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Protein

40S ribosomal protein S23

Gene

Rps23

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: GO_Central
  • translation regulator activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72649. Translation initiation complex formation.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-RNO-72702. Ribosomal scanning and start codon recognition.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S23
Gene namesi
Name:Rps23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi621039. Rps23.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: RGD
  • ribosome Source: UniProtKB
  • small ribosomal subunit Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 14314240S ribosomal protein S23PRO_0000146460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541N6-succinyllysineBy similarity
Modified residuei62 – 6213-hydroxyprolineBy similarity
Modified residuei135 – 1351N6-acetyllysineBy similarity

Post-translational modificationi

Hydroxylation at Pro-62 affects translation termination efficiency.By similarity

Keywords - PTMi

Acetylation, Hydroxylation

Proteomic databases

PaxDbiP62268.
PRIDEiP62268.

PTM databases

iPTMnetiP62268.
PhosphoSiteiP62268.
SwissPalmiP62268.

Expressioni

Gene expression databases

GenevisibleiP62268. RN.

Interactioni

Protein-protein interaction databases

BioGridi250780. 1 interaction.
IntActiP62268. 2 interactions.
MINTiMINT-4133195.
STRINGi10116.ENSRNOP00000022348.

Structurei

3D structure databases

ProteinModelPortaliP62268.
SMRiP62268. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S12P family.Curated

Phylogenomic databases

eggNOGiKOG1749. Eukaryota.
COG0048. LUCA.
GeneTreeiENSGT00550000074784.
HOGENOMiHOG000040064.
HOVERGENiHBG054200.
InParanoidiP62268.
KOiK02973.
OMAiMPGKKSP.
OrthoDBiEOG77DJ7H.
PhylomeDBiP62268.
TreeFamiTF300871.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005680. Ribosomal_S23_euk/arc.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00982. uS12_E_A. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI
60 70 80 90 100
VLEKVGVEAK QPNSAIRKCV RVQLIKNGKK ITAFVPNDGC LNFIEENDEV
110 120 130 140
LVAGFGRKGH AVGDIPGVRF KVVKVANVSL LALYKGKKER PRS
Length:143
Mass (Da):15,808
Last modified:January 23, 2007 - v3
Checksum:i8417A48B8CF0A8E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77398 Genomic DNA. Translation: CAA54584.1.
BC058134 mRNA. Translation: AAH58134.1.
PIRiS41955.
RefSeqiNP_511172.1. NM_078617.3.
UniGeneiRn.2139.

Genome annotation databases

EnsembliENSRNOT00000022348; ENSRNOP00000022348; ENSRNOG00000016580.
GeneIDi124323.
KEGGirno:124323.
UCSCiRGD:621039. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77398 Genomic DNA. Translation: CAA54584.1.
BC058134 mRNA. Translation: AAH58134.1.
PIRiS41955.
RefSeqiNP_511172.1. NM_078617.3.
UniGeneiRn.2139.

3D structure databases

ProteinModelPortaliP62268.
SMRiP62268. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250780. 1 interaction.
IntActiP62268. 2 interactions.
MINTiMINT-4133195.
STRINGi10116.ENSRNOP00000022348.

PTM databases

iPTMnetiP62268.
PhosphoSiteiP62268.
SwissPalmiP62268.

Proteomic databases

PaxDbiP62268.
PRIDEiP62268.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022348; ENSRNOP00000022348; ENSRNOG00000016580.
GeneIDi124323.
KEGGirno:124323.
UCSCiRGD:621039. rat.

Organism-specific databases

CTDi6228.
RGDi621039. Rps23.

Phylogenomic databases

eggNOGiKOG1749. Eukaryota.
COG0048. LUCA.
GeneTreeiENSGT00550000074784.
HOGENOMiHOG000040064.
HOVERGENiHBG054200.
InParanoidiP62268.
KOiK02973.
OMAiMPGKKSP.
OrthoDBiEOG77DJ7H.
PhylomeDBiP62268.
TreeFamiTF300871.

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72649. Translation initiation complex formation.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-RNO-72702. Ribosomal scanning and start codon recognition.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP62268.

Gene expression databases

GenevisibleiP62268. RN.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005680. Ribosomal_S23_euk/arc.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00982. uS12_E_A. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-16 AND 115-125.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiRS23_RAT
AccessioniPrimary (citable) accession number: P62268
Secondary accession number(s): P39028
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.