P62277 (RS13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S13

Gene names

Name:

RPS13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein S15P family.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome negative regulation of RNA splicing Inferred from direct assay PubMed 17881366. Source: UniProtKB nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic small ribosomal subunit Inferred from direct assay PubMed 15883184Ref.7. Source: UniProtKB nucleolus Inferred from direct assay PubMed 17881366. Source: UniProtKB
Molecular_function	mRNA binding Inferred from direct assay PubMed 17881366. Source: UniProtKB structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PDCD4	Q53EL6	2	EBI-351850,EBI-935824

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 151	151	40S ribosomal protein S13 HAMAP-Rule MF_01343_A		PRO_0000115661
Amino acid modifications
	Modified residue	27	1	N6-acetyllysine Ref.11
	Modified residue	38	1	Phosphotyrosine Ref.9
Experimental info
	Sequence conflict	82	1	P → S in AAC15854. Ref.8

Sequences

	Sequence		Length	Mass (Da)
	P62277 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 23F94D38F87B8D53	FASTA	151	17,222
	10 20 30 40 50 60 MGRMHAPGKG LSQSALPYRR SVPTWLKLTS DDVKEQIYKL AKKGLTPSQI GVILRDSHGV 70 80 90 100 110 120 AQVRFVTGNK ILRILKSKGL APDLPEDLYH LIKKAVAVRK HLERNRKDKD AKFRLILIES 130 140 150 RIHRLARYYK TKRVLPPNWK YESSTASALV A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and analysis of the human S13 ribosomal protein cDNA." Chadeneau C., Lemoullac B., Denis M.G. Nucleic Acids Res. 21:2945-2945(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Filipenko M.L. Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
[3]	"U14 snoRNAs are encoded in introns of human ribosomal protein S13 gene." Kenmochi N., Higa S., Yoshihama M., Tanaka T. Biochem. Biophys. Res. Commun. 228:371-374(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone, Brain, Muscle, Pancreas and Placenta.
[7]	"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-8. Tissue: Placenta.
[8]	Bhat K.S. Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-127.
[9]	"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J. Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-38, MASS SPECTROMETRY.
[10]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[11]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-27, MASS SPECTROMETRY.
[12]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L01124 mRNA. Translation: AAA60283.1. X79239 mRNA. Translation: CAA55821.1. D88010 Genomic DNA. Translation: BAA13528.1. AK312060 mRNA. Translation: BAG34996.1. CH471064 Genomic DNA. Translation: EAW68448.1. BC000475 mRNA. Translation: AAH00475.1. BC006772 mRNA. Translation: AAH06772.1. BC029732 mRNA. Translation: AAH29732.1. BC066322 mRNA. Translation: AAH66322.1. BC100032 mRNA. Translation: AAI00033.1. L05090 mRNA. Translation: AAC15854.1.
IPI	IPI00221089.
PIR	S34109.
RefSeq	NP_001008.1. NM_001017.2.
UniGene	Hs.446588.
3D structure databases
ProteinModelPortal	P62277.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62277. 13 interactions.
MINT	MINT-4999984.
STRING	9606.ENSP00000228140.
PTM databases
PhosphoSite	P62277.
Polymorphism databases
DMDM	50403608.
Proteomic databases
PaxDb	P62277.
PeptideAtlas	P62277.
PRIDE	P62277.
Protocols and materials databases
DNASU	6207.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000525634; ENSP00000435777; ENSG00000110700.
GeneID	6207.
KEGG	hsa:6207.
UCSC	uc001mmp.3. human.
Organism-specific databases
CTD	6207.
GeneCards	GC11M017055.
HGNC	HGNC:10386. RPS13.
HPA	HPA005985.
MIM	180476. gene.
neXtProt	NX_P62277.
PharmGKB	PA34785.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0184.
HOGENOM	HOG000180723.
HOVERGEN	HBG000938.
InParanoid	P62277.
KO	K02953.
OMA	MARMHAR.
OrthoDB	EOG4RJG2T.
PhylomeDB	P62277.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P62277.
Bgee	P62277.
CleanEx	HS_RPS13.
Genevestigator	P62277.
GermOnline	ENSG00000110700. Homo sapiens.
Family and domain databases
HAMAP	MF_01343_A. Ribosomal_S15_S13e_A.
InterPro	IPR012606. Ribosomal_S13/S15_N. IPR000589. Ribosomal_S15. IPR023029. Ribosomal_S15P. IPR009068. S15_NS1_RNA-bd. [Graphical view]
Pfam	PF08069. Ribosomal_S13_N. 1 hit. PF00312. Ribosomal_S15. 1 hit. [Graphical view]
SUPFAM	SSF47060. S15/NS1_bind. 1 hit.
PROSITE	PS00362. RIBOSOMAL_S15. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RPS13. human.
GenomeRNAi	6207.
NextBio	24107.
SOURCE	Search...

Entry information

Entry name

RS13_HUMAN

Accession

Primary (citable) accession number: P62277
Secondary accession number(s): B2R549 , P19116, Q02546, Q29200, Q498Y0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.