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P62266

- RS23_HUMAN

UniProt

P62266 - RS23_HUMAN

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Protein

40S ribosomal protein S23

Gene
RPS23
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. gene expression Source: Reactome
  3. mRNA metabolic process Source: Reactome
  4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  5. RNA metabolic process Source: Reactome
  6. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  7. translation Source: UniProtKB
  8. translational elongation Source: Reactome
  9. translational initiation Source: Reactome
  10. translational termination Source: Reactome
  11. viral life cycle Source: Reactome
  12. viral process Source: Reactome
  13. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S23
Gene namesi
Name:RPS23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:10410. RPS23.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. cytosolic small ribosomal subunit Source: UniProtKB
  4. nucleolus Source: HPA
  5. ribosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34813.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 14314240S ribosomal protein S23PRO_0000146457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541N6-succinyllysine By similarity
Modified residuei62 – 6213-hydroxyproline2 Publications
Modified residuei135 – 1351N6-acetyllysine1 Publication

Post-translational modificationi

Hydroxylation at Pro-62 affects translation termination efficiency.

Keywords - PTMi

Acetylation, Hydroxylation

Proteomic databases

MaxQBiP62266.
PaxDbiP62266.
PRIDEiP62266.

PTM databases

PhosphoSiteiP62266.

Expressioni

Gene expression databases

ArrayExpressiP62266.
BgeeiP62266.
CleanExiHS_RPS23.
GenevestigatoriP62266.

Organism-specific databases

HPAiHPA054853.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DCCP431462EBI-353072,EBI-1222919
LRRK2Q5S0072EBI-353072,EBI-5323863

Protein-protein interaction databases

BioGridi112142. 129 interactions.
IntActiP62266. 21 interactions.
MINTiMINT-5000369.
STRINGi9606.ENSP00000296674.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Aelectron microscopy5.00X1-143[»]
ProteinModelPortaliP62266.
SMRiP62266. Positions 1-142.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0048.
HOGENOMiHOG000040064.
HOVERGENiHBG054200.
InParanoidiP62266.
KOiK02973.
OMAiWHDKDYK.
OrthoDBiEOG77DJ7H.
PhylomeDBiP62266.
TreeFamiTF300871.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005680. Ribosomal_S23_euk/arc.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00982. S23_S12_E_A. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62266-1 [UniParc]FASTAAdd to Basket

« Hide

MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI    50
VLEKVGVEAK QPNSAIRKCV RVQLIKNGKK ITAFVPNDGC LNFIEENDEV 100
LVAGFGRKGH AVGDIPGVRF KVVKVANVSL LALYKGKKER PRS 143
Length:143
Mass (Da):15,808
Last modified:January 23, 2007 - v3
Checksum:i8417A48B8CF0A8E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14530 mRNA. Translation: BAA03400.1.
CR456996 mRNA. Translation: CAG33277.1.
BC070221 mRNA. Translation: AAH70221.1.
AB007158 Genomic DNA. Translation: BAA25822.1.
CCDSiCCDS47241.1.
PIRiS42105.
RefSeqiNP_001016.1. NM_001025.4.
UniGeneiHs.527193.

Genome annotation databases

EnsembliENST00000296674; ENSP00000296674; ENSG00000186468.
GeneIDi6228.
KEGGihsa:6228.
UCSCiuc003khu.3. human.

Polymorphism databases

DMDMi50403755.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D14530 mRNA. Translation: BAA03400.1 .
CR456996 mRNA. Translation: CAG33277.1 .
BC070221 mRNA. Translation: AAH70221.1 .
AB007158 Genomic DNA. Translation: BAA25822.1 .
CCDSi CCDS47241.1.
PIRi S42105.
RefSeqi NP_001016.1. NM_001025.4.
UniGenei Hs.527193.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3A electron microscopy 5.00 X 1-143 [» ]
ProteinModelPortali P62266.
SMRi P62266. Positions 1-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112142. 129 interactions.
IntActi P62266. 21 interactions.
MINTi MINT-5000369.
STRINGi 9606.ENSP00000296674.

PTM databases

PhosphoSitei P62266.

Polymorphism databases

DMDMi 50403755.

Proteomic databases

MaxQBi P62266.
PaxDbi P62266.
PRIDEi P62266.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296674 ; ENSP00000296674 ; ENSG00000186468 .
GeneIDi 6228.
KEGGi hsa:6228.
UCSCi uc003khu.3. human.

Organism-specific databases

CTDi 6228.
GeneCardsi GC05M081569.
HGNCi HGNC:10410. RPS23.
HPAi HPA054853.
MIMi 603683. gene.
neXtProti NX_P62266.
PharmGKBi PA34813.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0048.
HOGENOMi HOG000040064.
HOVERGENi HBG054200.
InParanoidi P62266.
KOi K02973.
OMAi WHDKDYK.
OrthoDBi EOG77DJ7H.
PhylomeDBi P62266.
TreeFami TF300871.

Enzyme and pathway databases

Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSi RPS23. human.
GeneWikii RPS23.
GenomeRNAii 6228.
NextBioi 24175.
PROi P62266.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62266.
Bgeei P62266.
CleanExi HS_RPS23.
Genevestigatori P62266.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
InterProi IPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005680. Ribosomal_S23_euk/arc.
[Graphical view ]
PANTHERi PTHR11652. PTHR11652. 1 hit.
Pfami PF00164. Ribosom_S12_S23. 1 hit.
[Graphical view ]
PIRSFi PIRSF002133. Ribosomal_S12/S23. 1 hit.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00982. S23_S12_E_A. 1 hit.
PROSITEi PS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A cDNA sequence of human ribosomal protein, homologue of yeast S28."
    Hori N., Murakawa K., Matoba R., Fukushima A., Okubo K., Matsubara K.
    Nucleic Acids Res. 21:4394-4394(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
    Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
    Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-10.
    Tissue: Placenta.
  5. "A map of 75 human ribosomal protein genes."
    Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
    Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 84-142.
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
  9. Cited for: HYDROXYLATION AT PRO-62.
  10. Cited for: HYDROXYLATION AT PRO-62.

Entry informationi

Entry nameiRS23_HUMAN
AccessioniPrimary (citable) accession number: P62266
Secondary accession number(s): P39028, Q6IB08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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