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P62244

- RS15A_HUMAN

UniProt

P62244 - RS15A_HUMAN

Protein

40S ribosomal protein S15a

Gene

RPS15A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. RNA binding Source: UniProtKB
    3. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. mRNA metabolic process Source: Reactome
    4. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    5. positive regulation of cell cycle Source: UniProtKB
    6. positive regulation of cell proliferation Source: UniProtKB
    7. response to virus Source: UniProtKB
    8. RNA metabolic process Source: Reactome
    9. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    10. translation Source: UniProtKB
    11. translational elongation Source: Reactome
    12. translational initiation Source: Reactome
    13. translational termination Source: Reactome
    14. viral life cycle Source: Reactome
    15. viral process Source: Reactome
    16. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S15a
    Gene namesi
    Name:RPS15A
    ORF Names:OK/SW-cl.82
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:10389. RPS15A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytosol Source: Reactome
    3. cytosolic small ribosomal subunit Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. membrane Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34788.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 13012940S ribosomal protein S15aPRO_0000126602Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei88 – 881N6-succinyllysineBy similarity

    Proteomic databases

    MaxQBiP62244.
    PaxDbiP62244.
    PeptideAtlasiP62244.
    PRIDEiP62244.

    2D gel databases

    SWISS-2DPAGEP62244.

    PTM databases

    PhosphoSiteiP62244.

    Miscellaneous databases

    PMAP-CutDBP62244.

    Expressioni

    Gene expression databases

    ArrayExpressiP62244.
    BgeeiP62244.
    CleanExiHS_RPS15A.
    GenevestigatoriP62244.

    Organism-specific databases

    HPAiHPA047103.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DDX39BQ138381EBI-347895,EBI-348622

    Protein-protein interaction databases

    BioGridi112124. 134 interactions.
    IntActiP62244. 16 interactions.
    MINTiMINT-1036414.
    STRINGi9606.ENSP00000318646.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Aelectron microscopy5.00W1-130[»]
    ProteinModelPortaliP62244.
    SMRiP62244. Positions 2-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S8P family.Curated

    Phylogenomic databases

    eggNOGiCOG0096.
    HOGENOMiHOG000204097.
    HOVERGENiHBG056618.
    InParanoidiP62244.
    KOiK02957.
    OMAiLPAKNFG.
    OrthoDBiEOG77Q4ZM.
    PhylomeDBiP62244.
    TreeFamiTF300067.

    Family and domain databases

    HAMAPiMF_01302_A. Ribosomal_S8_A.
    InterProiIPR000630. Ribosomal_S8.
    [Graphical view]
    PANTHERiPTHR11758. PTHR11758. 1 hit.
    PfamiPF00410. Ribosomal_S8. 1 hit.
    [Graphical view]
    SUPFAMiSSF56047. SSF56047. 1 hit.
    PROSITEiPS00053. RIBOSOMAL_S8. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62244-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF    50
    EIIDDHRAGK IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG 100
    FIVLTTSAGI MDHEEARRKH TGGKILGFFF 130
    Length:130
    Mass (Da):14,840
    Last modified:January 23, 2007 - v2
    Checksum:iD4AC1E8864E3A184
    GO

    Sequence cautioni

    The sequence CAA44568.1 differs from that shown. Reason: Frameshift at positions 24 and 37.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31R → C AA sequence (PubMed:8706699)Curated
    Sequence conflicti40 – 401V → L in CAA59127. 1 PublicationCurated
    Sequence conflicti79 – 791F → S in AAH01697. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62691 mRNA. Translation: CAA44568.1. Frameshift.
    X84407 mRNA. Translation: CAA59127.1.
    AY208299 mRNA. Translation: AAO48936.1.
    AB062400 mRNA. Translation: BAB93487.1.
    BC001697 mRNA. Translation: AAH01697.1.
    BC030569 mRNA. Translation: AAH30569.1.
    BC046113 mRNA. Translation: AAH46113.1.
    BC105273 mRNA. Translation: AAI05274.1.
    BC105292 mRNA. Translation: AAI05293.1.
    AB007154 Genomic DNA. Translation: BAA28592.1.
    CCDSiCCDS10571.1.
    PIRiS52339.
    RefSeqiNP_001010.2. NM_001019.4.
    NP_001025180.1. NM_001030009.1.
    UniGeneiHs.370504.

    Genome annotation databases

    EnsembliENST00000322989; ENSP00000318646; ENSG00000134419.
    ENST00000563390; ENSP00000457000; ENSG00000134419.
    ENST00000565420; ENSP00000458115; ENSG00000134419.
    ENST00000572008; ENSP00000458528; ENSG00000134419.
    GeneIDi6210.
    KEGGihsa:6210.
    UCSCiuc002dfh.1. human.

    Polymorphism databases

    DMDMi50403624.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62691 mRNA. Translation: CAA44568.1 . Frameshift.
    X84407 mRNA. Translation: CAA59127.1 .
    AY208299 mRNA. Translation: AAO48936.1 .
    AB062400 mRNA. Translation: BAB93487.1 .
    BC001697 mRNA. Translation: AAH01697.1 .
    BC030569 mRNA. Translation: AAH30569.1 .
    BC046113 mRNA. Translation: AAH46113.1 .
    BC105273 mRNA. Translation: AAI05274.1 .
    BC105292 mRNA. Translation: AAI05293.1 .
    AB007154 Genomic DNA. Translation: BAA28592.1 .
    CCDSi CCDS10571.1.
    PIRi S52339.
    RefSeqi NP_001010.2. NM_001019.4.
    NP_001025180.1. NM_001030009.1.
    UniGenei Hs.370504.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3A electron microscopy 5.00 W 1-130 [» ]
    ProteinModelPortali P62244.
    SMRi P62244. Positions 2-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112124. 134 interactions.
    IntActi P62244. 16 interactions.
    MINTi MINT-1036414.
    STRINGi 9606.ENSP00000318646.

    PTM databases

    PhosphoSitei P62244.

    Polymorphism databases

    DMDMi 50403624.

    2D gel databases

    SWISS-2DPAGE P62244.

    Proteomic databases

    MaxQBi P62244.
    PaxDbi P62244.
    PeptideAtlasi P62244.
    PRIDEi P62244.

    Protocols and materials databases

    DNASUi 6210.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322989 ; ENSP00000318646 ; ENSG00000134419 .
    ENST00000563390 ; ENSP00000457000 ; ENSG00000134419 .
    ENST00000565420 ; ENSP00000458115 ; ENSG00000134419 .
    ENST00000572008 ; ENSP00000458528 ; ENSG00000134419 .
    GeneIDi 6210.
    KEGGi hsa:6210.
    UCSCi uc002dfh.1. human.

    Organism-specific databases

    CTDi 6210.
    GeneCardsi GC16M018701.
    H-InvDB HIX0033054.
    HGNCi HGNC:10389. RPS15A.
    HPAi HPA047103.
    MIMi 603674. gene.
    neXtProti NX_P62244.
    PharmGKBi PA34788.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0096.
    HOGENOMi HOG000204097.
    HOVERGENi HBG056618.
    InParanoidi P62244.
    KOi K02957.
    OMAi LPAKNFG.
    OrthoDBi EOG77Q4ZM.
    PhylomeDBi P62244.
    TreeFami TF300067.

    Enzyme and pathway databases

    Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    GeneWikii RPS15A.
    GenomeRNAii 6210.
    NextBioi 24123.
    PMAP-CutDB P62244.
    PROi P62244.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62244.
    Bgeei P62244.
    CleanExi HS_RPS15A.
    Genevestigatori P62244.

    Family and domain databases

    HAMAPi MF_01302_A. Ribosomal_S8_A.
    InterProi IPR000630. Ribosomal_S8.
    [Graphical view ]
    PANTHERi PTHR11758. PTHR11758. 1 hit.
    Pfami PF00410. Ribosomal_S8. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56047. SSF56047. 1 hit.
    PROSITEi PS00053. RIBOSOMAL_S8. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Schwabe G.
      Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Mays G., Burchert-Graeve M.
      Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Carcinoma.
    3. "Human S15a expression is up-regulated by HBV X protein."
      Lian Z., Liu J., Li L., Li X., Tufan S.N.L., Wu M.-C., Wang H., Arbuthnot P., Kew M.K., Feitelson M.M.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
      Shichijo S., Itoh K.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon adenocarcinoma.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye, Lung and Skin.
    6. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
      Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
      Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-17 AND 33-60.
      Tissue: Placenta.
    7. "A map of 75 human ribosomal protein genes."
      Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
      Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-54.
    8. Cited for: PARTIAL PROTEIN SEQUENCE.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRS15A_HUMAN
    AccessioniPrimary (citable) accession number: P62244
    Secondary accession number(s): P39027
    , P39031, Q3MHD9, Q8C023, Q9BV24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3