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Protein

40S ribosomal protein S14

Gene

RPS14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • mRNA 5'-UTR binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • small ribosomal subunit rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: GO_Central
  • translation regulator activity Source: UniProtKB

GO - Biological processi

  • erythrocyte differentiation Source: UniProtKB
  • maturation of SSU-rRNA Source: UniProtKB
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • ribosomal small subunit assembly Source: UniProtKB
  • rRNA processing Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Protein family/group databases

MoonProtiP62263.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S14
Gene namesi
Name:RPS14
ORF Names:PRO2640
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:10387. RPS14.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • focal adhesion Source: UniProtKB
  • membrane Source: UniProtKB
  • mitochondrion Source: Ensembl
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

MalaCardsiRPS14.
Orphaneti86841. Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality.
PharmGKBiPA34786.

Polymorphism and mutation databases

BioMutaiRPS14.
DMDMi50403752.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 15115040S ribosomal protein S14PRO_0000123337Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161PhosphoserineCombined sources
Modified residuei133 – 1331PhosphothreonineCombined sources
Modified residuei139 – 1391PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP62263.
MaxQBiP62263.
PaxDbiP62263.
PeptideAtlasiP62263.
PRIDEiP62263.
TopDownProteomicsiP62263.

2D gel databases

SWISS-2DPAGEP62263.

PTM databases

iPTMnetiP62263.
PhosphoSiteiP62263.
SwissPalmiP62263.

Expressioni

Gene expression databases

BgeeiENSG00000164587.
CleanExiHS_RPS14.
ExpressionAtlasiP62263. baseline and differential.
GenevisibleiP62263. HS.

Organism-specific databases

HPAiHPA018504.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AK6Q9Y3D83EBI-352783,EBI-2896123

Protein-protein interaction databases

BioGridi112122. 239 interactions.
IntActiP62263. 46 interactions.
MINTiMINT-4999998.
STRINGi9606.ENSP00000311028.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SO1-151[»]
4V6Xelectron microscopy5.00AO1-151[»]
5A2Qelectron microscopy3.90O1-151[»]
5AJ0electron microscopy3.50BO1-151[»]
5FLXelectron microscopy3.90O1-151[»]
ProteinModelPortaliP62263.
SMRiP62263. Positions 16-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S11P family.Curated

Phylogenomic databases

eggNOGiKOG0407. Eukaryota.
COG0100. LUCA.
GeneTreeiENSGT00390000000703.
HOGENOMiHOG000111598.
HOVERGENiHBG053098.
InParanoidiP62263.
KOiK02955.
OMAiKWGVAHI.
OrthoDBiEOG091G0WO6.
PhylomeDBiP62263.
TreeFamiTF300125.

Family and domain databases

Gene3Di3.30.420.80. 1 hit.
HAMAPiMF_01310. Ribosomal_S11. 1 hit.
InterProiIPR001971. Ribosomal_S11.
IPR018102. Ribosomal_S11_CS.
[Graphical view]
PANTHERiPTHR11759. PTHR11759. 1 hit.
PfamiPF00411. Ribosomal_S11. 1 hit.
[Graphical view]
PIRSFiPIRSF002131. Ribosomal_S11. 1 hit.
PROSITEiPS00054. RIBOSOMAL_S11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRKGKEKK EEQVISLGPQ VAEGENVFGV CHIFASFNDT FVHVTDLSGK
60 70 80 90 100
ETICRVTGGM KVKADRDESS PYAAMLAAQD VAQRCKELGI TALHIKLRAT
110 120 130 140 150
GGNRTKTPGP GAQSALRALA RSGMKIGRIE DVTPIPSDST RRKGGRRGRR

L
Length:151
Mass (Da):16,273
Last modified:January 23, 2007 - v3
Checksum:i4F4387F9FADAC278
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13934 Genomic DNA. Translation: AAB59505.1.
AF116710 mRNA. Translation: AAF71130.1.
AK312179 mRNA. Translation: BAG35112.1.
CH471062 Genomic DNA. Translation: EAW61723.1.
CH471062 Genomic DNA. Translation: EAW61724.1.
CH471062 Genomic DNA. Translation: EAW61725.1.
CH471062 Genomic DNA. Translation: EAW61726.1.
BC001126 mRNA. Translation: AAH01126.1.
BC003401 mRNA. Translation: AAH03401.1.
BC006784 mRNA. Translation: AAH06784.1.
BC020515 mRNA. Translation: AAH20515.1.
BC091474 mRNA. Translation: AAH91474.1.
CCDSiCCDS4307.1.
PIRiA25220.
RefSeqiNP_001020241.1. NM_001025070.1.
NP_001020242.1. NM_001025071.1.
NP_005608.1. NM_005617.3.
UniGeneiHs.744846.

Genome annotation databases

EnsembliENST00000312037; ENSP00000311028; ENSG00000164587.
ENST00000401695; ENSP00000385958; ENSG00000164587.
ENST00000407193; ENSP00000385425; ENSG00000164587.
ENST00000521466; ENSP00000428509; ENSG00000164587.
GeneIDi6208.
KEGGihsa:6208.
UCSCiuc003lsh.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13934 Genomic DNA. Translation: AAB59505.1.
AF116710 mRNA. Translation: AAF71130.1.
AK312179 mRNA. Translation: BAG35112.1.
CH471062 Genomic DNA. Translation: EAW61723.1.
CH471062 Genomic DNA. Translation: EAW61724.1.
CH471062 Genomic DNA. Translation: EAW61725.1.
CH471062 Genomic DNA. Translation: EAW61726.1.
BC001126 mRNA. Translation: AAH01126.1.
BC003401 mRNA. Translation: AAH03401.1.
BC006784 mRNA. Translation: AAH06784.1.
BC020515 mRNA. Translation: AAH20515.1.
BC091474 mRNA. Translation: AAH91474.1.
CCDSiCCDS4307.1.
PIRiA25220.
RefSeqiNP_001020241.1. NM_001025070.1.
NP_001020242.1. NM_001025071.1.
NP_005608.1. NM_005617.3.
UniGeneiHs.744846.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SO1-151[»]
4V6Xelectron microscopy5.00AO1-151[»]
5A2Qelectron microscopy3.90O1-151[»]
5AJ0electron microscopy3.50BO1-151[»]
5FLXelectron microscopy3.90O1-151[»]
ProteinModelPortaliP62263.
SMRiP62263. Positions 16-140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112122. 239 interactions.
IntActiP62263. 46 interactions.
MINTiMINT-4999998.
STRINGi9606.ENSP00000311028.

Protein family/group databases

MoonProtiP62263.

PTM databases

iPTMnetiP62263.
PhosphoSiteiP62263.
SwissPalmiP62263.

Polymorphism and mutation databases

BioMutaiRPS14.
DMDMi50403752.

2D gel databases

SWISS-2DPAGEP62263.

Proteomic databases

EPDiP62263.
MaxQBiP62263.
PaxDbiP62263.
PeptideAtlasiP62263.
PRIDEiP62263.
TopDownProteomicsiP62263.

Protocols and materials databases

DNASUi6208.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312037; ENSP00000311028; ENSG00000164587.
ENST00000401695; ENSP00000385958; ENSG00000164587.
ENST00000407193; ENSP00000385425; ENSG00000164587.
ENST00000521466; ENSP00000428509; ENSG00000164587.
GeneIDi6208.
KEGGihsa:6208.
UCSCiuc003lsh.4. human.

Organism-specific databases

CTDi6208.
GeneCardsiRPS14.
HGNCiHGNC:10387. RPS14.
HPAiHPA018504.
MalaCardsiRPS14.
MIMi130620. gene.
neXtProtiNX_P62263.
Orphaneti86841. Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality.
PharmGKBiPA34786.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0407. Eukaryota.
COG0100. LUCA.
GeneTreeiENSGT00390000000703.
HOGENOMiHOG000111598.
HOVERGENiHBG053098.
InParanoidiP62263.
KOiK02955.
OMAiKWGVAHI.
OrthoDBiEOG091G0WO6.
PhylomeDBiP62263.
TreeFamiTF300125.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPS14. human.
GeneWikiiRPS14.
GenomeRNAii6208.
PROiP62263.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164587.
CleanExiHS_RPS14.
ExpressionAtlasiP62263. baseline and differential.
GenevisibleiP62263. HS.

Family and domain databases

Gene3Di3.30.420.80. 1 hit.
HAMAPiMF_01310. Ribosomal_S11. 1 hit.
InterProiIPR001971. Ribosomal_S11.
IPR018102. Ribosomal_S11_CS.
[Graphical view]
PANTHERiPTHR11759. PTHR11759. 1 hit.
PfamiPF00411. Ribosomal_S11. 1 hit.
[Graphical view]
PIRSFiPIRSF002131. Ribosomal_S11. 1 hit.
PROSITEiPS00054. RIBOSOMAL_S11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS14_HUMAN
AccessioniPrimary (citable) accession number: P62263
Secondary accession number(s): B2R5G5
, D3DQG5, P06366, Q5BJI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.