P62270 (RS18_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S18

Alternative name(s):
Ke-3
Short name=Ke3

Gene names

Name:

Rps18

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	152 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA By similarity. HAMAP-Rule MF_01315
Subcellular location	Cytoplasm HAMAP-Rule MF_01315.
Sequence similarities	Belongs to the ribosomal protein S13P family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ribosome biogenesis Inferred from Biological aspect of Ancestor. Source: RefGenome translation Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cytosol Inferred from Biological aspect of Ancestor. Source: RefGenome cytosolic small ribosomal subunit Inferred from electronic annotation. Source: Compara small ribosomal subunit Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Casp3	P70677	5	EBI-352460,EBI-1790419
Casp7	P97864	4	EBI-352460,EBI-5307197

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 152	151	40S ribosomal protein S18 HAMAP-Rule MF_01315		PRO_0000132213
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
	Modified residue	94	1	N6-acetyllysine By similarity
	Modified residue	106	1	N6-acetyllysine By similarity
Experimental info
	Sequence conflict	104	1	D → H in AAA16796. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P62270 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 4DAF0662C3F37F22	FASTA	152	17,719
	10 20 30 40 50 60 MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI DLTKRAGELT 70 80 90 100 110 120 EDEVERVITI MQNPRQYKIP DWFLNRQKDV KDGKYSQVLA NGLDNKLRED LERLKKIRAH 130 140 150 RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK KK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The murine MHC encodes a mammalian homolog of bacterial ribosomal protein S13." Macmurray A.J., Shin H.S. Mamm. Genome 2:87-95(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sequence of the mouse major histocomaptibility locus class II region." Rowen L., Qin S., Madan A., Loretz C., James R., Dors M., Mix L., Hall J., Lasky S., Hood L. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 129/SvJ.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Thymus.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M76763 mRNA. Translation: AAA16795.1. M76762 Unassigned DNA. Translation: AAA16796.1. AF100956 Genomic DNA. Translation: AAC69898.1. AF110520 Genomic DNA. Translation: AAC97978.1. AK050626 mRNA. Translation: BAC34350.1. BC081459 mRNA. Translation: AAH81459.1. BC081458 mRNA. Translation: AAH81458.1.
IPI	IPI00317590.
PIR	I76666.
RefSeq	NP_035426.1. NM_011296.2.
UniGene	Mm.298745. Mm.324762. Mm.440079.
3D structure databases
ProteinModelPortal	P62270.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62270. 3 interactions.
PTM databases
PhosphoSite	P62270.
Proteomic databases
PaxDb	P62270.
PRIDE	P62270.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000008812; ENSMUSP00000008812; ENSMUSG00000008668.
GeneID	20084.
KEGG	mmu:20084.
Organism-specific databases
CTD	6222.
MGI	MGI:98146. Rps18.
Phylogenomic databases
eggNOG	COG0099.
HOGENOM	HOG000039877.
HOVERGEN	HBG000200.
InParanoid	P62270.
KO	K02964.
OMA	FQHILRI.
OrthoDB	EOG4KSPM2.
Gene expression databases
ArrayExpress	P62270.
Bgee	P62270.
CleanEx	MM_RPS18.
Genevestigator	P62270.
GermOnline	ENSMUSG00000008668. Mus musculus.
Family and domain databases
HAMAP	MF_01315. Ribosomal_S13/S18.
InterPro	IPR001892. Ribosomal_S13. IPR010979. Ribosomal_S13-like_H2TH. IPR018269. Ribosomal_S13_CS. [Graphical view]
PANTHER	PTHR10871. PTHR10871. 1 hit.
Pfam	PF00416. Ribosomal_S13. 1 hit. [Graphical view]
PIRSF	PIRSF002134. Ribosomal_S13. 1 hit.
SUPFAM	SSF46946. Ribosomal_H2TH. 1 hit.
PROSITE	PS00646. RIBOSOMAL_S13_1. 1 hit. PS50159. RIBOSOMAL_S13_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	24155.
SOURCE	Search...

Entry information

Entry name

RS18_MOUSE

Accession

Primary (citable) accession number: P62270
Secondary accession number(s): P25232

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 75 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program