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Protein

40S ribosomal protein S14

Gene

RPS14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • mRNA 5'-UTR binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • small ribosomal subunit rRNA binding Source: GO_Central
  • structural constituent of ribosome Source: GO_Central
  • translation regulator activity Source: UniProtKB

GO - Biological processi

  • erythrocyte differentiation Source: UniProtKB
  • maturation of SSU-rRNA Source: UniProtKB
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • ribosomal small subunit assembly Source: UniProtKB
  • rRNA processing Source: Reactome
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Protein family/group databases

MoonProtiP62263

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S14
Alternative name(s):
Small ribosomal subunit protein uS111 Publication
Gene namesi
Name:RPS14
ORF Names:PRO2640
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164587.11
HGNCiHGNC:10387 RPS14
MIMi130620 gene
neXtProtiNX_P62263

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6208
MalaCardsiRPS14
OpenTargetsiENSG00000164587
Orphaneti86841 Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality
PharmGKBiPA34786

Polymorphism and mutation databases

BioMutaiRPS14
DMDMi50403752

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001233372 – 15140S ribosomal protein S14Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki63Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki106Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei133PhosphothreonineCombined sources1
Modified residuei139PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62263
MaxQBiP62263
PaxDbiP62263
PeptideAtlasiP62263
PRIDEiP62263
ProteomicsDBi57379
TopDownProteomicsiP62263

2D gel databases

SWISS-2DPAGEiP62263

PTM databases

iPTMnetiP62263
PhosphoSitePlusiP62263
SwissPalmiP62263

Expressioni

Gene expression databases

BgeeiENSG00000164587
CleanExiHS_RPS14
ExpressionAtlasiP62263 baseline and differential
GenevisibleiP62263 HS

Organism-specific databases

HPAiHPA018504

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112122, 254 interactors
CORUMiP62263
IntActiP62263, 53 interactors
MINTiP62263
STRINGi9606.ENSP00000311028

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SO1-151[»]
4V6Xelectron microscopy5.00AO1-151[»]
5A2Qelectron microscopy3.90O1-151[»]
5AJ0electron microscopy3.50BO1-151[»]
5FLXelectron microscopy3.90O1-151[»]
5LKSelectron microscopy3.60SO1-151[»]
5OA3electron microscopy4.30O1-151[»]
5T2Celectron microscopy3.60AO1-151[»]
5VYCX-ray6.00O1/O2/O3/O4/O5/O61-151[»]
6EK0electron microscopy2.90SO1-151[»]
6FECelectron microscopy6.30j16-151[»]
ProteinModelPortaliP62263
SMRiP62263
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0407 Eukaryota
COG0100 LUCA
GeneTreeiENSGT00390000000703
HOGENOMiHOG000111598
HOVERGENiHBG053098
InParanoidiP62263
KOiK02955
OMAiKVYVKGP
OrthoDBiEOG091G0WO6
PhylomeDBiP62263
TreeFamiTF300125

Family and domain databases

Gene3Di3.30.420.80, 1 hit
HAMAPiMF_01310 Ribosomal_S11, 1 hit
InterProiView protein in InterPro
IPR001971 Ribosomal_S11
IPR018102 Ribosomal_S11_CS
IPR036967 Ribosomal_S11_sf
PANTHERiPTHR11759 PTHR11759, 1 hit
PfamiView protein in Pfam
PF00411 Ribosomal_S11, 1 hit
PIRSFiPIRSF002131 Ribosomal_S11, 1 hit
PROSITEiView protein in PROSITE
PS00054 RIBOSOMAL_S11, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRKGKEKK EEQVISLGPQ VAEGENVFGV CHIFASFNDT FVHVTDLSGK
60 70 80 90 100
ETICRVTGGM KVKADRDESS PYAAMLAAQD VAQRCKELGI TALHIKLRAT
110 120 130 140 150
GGNRTKTPGP GAQSALRALA RSGMKIGRIE DVTPIPSDST RRKGGRRGRR

L
Length:151
Mass (Da):16,273
Last modified:January 23, 2007 - v3
Checksum:i4F4387F9FADAC278
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13934 Genomic DNA Translation: AAB59505.1
AF116710 mRNA Translation: AAF71130.1
AK312179 mRNA Translation: BAG35112.1
CH471062 Genomic DNA Translation: EAW61723.1
CH471062 Genomic DNA Translation: EAW61724.1
CH471062 Genomic DNA Translation: EAW61725.1
CH471062 Genomic DNA Translation: EAW61726.1
BC001126 mRNA Translation: AAH01126.1
BC003401 mRNA Translation: AAH03401.1
BC006784 mRNA Translation: AAH06784.1
BC020515 mRNA Translation: AAH20515.1
BC091474 mRNA Translation: AAH91474.1
CCDSiCCDS4307.1
PIRiA25220
RefSeqiNP_001020241.1, NM_001025070.1
NP_001020242.1, NM_001025071.1
NP_005608.1, NM_005617.3
UniGeneiHs.744846

Genome annotation databases

EnsembliENST00000312037; ENSP00000311028; ENSG00000164587
ENST00000401695; ENSP00000385958; ENSG00000164587
ENST00000407193; ENSP00000385425; ENSG00000164587
ENST00000521466; ENSP00000428509; ENSG00000164587
GeneIDi6208
KEGGihsa:6208
UCSCiuc003lsh.4 human

Similar proteinsi

Entry informationi

Entry nameiRS14_HUMAN
AccessioniPrimary (citable) accession number: P62263
Secondary accession number(s): B2R5G5
, D3DQG5, P06366, Q5BJI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 151 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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