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P62301

- RS13_MOUSE

UniProt

P62301 - RS13_MOUSE

Protein

40S ribosomal protein S13

Gene

Rps13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. mRNA binding Source: Ensembl
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. negative regulation of RNA splicing Source: Ensembl
    2. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S13
    Gene namesi
    Name:Rps13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1915302. Rps13.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: Ensembl
    2. nucleolus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 15115040S ribosomal protein S13PRO_0000115662Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271N6-acetyllysine; alternateBy similarity
    Modified residuei27 – 271N6-succinyllysine; alternate1 Publication
    Modified residuei34 – 341N6-succinyllysine1 Publication
    Modified residuei38 – 381PhosphotyrosineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP62301.
    PaxDbiP62301.
    PRIDEiP62301.

    PTM databases

    PhosphoSiteiP62301.

    Expressioni

    Gene expression databases

    BgeeiP62301.
    CleanExiMM_RPS13.
    GenevestigatoriP62301.

    Interactioni

    Protein-protein interaction databases

    BioGridi212630. 4 interactions.
    DIPiDIP-59976N.
    MINTiMINT-1863201.
    STRINGi10090.ENSMUSP00000082124.

    Structurei

    3D structure databases

    ProteinModelPortaliP62301.
    SMRiP62301. Positions 2-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S15P family.Curated

    Phylogenomic databases

    eggNOGiCOG0184.
    HOGENOMiHOG000180723.
    HOVERGENiHBG000938.
    InParanoidiP62301.
    KOiK02953.
    OMAiNWKYESA.
    OrthoDBiEOG7KH9MB.
    PhylomeDBiP62301.
    TreeFamiTF300190.

    Family and domain databases

    HAMAPiMF_01343_A. Ribosomal_S15_A.
    InterProiIPR012606. Ribosomal_S13/S15_N.
    IPR000589. Ribosomal_S15.
    IPR023029. Ribosomal_S15P.
    IPR009068. S15_NS1_RNA-bd.
    [Graphical view]
    PfamiPF08069. Ribosomal_S13_N. 1 hit.
    PF00312. Ribosomal_S15. 1 hit.
    [Graphical view]
    SUPFAMiSSF47060. SSF47060. 1 hit.
    PROSITEiPS00362. RIBOSOMAL_S15. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62301-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRMHAPGKG LSQSALPYRR SVPTWLKLTS DDVKEQIYKL AKKGLTPSQI    50
    GVILRDSHGV AQVRFVTGNK ILRILKSKGL APDLPEDLYH LIKKAVAVRK 100
    HLERNRKDKD AKFRLILIES RIHRLARYYK TKRVLPPNWK YESSTASALV 150
    A 151
    Length:151
    Mass (Da):17,222
    Last modified:January 23, 2007 - v2
    Checksum:i23F94D38F87B8D53
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012479 mRNA. Translation: BAB28268.1.
    AK018703 mRNA. Translation: BAB31354.1.
    AK076060 mRNA. Translation: BAC36154.1.
    CCDSiCCDS52370.1.
    RefSeqiNP_080809.1. NM_026533.3.
    XP_006544804.1. XM_006544741.1.
    UniGeneiMm.14798.
    Mm.345443.
    Mm.425541.

    Genome annotation databases

    EnsembliENSMUST00000170953; ENSMUSP00000126294; ENSMUSG00000090862.
    GeneIDi102642137.
    68052.
    KEGGimmu:102642137.
    mmu:68052.
    UCSCiuc009jje.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012479 mRNA. Translation: BAB28268.1 .
    AK018703 mRNA. Translation: BAB31354.1 .
    AK076060 mRNA. Translation: BAC36154.1 .
    CCDSi CCDS52370.1.
    RefSeqi NP_080809.1. NM_026533.3.
    XP_006544804.1. XM_006544741.1.
    UniGenei Mm.14798.
    Mm.345443.
    Mm.425541.

    3D structure databases

    ProteinModelPortali P62301.
    SMRi P62301. Positions 2-151.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212630. 4 interactions.
    DIPi DIP-59976N.
    MINTi MINT-1863201.
    STRINGi 10090.ENSMUSP00000082124.

    PTM databases

    PhosphoSitei P62301.

    Proteomic databases

    MaxQBi P62301.
    PaxDbi P62301.
    PRIDEi P62301.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000170953 ; ENSMUSP00000126294 ; ENSMUSG00000090862 .
    GeneIDi 102642137.
    68052.
    KEGGi mmu:102642137.
    mmu:68052.
    UCSCi uc009jje.2. mouse.

    Organism-specific databases

    CTDi 6207.
    MGIi MGI:1915302. Rps13.

    Phylogenomic databases

    eggNOGi COG0184.
    HOGENOMi HOG000180723.
    HOVERGENi HBG000938.
    InParanoidi P62301.
    KOi K02953.
    OMAi NWKYESA.
    OrthoDBi EOG7KH9MB.
    PhylomeDBi P62301.
    TreeFami TF300190.

    Enzyme and pathway databases

    Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Miscellaneous databases

    NextBioi 326320.
    PROi P62301.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62301.
    CleanExi MM_RPS13.
    Genevestigatori P62301.

    Family and domain databases

    HAMAPi MF_01343_A. Ribosomal_S15_A.
    InterProi IPR012606. Ribosomal_S13/S15_N.
    IPR000589. Ribosomal_S15.
    IPR023029. Ribosomal_S15P.
    IPR009068. S15_NS1_RNA-bd.
    [Graphical view ]
    Pfami PF08069. Ribosomal_S13_N. 1 hit.
    PF00312. Ribosomal_S15. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47060. SSF47060. 1 hit.
    PROSITEi PS00362. RIBOSOMAL_S15. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    2. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-27 AND LYS-34, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiRS13_MOUSE
    AccessioniPrimary (citable) accession number: P62301
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3