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Protein

40S ribosomal protein S23

Gene

Rps23

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-72649 Translation initiation complex formation
R-MMU-72689 Formation of a pool of free 40S subunits
R-MMU-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-MMU-72702 Ribosomal scanning and start codon recognition
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S23
Gene namesi
Name:Rps23
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913725 Rps23

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001464581 – 14340S ribosomal protein S23Add BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei54N6-succinyllysineCombined sources1
Modified residuei623-hydroxyprolineBy similarity1
Modified residuei135N6-acetyllysineBy similarity1

Post-translational modificationi

Hydroxylation at Pro-62 affects translation termination efficiency.By similarity

Keywords - PTMi

Acetylation, Hydroxylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP62267
MaxQBiP62267
PaxDbiP62267
PeptideAtlasiP62267
PRIDEiP62267
TopDownProteomicsiP62267

PTM databases

iPTMnetiP62267
PhosphoSitePlusiP62267
SwissPalmiP62267

Expressioni

Gene expression databases

BgeeiENSMUSG00000049517
CleanExiMM_RPS23
GenevisibleiP62267 MM

Interactioni

Subunit structurei

Component of the 40S small ribosomal subunit.By similarity

Protein-protein interaction databases

BioGridi211500, 3 interactors
IntActiP62267, 5 interactors
MINTiP62267
STRINGi10090.ENSMUSP00000054490

Structurei

3D structure databases

ProteinModelPortaliP62267
SMRiP62267
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1749 Eukaryota
COG0048 LUCA
GeneTreeiENSGT00550000074784
HOVERGENiHBG054200
InParanoidiP62267
KOiK02973
OMAiKFRWSQR
OrthoDBiEOG091G0R2G
TreeFamiTF300871

Family and domain databases

CDDicd03367 Ribosomal_S23, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006032 Ribosomal_S12/S23
IPR005680 Ribosomal_S23_euk/arc
PANTHERiPTHR11652 PTHR11652, 1 hit
PfamiView protein in Pfam
PF00164 Ribosom_S12_S23, 1 hit
PIRSFiPIRSF002133 Ribosomal_S12/S23, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00982 uS12_E_A, 1 hit
PROSITEiView protein in PROSITE
PS00055 RIBOSOMAL_S12, 1 hit

Sequencei

Sequence statusi: Complete.

P62267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI
60 70 80 90 100
VLEKVGVEAK QPNSAIRKCV RVQLIKNGKK ITAFVPNDGC LNFIEENDEV
110 120 130 140
LVAGFGRKGH AVGDIPGVRF KVVKVANVSL LALYKGKKER PRS
Length:143
Mass (Da):15,808
Last modified:January 23, 2007 - v3
Checksum:i8417A48B8CF0A8E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002573 mRNA Translation: BAB22198.1
AK010594 mRNA Translation: BAB27050.1
AK010608 mRNA Translation: BAB27058.1
AK012438 mRNA Translation: BAB28238.1
AK013720 mRNA Translation: BAB28969.1
AK050580 mRNA Translation: BAC34329.1
AK088085 mRNA Translation: BAC40136.1
AK166994 mRNA Translation: BAE39173.1
AK168587 mRNA Translation: BAE40456.1
BC002145 mRNA Translation: AAH02145.1
BC054435 mRNA Translation: AAH54435.1
BC078418 mRNA Translation: AAH78418.1
CCDSiCCDS26674.1
RefSeqiNP_077137.1, NM_024175.3
UniGeneiMm.306302

Genome annotation databases

EnsembliENSMUST00000051955; ENSMUSP00000054490; ENSMUSG00000049517
GeneIDi66475
KEGGimmu:66475
UCSCiuc007rjq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRS23_MOUSE
AccessioniPrimary (citable) accession number: P62267
Secondary accession number(s): P39028, Q542K7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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