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P62257

- UBE2H_MOUSE

UniProt

P62257 - UBE2H_MOUSE

Protein

Ubiquitin-conjugating enzyme E2 H

Gene

Ube2h

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A By similarity.By similarity

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei87 – 871Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. ubiquitin-protein transferase activity Source: UniProtKB

    GO - Biological processi

    1. protein K11-linked ubiquitination Source: UniProtKB
    2. protein K48-linked ubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 H (EC:6.3.2.19)
    Alternative name(s):
    UBCH2
    Ubiquitin carrier protein H
    Ubiquitin-conjugating enzyme E2-20K
    Ubiquitin-protein ligase H
    Gene namesi
    Name:Ube2h
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:104632. Ube2h.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183Ubiquitin-conjugating enzyme E2 HPRO_0000082487Add
    BLAST

    Proteomic databases

    MaxQBiP62257.
    PaxDbiP62257.
    PRIDEiP62257.

    PTM databases

    PhosphoSiteiP62257.

    Expressioni

    Gene expression databases

    ArrayExpressiP62257.
    BgeeiP62257.
    CleanExiMM_UBE2H.
    GenevestigatoriP62257.

    Interactioni

    Protein-protein interaction databases

    BioGridi204417. 1 interaction.
    STRINGi10090.ENSMUSP00000100058.

    Structurei

    3D structure databases

    ProteinModelPortaliP62257.
    SMRiP62257. Positions 4-155.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    HOGENOMiHOG000233452.
    HOVERGENiHBG063308.
    InParanoidiP62257.
    KOiK10576.
    OMAiCIESKHE.
    OrthoDBiEOG7Z3F66.
    PhylomeDBiP62257.
    TreeFamiTF101121.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62257-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPSPGKRR MDTDVVKLIE SKHEVTILGG LNEFVVKFYG PQGTPYEGGV    50
    WKVRVDLPDK YPFKSPSIGF MNKIFHPNID EASGTVCLDV INQTWTALYD 100
    LTNIFESFLP QLLAYPNPID PLNGDAAAMY LHRPEEYKQK IKEYIQKYAT 150
    EEALKEQEEG TGDSSSESSM SDFSEDEAQD MEL 183
    Length:183
    Mass (Da):20,655
    Last modified:July 5, 2004 - v1
    Checksum:i3DD5D365945F708C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19854 mRNA. Translation: AAA91975.1.
    BC008517 mRNA. Translation: AAH08517.1.
    CCDSiCCDS19969.1.
    PIRiJC4308.
    RefSeqiNP_033485.1. NM_009459.3.
    UniGeneiMm.332967.
    Mm.391754.

    Genome annotation databases

    EnsembliENSMUST00000102993; ENSMUSP00000100058; ENSMUSG00000039159.
    GeneIDi22214.
    KEGGimmu:22214.
    UCSCiuc009bey.3. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19854 mRNA. Translation: AAA91975.1 .
    BC008517 mRNA. Translation: AAH08517.1 .
    CCDSi CCDS19969.1.
    PIRi JC4308.
    RefSeqi NP_033485.1. NM_009459.3.
    UniGenei Mm.332967.
    Mm.391754.

    3D structure databases

    ProteinModelPortali P62257.
    SMRi P62257. Positions 4-155.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204417. 1 interaction.
    STRINGi 10090.ENSMUSP00000100058.

    PTM databases

    PhosphoSitei P62257.

    Proteomic databases

    MaxQBi P62257.
    PaxDbi P62257.
    PRIDEi P62257.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102993 ; ENSMUSP00000100058 ; ENSMUSG00000039159 .
    GeneIDi 22214.
    KEGGi mmu:22214.
    UCSCi uc009bey.3. mouse.

    Organism-specific databases

    CTDi 7328.
    MGIi MGI:104632. Ube2h.

    Phylogenomic databases

    eggNOGi COG5078.
    HOGENOMi HOG000233452.
    HOVERGENi HBG063308.
    InParanoidi P62257.
    KOi K10576.
    OMAi CIESKHE.
    OrthoDBi EOG7Z3F66.
    PhylomeDBi P62257.
    TreeFami TF101121.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 28676.
    PROi P62257.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62257.
    Bgeei P62257.
    CleanExi MM_UBE2H.
    Genevestigatori P62257.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR023313. UBQ-conjugating_AS.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation."
      Wefes I., Mastrandrea L.D., Haldeman M., Koury S.T., Tamburlin J., Pickart C.M., Finley D.
      Proc. Natl. Acad. Sci. U.S.A. 92:4982-4986(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "Characterization of a cDNA clone encoding E2-20K, a murine ubiquitin-conjugating enzyme."
      Wefes I., Kaiser P., Schneider R., Pickart C.M., Finley D.
      Gene 163:321-322(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiUBE2H_MOUSE
    AccessioniPrimary (citable) accession number: P62257
    Secondary accession number(s): P37286
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3