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P62257

- UBE2H_MOUSE

UniProt

P62257 - UBE2H_MOUSE

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Protein
Ubiquitin-conjugating enzyme E2 H
Gene
Ube2h
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A By similarity.

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. acid-amino acid ligase activity Source: InterPro
  3. ubiquitin-protein transferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. protein K11-linked ubiquitination Source: UniProtKB
  2. protein K48-linked ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 H (EC:6.3.2.19)
Alternative name(s):
UBCH2
Ubiquitin carrier protein H
Ubiquitin-conjugating enzyme E2-20K
Ubiquitin-protein ligase H
Gene namesi
Name:Ube2h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:104632. Ube2h.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Ubiquitin-conjugating enzyme E2 H
PRO_0000082487Add
BLAST

Proteomic databases

MaxQBiP62257.
PaxDbiP62257.
PRIDEiP62257.

PTM databases

PhosphoSiteiP62257.

Expressioni

Gene expression databases

ArrayExpressiP62257.
BgeeiP62257.
CleanExiMM_UBE2H.
GenevestigatoriP62257.

Interactioni

Protein-protein interaction databases

BioGridi204417. 1 interaction.
STRINGi10090.ENSMUSP00000100058.

Structurei

3D structure databases

ProteinModelPortaliP62257.
SMRiP62257. Positions 4-155.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5078.
HOGENOMiHOG000233452.
HOVERGENiHBG063308.
InParanoidiP62257.
KOiK10576.
OMAiCIESKHE.
OrthoDBiEOG7Z3F66.
PhylomeDBiP62257.
TreeFamiTF101121.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62257-1 [UniParc]FASTAAdd to Basket

« Hide

MSSPSPGKRR MDTDVVKLIE SKHEVTILGG LNEFVVKFYG PQGTPYEGGV    50
WKVRVDLPDK YPFKSPSIGF MNKIFHPNID EASGTVCLDV INQTWTALYD 100
LTNIFESFLP QLLAYPNPID PLNGDAAAMY LHRPEEYKQK IKEYIQKYAT 150
EEALKEQEEG TGDSSSESSM SDFSEDEAQD MEL 183
Length:183
Mass (Da):20,655
Last modified:July 5, 2004 - v1
Checksum:i3DD5D365945F708C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19854 mRNA. Translation: AAA91975.1.
BC008517 mRNA. Translation: AAH08517.1.
CCDSiCCDS19969.1.
PIRiJC4308.
RefSeqiNP_033485.1. NM_009459.3.
UniGeneiMm.332967.
Mm.391754.

Genome annotation databases

EnsembliENSMUST00000102993; ENSMUSP00000100058; ENSMUSG00000039159.
GeneIDi22214.
KEGGimmu:22214.
UCSCiuc009bey.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19854 mRNA. Translation: AAA91975.1 .
BC008517 mRNA. Translation: AAH08517.1 .
CCDSi CCDS19969.1.
PIRi JC4308.
RefSeqi NP_033485.1. NM_009459.3.
UniGenei Mm.332967.
Mm.391754.

3D structure databases

ProteinModelPortali P62257.
SMRi P62257. Positions 4-155.
ModBasei Search...

Protein-protein interaction databases

BioGridi 204417. 1 interaction.
STRINGi 10090.ENSMUSP00000100058.

PTM databases

PhosphoSitei P62257.

Proteomic databases

MaxQBi P62257.
PaxDbi P62257.
PRIDEi P62257.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102993 ; ENSMUSP00000100058 ; ENSMUSG00000039159 .
GeneIDi 22214.
KEGGi mmu:22214.
UCSCi uc009bey.3. mouse.

Organism-specific databases

CTDi 7328.
MGIi MGI:104632. Ube2h.

Phylogenomic databases

eggNOGi COG5078.
HOGENOMi HOG000233452.
HOVERGENi HBG063308.
InParanoidi P62257.
KOi K10576.
OMAi CIESKHE.
OrthoDBi EOG7Z3F66.
PhylomeDBi P62257.
TreeFami TF101121.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 28676.
PROi P62257.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62257.
Bgeei P62257.
CleanExi MM_UBE2H.
Genevestigatori P62257.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation."
    Wefes I., Mastrandrea L.D., Haldeman M., Koury S.T., Tamburlin J., Pickart C.M., Finley D.
    Proc. Natl. Acad. Sci. U.S.A. 92:4982-4986(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Characterization of a cDNA clone encoding E2-20K, a murine ubiquitin-conjugating enzyme."
    Wefes I., Kaiser P., Schneider R., Pickart C.M., Finley D.
    Gene 163:321-322(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiUBE2H_MOUSE
AccessioniPrimary (citable) accession number: P62257
Secondary accession number(s): P37286
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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