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P62269 (RS18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
40S ribosomal protein S18
Alternative name(s):
Ke-3
Short name=Ke3
Gene names
Name:RPS18
Synonyms:D6S218E
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length152 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the ribosomal protein S13P family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 15215140S ribosomal protein S18
PRO_0000132212

Amino acid modifications

Modified residue21N-acetylserine Ref.5
Modified residue81N6-acetyllysine Ref.7
Modified residue781N6-acetyllysine Ref.7
Modified residue941N6-acetyllysine Ref.7
Modified residue1061N6-acetyllysine Ref.7

Experimental info

Sequence conflict551R → S AA sequence Ref.6

Sequences

Sequence LengthMass (Da)Tools
P62269 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 4DAF0662C3F37F22

FASTA15217,719
        10         20         30         40         50         60 
MSLVIPEKFQ HILRVLNTNI DGRRKIAFAI TAIKGVGRRY AHVVLRKADI DLTKRAGELT 

        70         80         90        100        110        120 
EDEVERVITI MQNPRQYKIP DWFLNRQKDV KDGKYSQVLA NGLDNKLRED LERLKKIRAH 

       130        140        150 
RGLRHFWGLR VRGQHTKTTG RRGRTVGVSK KK 

« Hide

References

« Hide 'large scale' references
[1]"The human homolog of ribosomal protein S18."
Chassin D., Bellet D., Koman A.
Nucleic Acids Res. 21:745-745(1993) [PubMed: 8441687] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone and Brain.
[5]Bienvenut W.V., Heiserich L., Boulahbel H., Gottlieb E.
Submitted (NOV-2006) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-23; 25-34; 40-75; 79-86; 95-113 AND 125-130, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY.
Tissue: Colon carcinoma.
[6]"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
Eur. J. Biochem. 239:144-149(1996) [PubMed: 8706699] [Abstract]
Cited for: PROTEIN SEQUENCE OF 55-69.
Tissue: Placenta.
[7]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed: 19608861] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-8; LYS-78; LYS-94 AND LYS-106, MASS SPECTROMETRY.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69150 mRNA. Translation: CAB56794.1.
AL031228 Genomic DNA. Translation: CAA20231.1.
AL662827, AL713971 Genomic DNA. Translation: CAI17530.1.
AL713971, AL662827 Genomic DNA. Translation: CAI17656.1.
AL645940, AL662820 Genomic DNA. Translation: CAI18076.1.
AL662820, AL645940 Genomic DNA. Translation: CAI18127.1.
AL844527 Genomic DNA. Translation: CAI41848.1.
CR759817 Genomic DNA. Translation: CAQ08021.1.
CR759786 Genomic DNA. Translation: CAQ08251.1.
CH471081 Genomic DNA. Translation: EAX03695.1.
BC101786 mRNA. Translation: AAI01787.1.
BC101788 mRNA. Translation: AAI01789.1.
BC106063 mRNA. Translation: AAI06064.1.
IPIIPI00013296.
PIRS30393.
RefSeqNP_072045.1. NM_022551.2.
UniGeneHs.627414.

3D structure databases

ProteinModelPortalP62269.
SMRP62269. Positions 13-152.
ModBaseSearch...

Protein-protein interaction databases

IntActP62269. 11 interactions.
MINTMINT-1151113.
STRINGP62269.

PTM databases

PhosphoSiteP62269.

Polymorphism databases

DMDM50403625.

Proteomic databases

PeptideAtlasP62269.
PRIDEP62269.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000211372; ENSP00000211372; ENSG00000096150.
ENST00000434122; ENSP00000403175; ENSG00000226225.
ENST00000439602; ENSP00000393241; ENSG00000231500.
ENST00000454021; ENSP00000416110; ENSG00000235650.
ENST00000457341; ENSP00000412583; ENSG00000223367.
GeneID6222.
KEGGhsa:6222.
UCSCuc003odp.1. human.

Organism-specific databases

CTD6222.
GeneCardsGC06P033240.
HGNCHGNC:10401. RPS18.
MIM180473. gene.
neXtProtNX_P62269.
PharmGKBPA34801.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG16420.
HOGENOMHBG737405.
HOVERGENHBG000200.
InParanoidP62269.
OMAMNTNIDG.
OrthoDBEOG4KSPM2.
PhylomeDBP62269.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.
REACT_111217. Metabolism.
REACT_15380. Diabetes pathways.
REACT_17015. Metabolism of proteins.
REACT_1762. 3' -UTR-mediated translational regulation.
REACT_6167. Influenza Infection.
REACT_71. Gene Expression.

Gene expression databases

CleanExHS_RPS18.
GenevestigatorP62269.
GermOnlineENSG00000182498. Homo sapiens.

Family and domain databases

InterProIPR001892. Ribosomal_S13.
IPR010979. Ribosomal_S13-like_H2TH.
IPR018269. Ribosomal_S13_CS.
[Graphical view]
KOK02964.
PANTHERPTHR10871. PTHR10871. 1 hit.
PfamPF00416. Ribosomal_S13. 1 hit.
[Graphical view]
PIRSFPIRSF002134. Ribosomal_S13. 1 hit.
SUPFAMSSF46946. Ribosomal_H2TH. 1 hit.
PROSITEPS00646. RIBOSOMAL_S13_1. 1 hit.
PS50159. RIBOSOMAL_S13_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameRS18_HUMAN
AccessionPrimary (citable) accession number: P62269
Secondary accession number(s): P25232, Q5SUJ3, Q6IPF8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: January 25, 2012
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Ribosomal proteins

Ribosomal proteins families and list of entries

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families