Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein S23

Gene

RPS23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164248-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S23
Gene namesi
Name:RPS23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:10410. RPS23.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: Reactome
  • ribosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi6228.
OpenTargetsiENSG00000186468.
PharmGKBiPA34813.

Polymorphism and mutation databases

BioMutaiRPS23.
DMDMi50403755.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001464572 – 14340S ribosomal protein S23Add BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54N6-succinyllysineBy similarity1
Modified residuei623-hydroxyproline2 Publications1
Modified residuei135N6-acetyllysineCombined sources1

Post-translational modificationi

Hydroxylation at Pro-62 affects translation termination efficiency.2 Publications

Keywords - PTMi

Acetylation, Hydroxylation

Proteomic databases

EPDiP62266.
MaxQBiP62266.
PaxDbiP62266.
PeptideAtlasiP62266.
PRIDEiP62266.
TopDownProteomicsiP62266.

PTM databases

iPTMnetiP62266.
PhosphoSitePlusiP62266.
SwissPalmiP62266.

Expressioni

Gene expression databases

BgeeiENSG00000186468.
CleanExiHS_RPS23.
ExpressionAtlasiP62266. baseline and differential.
GenevisibleiP62266. HS.

Organism-specific databases

HPAiHPA054853.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DCCP431462EBI-353072,EBI-1222919
LRRK2Q5S0072EBI-353072,EBI-5323863

Protein-protein interaction databases

BioGridi112142. 149 interactors.
IntActiP62266. 32 interactors.
MINTiMINT-5000369.
STRINGi9606.ENSP00000296674.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CXGelectron microscopy8.70X1-143[»]
4CXHelectron microscopy8.90X1-143[»]
4UG0electron microscopy-SX1-143[»]
4V6Xelectron microscopy5.00AX1-143[»]
5A2Qelectron microscopy3.90X1-143[»]
5AJ0electron microscopy3.50BX1-143[»]
5FLXelectron microscopy3.90X1-143[»]
ProteinModelPortaliP62266.
SMRiP62266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S12P family.Curated

Phylogenomic databases

eggNOGiKOG1749. Eukaryota.
COG0048. LUCA.
GeneTreeiENSGT00550000074784.
HOGENOMiHOG000040064.
HOVERGENiHBG054200.
InParanoidiP62266.
KOiK02973.
OMAiMPGKKSP.
OrthoDBiEOG091G0R2G.
PhylomeDBiP62266.
TreeFamiTF300871.

Family and domain databases

CDDicd03367. Ribosomal_S23. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005680. Ribosomal_S23_euk/arc.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00982. uS12_E_A. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62266-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI
60 70 80 90 100
VLEKVGVEAK QPNSAIRKCV RVQLIKNGKK ITAFVPNDGC LNFIEENDEV
110 120 130 140
LVAGFGRKGH AVGDIPGVRF KVVKVANVSL LALYKGKKER PRS
Length:143
Mass (Da):15,808
Last modified:January 23, 2007 - v3
Checksum:i8417A48B8CF0A8E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14530 mRNA. Translation: BAA03400.1.
CR456996 mRNA. Translation: CAG33277.1.
BC070221 mRNA. Translation: AAH70221.1.
AB007158 Genomic DNA. Translation: BAA25822.1.
CCDSiCCDS47241.1.
PIRiS42105.
RefSeqiNP_001016.1. NM_001025.4.
UniGeneiHs.527193.

Genome annotation databases

EnsembliENST00000296674; ENSP00000296674; ENSG00000186468.
GeneIDi6228.
KEGGihsa:6228.
UCSCiuc003khu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14530 mRNA. Translation: BAA03400.1.
CR456996 mRNA. Translation: CAG33277.1.
BC070221 mRNA. Translation: AAH70221.1.
AB007158 Genomic DNA. Translation: BAA25822.1.
CCDSiCCDS47241.1.
PIRiS42105.
RefSeqiNP_001016.1. NM_001025.4.
UniGeneiHs.527193.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CXGelectron microscopy8.70X1-143[»]
4CXHelectron microscopy8.90X1-143[»]
4UG0electron microscopy-SX1-143[»]
4V6Xelectron microscopy5.00AX1-143[»]
5A2Qelectron microscopy3.90X1-143[»]
5AJ0electron microscopy3.50BX1-143[»]
5FLXelectron microscopy3.90X1-143[»]
ProteinModelPortaliP62266.
SMRiP62266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112142. 149 interactors.
IntActiP62266. 32 interactors.
MINTiMINT-5000369.
STRINGi9606.ENSP00000296674.

PTM databases

iPTMnetiP62266.
PhosphoSitePlusiP62266.
SwissPalmiP62266.

Polymorphism and mutation databases

BioMutaiRPS23.
DMDMi50403755.

Proteomic databases

EPDiP62266.
MaxQBiP62266.
PaxDbiP62266.
PeptideAtlasiP62266.
PRIDEiP62266.
TopDownProteomicsiP62266.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296674; ENSP00000296674; ENSG00000186468.
GeneIDi6228.
KEGGihsa:6228.
UCSCiuc003khu.4. human.

Organism-specific databases

CTDi6228.
DisGeNETi6228.
GeneCardsiRPS23.
HGNCiHGNC:10410. RPS23.
HPAiHPA054853.
MIMi603683. gene.
neXtProtiNX_P62266.
OpenTargetsiENSG00000186468.
PharmGKBiPA34813.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1749. Eukaryota.
COG0048. LUCA.
GeneTreeiENSGT00550000074784.
HOGENOMiHOG000040064.
HOVERGENiHBG054200.
InParanoidiP62266.
KOiK02973.
OMAiMPGKKSP.
OrthoDBiEOG091G0R2G.
PhylomeDBiP62266.
TreeFamiTF300871.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164248-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPS23. human.
GeneWikiiRPS23.
GenomeRNAii6228.
PROiP62266.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186468.
CleanExiHS_RPS23.
ExpressionAtlasiP62266. baseline and differential.
GenevisibleiP62266. HS.

Family and domain databases

CDDicd03367. Ribosomal_S23. 1 hit.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005680. Ribosomal_S23_euk/arc.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00982. uS12_E_A. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS23_HUMAN
AccessioniPrimary (citable) accession number: P62266
Secondary accession number(s): P39028, Q6IB08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.