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P62263

- RS14_HUMAN

UniProt

P62263 - RS14_HUMAN

Protein

40S ribosomal protein S14

Gene

RPS14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. mRNA 5'-UTR binding Source: UniProtKB
    2. poly(A) RNA binding Source: UniProtKB
    3. RNA binding Source: UniProtKB
    4. structural constituent of ribosome Source: InterPro
    5. translation regulator activity Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. erythrocyte differentiation Source: UniProtKB
    3. gene expression Source: Reactome
    4. maturation of SSU-rRNA Source: UniProtKB
    5. mRNA metabolic process Source: Reactome
    6. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    7. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    8. regulation of translation Source: GOC
    9. ribosomal small subunit assembly Source: UniProtKB
    10. RNA metabolic process Source: Reactome
    11. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    12. translation Source: UniProtKB
    13. translational elongation Source: Reactome
    14. translational initiation Source: Reactome
    15. translational termination Source: Reactome
    16. viral life cycle Source: Reactome
    17. viral process Source: Reactome
    18. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S14
    Gene namesi
    Name:RPS14
    ORF Names:PRO2640
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:10387. RPS14.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. cytosolic small ribosomal subunit Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. membrane Source: UniProtKB
    5. mitochondrion Source: Ensembl
    6. nucleolus Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti86841. Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality.
    PharmGKBiPA34786.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 15115040S ribosomal protein S14PRO_0000123337Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei133 – 1331Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP62263.
    PaxDbiP62263.
    PeptideAtlasiP62263.
    PRIDEiP62263.

    2D gel databases

    SWISS-2DPAGEP62263.

    PTM databases

    PhosphoSiteiP62263.

    Expressioni

    Gene expression databases

    ArrayExpressiP62263.
    BgeeiP62263.
    CleanExiHS_RPS14.
    GenevestigatoriP62263.

    Organism-specific databases

    HPAiHPA018504.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAGEB2O154791EBI-352783,EBI-1057615
    RIPK2O433531EBI-352783,EBI-358522
    TRIP6Q156541EBI-352783,EBI-742327

    Protein-protein interaction databases

    BioGridi112122. 117 interactions.
    IntActiP62263. 26 interactions.
    MINTiMINT-4999998.
    STRINGi9606.ENSP00000311028.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Aelectron microscopy5.00O1-151[»]
    ProteinModelPortaliP62263.
    SMRiP62263. Positions 16-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S11P family.Curated

    Phylogenomic databases

    eggNOGiCOG0100.
    HOGENOMiHOG000111598.
    HOVERGENiHBG053098.
    InParanoidiP62263.
    KOiK02955.
    OMAiLHVKIRA.
    OrthoDBiEOG77DJ81.
    PhylomeDBiP62263.
    TreeFamiTF300125.

    Family and domain databases

    Gene3Di3.30.420.80. 1 hit.
    HAMAPiMF_01310. Ribosomal_S11.
    InterProiIPR001971. Ribosomal_S11.
    IPR018102. Ribosomal_S11_CS.
    [Graphical view]
    PANTHERiPTHR11759. PTHR11759. 1 hit.
    PfamiPF00411. Ribosomal_S11. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002131. Ribosomal_S11. 1 hit.
    PROSITEiPS00054. RIBOSOMAL_S11. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62263-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPRKGKEKK EEQVISLGPQ VAEGENVFGV CHIFASFNDT FVHVTDLSGK    50
    ETICRVTGGM KVKADRDESS PYAAMLAAQD VAQRCKELGI TALHIKLRAT 100
    GGNRTKTPGP GAQSALRALA RSGMKIGRIE DVTPIPSDST RRKGGRRGRR 150
    L 151
    Length:151
    Mass (Da):16,273
    Last modified:January 23, 2007 - v3
    Checksum:i4F4387F9FADAC278
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13934 Genomic DNA. Translation: AAB59505.1.
    AF116710 mRNA. Translation: AAF71130.1.
    AK312179 mRNA. Translation: BAG35112.1.
    CH471062 Genomic DNA. Translation: EAW61723.1.
    CH471062 Genomic DNA. Translation: EAW61724.1.
    CH471062 Genomic DNA. Translation: EAW61725.1.
    CH471062 Genomic DNA. Translation: EAW61726.1.
    BC001126 mRNA. Translation: AAH01126.1.
    BC003401 mRNA. Translation: AAH03401.1.
    BC006784 mRNA. Translation: AAH06784.1.
    BC020515 mRNA. Translation: AAH20515.1.
    BC091474 mRNA. Translation: AAH91474.1.
    CCDSiCCDS4307.1.
    PIRiA25220.
    RefSeqiNP_001020241.1. NM_001025070.1.
    NP_001020242.1. NM_001025071.1.
    NP_005608.1. NM_005617.3.
    UniGeneiHs.744846.

    Genome annotation databases

    EnsembliENST00000312037; ENSP00000311028; ENSG00000164587.
    ENST00000401695; ENSP00000385958; ENSG00000164587.
    ENST00000407193; ENSP00000385425; ENSG00000164587.
    ENST00000521466; ENSP00000428509; ENSG00000164587.
    GeneIDi6208.
    KEGGihsa:6208.
    UCSCiuc003lsh.3. human.

    Polymorphism databases

    DMDMi50403752.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13934 Genomic DNA. Translation: AAB59505.1 .
    AF116710 mRNA. Translation: AAF71130.1 .
    AK312179 mRNA. Translation: BAG35112.1 .
    CH471062 Genomic DNA. Translation: EAW61723.1 .
    CH471062 Genomic DNA. Translation: EAW61724.1 .
    CH471062 Genomic DNA. Translation: EAW61725.1 .
    CH471062 Genomic DNA. Translation: EAW61726.1 .
    BC001126 mRNA. Translation: AAH01126.1 .
    BC003401 mRNA. Translation: AAH03401.1 .
    BC006784 mRNA. Translation: AAH06784.1 .
    BC020515 mRNA. Translation: AAH20515.1 .
    BC091474 mRNA. Translation: AAH91474.1 .
    CCDSi CCDS4307.1.
    PIRi A25220.
    RefSeqi NP_001020241.1. NM_001025070.1.
    NP_001020242.1. NM_001025071.1.
    NP_005608.1. NM_005617.3.
    UniGenei Hs.744846.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3A electron microscopy 5.00 O 1-151 [» ]
    ProteinModelPortali P62263.
    SMRi P62263. Positions 16-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112122. 117 interactions.
    IntActi P62263. 26 interactions.
    MINTi MINT-4999998.
    STRINGi 9606.ENSP00000311028.

    PTM databases

    PhosphoSitei P62263.

    Polymorphism databases

    DMDMi 50403752.

    2D gel databases

    SWISS-2DPAGE P62263.

    Proteomic databases

    MaxQBi P62263.
    PaxDbi P62263.
    PeptideAtlasi P62263.
    PRIDEi P62263.

    Protocols and materials databases

    DNASUi 6208.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312037 ; ENSP00000311028 ; ENSG00000164587 .
    ENST00000401695 ; ENSP00000385958 ; ENSG00000164587 .
    ENST00000407193 ; ENSP00000385425 ; ENSG00000164587 .
    ENST00000521466 ; ENSP00000428509 ; ENSG00000164587 .
    GeneIDi 6208.
    KEGGi hsa:6208.
    UCSCi uc003lsh.3. human.

    Organism-specific databases

    CTDi 6208.
    GeneCardsi GC05M149803.
    HGNCi HGNC:10387. RPS14.
    HPAi HPA018504.
    MIMi 130620. gene.
    neXtProti NX_P62263.
    Orphaneti 86841. Myelodysplastic syndrome associated with isolated del(5q) chromosome abnormality.
    PharmGKBi PA34786.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0100.
    HOGENOMi HOG000111598.
    HOVERGENi HBG053098.
    InParanoidi P62263.
    KOi K02955.
    OMAi LHVKIRA.
    OrthoDBi EOG77DJ81.
    PhylomeDBi P62263.
    TreeFami TF300125.

    Enzyme and pathway databases

    Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPS14. human.
    GeneWikii RPS14.
    GenomeRNAii 6208.
    NextBioi 24111.
    PROi P62263.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62263.
    Bgeei P62263.
    CleanExi HS_RPS14.
    Genevestigatori P62263.

    Family and domain databases

    Gene3Di 3.30.420.80. 1 hit.
    HAMAPi MF_01310. Ribosomal_S11.
    InterProi IPR001971. Ribosomal_S11.
    IPR018102. Ribosomal_S11_CS.
    [Graphical view ]
    PANTHERi PTHR11759. PTHR11759. 1 hit.
    Pfami PF00411. Ribosomal_S11. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002131. Ribosomal_S11. 1 hit.
    PROSITEi PS00054. RIBOSOMAL_S11. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homologous ribosomal proteins in bacteria, yeast, and humans."
      Chen I.-T., Dixit A., Rhoads D.D., Roufa D.J.
      Proc. Natl. Acad. Sci. U.S.A. 83:6907-6911(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Primary structure of human ribosomal protein S14 and the gene that encodes it."
      Rhoads D.D., Dixit A., Roufa D.J.
      Mol. Cell. Biol. 6:2774-2783(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver."
      Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., Liu M., He F.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal liver.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary, Placenta and Skin.
    7. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
      Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
      Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-15.
      Tissue: Placenta.
    8. "Fine-structure map of the human ribosomal protein gene RPS14."
      Diaz J.-J., Roufa D.J.
      Mol. Cell. Biol. 12:1680-1686(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRS14_HUMAN
    AccessioniPrimary (citable) accession number: P62263
    Secondary accession number(s): B2R5G5
    , D3DQG5, P06366, Q5BJI0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3