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P62267

- RS23_MOUSE

UniProt

P62267 - RS23_MOUSE

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Protein

40S ribosomal protein S23

Gene

Rps23

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S23
Gene namesi
Name:Rps23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1913725. Rps23.

Subcellular locationi

GO - Cellular componenti

  1. cytosolic small ribosomal subunit Source: Ensembl
  2. nucleolus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 14314240S ribosomal protein S23PRO_0000146458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541N6-succinyllysine1 Publication
Modified residuei62 – 6213-hydroxyprolineBy similarity
Modified residuei135 – 1351N6-acetyllysineBy similarity

Post-translational modificationi

Hydroxylation at Pro-62 affects translation termination efficiency.By similarity

Keywords - PTMi

Acetylation, Hydroxylation

Proteomic databases

MaxQBiP62267.
PaxDbiP62267.
PRIDEiP62267.

PTM databases

PhosphoSiteiP62267.

Expressioni

Gene expression databases

BgeeiP62267.
CleanExiMM_RPS23.
ExpressionAtlasiP62267. baseline and differential.
GenevestigatoriP62267.

Interactioni

Protein-protein interaction databases

BioGridi211500. 9 interactions.
IntActiP62267. 5 interactions.
MINTiMINT-1857177.

Structurei

3D structure databases

ProteinModelPortaliP62267.
SMRiP62267. Positions 1-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S12P family.Curated

Phylogenomic databases

eggNOGiCOG0048.
GeneTreeiENSGT00550000074784.
HOVERGENiHBG054200.
InParanoidiP62267.
KOiK02973.
OMAiWHDKDYK.
OrthoDBiEOG77DJ7H.
TreeFamiTF300871.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005680. Ribosomal_S23_euk/arc.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00982. S23_S12_E_A. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62267-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI
60 70 80 90 100
VLEKVGVEAK QPNSAIRKCV RVQLIKNGKK ITAFVPNDGC LNFIEENDEV
110 120 130 140
LVAGFGRKGH AVGDIPGVRF KVVKVANVSL LALYKGKKER PRS
Length:143
Mass (Da):15,808
Last modified:January 23, 2007 - v3
Checksum:i8417A48B8CF0A8E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002573 mRNA. Translation: BAB22198.1.
AK010594 mRNA. Translation: BAB27050.1.
AK010608 mRNA. Translation: BAB27058.1.
AK012438 mRNA. Translation: BAB28238.1.
AK013720 mRNA. Translation: BAB28969.1.
AK050580 mRNA. Translation: BAC34329.1.
AK088085 mRNA. Translation: BAC40136.1.
AK166994 mRNA. Translation: BAE39173.1.
AK168587 mRNA. Translation: BAE40456.1.
BC002145 mRNA. Translation: AAH02145.1.
BC054435 mRNA. Translation: AAH54435.1.
BC078418 mRNA. Translation: AAH78418.1.
CCDSiCCDS26674.1.
RefSeqiNP_077137.1. NM_024175.3.
UniGeneiMm.306302.

Genome annotation databases

EnsembliENSMUST00000051955; ENSMUSP00000054490; ENSMUSG00000049517.
GeneIDi66475.
KEGGimmu:66475.
UCSCiuc007rjq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002573 mRNA. Translation: BAB22198.1 .
AK010594 mRNA. Translation: BAB27050.1 .
AK010608 mRNA. Translation: BAB27058.1 .
AK012438 mRNA. Translation: BAB28238.1 .
AK013720 mRNA. Translation: BAB28969.1 .
AK050580 mRNA. Translation: BAC34329.1 .
AK088085 mRNA. Translation: BAC40136.1 .
AK166994 mRNA. Translation: BAE39173.1 .
AK168587 mRNA. Translation: BAE40456.1 .
BC002145 mRNA. Translation: AAH02145.1 .
BC054435 mRNA. Translation: AAH54435.1 .
BC078418 mRNA. Translation: AAH78418.1 .
CCDSi CCDS26674.1.
RefSeqi NP_077137.1. NM_024175.3.
UniGenei Mm.306302.

3D structure databases

ProteinModelPortali P62267.
SMRi P62267. Positions 1-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211500. 9 interactions.
IntActi P62267. 5 interactions.
MINTi MINT-1857177.

PTM databases

PhosphoSitei P62267.

Proteomic databases

MaxQBi P62267.
PaxDbi P62267.
PRIDEi P62267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000051955 ; ENSMUSP00000054490 ; ENSMUSG00000049517 .
GeneIDi 66475.
KEGGi mmu:66475.
UCSCi uc007rjq.2. mouse.

Organism-specific databases

CTDi 6228.
MGIi MGI:1913725. Rps23.

Phylogenomic databases

eggNOGi COG0048.
GeneTreei ENSGT00550000074784.
HOVERGENi HBG054200.
InParanoidi P62267.
KOi K02973.
OMAi WHDKDYK.
OrthoDBi EOG77DJ7H.
TreeFami TF300871.

Enzyme and pathway databases

Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

NextBioi 24175.
PROi P62267.
SOURCEi Search...

Gene expression databases

Bgeei P62267.
CleanExi MM_RPS23.
ExpressionAtlasi P62267. baseline and differential.
Genevestigatori P62267.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
InterProi IPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005680. Ribosomal_S23_euk/arc.
[Graphical view ]
PANTHERi PTHR11652. PTHR11652. 1 hit.
Pfami PF00164. Ribosom_S12_S23. 1 hit.
[Graphical view ]
PIRSFi PIRSF002133. Ribosomal_S12/S23. 1 hit.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00982. S23_S12_E_A. 1 hit.
PROSITEi PS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Hippocampus, Kidney and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-54, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiRS23_MOUSE
AccessioniPrimary (citable) accession number: P62267
Secondary accession number(s): P39028, Q542K7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3