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Protein

40S ribosomal protein S15a

Gene

Rps15a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72649. Translation initiation complex formation.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-MMU-72702. Ribosomal scanning and start codon recognition.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S15a
Gene namesi
Name:Rps15a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2389091. Rps15a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001266032 – 13040S ribosomal protein S15aAdd BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88N6-succinyllysineCombined sources1

Proteomic databases

EPDiP62245.
PaxDbiP62245.
PeptideAtlasiP62245.
PRIDEiP62245.
TopDownProteomicsiP62245.

PTM databases

iPTMnetiP62245.
PhosphoSitePlusiP62245.

Expressioni

Gene expression databases

BgeeiENSMUSG00000008683.
CleanExiMM_RPS15A.
ExpressionAtlasiP62245. baseline and differential.
GenevisibleiP62245. MM.

Interactioni

Protein-protein interaction databases

BioGridi234473. 3 interactors.
IntActiP62245. 5 interactors.
MINTiMINT-4153368.
STRINGi10090.ENSMUSP00000102198.

Structurei

3D structure databases

ProteinModelPortaliP62245.
SMRiP62245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S8P family.Curated

Phylogenomic databases

eggNOGiKOG1754. Eukaryota.
COG0096. LUCA.
GeneTreeiENSGT00390000003021.
HOGENOMiHOG000204097.
HOVERGENiHBG056618.
InParanoidiP62245.
KOiK02957.
OMAiWEKQFLP.
OrthoDBiEOG091G0TSE.
PhylomeDBiP62245.
TreeFamiTF300067.

Family and domain databases

HAMAPiMF_01302_A. Ribosomal_S8_A. 1 hit.
InterProiIPR000630. Ribosomal_S8.
[Graphical view]
PANTHERiPTHR11758. PTHR11758. 1 hit.
PfamiPF00410. Ribosomal_S8. 1 hit.
[Graphical view]
SUPFAMiSSF56047. SSF56047. 1 hit.
PROSITEiPS00053. RIBOSOMAL_S8. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62245-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF
60 70 80 90 100
EIIDDHRAGK IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG
110 120 130
FIVLTTSAGI MDHEEARRKH TGGKILGFFF
Length:130
Mass (Da):14,840
Last modified:January 23, 2007 - v2
Checksum:iD4AC1E8864E3A184
GO

Sequence cautioni

The sequence AAH51205 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14I → N in BAC27909 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051205 mRNA. Translation: AAH51205.1. Different initiation.
BC054792 mRNA. Translation: AAH54792.1.
BC055697 mRNA. Translation: AAH55697.1.
BC076563 mRNA. Translation: AAH76563.1.
BC081428 mRNA. Translation: AAH81428.1.
AK010652 mRNA. Translation: BAB27092.1.
AK011514 mRNA. Translation: BAB27669.1.
AK012485 mRNA. Translation: BAB28272.1.
AK012618 mRNA. Translation: BAB28359.1.
AK019235 mRNA. Translation: BAB31617.1.
AK028135 mRNA. Translation: BAC25764.1.
AK032522 mRNA. Translation: BAC27909.1.
CCDSiCCDS21768.1.
RefSeqiNP_733769.1. NM_170669.2.
UniGeneiMm.288212.

Genome annotation databases

EnsembliENSMUST00000106588; ENSMUSP00000102198; ENSMUSG00000008683.
ENSMUST00000131374; ENSMUSP00000119975; ENSMUSG00000008683.
ENSMUST00000172457; ENSMUSP00000127791; ENSMUSG00000008683.
GeneIDi267019.
KEGGimmu:267019.
UCSCiuc009jjn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC051205 mRNA. Translation: AAH51205.1. Different initiation.
BC054792 mRNA. Translation: AAH54792.1.
BC055697 mRNA. Translation: AAH55697.1.
BC076563 mRNA. Translation: AAH76563.1.
BC081428 mRNA. Translation: AAH81428.1.
AK010652 mRNA. Translation: BAB27092.1.
AK011514 mRNA. Translation: BAB27669.1.
AK012485 mRNA. Translation: BAB28272.1.
AK012618 mRNA. Translation: BAB28359.1.
AK019235 mRNA. Translation: BAB31617.1.
AK028135 mRNA. Translation: BAC25764.1.
AK032522 mRNA. Translation: BAC27909.1.
CCDSiCCDS21768.1.
RefSeqiNP_733769.1. NM_170669.2.
UniGeneiMm.288212.

3D structure databases

ProteinModelPortaliP62245.
SMRiP62245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234473. 3 interactors.
IntActiP62245. 5 interactors.
MINTiMINT-4153368.
STRINGi10090.ENSMUSP00000102198.

PTM databases

iPTMnetiP62245.
PhosphoSitePlusiP62245.

Proteomic databases

EPDiP62245.
PaxDbiP62245.
PeptideAtlasiP62245.
PRIDEiP62245.
TopDownProteomicsiP62245.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106588; ENSMUSP00000102198; ENSMUSG00000008683.
ENSMUST00000131374; ENSMUSP00000119975; ENSMUSG00000008683.
ENSMUST00000172457; ENSMUSP00000127791; ENSMUSG00000008683.
GeneIDi267019.
KEGGimmu:267019.
UCSCiuc009jjn.1. mouse.

Organism-specific databases

CTDi6210.
MGIiMGI:2389091. Rps15a.

Phylogenomic databases

eggNOGiKOG1754. Eukaryota.
COG0096. LUCA.
GeneTreeiENSGT00390000003021.
HOGENOMiHOG000204097.
HOVERGENiHBG056618.
InParanoidiP62245.
KOiK02957.
OMAiWEKQFLP.
OrthoDBiEOG091G0TSE.
PhylomeDBiP62245.
TreeFamiTF300067.

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72649. Translation initiation complex formation.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-MMU-72702. Ribosomal scanning and start codon recognition.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP62245.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008683.
CleanExiMM_RPS15A.
ExpressionAtlasiP62245. baseline and differential.
GenevisibleiP62245. MM.

Family and domain databases

HAMAPiMF_01302_A. Ribosomal_S8_A. 1 hit.
InterProiIPR000630. Ribosomal_S8.
[Graphical view]
PANTHERiPTHR11758. PTHR11758. 1 hit.
PfamiPF00410. Ribosomal_S8. 1 hit.
[Graphical view]
SUPFAMiSSF56047. SSF56047. 1 hit.
PROSITEiPS00053. RIBOSOMAL_S8. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS15A_MOUSE
AccessioniPrimary (citable) accession number: P62245
Secondary accession number(s): P39027
, P39031, Q8C023, Q9BV24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.