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Protein

40S ribosomal protein S13

Gene

RPS13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 5.8S rRNA binding Source: Ensembl
  • mRNA binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • small ribosomal subunit rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110700-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S13
Gene namesi
Name:RPS13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:10386. RPS13.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • focal adhesion Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • ribosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi6207.
OpenTargetsiENSG00000110700.
PharmGKBiPA34785.

Polymorphism and mutation databases

BioMutaiRPS13.
DMDMi50403608.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001156612 – 15140S ribosomal protein S13Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27N6-acetyllysine; alternateCombined sources1
Modified residuei27N6-succinyllysine; alternateBy similarity1
Modified residuei30PhosphoserineCombined sources1
Modified residuei34N6-succinyllysineBy similarity1
Modified residuei38PhosphotyrosineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP62277.
MaxQBiP62277.
PaxDbiP62277.
PeptideAtlasiP62277.
PRIDEiP62277.
TopDownProteomicsiP62277.

PTM databases

iPTMnetiP62277.
PhosphoSitePlusiP62277.
SwissPalmiP62277.

Expressioni

Gene expression databases

BgeeiENSG00000110700.
CleanExiHS_RPS13.
ExpressionAtlasiP62277. baseline and differential.
GenevisibleiP62277. HS.

Organism-specific databases

HPAiHPA005985.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PDCD4Q53EL62EBI-351850,EBI-935824

Protein-protein interaction databases

BioGridi112121. 181 interactors.
IntActiP62277. 42 interactors.
MINTiMINT-4999984.
STRINGi9606.ENSP00000435777.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SN1-151[»]
4V6Xelectron microscopy5.00AN1-151[»]
5A2Qelectron microscopy3.90N1-151[»]
5AJ0electron microscopy3.50BN1-151[»]
5FLXelectron microscopy3.90N1-151[»]
ProteinModelPortaliP62277.
SMRiP62277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S15P family.Curated

Phylogenomic databases

eggNOGiKOG0400. Eukaryota.
COG0184. LUCA.
GeneTreeiENSGT00390000017491.
HOGENOMiHOG000180723.
HOVERGENiHBG000938.
InParanoidiP62277.
KOiK02953.
OMAiWHLVKKA.
OrthoDBiEOG091G0X8F.
PhylomeDBiP62277.
TreeFamiTF300190.

Family and domain databases

CDDicd00353. Ribosomal_S15p_S13e. 1 hit.
HAMAPiMF_01343_A. Ribosomal_S15_A. 1 hit.
InterProiIPR012606. Ribosomal_S13/S15_N.
IPR000589. Ribosomal_S15.
IPR023029. Ribosomal_S15P.
IPR009068. S15_NS1_RNA-bd.
[Graphical view]
PfamiPF08069. Ribosomal_S13_N. 1 hit.
PF00312. Ribosomal_S15. 1 hit.
[Graphical view]
SMARTiSM01386. Ribosomal_S13_N. 1 hit.
SM01387. Ribosomal_S15. 1 hit.
[Graphical view]
SUPFAMiSSF47060. SSF47060. 1 hit.
PROSITEiPS00362. RIBOSOMAL_S15. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRMHAPGKG LSQSALPYRR SVPTWLKLTS DDVKEQIYKL AKKGLTPSQI
60 70 80 90 100
GVILRDSHGV AQVRFVTGNK ILRILKSKGL APDLPEDLYH LIKKAVAVRK
110 120 130 140 150
HLERNRKDKD AKFRLILIES RIHRLARYYK TKRVLPPNWK YESSTASALV

A
Length:151
Mass (Da):17,222
Last modified:January 23, 2007 - v2
Checksum:i23F94D38F87B8D53
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82P → S in AAC15854 (Ref. 8) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01124 mRNA. Translation: AAA60283.1.
X79239 mRNA. Translation: CAA55821.1.
D88010 Genomic DNA. Translation: BAA13528.1.
AK312060 mRNA. Translation: BAG34996.1.
CH471064 Genomic DNA. Translation: EAW68448.1.
BC000475 mRNA. Translation: AAH00475.1.
BC006772 mRNA. Translation: AAH06772.1.
BC029732 mRNA. Translation: AAH29732.1.
BC066322 mRNA. Translation: AAH66322.1.
BC100032 mRNA. Translation: AAI00033.1.
L05090 mRNA. Translation: AAC15854.1.
CCDSiCCDS7823.1.
PIRiS34109.
RefSeqiNP_001008.1. NM_001017.2.
UniGeneiHs.446588.

Genome annotation databases

EnsembliENST00000525634; ENSP00000435777; ENSG00000110700.
GeneIDi6207.
KEGGihsa:6207.
UCSCiuc001mmp.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L01124 mRNA. Translation: AAA60283.1.
X79239 mRNA. Translation: CAA55821.1.
D88010 Genomic DNA. Translation: BAA13528.1.
AK312060 mRNA. Translation: BAG34996.1.
CH471064 Genomic DNA. Translation: EAW68448.1.
BC000475 mRNA. Translation: AAH00475.1.
BC006772 mRNA. Translation: AAH06772.1.
BC029732 mRNA. Translation: AAH29732.1.
BC066322 mRNA. Translation: AAH66322.1.
BC100032 mRNA. Translation: AAI00033.1.
L05090 mRNA. Translation: AAC15854.1.
CCDSiCCDS7823.1.
PIRiS34109.
RefSeqiNP_001008.1. NM_001017.2.
UniGeneiHs.446588.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SN1-151[»]
4V6Xelectron microscopy5.00AN1-151[»]
5A2Qelectron microscopy3.90N1-151[»]
5AJ0electron microscopy3.50BN1-151[»]
5FLXelectron microscopy3.90N1-151[»]
ProteinModelPortaliP62277.
SMRiP62277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112121. 181 interactors.
IntActiP62277. 42 interactors.
MINTiMINT-4999984.
STRINGi9606.ENSP00000435777.

PTM databases

iPTMnetiP62277.
PhosphoSitePlusiP62277.
SwissPalmiP62277.

Polymorphism and mutation databases

BioMutaiRPS13.
DMDMi50403608.

Proteomic databases

EPDiP62277.
MaxQBiP62277.
PaxDbiP62277.
PeptideAtlasiP62277.
PRIDEiP62277.
TopDownProteomicsiP62277.

Protocols and materials databases

DNASUi6207.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000525634; ENSP00000435777; ENSG00000110700.
GeneIDi6207.
KEGGihsa:6207.
UCSCiuc001mmp.4. human.

Organism-specific databases

CTDi6207.
DisGeNETi6207.
GeneCardsiRPS13.
HGNCiHGNC:10386. RPS13.
HPAiHPA005985.
MIMi180476. gene.
neXtProtiNX_P62277.
OpenTargetsiENSG00000110700.
PharmGKBiPA34785.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0400. Eukaryota.
COG0184. LUCA.
GeneTreeiENSGT00390000017491.
HOGENOMiHOG000180723.
HOVERGENiHBG000938.
InParanoidiP62277.
KOiK02953.
OMAiWHLVKKA.
OrthoDBiEOG091G0X8F.
PhylomeDBiP62277.
TreeFamiTF300190.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000110700-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPS13. human.
GeneWikiiRPS13.
GenomeRNAii6207.
PROiP62277.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000110700.
CleanExiHS_RPS13.
ExpressionAtlasiP62277. baseline and differential.
GenevisibleiP62277. HS.

Family and domain databases

CDDicd00353. Ribosomal_S15p_S13e. 1 hit.
HAMAPiMF_01343_A. Ribosomal_S15_A. 1 hit.
InterProiIPR012606. Ribosomal_S13/S15_N.
IPR000589. Ribosomal_S15.
IPR023029. Ribosomal_S15P.
IPR009068. S15_NS1_RNA-bd.
[Graphical view]
PfamiPF08069. Ribosomal_S13_N. 1 hit.
PF00312. Ribosomal_S15. 1 hit.
[Graphical view]
SMARTiSM01386. Ribosomal_S13_N. 1 hit.
SM01387. Ribosomal_S15. 1 hit.
[Graphical view]
SUPFAMiSSF47060. SSF47060. 1 hit.
PROSITEiPS00362. RIBOSOMAL_S15. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS13_HUMAN
AccessioniPrimary (citable) accession number: P62277
Secondary accession number(s): B2R549
, P19116, Q02546, Q29200, Q498Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.