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P62257

- UBE2H_MOUSE

UniProt

P62257 - UBE2H_MOUSE

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Protein

Ubiquitin-conjugating enzyme E2 H

Gene

Ube2h

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A (By similarity).By similarity

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei87 – 871Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  1. protein K11-linked ubiquitination Source: UniProtKB
  2. protein K48-linked ubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 H (EC:6.3.2.19)
Alternative name(s):
UBCH2
Ubiquitin carrier protein H
Ubiquitin-conjugating enzyme E2-20K
Ubiquitin-protein ligase H
Gene namesi
Name:Ube2h
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:104632. Ube2h.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Ubiquitin-conjugating enzyme E2 HPRO_0000082487Add
BLAST

Proteomic databases

MaxQBiP62257.
PaxDbiP62257.
PRIDEiP62257.

PTM databases

PhosphoSiteiP62257.

Expressioni

Gene expression databases

BgeeiP62257.
CleanExiMM_UBE2H.
ExpressionAtlasiP62257. baseline and differential.
GenevestigatoriP62257.

Interactioni

Protein-protein interaction databases

BioGridi204417. 1 interaction.
STRINGi10090.ENSMUSP00000100058.

Structurei

3D structure databases

ProteinModelPortaliP62257.
SMRiP62257. Positions 4-155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
HOGENOMiHOG000233452.
HOVERGENiHBG063308.
InParanoidiP62257.
KOiK10576.
OMAiCIESKHE.
OrthoDBiEOG7Z3F66.
PhylomeDBiP62257.
TreeFamiTF101121.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62257-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSPSPGKRR MDTDVVKLIE SKHEVTILGG LNEFVVKFYG PQGTPYEGGV
60 70 80 90 100
WKVRVDLPDK YPFKSPSIGF MNKIFHPNID EASGTVCLDV INQTWTALYD
110 120 130 140 150
LTNIFESFLP QLLAYPNPID PLNGDAAAMY LHRPEEYKQK IKEYIQKYAT
160 170 180
EEALKEQEEG TGDSSSESSM SDFSEDEAQD MEL
Length:183
Mass (Da):20,655
Last modified:July 5, 2004 - v1
Checksum:i3DD5D365945F708C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19854 mRNA. Translation: AAA91975.1.
BC008517 mRNA. Translation: AAH08517.1.
CCDSiCCDS19969.1.
PIRiJC4308.
RefSeqiNP_033485.1. NM_009459.3.
UniGeneiMm.332967.
Mm.391754.

Genome annotation databases

EnsembliENSMUST00000102993; ENSMUSP00000100058; ENSMUSG00000039159.
GeneIDi22214.
KEGGimmu:22214.
UCSCiuc009bey.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19854 mRNA. Translation: AAA91975.1 .
BC008517 mRNA. Translation: AAH08517.1 .
CCDSi CCDS19969.1.
PIRi JC4308.
RefSeqi NP_033485.1. NM_009459.3.
UniGenei Mm.332967.
Mm.391754.

3D structure databases

ProteinModelPortali P62257.
SMRi P62257. Positions 4-155.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204417. 1 interaction.
STRINGi 10090.ENSMUSP00000100058.

PTM databases

PhosphoSitei P62257.

Proteomic databases

MaxQBi P62257.
PaxDbi P62257.
PRIDEi P62257.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102993 ; ENSMUSP00000100058 ; ENSMUSG00000039159 .
GeneIDi 22214.
KEGGi mmu:22214.
UCSCi uc009bey.3. mouse.

Organism-specific databases

CTDi 7328.
MGIi MGI:104632. Ube2h.

Phylogenomic databases

eggNOGi COG5078.
HOGENOMi HOG000233452.
HOVERGENi HBG063308.
InParanoidi P62257.
KOi K10576.
OMAi CIESKHE.
OrthoDBi EOG7Z3F66.
PhylomeDBi P62257.
TreeFami TF101121.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 28676.
PROi P62257.
SOURCEi Search...

Gene expression databases

Bgeei P62257.
CleanExi MM_UBE2H.
ExpressionAtlasi P62257. baseline and differential.
Genevestigatori P62257.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 1 hit.
PROSITEi PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation."
    Wefes I., Mastrandrea L.D., Haldeman M., Koury S.T., Tamburlin J., Pickart C.M., Finley D.
    Proc. Natl. Acad. Sci. U.S.A. 92:4982-4986(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Characterization of a cDNA clone encoding E2-20K, a murine ubiquitin-conjugating enzyme."
    Wefes I., Kaiser P., Schneider R., Pickart C.M., Finley D.
    Gene 163:321-322(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiUBE2H_MOUSE
AccessioniPrimary (citable) accession number: P62257
Secondary accession number(s): P37286
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3