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P62267

- RS23_MOUSE

UniProt

P62267 - RS23_MOUSE

Protein

40S ribosomal protein S23

Gene

Rps23

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S23
    Gene namesi
    Name:Rps23
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1913725. Rps23.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 14314240S ribosomal protein S23PRO_0000146458Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei54 – 541N6-succinyllysine1 Publication
    Modified residuei62 – 6213-hydroxyprolineBy similarity
    Modified residuei135 – 1351N6-acetyllysineBy similarity

    Post-translational modificationi

    Hydroxylation at Pro-62 affects translation termination efficiency.By similarity

    Keywords - PTMi

    Acetylation, Hydroxylation

    Proteomic databases

    MaxQBiP62267.
    PaxDbiP62267.
    PRIDEiP62267.

    PTM databases

    PhosphoSiteiP62267.

    Expressioni

    Gene expression databases

    BgeeiP62267.
    CleanExiMM_RPS23.
    GenevestigatoriP62267.

    Interactioni

    Protein-protein interaction databases

    BioGridi211500. 9 interactions.
    IntActiP62267. 5 interactions.
    MINTiMINT-1857177.

    Structurei

    3D structure databases

    ProteinModelPortaliP62267.
    SMRiP62267. Positions 1-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S12P family.Curated

    Phylogenomic databases

    eggNOGiCOG0048.
    GeneTreeiENSGT00550000074784.
    HOVERGENiHBG054200.
    InParanoidiP62267.
    KOiK02973.
    OMAiWHDKDYK.
    OrthoDBiEOG77DJ7H.
    TreeFamiTF300871.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR006032. Ribosomal_S12/S23.
    IPR005680. Ribosomal_S23_euk/arc.
    [Graphical view]
    PANTHERiPTHR11652. PTHR11652. 1 hit.
    PfamiPF00164. Ribosom_S12_S23. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00982. S23_S12_E_A. 1 hit.
    PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62267-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI    50
    VLEKVGVEAK QPNSAIRKCV RVQLIKNGKK ITAFVPNDGC LNFIEENDEV 100
    LVAGFGRKGH AVGDIPGVRF KVVKVANVSL LALYKGKKER PRS 143
    Length:143
    Mass (Da):15,808
    Last modified:January 23, 2007 - v3
    Checksum:i8417A48B8CF0A8E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002573 mRNA. Translation: BAB22198.1.
    AK010594 mRNA. Translation: BAB27050.1.
    AK010608 mRNA. Translation: BAB27058.1.
    AK012438 mRNA. Translation: BAB28238.1.
    AK013720 mRNA. Translation: BAB28969.1.
    AK050580 mRNA. Translation: BAC34329.1.
    AK088085 mRNA. Translation: BAC40136.1.
    AK166994 mRNA. Translation: BAE39173.1.
    AK168587 mRNA. Translation: BAE40456.1.
    BC002145 mRNA. Translation: AAH02145.1.
    BC054435 mRNA. Translation: AAH54435.1.
    BC078418 mRNA. Translation: AAH78418.1.
    CCDSiCCDS26674.1.
    RefSeqiNP_077137.1. NM_024175.3.
    UniGeneiMm.306302.

    Genome annotation databases

    EnsembliENSMUST00000051955; ENSMUSP00000054490; ENSMUSG00000049517.
    GeneIDi66475.
    KEGGimmu:66475.
    UCSCiuc007rjq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002573 mRNA. Translation: BAB22198.1 .
    AK010594 mRNA. Translation: BAB27050.1 .
    AK010608 mRNA. Translation: BAB27058.1 .
    AK012438 mRNA. Translation: BAB28238.1 .
    AK013720 mRNA. Translation: BAB28969.1 .
    AK050580 mRNA. Translation: BAC34329.1 .
    AK088085 mRNA. Translation: BAC40136.1 .
    AK166994 mRNA. Translation: BAE39173.1 .
    AK168587 mRNA. Translation: BAE40456.1 .
    BC002145 mRNA. Translation: AAH02145.1 .
    BC054435 mRNA. Translation: AAH54435.1 .
    BC078418 mRNA. Translation: AAH78418.1 .
    CCDSi CCDS26674.1.
    RefSeqi NP_077137.1. NM_024175.3.
    UniGenei Mm.306302.

    3D structure databases

    ProteinModelPortali P62267.
    SMRi P62267. Positions 1-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211500. 9 interactions.
    IntActi P62267. 5 interactions.
    MINTi MINT-1857177.

    PTM databases

    PhosphoSitei P62267.

    Proteomic databases

    MaxQBi P62267.
    PaxDbi P62267.
    PRIDEi P62267.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000051955 ; ENSMUSP00000054490 ; ENSMUSG00000049517 .
    GeneIDi 66475.
    KEGGi mmu:66475.
    UCSCi uc007rjq.2. mouse.

    Organism-specific databases

    CTDi 6228.
    MGIi MGI:1913725. Rps23.

    Phylogenomic databases

    eggNOGi COG0048.
    GeneTreei ENSGT00550000074784.
    HOVERGENi HBG054200.
    InParanoidi P62267.
    KOi K02973.
    OMAi WHDKDYK.
    OrthoDBi EOG77DJ7H.
    TreeFami TF300871.

    Enzyme and pathway databases

    Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Miscellaneous databases

    NextBioi 24175.
    PROi P62267.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62267.
    CleanExi MM_RPS23.
    Genevestigatori P62267.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR006032. Ribosomal_S12/S23.
    IPR005680. Ribosomal_S23_euk/arc.
    [Graphical view ]
    PANTHERi PTHR11652. PTHR11652. 1 hit.
    Pfami PF00164. Ribosom_S12_S23. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002133. Ribosomal_S12/S23. 1 hit.
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00982. S23_S12_E_A. 1 hit.
    PROSITEi PS00055. RIBOSOMAL_S12. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Hippocampus, Kidney and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-54, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiRS23_MOUSE
    AccessioniPrimary (citable) accession number: P62267
    Secondary accession number(s): P39028, Q542K7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 103 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3