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Protein

40S ribosomal protein S15a

Gene

RPS15A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • positive regulation of cell cycle Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • response to virus Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S15a
Alternative name(s):
Small ribosomal subunit protein uS81 Publication
Gene namesi
Name:RPS15A
ORF Names:OK/SW-cl.82
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000134419.15
HGNCiHGNC:10389 RPS15A
MIMi603674 gene
neXtProtiNX_P62244

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6210
OpenTargetsiENSG00000134419
PharmGKBiPA34788

Polymorphism and mutation databases

BioMutaiRPS15A
DMDMi50403624

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001266022 – 13040S ribosomal protein S15aAdd BLAST129

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei88N6-succinyllysineBy similarity1

Proteomic databases

EPDiP62244
MaxQBiP62244
PaxDbiP62244
PeptideAtlasiP62244
PRIDEiP62244
TopDownProteomicsiP62244

2D gel databases

SWISS-2DPAGEiP62244

PTM databases

iPTMnetiP62244
PhosphoSitePlusiP62244
SwissPalmiP62244

Miscellaneous databases

PMAP-CutDBiP62244

Expressioni

Gene expression databases

BgeeiENSG00000134419
CleanExiHS_RPS15A
ExpressionAtlasiP62244 baseline and differential
GenevisibleiP62244 HS

Organism-specific databases

HPAiHPA047103

Interactioni

Protein-protein interaction databases

BioGridi112124, 185 interactors
CORUMiP62244
IntActiP62244, 31 interactors
MINTiP62244
STRINGi9606.ENSP00000318646

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SW1-130[»]
4V6Xelectron microscopy5.00AW1-130[»]
5A2Qelectron microscopy3.90W1-130[»]
5AJ0electron microscopy3.50BW1-130[»]
5FLXelectron microscopy3.90W1-130[»]
5LKSelectron microscopy3.60SW1-130[»]
5OA3electron microscopy4.30W1-130[»]
5T2Celectron microscopy3.60AP1-130[»]
5VYCX-ray6.00W1/W2/W3/W4/W5/W61-130[»]
6EK0electron microscopy2.90SW1-130[»]
6FECelectron microscopy6.30a2-130[»]
ProteinModelPortaliP62244
SMRiP62244
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1754 Eukaryota
COG0096 LUCA
GeneTreeiENSGT00390000005707
HOGENOMiHOG000204097
HOVERGENiHBG056618
InParanoidiP62244
KOiK02957
OMAiYGIMDHE
OrthoDBiEOG091G0TSE
PhylomeDBiP62244
TreeFamiTF300067

Family and domain databases

HAMAPiMF_01302_A Ribosomal_S8_A, 1 hit
InterProiView protein in InterPro
IPR000630 Ribosomal_S8
IPR035987 Ribosomal_S8_sf
PANTHERiPTHR11758 PTHR11758, 1 hit
PfamiView protein in Pfam
PF00410 Ribosomal_S8, 1 hit
SUPFAMiSSF56047 SSF56047, 1 hit
PROSITEiView protein in PROSITE
PS00053 RIBOSOMAL_S8, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF
60 70 80 90 100
EIIDDHRAGK IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG
110 120 130
FIVLTTSAGI MDHEEARRKH TGGKILGFFF
Length:130
Mass (Da):14,840
Last modified:January 23, 2007 - v2
Checksum:iD4AC1E8864E3A184
GO

Sequence cautioni

The sequence CAA44568 differs from that shown. Reason: Frameshift at positions 24 and 37.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3R → C AA sequence (PubMed:8706699).Curated1
Sequence conflicti40V → L in CAA59127 (Ref. 2) Curated1
Sequence conflicti79F → S in AAH01697 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62691 mRNA Translation: CAA44568.1 Frameshift.
X84407 mRNA Translation: CAA59127.1
AY208299 mRNA Translation: AAO48936.1
AB062400 mRNA Translation: BAB93487.1
BC001697 mRNA Translation: AAH01697.1
BC030569 mRNA Translation: AAH30569.1
BC046113 mRNA Translation: AAH46113.1
BC105273 mRNA Translation: AAI05274.1
BC105292 mRNA Translation: AAI05293.1
AB007154 Genomic DNA Translation: BAA28592.1
CCDSiCCDS10571.1
PIRiS52339
RefSeqiNP_001010.2, NM_001019.4
NP_001025180.1, NM_001030009.1
UniGeneiHs.370504

Genome annotation databases

EnsembliENST00000322989; ENSP00000318646; ENSG00000134419
ENST00000563390; ENSP00000457000; ENSG00000134419
ENST00000565420; ENSP00000458115; ENSG00000134419
ENST00000572008; ENSP00000458528; ENSG00000134419
GeneIDi6210
KEGGihsa:6210
UCSCiuc002dfh.2 human

Similar proteinsi

Entry informationi

Entry nameiRS15A_HUMAN
AccessioniPrimary (citable) accession number: P62244
Secondary accession number(s): P39027
, P39031, Q3MHD9, Q8C023, Q9BV24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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