Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P62244 (RS15A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
40S ribosomal protein S15a
Gene names
Name:RPS15A
ORF Names:OK/SW-cl.82
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length130 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ribosomal protein S8P family.

Sequence caution

The sequence CAA44568.1 differs from that shown. Reason: Frameshift at positions 24 and 37.

Ontologies

Keywords
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processRNA metabolic process

Traceable author statement. Source: Reactome

SRP-dependent cotranslational protein targeting to membrane

Traceable author statement. Source: Reactome

cellular protein metabolic process

Traceable author statement. Source: Reactome

gene expression

Traceable author statement. Source: Reactome

mRNA metabolic process

Traceable author statement. Source: Reactome

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Traceable author statement. Source: Reactome

positive regulation of cell cycle

Inferred from direct assay PubMed 15108328. Source: UniProtKB

positive regulation of cell proliferation

Inferred from direct assay PubMed 15108328. Source: UniProtKB

response to virus

Inferred from direct assay PubMed 15108328. Source: UniProtKB

translation

Non-traceable author statement Ref.7. Source: UniProtKB

translational elongation

Traceable author statement. Source: Reactome

translational initiation

Traceable author statement. Source: Reactome

translational termination

Traceable author statement. Source: Reactome

viral life cycle

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

viral transcription

Traceable author statement. Source: Reactome

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15108328. Source: UniProtKB

cytosol

Traceable author statement. Source: Reactome

cytosolic small ribosomal subunit

Inferred from direct assay PubMed 15883184Ref.6. Source: UniProtKB

extracellular vesicular exosome

Inferred from direct assay PubMed 20458337PubMed 23376485. Source: UniProt

   Molecular_functionRNA binding

Non-traceable author statement Ref.7. Source: UniProtKB

poly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

structural constituent of ribosome

Inferred from direct assay PubMed 15883184. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DDX39BQ138381EBI-347895,EBI-348622

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 13012940S ribosomal protein S15a HAMAP-Rule MF_01302_A
PRO_0000126602

Amino acid modifications

Modified residue881N6-succinyllysine By similarity

Experimental info

Sequence conflict31R → C AA sequence Ref.6
Sequence conflict401V → L in CAA59127. Ref.2
Sequence conflict791F → S in AAH01697. Ref.5

Sequences

Sequence LengthMass (Da)Tools
P62244 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: D4AC1E8864E3A184

FASTA13014,840
        10         20         30         40         50         60 
MVRMNVLADA LKSINNAEKR GKRQVLIRPC SKVIVRFLTV MMKHGYIGEF EIIDDHRAGK 

        70         80         90        100        110        120 
IVVNLTGRLN KCGVISPRFD VQLKDLEKWQ NNLLPSRQFG FIVLTTSAGI MDHEEARRKH 

       130 
TGGKILGFFF 

« Hide

References

« Hide 'large scale' references
[1]Schwabe G.
Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Mays G., Burchert-Graeve M.
Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Carcinoma.
[3]"Human S15a expression is up-regulated by HBV X protein."
Lian Z., Liu J., Li L., Li X., Tufan S.N.L., Wu M.-C., Wang H., Arbuthnot P., Kew M.K., Feitelson M.M.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
Shichijo S., Itoh K.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon adenocarcinoma.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye, Lung and Skin.
[6]"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-17 AND 33-60.
Tissue: Placenta.
[7]"A map of 75 human ribosomal protein genes."
Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C.
Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-54.
[8]"The primary structure of rat ribosomal protein S15a."
Chan Y.-L., Olvera J., Paz V., Wool I.G.
Biochem. Biophys. Res. Commun. 200:1498-1504(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Structures of the human and Drosophila 80S ribosome."
Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M., Wilson D.N., Beckmann R.
Nature 497:80-85(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62691 mRNA. Translation: CAA44568.1. Frameshift.
X84407 mRNA. Translation: CAA59127.1.
AY208299 mRNA. Translation: AAO48936.1.
AB062400 mRNA. Translation: BAB93487.1.
BC001697 mRNA. Translation: AAH01697.1.
BC030569 mRNA. Translation: AAH30569.1.
BC046113 mRNA. Translation: AAH46113.1.
BC105273 mRNA. Translation: AAI05274.1.
BC105292 mRNA. Translation: AAI05293.1.
AB007154 Genomic DNA. Translation: BAA28592.1.
CCDSCCDS10571.1.
PIRS52339.
RefSeqNP_001010.2. NM_001019.4.
NP_001025180.1. NM_001030009.1.
UniGeneHs.370504.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Aelectron microscopy5.00W1-130[»]
ProteinModelPortalP62244.
SMRP62244. Positions 2-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112124. 140 interactions.
IntActP62244. 15 interactions.
MINTMINT-1036414.
STRING9606.ENSP00000318646.

PTM databases

PhosphoSiteP62244.

Polymorphism databases

DMDM50403624.

2D gel databases

SWISS-2DPAGEP62244.

Proteomic databases

MaxQBP62244.
PaxDbP62244.
PeptideAtlasP62244.
PRIDEP62244.

Protocols and materials databases

DNASU6210.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322989; ENSP00000318646; ENSG00000134419.
ENST00000563390; ENSP00000457000; ENSG00000134419.
ENST00000565420; ENSP00000458115; ENSG00000134419.
ENST00000572008; ENSP00000458528; ENSG00000134419.
GeneID6210.
KEGGhsa:6210.
UCSCuc002dfh.1. human.

Organism-specific databases

CTD6210.
GeneCardsGC16M018701.
H-InvDBHIX0033054.
HGNCHGNC:10389. RPS15A.
HPAHPA047103.
MIM603674. gene.
neXtProtNX_P62244.
PharmGKBPA34788.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0096.
HOGENOMHOG000204097.
HOVERGENHBG056618.
InParanoidP62244.
KOK02957.
OMALPAKNFG.
OrthoDBEOG77Q4ZM.
PhylomeDBP62244.
TreeFamTF300067.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.
REACT_17015. Metabolism of proteins.
REACT_1762. 3' -UTR-mediated translational regulation.
REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressP62244.
BgeeP62244.
CleanExHS_RPS15A.
GenevestigatorP62244.

Family and domain databases

HAMAPMF_01302_A. Ribosomal_S8_A.
InterProIPR000630. Ribosomal_S8.
[Graphical view]
PANTHERPTHR11758. PTHR11758. 1 hit.
PfamPF00410. Ribosomal_S8. 1 hit.
[Graphical view]
SUPFAMSSF56047. SSF56047. 1 hit.
PROSITEPS00053. RIBOSOMAL_S8. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiRPS15A.
GenomeRNAi6210.
NextBio24123.
PMAP-CutDBP62244.
PROP62244.
SOURCESearch...

Entry information

Entry nameRS15A_HUMAN
AccessionPrimary (citable) accession number: P62244
Secondary accession number(s): P39027 expand/collapse secondary AC list , P39031, Q3MHD9, Q8C023, Q9BV24
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM