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Protein

40S ribosomal protein S16

Gene

RPS16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-9010553. Regulation of expression of SLITs and ROBOs.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S16
Alternative name(s):
Small ribosomal subunit protein uS91 Publication
Gene namesi
Name:RPS16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105193.8.
HGNCiHGNC:10396. RPS16.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6217.
OpenTargetsiENSG00000105193.
PharmGKBiPA34796.

Polymorphism and mutation databases

BioMutaiRPS16.
DMDMi50403607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001114792 – 14640S ribosomal protein S16Add BLAST145

Proteomic databases

EPDiP62249.
MaxQBiP62249.
PaxDbiP62249.
PeptideAtlasiP62249.
PRIDEiP62249.
TopDownProteomicsiP62249.

PTM databases

iPTMnetiP62249.
PhosphoSitePlusiP62249.
SwissPalmiP62249.

Expressioni

Gene expression databases

BgeeiENSG00000105193.
CleanExiHS_RPS16.
ExpressionAtlasiP62249. baseline and differential.
GenevisibleiP62249. HS.

Organism-specific databases

HPAiHPA064222.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0072EBI-352480,EBI-5323863

Protein-protein interaction databases

BioGridi112131. 277 interactors.
CORUMiP62249.
DIPiDIP-33200N.
IntActiP62249. 45 interactors.
MINTiMINT-5001167.
STRINGi9606.ENSP00000251453.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SQ1-146[»]
4V6Xelectron microscopy5.00AQ1-146[»]
5A2Qelectron microscopy3.90Q1-146[»]
5AJ0electron microscopy3.50BQ1-146[»]
5FLXelectron microscopy3.90Q1-146[»]
5LKSelectron microscopy3.60SQ1-146[»]
5OA3electron microscopy4.30Q1-146[»]
5T2Celectron microscopy3.60Ay1-146[»]
5VYCX-ray6.00Q1/Q2/Q3/Q4/Q5/Q61-146[»]
ProteinModelPortaliP62249.
SMRiP62249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1753. Eukaryota.
COG0103. LUCA.
GeneTreeiENSGT00390000013067.
HOGENOMiHOG000019803.
HOVERGENiHBG055171.
InParanoidiP62249.
KOiK02960.
OMAiHVSQIYA.
PhylomeDBiP62249.
TreeFamiTF300088.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
InterProiView protein in InterPro
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR000754. Ribosomal_S9.
IPR020574. Ribosomal_S9_CS.
PANTHERiPTHR21569. PTHR21569. 1 hit.
PfamiView protein in Pfam
PF00380. Ribosomal_S9. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
PROSITEiView protein in PROSITE
PS00360. RIBOSOMAL_S9. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKGPLQSV QVFGRKKTAT AVAHCKRGNG LIKVNGRPLE MIEPRTLQYK
60 70 80 90 100
LLEPVLLLGK ERFAGVDIRV RVKGGGHVAQ IYAIRQSISK ALVAYYQKYV
110 120 130 140
DEASKKEIKD ILIQYDRTLL VADPRRCESK KFGGPGARAR YQKSYR
Length:146
Mass (Da):16,445
Last modified:January 23, 2007 - v2
Checksum:i519BCFB91BB68A15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60854 mRNA. Translation: AAA60583.1.
AB061841 Genomic DNA. Translation: BAB79479.1.
AK315498 mRNA. Translation: BAG37882.1.
CH471126 Genomic DNA. Translation: EAW56894.1.
BC004324 mRNA. Translation: AAH04324.1.
BC007977 mRNA. Translation: AAH07977.1.
CCDSiCCDS12535.1.
PIRiA39760. R3HU16.
RefSeqiNP_001011.1. NM_001020.5.
UniGeneiHs.397609.

Genome annotation databases

EnsembliENST00000251453; ENSP00000251453; ENSG00000105193.
GeneIDi6217.
KEGGihsa:6217.
UCSCiuc002olk.4. human.

Similar proteinsi

Entry informationi

Entry nameiRS16_HUMAN
AccessioniPrimary (citable) accession number: P62249
Secondary accession number(s): B2RDD5, P17008
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families