P62273 (RS29_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S29

Gene names

Name:

RPS29

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	56 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Cofactor	Binds 1 zinc ion per subunit Potential.
Sequence similarities	Belongs to the ribosomal protein S14P family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	endocrine pancreas development Traceable author statement. Source: Reactome mRNA metabolic process Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular component	cytosolic small ribosomal subunit Inferred from direct assay Ref.5. Source: UniProtKB
Molecular function	structural constituent of ribosome Inferred from direct assay. Source: UniProtKB zinc ion binding Inferred from direct assay Ref.2. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
DDX56	Q9NY93	1	EBI-1054121,EBI-372376
EIF1B	O60739	1	EBI-1054121,EBI-1043343
EIF4A2	Q14240	1	EBI-1054121,EBI-73473
EXT2	Q93063	1	EBI-1054121,EBI-1047761
STYXL1	Q9Y6J8	1	EBI-1054121,EBI-1044511

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.5 Ref.6
	Chain	2 – 56	55	40S ribosomal protein S29		PRO_0000131019
Sites
	Metal binding	21	1	Zinc Potential
	Metal binding	24	1	Zinc Potential
	Metal binding	39	1	Zinc Potential
	Metal binding	42	1	Zinc Potential
Amino acid modifications
	Modified residue	48	1	N6-acetyllysine Ref.8

Sequences

	Sequence		Length	Mass (Da)
	P62273 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 41325122B493EFF9	FASTA	56	6,677
	10 20 30 40 50 MGHQQLYWSH PRKFGQGSRS CRVCSNRHGL IRKYGLNMCR QCFRQYAKDI GFIKLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs." Frigerio J.-M., Dagorn J.-C., Iovanna J.L. Biochim. Biophys. Acta 1262:64-68(1995) [PubMed: 7772601] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon.
[2]	"The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells." Kondoh N., Noda M., Fisher R.J., Schweinfest C.W., Papas T.S., Kondoh A., Samuel K.P., Oikawa T. Biochim. Biophys. Acta 1313:41-46(1996) [PubMed: 8781548] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon.
[3]	"The human ribosomal protein genes: sequencing and comparative analysis of 73 genes." Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N. Genome Res. 12:379-390(2002) [PubMed: 11875025] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood and Eye.
[5]	"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed: 8706699] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-11. Tissue: Placenta.
[6]	Bienvenut W.V., Murray L., Brunton V.G., Frame M.C. Submitted (FEB-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-12 AND 49-56, CLEAVAGE OF INITIATOR METHIONINE, MASS SPECTROMETRY. Tissue: Colon adenocarcinoma.
[7]	"A map of 75 human ribosomal protein genes." Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C. Genome Res. 8:509-523(1998) [PubMed: 9582194] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-54.
[8]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-48, MASS SPECTROMETRY.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U14973 mRNA. Translation: AAA85661.1. L31610 mRNA. Translation: AAB27426.1. AB061847 Genomic DNA. Translation: BAB79485.1. BC032813 mRNA. Translation: AAH32813.1. BC035313 mRNA. Translation: AAH35313.1. AB007165 Genomic DNA. Translation: BAA25827.1.
IPI	IPI00182289.
PIR	S55919.
RefSeq	NP_001023.1. NM_001032.3.
UniGene	Hs.156367.
3D structure databases
ProteinModelPortal	P62273.
SMR	P62273. Positions 6-54.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62273. 4 interactions.
STRING	P62273.
PTM databases
PhosphoSite	P62273.
Polymorphism databases
DMDM	50403626.
Proteomic databases
PRIDE	P62273.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000245458; ENSP00000245458; ENSG00000213741.
GeneID	6235.
KEGG	hsa:6235.
UCSC	uc001wwm.1. human.
Organism-specific databases
CTD	6235.
GeneCards	GC14M050043.
HGNC	HGNC:10419. RPS29.
HPA	HPA004107.
MIM	603633. gene.
neXtProt	NX_P62273.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG21670.
GeneTree	ENSGT00390000005814.
HOVERGEN	HBG004459.
PhylomeDB	P62273.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology. REACT_111217. Metabolism. REACT_15380. Diabetes pathways. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_6167. Influenza Infection. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P62273.
Bgee	P62273.
CleanEx	HS_RPS29.
Genevestigator	P62273.
GermOnline	ENSG00000125385. Homo sapiens.
Family and domain databases
InterPro	IPR001209. Ribosomal_S14. IPR018271. Ribosomal_S14_CS. [Graphical view]
KO	K02980.
Pfam	PF00253. Ribosomal_S14. 1 hit. [Graphical view]
PROSITE	PS00527. RIBOSOMAL_S14. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	24205.
SOURCE	Search...

Entry information

Entry name

RS29_HUMAN

Accession

Primary (citable) accession number: P62273
Secondary accession number(s): P30054

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	January 23, 2007
Last modified:	January 25, 2012
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.