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P62244

- RS15A_HUMAN

UniProt

P62244 - RS15A_HUMAN

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Protein

40S ribosomal protein S15a

Gene

RPS15A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. RNA binding Source: UniProtKB
  3. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. gene expression Source: Reactome
  3. mRNA metabolic process Source: Reactome
  4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  5. positive regulation of cell cycle Source: UniProtKB
  6. positive regulation of cell proliferation Source: UniProtKB
  7. response to virus Source: UniProtKB
  8. RNA metabolic process Source: Reactome
  9. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  10. translation Source: UniProtKB
  11. translational elongation Source: Reactome
  12. translational initiation Source: Reactome
  13. translational termination Source: Reactome
  14. viral life cycle Source: Reactome
  15. viral process Source: Reactome
  16. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S15a
Gene namesi
Name:RPS15A
ORF Names:OK/SW-cl.82
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:10389. RPS15A.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytosol Source: Reactome
  3. cytosolic small ribosomal subunit Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProt
  5. membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34788.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 13012940S ribosomal protein S15aPRO_0000126602Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei88 – 881N6-succinyllysineBy similarity

Proteomic databases

MaxQBiP62244.
PaxDbiP62244.
PeptideAtlasiP62244.
PRIDEiP62244.

2D gel databases

SWISS-2DPAGEP62244.

PTM databases

PhosphoSiteiP62244.

Miscellaneous databases

PMAP-CutDBP62244.

Expressioni

Gene expression databases

BgeeiP62244.
CleanExiHS_RPS15A.
ExpressionAtlasiP62244. baseline and differential.
GenevestigatoriP62244.

Organism-specific databases

HPAiHPA047103.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DDX39BQ138381EBI-347895,EBI-348622

Protein-protein interaction databases

BioGridi112124. 138 interactions.
IntActiP62244. 16 interactions.
MINTiMINT-1036414.
STRINGi9606.ENSP00000318646.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Aelectron microscopy5.00W1-130[»]
ProteinModelPortaliP62244.
SMRiP62244. Positions 2-130.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S8P family.Curated

Phylogenomic databases

eggNOGiCOG0096.
GeneTreeiENSGT00390000003021.
HOGENOMiHOG000204097.
HOVERGENiHBG056618.
InParanoidiP62244.
KOiK02957.
OMAiLPAKNFG.
OrthoDBiEOG77Q4ZM.
PhylomeDBiP62244.
TreeFamiTF300067.

Family and domain databases

HAMAPiMF_01302_A. Ribosomal_S8_A.
InterProiIPR000630. Ribosomal_S8.
[Graphical view]
PANTHERiPTHR11758. PTHR11758. 1 hit.
PfamiPF00410. Ribosomal_S8. 1 hit.
[Graphical view]
SUPFAMiSSF56047. SSF56047. 1 hit.
PROSITEiPS00053. RIBOSOMAL_S8. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62244-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF
60 70 80 90 100
EIIDDHRAGK IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG
110 120 130
FIVLTTSAGI MDHEEARRKH TGGKILGFFF
Length:130
Mass (Da):14,840
Last modified:January 23, 2007 - v2
Checksum:iD4AC1E8864E3A184
GO

Sequence cautioni

The sequence CAA44568.1 differs from that shown. Reason: Frameshift at positions 24 and 37. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31R → C AA sequence (PubMed:8706699)Curated
Sequence conflicti40 – 401V → L in CAA59127. 1 PublicationCurated
Sequence conflicti79 – 791F → S in AAH01697. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62691 mRNA. Translation: CAA44568.1. Frameshift.
X84407 mRNA. Translation: CAA59127.1.
AY208299 mRNA. Translation: AAO48936.1.
AB062400 mRNA. Translation: BAB93487.1.
BC001697 mRNA. Translation: AAH01697.1.
BC030569 mRNA. Translation: AAH30569.1.
BC046113 mRNA. Translation: AAH46113.1.
BC105273 mRNA. Translation: AAI05274.1.
BC105292 mRNA. Translation: AAI05293.1.
AB007154 Genomic DNA. Translation: BAA28592.1.
CCDSiCCDS10571.1.
PIRiS52339.
RefSeqiNP_001010.2. NM_001019.4.
NP_001025180.1. NM_001030009.1.
UniGeneiHs.370504.

Genome annotation databases

EnsembliENST00000322989; ENSP00000318646; ENSG00000134419.
ENST00000563390; ENSP00000457000; ENSG00000134419.
ENST00000565420; ENSP00000458115; ENSG00000134419.
ENST00000572008; ENSP00000458528; ENSG00000134419.
GeneIDi6210.
KEGGihsa:6210.
UCSCiuc002dfh.1. human.

Polymorphism databases

DMDMi50403624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62691 mRNA. Translation: CAA44568.1 . Frameshift.
X84407 mRNA. Translation: CAA59127.1 .
AY208299 mRNA. Translation: AAO48936.1 .
AB062400 mRNA. Translation: BAB93487.1 .
BC001697 mRNA. Translation: AAH01697.1 .
BC030569 mRNA. Translation: AAH30569.1 .
BC046113 mRNA. Translation: AAH46113.1 .
BC105273 mRNA. Translation: AAI05274.1 .
BC105292 mRNA. Translation: AAI05293.1 .
AB007154 Genomic DNA. Translation: BAA28592.1 .
CCDSi CCDS10571.1.
PIRi S52339.
RefSeqi NP_001010.2. NM_001019.4.
NP_001025180.1. NM_001030009.1.
UniGenei Hs.370504.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3A electron microscopy 5.00 W 1-130 [» ]
ProteinModelPortali P62244.
SMRi P62244. Positions 2-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112124. 138 interactions.
IntActi P62244. 16 interactions.
MINTi MINT-1036414.
STRINGi 9606.ENSP00000318646.

PTM databases

PhosphoSitei P62244.

Polymorphism databases

DMDMi 50403624.

2D gel databases

SWISS-2DPAGE P62244.

Proteomic databases

MaxQBi P62244.
PaxDbi P62244.
PeptideAtlasi P62244.
PRIDEi P62244.

Protocols and materials databases

DNASUi 6210.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322989 ; ENSP00000318646 ; ENSG00000134419 .
ENST00000563390 ; ENSP00000457000 ; ENSG00000134419 .
ENST00000565420 ; ENSP00000458115 ; ENSG00000134419 .
ENST00000572008 ; ENSP00000458528 ; ENSG00000134419 .
GeneIDi 6210.
KEGGi hsa:6210.
UCSCi uc002dfh.1. human.

Organism-specific databases

CTDi 6210.
GeneCardsi GC16M018701.
H-InvDB HIX0033054.
HGNCi HGNC:10389. RPS15A.
HPAi HPA047103.
MIMi 603674. gene.
neXtProti NX_P62244.
PharmGKBi PA34788.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0096.
GeneTreei ENSGT00390000003021.
HOGENOMi HOG000204097.
HOVERGENi HBG056618.
InParanoidi P62244.
KOi K02957.
OMAi LPAKNFG.
OrthoDBi EOG77Q4ZM.
PhylomeDBi P62244.
TreeFami TF300067.

Enzyme and pathway databases

Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSi RPS15A. human.
GeneWikii RPS15A.
GenomeRNAii 6210.
NextBioi 24123.
PMAP-CutDB P62244.
PROi P62244.
SOURCEi Search...

Gene expression databases

Bgeei P62244.
CleanExi HS_RPS15A.
ExpressionAtlasi P62244. baseline and differential.
Genevestigatori P62244.

Family and domain databases

HAMAPi MF_01302_A. Ribosomal_S8_A.
InterProi IPR000630. Ribosomal_S8.
[Graphical view ]
PANTHERi PTHR11758. PTHR11758. 1 hit.
Pfami PF00410. Ribosomal_S8. 1 hit.
[Graphical view ]
SUPFAMi SSF56047. SSF56047. 1 hit.
PROSITEi PS00053. RIBOSOMAL_S8. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Schwabe G.
    Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Mays G., Burchert-Graeve M.
    Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Carcinoma.
  3. "Human S15a expression is up-regulated by HBV X protein."
    Lian Z., Liu J., Li L., Li X., Tufan S.N.L., Wu M.-C., Wang H., Arbuthnot P., Kew M.K., Feitelson M.M.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
    Shichijo S., Itoh K.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon adenocarcinoma.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye, Lung and Skin.
  6. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
    Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
    Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-17 AND 33-60.
    Tissue: Placenta.
  7. "A map of 75 human ribosomal protein genes."
    Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
    Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-54.
  8. Cited for: PARTIAL PROTEIN SEQUENCE.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRS15A_HUMAN
AccessioniPrimary (citable) accession number: P62244
Secondary accession number(s): P39027
, P39031, Q3MHD9, Q8C023, Q9BV24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3