.40E/H1-92[»]
    3S6NX-ray2.50E1-92[»]
    4F77X-ray3.10C/K/S/a/i/q/y1-92[»]
    4F7UX-ray1.90E/H1-92[»]
    ProteinModelPortaliP62304.
    SMRiP62304. Positions 14-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP62304.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the snRNP Sm proteins family.Curated

    Phylogenomic databases

    eggNOGiCOG1958.
    HOVERGENiHBG003229.
    InParanoidiP62304.
    KOiK11097.
    OMAiFDEFMNI.
    OrthoDBiEOG7GFB5W.
    PhylomeDBiP62304.
    TreeFamiTF314419.

    Family and domain databases

    InterProiIPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR027078. snRNP-E.
    [Graphical view]
    PANTHERiPTHR11193. PTHR11193. 1 hit.
    PfamiPF01423. LSM. 1 hit.
    [Graphical view]
    SMARTiSM00651. Sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF50182. SSF50182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P62304-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYRGQGQKV QKVMVQPINL IFRYLQNRSR IQVWLYEQVN MRIEGCIIGF   50
    DEYMNLVLDD AEEIHSKTKS RKQLGRIMLK GDNITLLQSV SN 92
    Length:92
    Mass (Da):10,804
    Last modified:July 5, 2004 - v1
    Checksum:i7D8881CE1F4FA2FD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451G → S in HYPT11; does not affect subcellular localization. 1 Publication
    VAR_069619

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37716 mRNA. Translation: AAA90926.1.
    M15919 mRNA. Translation: AAA36621.1.
    X12466 mRNA. Translation: CAA31007.1.
    AK312130 mRNA. Translation: BAG35066.1.
    CH471067 Genomic DNA. Translation: EAW91494.1.
    BC002639 mRNA. Translation: AAH02639.1.
    BC090951 mRNA. Translation: AAH90951.1.
    M21258, M21253 Genomic DNA. Translation: AAB59365.1. Sequence problems.
    CCDSiCCDS30979.1.
    PIRiA32127.
    RefSeqiNP_003085.1. NM_003094.2.
    UniGeneiHs.334612.
    Hs.654418.

    Genome annotation databases

    EnsembliENST00000414487; ENSP00000400591; ENSG00000182004.
    GeneIDi6635.
    KEGGihsa:6635.
    UCSCiuc001hai.3. human.

    Polymorphism databases

    DMDMi61237380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M37716 mRNA. Translation: AAA90926.1 .
    M15919 mRNA. Translation: AAA36621.1 .
    X12466 mRNA. Translation: CAA31007.1 .
    AK312130 mRNA. Translation: BAG35066.1 .
    CH471067 Genomic DNA. Translation: EAW91494.1 .
    BC002639 mRNA. Translation: AAH02639.1 .
    BC090951 mRNA. Translation: AAH90951.1 .
    M21258 , M21253 Genomic DNA. Translation: AAB59365.1 . Sequence problems.
    CCDSi CCDS30979.1.
    PIRi A32127.
    RefSeqi NP_003085.1. NM_003094.2.
    UniGenei Hs.334612.
    Hs.654418.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VU2 X-ray 3.10 C/K/S/a/i/q/y 1-92 [» ]
    1VU3 X-ray 3.10 C/K/S/a/i/q 1-92 [» ]
    2Y9A X-ray 3.60 E/L/S 1-92 [» ]
    2Y9B X-ray 3.60 E/L/S 1-92 [» ]
    2Y9C X-ray 3.60 E/L/S 1-92 [» ]
    2Y9D X-ray 3.60 E/L/S 1-92 [» ]
    3CW1 X-ray 5.49 E/W/X/Y 1-92 [» ]
    3PGW X-ray 4.40 E/H 1-92 [» ]
    3S6N X-ray 2.50 E 1-92 [» ]
    4F77 X-ray 3.10 C/K/S/a/i/q/y 1-92 [» ]
    4F7U X-ray 1.90 E/H 1-92 [» ]
    ProteinModelPortali P62304.
    SMRi P62304. Positions 14-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112519. 54 interactions.
    DIPi DIP-31220N.
    IntActi P62304. 29 interactions.
    MINTi MINT-225773.
    STRINGi 9606.ENSP00000400591.

    PTM databases

    PhosphoSitei P62304.

    Polymorphism databases

    DMDMi 61237380.

    Proteomic databases

    MaxQBi P62304.
    PaxDbi P62304.
    PRIDEi P62304.

    Protocols and materials databases

    DNASUi 6635.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000414487 ; ENSP00000400591 ; ENSG00000182004 .
    GeneIDi 6635.
    KEGGi hsa:6635.
    UCSCi uc001hai.3. human.

    Organism-specific databases

    CTDi 6635.
    GeneCardsi GC01P203834.
    HGNCi HGNC:11161. SNRPE.
    MIMi 128260. gene.
    615059. phenotype.
    neXtProti NX_P62304.
    Orphaneti 55654. Hypotrichosis simplex.
    PharmGKBi PA36002.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1958.
    HOVERGENi HBG003229.
    InParanoidi P62304.
    KOi K11097.
    OMAi FDEFMNI.
    OrthoDBi EOG7GFB5W.
    PhylomeDBi P62304.
    TreeFami TF314419.

    Enzyme and pathway databases

    Reactomei REACT_11066. snRNP Assembly.
    REACT_1364. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
    REACT_1753. mRNA Splicing - Minor Pathway.
    REACT_185. SLBP independent Processing of Histone Pre-mRNAs.
    REACT_467. mRNA Splicing - Major Pathway.

    Miscellaneous databases

    ChiTaRSi SNRPE. human.
    EvolutionaryTracei P62304.
    GenomeRNAii 6635.
    NextBioi 25849.
    PROi P62304.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62304.
    Bgeei P62304.
    CleanExi HS_SNRPE.
    Genevestigatori P62304.

    Family and domain databases

    InterProi IPR010920. LSM_dom.
    IPR001163. Ribonucl_LSM.
    IPR006649. Ribonucl_LSM_euk/arc.
    IPR027078. snRNP-E.
    [Graphical view ]
    PANTHERi PTHR11193. PTHR11193. 1 hit.
    Pfami PF01423. LSM. 1 hit.
    [Graphical view ]
    SMARTi SM00651. Sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50182. SSF50182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins."
      Stanford D.R., Perry C.A., Holicky E., Rohleder A.M., Wieben E.D.
      J. Biol. Chem. 263:17772-17779(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Uterus.
    6. "DNA sequence of a human Sm autoimmune antigen. The multigene family contains a processed pseudogene."
      Stanford D.R., Rohleder A., Neiswanger K., Wieben E.D.
      J. Biol. Chem. 262:9931-9934(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-92.
    7. "Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein."
      Pillai R.S., Will C.L., Luehrmann R., Schuemperli D., Mueller B.
      EMBO J. 20:5470-5479(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE U7 SNRNP COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    8. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
      Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
      RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
    9. "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."
      Will C.L., Schneider C., Hossbach M., Urlaub H., Rauhut R., Elbashir S., Tuschl T., Luehrmann R.
      RNA 10:929-941(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH THE U11/U12 SPLICEOSOME, IDENTIFICATION BY MASS SPECTROMETRY.
    10. "An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."
      Chari A., Golas M.M., Klingenhager M., Neuenkirchen N., Sander B., Englbrecht C., Sickmann A., Stark H., Fischer U.
      Cell 135:497-509(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN SNRNP BIOGENESIS, IDENTIFICATION IN 6S PICLN-SM COMPLEX, IDENTIFICATION IN SMN-SM COMPLEX, SUBCELLULAR LOCATION.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomal-dominant hypotrichosis simplex."
      Pasternack S.M., Refke M., Paknia E., Hennies H.C., Franz T., Schaefer N., Fryer A., van Steensel M., Sweeney E., Just M., Grimm C., Kruse R., Ferrandiz C., Noethen M.M., Fischer U., Betz R.C.
      Am. J. Hum. Genet. 92:81-87(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, VARIANT HYPT11 SER-45, CHARACTERIZATION OF VARIANT HYPT11 SER-45.
    13. "Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution."
      Pomeranz Krummel D.A., Oubridge C., Leung A.K., Li J., Nagai K.
      Nature 458:475-480(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (5.49 ANGSTROMS) IN SPLICEOSOMAL U1 SNRNP.
    14. "Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis."
      Leung A.K., Nagai K., Li J.
      Nature 473:536-539(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.60 ANGSTROMS) IN SPLICEOSOMAL CORE U4 SNRNP.
    15. "Structural basis of assembly chaperone-mediated snRNP formation."
      Grimm C., Chari A., Pelz J.P., Kuper J., Kisker C., Diederichs K., Stark H., Schindelin H., Fischer U.
      Mol. Cell 49:692-703(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN 6S PICLN-SM COMPLEX, IDENTIFICATION IN 6S PICLN-SM COMPLEX, FUNCTION IN CORE U1 SNRNP BIOGENESIS.

    Entry informationi

    Entry nameiRUXE_HUMAN
    AccessioniPrimary (citable) accession number: P62304
    Secondary accession number(s): B2R5B9
    , P08578, Q15498, Q5BKT2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Patients with systemic lupus erythematosus produce antibodies which interact with snRNP proteins.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3