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Protein

40S ribosomal protein S29

Gene

RPS29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi21ZincCombined sources1
Metal bindingi24ZincCombined sources1
Metal bindingi39ZincCombined sources1
Metal bindingi42ZincCombined sources1

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S29
Alternative name(s):
Small ribosomal subunit protein uS141 Publication
Gene namesi
Name:RPS29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000213741.8
HGNCiHGNC:10419 RPS29
MIMi603633 gene
neXtProtiNX_P62273

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 13 (DBA13)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:615909
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07132831I → F in DBA13; results in reduced protein expression; results in pre-rRNA processing defect. 1 PublicationCorresponds to variant dbSNP:rs587777568EnsemblClinVar.1
Natural variantiVAR_07132950I → T in DBA13; results in reduced protein expression; results in pre-rRNA processing defect. 1 PublicationCorresponds to variant dbSNP:rs587777569EnsemblClinVar.1

Keywords - Diseasei

Diamond-Blackfan anemia, Disease mutation

Organism-specific databases

DisGeNETi6235
MalaCardsiRPS29
MIMi615909 phenotype
OpenTargetsiENSG00000213741
Orphaneti124 Blackfan-Diamond anemia
PharmGKBiPA34826

Polymorphism and mutation databases

DMDMi50403626

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001310192 – 5640S ribosomal protein S29Add BLAST55

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei12Omega-N-methylarginineCombined sources1
Modified residuei48N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP62273
MaxQBiP62273
PaxDbiP62273
PeptideAtlasiP62273
PRIDEiP62273
TopDownProteomicsiP62273-1 [P62273-1]
P62273-2 [P62273-2]

PTM databases

iPTMnetiP62273
PhosphoSitePlusiP62273
SwissPalmiP62273

Expressioni

Gene expression databases

BgeeiENSG00000213741
CleanExiHS_RPS29
ExpressionAtlasiP62273 baseline and differential
GenevisibleiP62273 HS

Organism-specific databases

HPAiHPA004107

Interactioni

Subunit structurei

Component of the 40S small ribosomal subunit.3 Publications

Protein-protein interaction databases

BioGridi112149, 69 interactors
CORUMiP62273
IntActiP62273, 18 interactors
MINTiP62273
STRINGi9606.ENSP00000379339

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Sd1-56[»]
4V6Xelectron microscopy5.00Ad1-56[»]
5A2Qelectron microscopy3.90d2-56[»]
5AJ0electron microscopy3.50Bd1-56[»]
5FLXelectron microscopy3.90d1-56[»]
5LKSelectron microscopy3.60Sd1-56[»]
5OA3electron microscopy4.30d2-56[»]
5T2Celectron microscopy3.60AG1-56[»]
5VYCX-ray6.00d1/d2/d3/d4/d5/d61-56[»]
6EK0electron microscopy2.90Sd1-56[»]
6FECelectron microscopy6.30J4-56[»]
ProteinModelPortaliP62273
SMRiP62273
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3506 Eukaryota
COG0199 LUCA
GeneTreeiENSGT00390000005814
HOVERGENiHBG004459
InParanoidiP62273
KOiK02980
OMAiHCFREIA
OrthoDBiEOG091G16GE
PhylomeDBiP62273
TreeFamiTF300217

Family and domain databases

InterProiView protein in InterPro
IPR001209 Ribosomal_S14
IPR018271 Ribosomal_S14_CS
PfamiView protein in Pfam
PF00253 Ribosomal_S14, 1 hit
PROSITEiView protein in PROSITE
PS00527 RIBOSOMAL_S14, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P62273-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGHQQLYWSH PRKFGQGSRS CRVCSNRHGL IRKYGLNMCR QCFRQYAKDI

GFIKLD
Length:56
Mass (Da):6,677
Last modified:January 23, 2007 - v2
Checksum:i41325122B493EFF9
GO
Isoform 2 (identifier: P62273-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-56: KLD → KKDLSCLPWHCLWR

Show »
Length:67
Mass (Da):8,087
Checksum:i4B12A162293EE2F4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07132831I → F in DBA13; results in reduced protein expression; results in pre-rRNA processing defect. 1 PublicationCorresponds to variant dbSNP:rs587777568EnsemblClinVar.1
Natural variantiVAR_07132950I → T in DBA13; results in reduced protein expression; results in pre-rRNA processing defect. 1 PublicationCorresponds to variant dbSNP:rs587777569EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04284454 – 56KLD → KKDLSCLPWHCLWR in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14973 mRNA Translation: AAA85661.1
L31610 mRNA Translation: AAB27426.1
AB061847 Genomic DNA Translation: BAB79485.1
AL139099 Genomic DNA No translation available.
BC015974 mRNA Translation: AAH15974.2
BC032813 mRNA Translation: AAH32813.1
BC035313 mRNA Translation: AAH35313.1
AB007165 Genomic DNA Translation: BAA25827.1
CCDSiCCDS32072.1 [P62273-2]
CCDS9685.1 [P62273-1]
PIRiS55919
RefSeqiNP_001023.1, NM_001032.4 [P62273-1]
NP_001025172.1, NM_001030001.2 [P62273-2]
UniGeneiHs.156367

Genome annotation databases

EnsembliENST00000245458; ENSP00000245458; ENSG00000213741 [P62273-1]
ENST00000396020; ENSP00000379339; ENSG00000213741 [P62273-2]
GeneIDi6235
KEGGihsa:6235
UCSCiuc001wwl.5 human [P62273-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRS29_HUMAN
AccessioniPrimary (citable) accession number: P62273
Secondary accession number(s): A8MZ73, P30054
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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