P62273 (RS29_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S29

Gene names

Name:

RPS29

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	56 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Cofactor	Binds 1 zinc ion per subunit Potential.
Sequence similarities	Belongs to the ribosomal protein S14P family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	Metal-binding Zinc
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic small ribosomal subunit Inferred from direct assay PubMed 15883184Ref.6. Source: UniProtKB
Molecular_function	structural constituent of ribosome Inferred from direct assay PubMed 15883184. Source: UniProtKB zinc ion binding Inferred from direct assay Ref.2. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DDX56	Q9NY93	1	EBI-1054121,EBI-372376
EIF1B	O60739	1	EBI-1054121,EBI-1043343
EIF4A2	Q14240	1	EBI-1054121,EBI-73473
EXT2	Q93063	1	EBI-1054121,EBI-1047761
STYXL1	Q9Y6J8	1	EBI-1054121,EBI-1044511

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P62273-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P62273-2)

The sequence of this isoform differs from the canonical sequence as follows:
     54-56: KLD → KKDLSCLPWHCLWR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.6 Ref.7
	Chain	2 – 56	55	40S ribosomal protein S29		PRO_0000131019
Sites
	Metal binding	21	1	Zinc Potential
	Metal binding	24	1	Zinc Potential
	Metal binding	39	1	Zinc Potential
	Metal binding	42	1	Zinc Potential
Amino acid modifications
	Modified residue	48	1	N6-acetyllysine Ref.9
Natural variations
	Alternative sequence	54 – 56	3	KLD → KKDLSCLPWHCLWR in isoform 2.		VSP_042844

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 41325122B493EFF9	FASTA	56	6,677
	10 20 30 40 50 MGHQQLYWSH PRKFGQGSRS CRVCSNRHGL IRKYGLNMCR QCFRQYAKDI GFIKLD
	Isoform 2 [UniParc]. Checksum: 4B12A162293EE2F4	FASTA	67	8,087
	10 20 30 40 50 60 MGHQQLYWSH PRKFGQGSRS CRVCSNRHGL IRKYGLNMCR QCFRQYAKDI GFIKKDLSCL PWHCLWR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs." Frigerio J.-M., Dagorn J.-C., Iovanna J.L. Biochim. Biophys. Acta 1262:64-68(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Colon.
[2]	"The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells." Kondoh N., Noda M., Fisher R.J., Schweinfest C.W., Papas T.S., Kondoh A., Samuel K.P., Oikawa T. Biochim. Biophys. Acta 1313:41-46(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Colon.
[3]	"The human ribosomal protein genes: sequencing and comparative analysis of 73 genes." Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N. Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[4]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Blood, Bone marrow and Eye.
[6]	"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-11. Tissue: Placenta.
[7]	Bienvenut W.V., Murray L., Brunton V.G., Frame M.C. Submitted (FEB-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-12 AND 49-56, CLEAVAGE OF INITIATOR METHIONINE, MASS SPECTROMETRY. Tissue: Colon adenocarcinoma.
[8]	"A map of 75 human ribosomal protein genes." Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C. Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-54.
[9]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-48, MASS SPECTROMETRY.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U14973 mRNA. Translation: AAA85661.1. L31610 mRNA. Translation: AAB27426.1. AB061847 Genomic DNA. Translation: BAB79485.1. AL139099 Genomic DNA. No translation available. BC015974 mRNA. Translation: AAH15974.2. BC032813 mRNA. Translation: AAH32813.1. BC035313 mRNA. Translation: AAH35313.1. AB007165 Genomic DNA. Translation: BAA25827.1.
IPI	IPI00182289.
PIR	S55919.
RefSeq	NP_001023.1. NM_001032.4. NP_001025172.1. NM_001030001.2.
UniGene	Hs.156367.
3D structure databases
ProteinModelPortal	P62273.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62273. 5 interactions.
STRING	9606.ENSP00000379339.
PTM databases
PhosphoSite	P62273.
Polymorphism databases
DMDM	50403626.
Proteomic databases
PaxDb	P62273.
PRIDE	P62273.
Protocols and materials databases
DNASU	6235.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000245458; ENSP00000245458; ENSG00000213741. ENST00000396020; ENSP00000379339; ENSG00000213741.
GeneID	6235.
KEGG	hsa:6235.
UCSC	uc001wwm.3. human.
Organism-specific databases
CTD	6235.
GeneCards	GC14M050043.
HGNC	HGNC:10419. RPS29.
HPA	HPA004107.
MIM	603633. gene.
neXtProt	NX_P62273.
PharmGKB	PA34826.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0199.
HOVERGEN	HBG004459.
KO	K02980.
OMA	WFSHPRN.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
Bgee	P62273.
CleanEx	HS_RPS29.
Genevestigator	P62273.
GermOnline	ENSG00000125385. Homo sapiens.
Family and domain databases
InterPro	IPR001209. Ribosomal_S14. IPR018271. Ribosomal_S14_CS. [Graphical view]
Pfam	PF00253. Ribosomal_S14. 1 hit. [Graphical view]
PROSITE	PS00527. RIBOSOMAL_S14. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6235.
NextBio	24205.
SOURCE	Search...

Entry information

Entry name

RS29_HUMAN

Accession

Primary (citable) accession number: P62273
Secondary accession number(s): A8MZ73, P30054

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.