P62263 (RS14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S14

Gene names

Name:	RPS14
ORF Names:	PRO2640

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein S11P family.

Ontologies

Keywords
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome erythrocyte differentiation Inferred from mutant phenotype PubMed 18202658. Source: UniProtKB maturation of SSU-rRNA Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 7867928. Source: UniProtKB nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome ribosomal small subunit assembly Inferred from mutant phenotype PubMed 9152021. Source: UniProtKB translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic small ribosomal subunit Inferred from direct assay PubMed 15883184Ref.7PubMed 9152021. Source: UniProtKB mitochondrion Inferred from electronic annotation. Source: Compara nucleolus Inferred from direct assay PubMed 9152021. Source: UniProtKB
Molecular_function	mRNA 5'-UTR binding Inferred from direct assay PubMed 7867928. Source: UniProtKB structural constituent of ribosome Inferred from electronic annotation. Source: InterPro translation regulator activity Inferred from mutant phenotype PubMed 3683397. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MAGEB2	O15479	1	EBI-352783,EBI-1057615
RIPK2	O43353	1	EBI-352783,EBI-358522
TRIP6	Q15654	1	EBI-352783,EBI-742327

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.7
	Chain	2 – 151	150	40S ribosomal protein S14 HAMAP-Rule MF_01310		PRO_0000123337
Amino acid modifications
	Modified residue	133	1	Phosphothreonine Ref.10

Sequences

	Sequence		Length	Mass (Da)
	P62263 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 4F4387F9FADAC278	FASTA	151	16,273
	10 20 30 40 50 60 MAPRKGKEKK EEQVISLGPQ VAEGENVFGV CHIFASFNDT FVHVTDLSGK ETICRVTGGM 70 80 90 100 110 120 KVKADRDESS PYAAMLAAQD VAQRCKELGI TALHIKLRAT GGNRTKTPGP GAQSALRALA 130 140 150 RSGMKIGRIE DVTPIPSDST RRKGGRRGRR L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homologous ribosomal proteins in bacteria, yeast, and humans." Chen I.-T., Dixit A., Rhoads D.D., Roufa D.J. Proc. Natl. Acad. Sci. U.S.A. 83:6907-6911(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Primary structure of human ribosomal protein S14 and the gene that encodes it." Rhoads D.D., Dixit A., Roufa D.J. Mol. Cell. Biol. 6:2774-2783(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver." Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., Liu M., He F. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Fetal liver.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary, Placenta and Skin.
[7]	"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-15. Tissue: Placenta.
[8]	"Fine-structure map of the human ribosomal protein gene RPS14." Diaz J.-J., Roufa D.J. Mol. Cell. Biol. 12:1680-1686(1992) [PubMed] [Europe PMC] [Abstract] Cited for: MUTAGENESIS.
[9]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Platelet.
[10]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-133, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[12]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M13934 Genomic DNA. Translation: AAB59505.1. AF116710 mRNA. Translation: AAF71130.1. AK312179 mRNA. Translation: BAG35112.1. CH471062 Genomic DNA. Translation: EAW61723.1. CH471062 Genomic DNA. Translation: EAW61724.1. CH471062 Genomic DNA. Translation: EAW61725.1. CH471062 Genomic DNA. Translation: EAW61726.1. BC001126 mRNA. Translation: AAH01126.1. BC003401 mRNA. Translation: AAH03401.1. BC006784 mRNA. Translation: AAH06784.1. BC020515 mRNA. Translation: AAH20515.1. BC091474 mRNA. Translation: AAH91474.1.
IPI	IPI00026271.
PIR	A25220.
RefSeq	NP_001020241.1. NM_001025070.1. NP_001020242.1. NM_001025071.1. NP_005608.1. NM_005617.3.
UniGene	Hs.381126.
3D structure databases
ProteinModelPortal	P62263.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62263. 14 interactions.
MINT	MINT-4999998.
STRING	9606.ENSP00000311028.
PTM databases
PhosphoSite	P62263.
Polymorphism databases
DMDM	50403752.
2D gel databases
SWISS-2DPAGE	P62263.
Proteomic databases
PaxDb	P62263.
PeptideAtlas	P62263.
PRIDE	P62263.
Protocols and materials databases
DNASU	6208.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312037; ENSP00000311028; ENSG00000164587. ENST00000401695; ENSP00000385958; ENSG00000164587. ENST00000407193; ENSP00000385425; ENSG00000164587. ENST00000521466; ENSP00000428509; ENSG00000164587.
GeneID	6208.
KEGG	hsa:6208.
UCSC	uc003lsh.3. human.
Organism-specific databases
CTD	6208.
GeneCards	GC05M149803.
HGNC	HGNC:10387. RPS14.
HPA	HPA018504.
MIM	130620. gene.
neXtProt	NX_P62263.
Orphanet	86841. Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality.
PharmGKB	PA34786.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0100.
HOGENOM	HOG000111598.
HOVERGEN	HBG053098.
InParanoid	P62263.
KO	K02955.
OMA	GGNGTKT.
OrthoDB	EOG4ZPDWM.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P62263.
Bgee	P62263.
CleanEx	HS_RPS14.
Genevestigator	P62263.
GermOnline	ENSG00000164587. Homo sapiens.
Family and domain databases
Gene3D	3.30.420.80. 1 hit.
HAMAP	MF_01310. Ribosomal_S11.
InterPro	IPR001971. Ribosomal_S11. IPR018102. Ribosomal_S11_CS. [Graphical view]
PANTHER	PTHR11759. PTHR11759. 1 hit.
Pfam	PF00411. Ribosomal_S11. 1 hit. [Graphical view]
PIRSF	PIRSF002131. Ribosomal_S11. 1 hit.
PROSITE	PS00054. RIBOSOMAL_S11. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RPS14. human.
GenomeRNAi	6208.
NextBio	24111.
SOURCE	Search...

Entry information

Entry name

RS14_HUMAN

Accession

Primary (citable) accession number: P62263
Secondary accession number(s): B2R5G5 , D3DQG5, P06366, Q5BJI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 98 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.