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P62270

- RS18_MOUSE

UniProt

P62270 - RS18_MOUSE

Protein

40S ribosomal protein S18

Gene

Rps18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. rRNA binding Source: UniProtKB-KW
    3. structural constituent of ribosome Source: RefGenome

    GO - Biological processi

    1. ribosome biogenesis Source: RefGenome
    2. translation Source: RefGenome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S18
    Alternative name(s):
    Ke-3
    Short name:
    Ke3
    Gene namesi
    Name:Rps18
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:98146. Rps18.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: RefGenome
    2. small ribosomal subunit Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 15215140S ribosomal protein S18PRO_0000132213Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei94 – 941N6-acetyllysineBy similarity
    Modified residuei106 – 1061N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP62270.
    PaxDbiP62270.
    PRIDEiP62270.

    PTM databases

    PhosphoSiteiP62270.

    Expressioni

    Gene expression databases

    BgeeiP62270.
    CleanExiMM_RPS18.
    GenevestigatoriP62270.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Casp3P706775EBI-352460,EBI-1790419
    Casp7P978644EBI-352460,EBI-5307197

    Protein-protein interaction databases

    BioGridi203006. 1 interaction.
    IntActiP62270. 5 interactions.
    MINTiMINT-1865215.

    Structurei

    3D structure databases

    ProteinModelPortaliP62270.
    SMRiP62270. Positions 6-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S13P family.Curated

    Phylogenomic databases

    eggNOGiCOG0099.
    HOGENOMiHOG000039877.
    HOVERGENiHBG000200.
    InParanoidiP62270.
    KOiK02964.
    OMAiQHILRVM.
    OrthoDBiEOG7Q5HG2.
    PhylomeDBiP62270.
    TreeFamiTF317649.

    Family and domain databases

    Gene3Di4.10.910.10. 1 hit.
    HAMAPiMF_01315. Ribosomal_S13_S18.
    InterProiIPR027437. 30s_Rbsml_prot_S13_C.
    IPR001892. Ribosomal_S13.
    IPR010979. Ribosomal_S13-like_H2TH.
    IPR018269. Ribosomal_S13_CS.
    [Graphical view]
    PfamiPF00416. Ribosomal_S13. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002134. Ribosomal_S13. 1 hit.
    SUPFAMiSSF46946. SSF46946. 1 hit.
    PROSITEiPS00646. RIBOSOMAL_S13_1. 1 hit.
    PS50159. RIBOSOMAL_S13_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62270-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI    50
    DLTKRAGELT EDEVERVITI MQNPRQYKIP DWFLNRQKDV KDGKYSQVLA 100
    NGLDNKLRED LERLKKIRAH RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK 150
    KK 152
    Length:152
    Mass (Da):17,719
    Last modified:January 23, 2007 - v3
    Checksum:i4DAF0662C3F37F22
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti104 – 1041D → H in AAA16796. (PubMed:1543907)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76763 mRNA. Translation: AAA16795.1.
    M76762 Unassigned DNA. Translation: AAA16796.1.
    AF100956 Genomic DNA. Translation: AAC69898.1.
    AF110520 Genomic DNA. Translation: AAC97978.1.
    AK050626 mRNA. Translation: BAC34350.1.
    BC081459 mRNA. Translation: AAH81459.1.
    BC081458 mRNA. Translation: AAH81458.1.
    CCDSiCCDS37573.1.
    PIRiI76666.
    RefSeqiNP_035426.1. NM_011296.2.
    UniGeneiMm.298745.
    Mm.324762.
    Mm.440079.

    Genome annotation databases

    EnsembliENSMUST00000008812; ENSMUSP00000008812; ENSMUSG00000008668.
    GeneIDi20084.
    KEGGimmu:20084.
    UCSCiuc008cak.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M76763 mRNA. Translation: AAA16795.1 .
    M76762 Unassigned DNA. Translation: AAA16796.1 .
    AF100956 Genomic DNA. Translation: AAC69898.1 .
    AF110520 Genomic DNA. Translation: AAC97978.1 .
    AK050626 mRNA. Translation: BAC34350.1 .
    BC081459 mRNA. Translation: AAH81459.1 .
    BC081458 mRNA. Translation: AAH81458.1 .
    CCDSi CCDS37573.1.
    PIRi I76666.
    RefSeqi NP_035426.1. NM_011296.2.
    UniGenei Mm.298745.
    Mm.324762.
    Mm.440079.

    3D structure databases

    ProteinModelPortali P62270.
    SMRi P62270. Positions 6-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203006. 1 interaction.
    IntActi P62270. 5 interactions.
    MINTi MINT-1865215.

    PTM databases

    PhosphoSitei P62270.

    Proteomic databases

    MaxQBi P62270.
    PaxDbi P62270.
    PRIDEi P62270.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000008812 ; ENSMUSP00000008812 ; ENSMUSG00000008668 .
    GeneIDi 20084.
    KEGGi mmu:20084.
    UCSCi uc008cak.1. mouse.

    Organism-specific databases

    CTDi 6222.
    MGIi MGI:98146. Rps18.

    Phylogenomic databases

    eggNOGi COG0099.
    HOGENOMi HOG000039877.
    HOVERGENi HBG000200.
    InParanoidi P62270.
    KOi K02964.
    OMAi QHILRVM.
    OrthoDBi EOG7Q5HG2.
    PhylomeDBi P62270.
    TreeFami TF317649.

    Enzyme and pathway databases

    Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Miscellaneous databases

    NextBioi 24155.
    PROi P62270.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62270.
    CleanExi MM_RPS18.
    Genevestigatori P62270.

    Family and domain databases

    Gene3Di 4.10.910.10. 1 hit.
    HAMAPi MF_01315. Ribosomal_S13_S18.
    InterProi IPR027437. 30s_Rbsml_prot_S13_C.
    IPR001892. Ribosomal_S13.
    IPR010979. Ribosomal_S13-like_H2TH.
    IPR018269. Ribosomal_S13_CS.
    [Graphical view ]
    Pfami PF00416. Ribosomal_S13. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002134. Ribosomal_S13. 1 hit.
    SUPFAMi SSF46946. SSF46946. 1 hit.
    PROSITEi PS00646. RIBOSOMAL_S13_1. 1 hit.
    PS50159. RIBOSOMAL_S13_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The murine MHC encodes a mammalian homolog of bacterial ribosomal protein S13."
      Macmurray A.J., Shin H.S.
      Mamm. Genome 2:87-95(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sequence of the mouse major histocomaptibility locus class II region."
      Rowen L., Qin S., Madan A., Loretz C., James R., Dors M., Mix L., Hall J., Lasky S., Hood L.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 129/SvJ.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiRS18_MOUSE
    AccessioniPrimary (citable) accession number: P62270
    Secondary accession number(s): P25232
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 90 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3