Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein S18

Gene

Rps18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.By similarity

GO - Molecular functioni

  • protein kinase binding Source: RGD
  • RNA binding Source: RGD
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-RNO-72649. Translation initiation complex formation.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-RNO-72702. Ribosomal scanning and start codon recognition.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S18
Gene namesi
Name:Rps18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componentsi: Chromosome 10, Chromosome 20

Organism-specific databases

RGDi3595. Rps18.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001322152 – 15240S ribosomal protein S18Add BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei94N6-acetyllysine; alternateBy similarity1
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei106N6-acetyllysine; alternateBy similarity1
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP62271.
PRIDEiP62271.

PTM databases

iPTMnetiP62271.
PhosphoSitePlusiP62271.

Expressioni

Gene expression databases

BgeeiENSRNOG00000033152.
ExpressionAtlasiP62271. baseline.
GenevisibleiP62271. RN.

Interactioni

GO - Molecular functioni

  • protein kinase binding Source: RGD

Protein-protein interaction databases

BioGridi254650. 2 interactors.
IntActiP62271. 3 interactors.
MINTiMINT-4576366.
STRINGi10116.ENSRNOP00000047371.

Structurei

3D structure databases

ProteinModelPortaliP62271.
SMRiP62271.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3311. Eukaryota.
COG0099. LUCA.
GeneTreeiENSGT00390000012691.
HOGENOMiHOG000039877.
HOVERGENiHBG000200.
InParanoidiP62271.
KOiK02964.
OMAiHKRGQKV.
OrthoDBiEOG091G0W4F.
PhylomeDBiP62271.
TreeFamiTF317649.

Family and domain databases

Gene3Di4.10.910.10. 1 hit.
HAMAPiMF_01315. Ribosomal_S13_S18. 1 hit.
InterProiView protein in InterPro
IPR027437. 30s_Rbsml_prot_S13_C.
IPR001892. Ribosomal_S13.
IPR010979. Ribosomal_S13-like_H2TH.
IPR018269. Ribosomal_S13_CS.
PfamiView protein in Pfam
PF00416. Ribosomal_S13. 1 hit.
PIRSFiPIRSF002134. Ribosomal_S13. 1 hit.
SUPFAMiSSF46946. SSF46946. 1 hit.
PROSITEiView protein in PROSITE
PS00646. RIBOSOMAL_S13_1. 1 hit.
PS50159. RIBOSOMAL_S13_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62271-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI
60 70 80 90 100
DLTKRAGELT EDEVERVITI MQNPRQYKIP DWFLNRQKDV KDGKYSQVLA
110 120 130 140 150
NGLDNKLRED LERLKKIRAH RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK

KK
Length:152
Mass (Da):17,719
Last modified:January 23, 2007 - v3
Checksum:i4DAF0662C3F37F22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57529 mRNA. Translation: CAA40750.1.
BX883042 Genomic DNA. Translation: CAE83925.1.
BC126072 mRNA. Translation: AAI26073.1.
PIRiJH0419. R3RT18.
RefSeqiNP_998722.1. NM_213557.1.
XP_002724624.1. XM_002724578.5.
XP_002727879.1. XM_002727833.5.
UniGeneiRn.42766.

Genome annotation databases

EnsembliENSRNOT00000046010; ENSRNOP00000047371; ENSRNOG00000033152.
ENSRNOT00000092476; ENSRNOP00000075857; ENSRNOG00000028505.
GeneIDi100360679.
294282.
KEGGirno:100360679.
rno:294282.
UCSCiRGD:3595. rat.

Similar proteinsi

Entry informationi

Entry nameiRS18_RAT
AccessioniPrimary (citable) accession number: P62271
Secondary accession number(s): A0JN05, P25232
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families