Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein S23

Gene

Rps23

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy.By similarity

GO - Molecular functioni

  • RNA binding Source: RGD
  • structural constituent of ribosome Source: UniProtKB
  • translation regulator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S23
Gene namesi
Name:Rps23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi621039 Rps23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001464602 – 14340S ribosomal protein S23Add BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei54N6-succinyllysineBy similarity1
Modified residuei623-hydroxyprolineBy similarity1
Modified residuei135N6-acetyllysineBy similarity1

Post-translational modificationi

Hydroxylation at Pro-62 affects translation termination efficiency.By similarity

Keywords - PTMi

Acetylation, Hydroxylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP62268
PRIDEiP62268

PTM databases

iPTMnetiP62268
PhosphoSitePlusiP62268
SwissPalmiP62268

Expressioni

Gene expression databases

BgeeiENSRNOG00000016580
GenevisibleiP62268 RN

Interactioni

Subunit structurei

Component of the 40S small ribosomal subunit.By similarity

Protein-protein interaction databases

BioGridi250780, 1 interactor
IntActiP62268, 2 interactors
STRINGi10116.ENSRNOP00000022348

Structurei

3D structure databases

ProteinModelPortaliP62268
SMRiP62268
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1749 Eukaryota
COG0048 LUCA
GeneTreeiENSGT00550000074784
HOGENOMiHOG000040064
HOVERGENiHBG054200
InParanoidiP62268
KOiK02973
OMAiKFRWSQR
OrthoDBiEOG091G0R2G
PhylomeDBiP62268
TreeFamiTF300871

Family and domain databases

CDDicd03367 Ribosomal_S23, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006032 Ribosomal_S12/S23
IPR005680 Ribosomal_S23_euk/arc
PANTHERiPTHR11652 PTHR11652, 1 hit
PfamiView protein in Pfam
PF00164 Ribosom_S12_S23, 1 hit
PIRSFiPIRSF002133 Ribosomal_S12/S23, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00982 uS12_E_A, 1 hit
PROSITEiView protein in PROSITE
PS00055 RIBOSOMAL_S12, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI
60 70 80 90 100
VLEKVGVEAK QPNSAIRKCV RVQLIKNGKK ITAFVPNDGC LNFIEENDEV
110 120 130 140
LVAGFGRKGH AVGDIPGVRF KVVKVANVSL LALYKGKKER PRS
Length:143
Mass (Da):15,808
Last modified:January 23, 2007 - v3
Checksum:i8417A48B8CF0A8E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77398 Genomic DNA Translation: CAA54584.1
BC058134 mRNA Translation: AAH58134.1
PIRiS41955
RefSeqiNP_511172.1, NM_078617.3
UniGeneiRn.2139

Genome annotation databases

EnsembliENSRNOT00000022348; ENSRNOP00000022348; ENSRNOG00000016580
GeneIDi124323
KEGGirno:124323
UCSCiRGD:621039 rat

Similar proteinsi

Entry informationi

Entry nameiRS23_RAT
AccessioniPrimary (citable) accession number: P62268
Secondary accession number(s): P39028
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 111 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health