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Protein

40S ribosomal protein S29

Gene

RPS29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi21ZincSequence analysis1
Metal bindingi24ZincSequence analysis1
Metal bindingi39ZincSequence analysis1
Metal bindingi42ZincSequence analysis1

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33602-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S29
Gene namesi
Name:RPS29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:10419. RPS29.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • nucleoplasm Source: Reactome
  • small ribosomal subunit Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 13 (DBA13)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:615909
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07132831I → F in DBA13; results in reduced protein expression; results in pre-rRNA processing defect. 1 PublicationCorresponds to variant rs587777568dbSNPEnsembl.1
Natural variantiVAR_07132950I → T in DBA13; results in reduced protein expression; results in pre-rRNA processing defect. 1 PublicationCorresponds to variant rs587777569dbSNPEnsembl.1

Keywords - Diseasei

Diamond-Blackfan anemia, Disease mutation

Organism-specific databases

DisGeNETi6235.
MalaCardsiRPS29.
MIMi615909. phenotype.
OpenTargetsiENSG00000213741.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34826.

Polymorphism and mutation databases

DMDMi50403626.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001310192 – 5640S ribosomal protein S29Add BLAST55

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei12Omega-N-methylarginineCombined sources1
Modified residuei48N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP62273.
MaxQBiP62273.
PaxDbiP62273.
PeptideAtlasiP62273.
PRIDEiP62273.
TopDownProteomicsiP62273-1. [P62273-1]
P62273-2. [P62273-2]

PTM databases

iPTMnetiP62273.
PhosphoSitePlusiP62273.
SwissPalmiP62273.

Expressioni

Gene expression databases

BgeeiENSG00000213741.
CleanExiHS_RPS29.
ExpressionAtlasiP62273. baseline and differential.
GenevisibleiP62273. HS.

Organism-specific databases

HPAiHPA004107.

Interactioni

Protein-protein interaction databases

BioGridi112149. 65 interactors.
IntActiP62273. 17 interactors.
MINTiMINT-4133209.
STRINGi9606.ENSP00000379339.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Sd1-56[»]
4V6Xelectron microscopy5.00Ad1-56[»]
5A2Qelectron microscopy3.90d2-56[»]
5AJ0electron microscopy3.50Bd1-56[»]
5FLXelectron microscopy3.90d1-56[»]
ProteinModelPortaliP62273.
SMRiP62273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S14P family.Curated

Phylogenomic databases

eggNOGiKOG3506. Eukaryota.
COG0199. LUCA.
GeneTreeiENSGT00390000005814.
HOVERGENiHBG004459.
InParanoidiP62273.
KOiK02980.
OMAiCFREKAA.
OrthoDBiEOG091G16GE.
PhylomeDBiP62273.
TreeFamiTF300217.

Family and domain databases

InterProiIPR001209. Ribosomal_S14.
IPR018271. Ribosomal_S14_CS.
[Graphical view]
PfamiPF00253. Ribosomal_S14. 1 hit.
[Graphical view]
PROSITEiPS00527. RIBOSOMAL_S14. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P62273-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGHQQLYWSH PRKFGQGSRS CRVCSNRHGL IRKYGLNMCR QCFRQYAKDI

GFIKLD
Length:56
Mass (Da):6,677
Last modified:January 23, 2007 - v2
Checksum:i41325122B493EFF9
GO
Isoform 2 (identifier: P62273-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-56: KLD → KKDLSCLPWHCLWR

Show »
Length:67
Mass (Da):8,087
Checksum:i4B12A162293EE2F4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07132831I → F in DBA13; results in reduced protein expression; results in pre-rRNA processing defect. 1 PublicationCorresponds to variant rs587777568dbSNPEnsembl.1
Natural variantiVAR_07132950I → T in DBA13; results in reduced protein expression; results in pre-rRNA processing defect. 1 PublicationCorresponds to variant rs587777569dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04284454 – 56KLD → KKDLSCLPWHCLWR in isoform 2. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14973 mRNA. Translation: AAA85661.1.
L31610 mRNA. Translation: AAB27426.1.
AB061847 Genomic DNA. Translation: BAB79485.1.
AL139099 Genomic DNA. No translation available.
BC015974 mRNA. Translation: AAH15974.2.
BC032813 mRNA. Translation: AAH32813.1.
BC035313 mRNA. Translation: AAH35313.1.
AB007165 Genomic DNA. Translation: BAA25827.1.
CCDSiCCDS32072.1. [P62273-2]
CCDS9685.1. [P62273-1]
PIRiS55919.
RefSeqiNP_001023.1. NM_001032.4. [P62273-1]
NP_001025172.1. NM_001030001.2. [P62273-2]
UniGeneiHs.156367.

Genome annotation databases

EnsembliENST00000245458; ENSP00000245458; ENSG00000213741. [P62273-1]
ENST00000396020; ENSP00000379339; ENSG00000213741. [P62273-2]
ENST00000611563; ENSP00000479892; ENSG00000213741. [P62273-1]
GeneIDi6235.
KEGGihsa:6235.
UCSCiuc001wwl.5. human. [P62273-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14973 mRNA. Translation: AAA85661.1.
L31610 mRNA. Translation: AAB27426.1.
AB061847 Genomic DNA. Translation: BAB79485.1.
AL139099 Genomic DNA. No translation available.
BC015974 mRNA. Translation: AAH15974.2.
BC032813 mRNA. Translation: AAH32813.1.
BC035313 mRNA. Translation: AAH35313.1.
AB007165 Genomic DNA. Translation: BAA25827.1.
CCDSiCCDS32072.1. [P62273-2]
CCDS9685.1. [P62273-1]
PIRiS55919.
RefSeqiNP_001023.1. NM_001032.4. [P62273-1]
NP_001025172.1. NM_001030001.2. [P62273-2]
UniGeneiHs.156367.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Sd1-56[»]
4V6Xelectron microscopy5.00Ad1-56[»]
5A2Qelectron microscopy3.90d2-56[»]
5AJ0electron microscopy3.50Bd1-56[»]
5FLXelectron microscopy3.90d1-56[»]
ProteinModelPortaliP62273.
SMRiP62273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112149. 65 interactors.
IntActiP62273. 17 interactors.
MINTiMINT-4133209.
STRINGi9606.ENSP00000379339.

PTM databases

iPTMnetiP62273.
PhosphoSitePlusiP62273.
SwissPalmiP62273.

Polymorphism and mutation databases

DMDMi50403626.

Proteomic databases

EPDiP62273.
MaxQBiP62273.
PaxDbiP62273.
PeptideAtlasiP62273.
PRIDEiP62273.
TopDownProteomicsiP62273-1. [P62273-1]
P62273-2. [P62273-2]

Protocols and materials databases

DNASUi6235.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245458; ENSP00000245458; ENSG00000213741. [P62273-1]
ENST00000396020; ENSP00000379339; ENSG00000213741. [P62273-2]
ENST00000611563; ENSP00000479892; ENSG00000213741. [P62273-1]
GeneIDi6235.
KEGGihsa:6235.
UCSCiuc001wwl.5. human. [P62273-1]

Organism-specific databases

CTDi6235.
DisGeNETi6235.
GeneCardsiRPS29.
HGNCiHGNC:10419. RPS29.
HPAiHPA004107.
MalaCardsiRPS29.
MIMi603633. gene.
615909. phenotype.
neXtProtiNX_P62273.
OpenTargetsiENSG00000213741.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34826.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3506. Eukaryota.
COG0199. LUCA.
GeneTreeiENSGT00390000005814.
HOVERGENiHBG004459.
InParanoidiP62273.
KOiK02980.
OMAiCFREKAA.
OrthoDBiEOG091G16GE.
PhylomeDBiP62273.
TreeFamiTF300217.

Enzyme and pathway databases

BioCyciZFISH:G66-33602-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

GeneWikiiRPS29.
GenomeRNAii6235.
PROiP62273.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213741.
CleanExiHS_RPS29.
ExpressionAtlasiP62273. baseline and differential.
GenevisibleiP62273. HS.

Family and domain databases

InterProiIPR001209. Ribosomal_S14.
IPR018271. Ribosomal_S14_CS.
[Graphical view]
PfamiPF00253. Ribosomal_S14. 1 hit.
[Graphical view]
PROSITEiPS00527. RIBOSOMAL_S14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS29_HUMAN
AccessioniPrimary (citable) accession number: P62273
Secondary accession number(s): A8MZ73, P30054
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.