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Protein

14-3-3 protein epsilon

Gene

YWHAE

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-111447. Activation of BAD and translocation to mitochondria.
R-BTA-1445148. Translocation of GLUT4 to the plasma membrane.
R-BTA-2028269. Signaling by Hippo.
R-BTA-205025. NADE modulates death signalling.
R-BTA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-BTA-3371453. Regulation of HSF1-mediated heat shock response.
R-BTA-3371511. HSF1 activation.
R-BTA-380259. Loss of Nlp from mitotic centrosomes.
R-BTA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-BTA-5620912. Anchoring of the basal body to the plasma membrane.
R-BTA-5625740. RHO GTPases activate PKNs.
R-BTA-5628897. TP53 Regulates Metabolic Genes.
R-BTA-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein epsilon
Short name:
14-3-3E
Gene namesi
Name:YWHAE
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 25525514-3-3 protein epsilonPRO_0000058617Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei50 – 501N6-acetyllysineBy similarity
Modified residuei65 – 651PhosphoserineBy similarity
Modified residuei69 – 691N6-acetyllysineBy similarity
Modified residuei118 – 1181N6-acetyllysineBy similarity
Modified residuei123 – 1231N6-acetyllysineBy similarity
Modified residuei131 – 1311PhosphotyrosineBy similarity
Modified residuei137 – 1371PhosphothreonineBy similarity
Modified residuei210 – 2101PhosphoserineBy similarity
Modified residuei232 – 2321PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP62261.
PRIDEiP62261.

Interactioni

Subunit structurei

Homodimer. Heterodimerizes with YWHAZ. Interacts with NDEL1, ARHGEF28 and TIAM2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with phosphorylated GRB10. Interacts with PKA-phosphorylated AANAT. Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with KSR1. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with DENND1A (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei57 – 571Interaction with phosphoserine on interacting proteinBy similarity
Sitei130 – 1301Interaction with phosphoserine on interacting proteinBy similarity

Protein-protein interaction databases

BioGridi159403. 1 interaction.
STRINGi9913.ENSBTAP00000007442.

Structurei

3D structure databases

ProteinModelPortaliP62261.
SMRiP62261. Positions 3-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.
InParanoidiP62261.
KOiK06630.
OMAiMQESDKP.
OrthoDBiEOG7HHWT3.
TreeFamiTF102003.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62261-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK
60 70 80 90 100
NVIGARRASW RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI
110 120 130 140 150
LDVLDKHLIP AANTGESKVF YYKMKGDYHR YLAEFATGND RKEAAENSLV
160 170 180 190 200
AYKAASDIAM TELPPTHPIR LGLALNFSVF YYEILNSPDR ACRLAKAAFD
210 220 230 240 250
DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE EQNKEALQDV

EDENQ
Length:255
Mass (Da):29,174
Last modified:July 5, 2004 - v1
Checksum:i07817CCBD1F75B26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043735 mRNA. Translation: AAC61927.1.
BC102928 mRNA. Translation: AAI02929.1.
RefSeqiNP_776916.1. NM_174491.3.
UniGeneiBt.4035.

Genome annotation databases

EnsembliENSBTAT00000007442; ENSBTAP00000007442; ENSBTAG00000005664.
GeneIDi282125.
KEGGibta:282125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043735 mRNA. Translation: AAC61927.1.
BC102928 mRNA. Translation: AAI02929.1.
RefSeqiNP_776916.1. NM_174491.3.
UniGeneiBt.4035.

3D structure databases

ProteinModelPortaliP62261.
SMRiP62261. Positions 3-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi159403. 1 interaction.
STRINGi9913.ENSBTAP00000007442.

Proteomic databases

PaxDbiP62261.
PRIDEiP62261.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007442; ENSBTAP00000007442; ENSBTAG00000005664.
GeneIDi282125.
KEGGibta:282125.

Organism-specific databases

CTDi7531.

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.
InParanoidiP62261.
KOiK06630.
OMAiMQESDKP.
OrthoDBiEOG7HHWT3.
TreeFamiTF102003.

Enzyme and pathway databases

ReactomeiR-BTA-111447. Activation of BAD and translocation to mitochondria.
R-BTA-1445148. Translocation of GLUT4 to the plasma membrane.
R-BTA-2028269. Signaling by Hippo.
R-BTA-205025. NADE modulates death signalling.
R-BTA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-BTA-3371453. Regulation of HSF1-mediated heat shock response.
R-BTA-3371511. HSF1 activation.
R-BTA-380259. Loss of Nlp from mitotic centrosomes.
R-BTA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-BTA-5620912. Anchoring of the basal body to the plasma membrane.
R-BTA-5625740. RHO GTPases activate PKNs.
R-BTA-5628897. TP53 Regulates Metabolic Genes.
R-BTA-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.

Miscellaneous databases

NextBioi20805962.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of 14-3-3 proteins in bovine retinal photoreceptors."
    Jones J.M., Niikura T., Pinke R.M., Guo W., Molday L., Leykam J., McConnell D.G.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.
  3. "Activation of protein kinase C by purified bovine brain 14-3-3: comparison with tyrosine hydroxylase activation."
    Tanji M., Horwitz R., Rosenfeld G., Waymire J.C.
    J. Neurochem. 63:1908-1916(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry namei1433E_BOVIN
AccessioniPrimary (citable) accession number: P62261
Secondary accession number(s): P29360
, P42655, Q3ZC40, Q63631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.